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Fusion gene ID: 14510 |
FusionGeneSummary for GCNT2_OSM |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GCNT2_OSM | Fusion gene ID: 14510 | Hgene | Tgene | Gene symbol | GCNT2 | OSM | Gene ID | 2651 | 83605 |
| Gene name | glucosaminyl (N-acetyl) transferase 2 (I blood group) | CCM2 scaffold protein | |
| Synonyms | CCAT|CTRCT13|GCNT2C|GCNT5|IGNT|II|NACGT1|NAGCT1|ULG3|bA360O19.2|bA421M1.1 | C7orf22|OSM|PP10187 | |
| Cytomap | 6p24.3-p24.2 | 7p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferaseI beta-1,6-N-acetylglucosaminyltransferaseIi blood groupbeta-1,6-N-acetylglucosaminyltransferase 2glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | cerebral cavernous malformations 2 proteinCCM2 scaffolding proteincerebral cavernous malformation 2malcaverninosmosensing scaffold for MEKK3 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8N0V5 | P13725 | |
| Ensembl transtripts involved in fusion gene | ENST00000410107, ENST00000397423, ENST00000495262, ENST00000379597, ENST00000316170, ENST00000265012, | ENST00000215781, ENST00000403389, ENST00000403463, | |
| Fusion gene scores | * DoF score | 3 X 4 X 2=24 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: GCNT2 [Title/Abstract] AND OSM [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-55-6978-01A | GCNT2 | chr6 | 10530069 | + | OSM | chr22 | 30661133 | - |
| TCGA | LD | LUAD | TCGA-55-6978-01A | GCNT2 | chr6 | 10529074 | + | OSM | chr22 | 30661133 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000410107 | ENST00000215781 | GCNT2 | chr6 | 10530069 | + | OSM | chr22 | 30661133 | - |
| intron-5UTR | ENST00000410107 | ENST00000403389 | GCNT2 | chr6 | 10530069 | + | OSM | chr22 | 30661133 | - |
| intron-intron | ENST00000410107 | ENST00000403463 | GCNT2 | chr6 | 10530069 | + | OSM | chr22 | 30661133 | - |
| intron-3CDS | ENST00000397423 | ENST00000215781 | GCNT2 | chr6 | 10530069 | + | OSM | chr22 | 30661133 | - |
| intron-5UTR | ENST00000397423 | ENST00000403389 | GCNT2 | chr6 | 10530069 | + | OSM | chr22 | 30661133 | - |
| intron-intron | ENST00000397423 | ENST00000403463 | GCNT2 | chr6 | 10530069 | + | OSM | chr22 | 30661133 | - |
| In-frame | ENST00000495262 | ENST00000215781 | GCNT2 | chr6 | 10530069 | + | OSM | chr22 | 30661133 | - |
| 5CDS-5UTR | ENST00000495262 | ENST00000403389 | GCNT2 | chr6 | 10530069 | + | OSM | chr22 | 30661133 | - |
| 5CDS-intron | ENST00000495262 | ENST00000403463 | GCNT2 | chr6 | 10530069 | + | OSM | chr22 | 30661133 | - |
| In-frame | ENST00000379597 | ENST00000215781 | GCNT2 | chr6 | 10530069 | + | OSM | chr22 | 30661133 | - |
| 5CDS-5UTR | ENST00000379597 | ENST00000403389 | GCNT2 | chr6 | 10530069 | + | OSM | chr22 | 30661133 | - |
| 5CDS-intron | ENST00000379597 | ENST00000403463 | GCNT2 | chr6 | 10530069 | + | OSM | chr22 | 30661133 | - |
| intron-3CDS | ENST00000316170 | ENST00000215781 | GCNT2 | chr6 | 10530069 | + | OSM | chr22 | 30661133 | - |
| intron-5UTR | ENST00000316170 | ENST00000403389 | GCNT2 | chr6 | 10530069 | + | OSM | chr22 | 30661133 | - |
| intron-intron | ENST00000316170 | ENST00000403463 | GCNT2 | chr6 | 10530069 | + | OSM | chr22 | 30661133 | - |
| intron-3CDS | ENST00000265012 | ENST00000215781 | GCNT2 | chr6 | 10530069 | + | OSM | chr22 | 30661133 | - |
| intron-5UTR | ENST00000265012 | ENST00000403389 | GCNT2 | chr6 | 10530069 | + | OSM | chr22 | 30661133 | - |
| intron-intron | ENST00000265012 | ENST00000403463 | GCNT2 | chr6 | 10530069 | + | OSM | chr22 | 30661133 | - |
| intron-3CDS | ENST00000410107 | ENST00000215781 | GCNT2 | chr6 | 10529074 | + | OSM | chr22 | 30661133 | - |
| intron-5UTR | ENST00000410107 | ENST00000403389 | GCNT2 | chr6 | 10529074 | + | OSM | chr22 | 30661133 | - |
| intron-intron | ENST00000410107 | ENST00000403463 | GCNT2 | chr6 | 10529074 | + | OSM | chr22 | 30661133 | - |
| 3UTR-3CDS | ENST00000397423 | ENST00000215781 | GCNT2 | chr6 | 10529074 | + | OSM | chr22 | 30661133 | - |
| 3UTR-5UTR | ENST00000397423 | ENST00000403389 | GCNT2 | chr6 | 10529074 | + | OSM | chr22 | 30661133 | - |
| 3UTR-intron | ENST00000397423 | ENST00000403463 | GCNT2 | chr6 | 10529074 | + | OSM | chr22 | 30661133 | - |
| 5UTR-3CDS | ENST00000495262 | ENST00000215781 | GCNT2 | chr6 | 10529074 | + | OSM | chr22 | 30661133 | - |
| 5UTR-5UTR | ENST00000495262 | ENST00000403389 | GCNT2 | chr6 | 10529074 | + | OSM | chr22 | 30661133 | - |
| 5UTR-intron | ENST00000495262 | ENST00000403463 | GCNT2 | chr6 | 10529074 | + | OSM | chr22 | 30661133 | - |
| 5UTR-3CDS | ENST00000379597 | ENST00000215781 | GCNT2 | chr6 | 10529074 | + | OSM | chr22 | 30661133 | - |
| 5UTR-5UTR | ENST00000379597 | ENST00000403389 | GCNT2 | chr6 | 10529074 | + | OSM | chr22 | 30661133 | - |
| 5UTR-intron | ENST00000379597 | ENST00000403463 | GCNT2 | chr6 | 10529074 | + | OSM | chr22 | 30661133 | - |
| intron-3CDS | ENST00000316170 | ENST00000215781 | GCNT2 | chr6 | 10529074 | + | OSM | chr22 | 30661133 | - |
| intron-5UTR | ENST00000316170 | ENST00000403389 | GCNT2 | chr6 | 10529074 | + | OSM | chr22 | 30661133 | - |
| intron-intron | ENST00000316170 | ENST00000403463 | GCNT2 | chr6 | 10529074 | + | OSM | chr22 | 30661133 | - |
| intron-3CDS | ENST00000265012 | ENST00000215781 | GCNT2 | chr6 | 10529074 | + | OSM | chr22 | 30661133 | - |
| intron-5UTR | ENST00000265012 | ENST00000403389 | GCNT2 | chr6 | 10529074 | + | OSM | chr22 | 30661133 | - |
| intron-intron | ENST00000265012 | ENST00000403463 | GCNT2 | chr6 | 10529074 | + | OSM | chr22 | 30661133 | - |
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FusionProtFeatures for GCNT2_OSM |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GCNT2 | OSM |
| Branching enzyme that converts linear into branchedpoly-N-acetyllactosaminoglycans. Introduces the blood group Iantigen during embryonic development. It is closely associatedwith the development and maturation of erythroid cells.{ECO:0000269|PubMed:7579796, ECO:0000269|PubMed:8449405}. Isoform C: Determines the expression of the blood groupI antigen in erythrocytes. {ECO:0000269|PubMed:12468428}. | Growth regulator. Inhibits the proliferation of a numberof tumor cell lines. Stimulates proliferation of AIDS-KS cells. Itregulates cytokine production, including IL-6, G-CSF and GM-CSFfrom endothelial cells. Uses both type I OSM receptor(heterodimers composed of LIPR and IL6ST) and type II OSM receptor(heterodimers composed of OSMR and IL6ST). Involved in thematuration of fetal hepatocytes, thereby promoting liverdevelopment and regeneration (By similarity). {ECO:0000250,ECO:0000269|PubMed:1542792, ECO:0000269|PubMed:1542793}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GCNT2_OSM |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GCNT2_ENST00000495262_chr6_10530069_+_OSM_ENST00000215781_chr22_30661133_-_550aa MMGSWKHCLFSASLISALIFVFVYNTELWENKRFLRAALSNASLLAEACHQIFEGKVFYPTENALKTTLDEATCYEYMVRSHYVTETLSE EEAGFPLAYTVTIHKDFGTFERLFRAIYMPQNVYCVHLDQKATDAFKGAVKQLLSCFPNAFLASKKESVVYGGISRLQADLNCLEDLVAS EVPWKYVINTCGQDFPLKTNREIVQYLKGFKGKNITPGVLPPDHAVGRTKYVHQELLNHKNSYVIKTTKLKTPPPHDMVIYFGTAYVALT RDFANFVLQDQLALDLLSWSKDTYSPDEHFWVTLNRIPGLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQ GLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCM AQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKR >In-frame_GCNT2_ENST00000379597_chr6_10530069_+_OSM_ENST00000215781_chr22_30661133_-_550aa MMGSWKHCLFSASLISALIFVFVYNTELWENKRFLRAALSNASLLAEACHQIFEGKVFYPTENALKTTLDEATCYEYMVRSHYVTETLSE EEAGFPLAYTVTIHKDFGTFERLFRAIYMPQNVYCVHLDQKATDAFKGAVKQLLSCFPNAFLASKKESVVYGGISRLQADLNCLEDLVAS EVPWKYVINTCGQDFPLKTNREIVQYLKGFKGKNITPGVLPPDHAVGRTKYVHQELLNHKNSYVIKTTKLKTPPPHDMVIYFGTAYVALT RDFANFVLQDQLALDLLSWSKDTYSPDEHFWVTLNRIPGLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQ GLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCM AQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GCNT2_ENST00000495262_chr6_10530069_+_OSM_ENST00000215781_chr22_30661133_-_1650nt ATGATGGGCTCTTGGAAGCACTGTCTTTTTAGCGCGTCTCTTATCTCTGCCCTGATTTTTGTATTTGTTTACAATACTGAGTTATGGGAG AATAAACGTTTTCTGAGGGCAGCTCTGTCCAATGCTTCACTGTTAGCAGAAGCCTGTCATCAGATTTTTGAGGGGAAAGTTTTTTACCCA ACAGAAAATGCATTGAAAACTACCCTTGATGAAGCTACCTGCTATGAGTACATGGTTCGAAGCCACTATGTAACAGAAACACTCTCTGAA GAAGAGGCTGGGTTCCCTTTAGCTTACACAGTGACCATCCACAAAGACTTCGGCACTTTTGAGAGGCTCTTCAGGGCGATTTATATGCCC CAAAATGTCTACTGTGTGCACCTGGATCAGAAGGCGACGGATGCCTTTAAAGGTGCAGTGAAACAGTTACTCAGCTGCTTCCCAAATGCT TTTCTGGCTTCCAAGAAGGAGTCGGTTGTCTATGGGGGGATCTCCAGGCTCCAGGCTGACCTGAACTGCCTGGAAGACCTTGTGGCCTCT GAAGTTCCCTGGAAGTATGTCATCAACACCTGCGGGCAAGACTTTCCCCTGAAAACCAACAGGGAAATAGTTCAGTATCTGAAGGGATTT AAAGGGAAAAATATCACCCCCGGAGTGCTGCCTCCTGACCACGCTGTTGGACGGACTAAATACGTCCACCAAGAACTGTTAAACCACAAA AATTCCTACGTGATTAAAACAACAAAATTAAAAACTCCTCCTCCTCATGACATGGTGATTTACTTTGGCACGGCCTACGTGGCTCTCACA AGGGACTTTGCTAACTTCGTCCTCCAAGACCAGCTCGCACTTGACTTACTCTCCTGGTCCAAGGACACCTACAGCCCCGACGAACATTTC TGGGTGACACTCAACAGGATTCCCGGTCTGGTCCTTGCACTCCTGTTTCCAAGCATGGCGAGCATGGCGGCTATAGGCAGCTGCTCGAAA GAGTACCGCGTGCTCCTTGGCCAGCTCCAGAAGCAGACAGATCTCATGCAGGACACCAGCAGACTCCTGGACCCCTATATACGTATCCAA GGCCTGGATGTTCCTAAACTGAGAGAGCACTGCAGGGAGCGCCCCGGGGCCTTCCCCAGTGAGGAGACCCTGAGGGGGCTGGGCAGGCGG GGCTTCCTGCAGACCCTCAATGCCACACTGGGCTGCGTCCTGCACAGACTGGCCGACTTAGAGCAGCGCCTCCCCAAGGCCCAGGATTTG GAGAGGTCTGGGCTGAACATCGAGGACTTGGAGAAGCTGCAGATGGCGAGGCCGAACATCCTCGGGCTCAGGAACAACATCTACTGCATG GCCCAGCTGCTGGACAACTCAGACACGGCTGAGCCCACGAAGGCTGGCCGGGGGGCCTCTCAGCCGCCCACCCCCACCCCTGCCTCGGAT GCTTTTCAGCGCAAGCTGGAGGGCTGCAGGTTCCTGCATGGCTACCATCGCTTCATGCACTCAGTGGGGCGGGTCTTCAGCAAGTGGGGG GAGAGCCCGAACCGGAGCCGGAGACACAGCCCCCACCAGGCCCTGAGGAAGGGGGTGCGCAGGACCAGACCCTCCAGGAAAGGCAAGAGA >In-frame_GCNT2_ENST00000379597_chr6_10530069_+_OSM_ENST00000215781_chr22_30661133_-_1650nt ATGATGGGCTCTTGGAAGCACTGTCTTTTTAGCGCGTCTCTTATCTCTGCCCTGATTTTTGTATTTGTTTACAATACTGAGTTATGGGAG AATAAACGTTTTCTGAGGGCAGCTCTGTCCAATGCTTCACTGTTAGCAGAAGCCTGTCATCAGATTTTTGAGGGGAAAGTTTTTTACCCA ACAGAAAATGCATTGAAAACTACCCTTGATGAAGCTACCTGCTATGAGTACATGGTTCGAAGCCACTATGTAACAGAAACACTCTCTGAA GAAGAGGCTGGGTTCCCTTTAGCTTACACAGTGACCATCCACAAAGACTTCGGCACTTTTGAGAGGCTCTTCAGGGCGATTTATATGCCC CAAAATGTCTACTGTGTGCACCTGGATCAGAAGGCGACGGATGCCTTTAAAGGTGCAGTGAAACAGTTACTCAGCTGCTTCCCAAATGCT TTTCTGGCTTCCAAGAAGGAGTCGGTTGTCTATGGGGGGATCTCCAGGCTCCAGGCTGACCTGAACTGCCTGGAAGACCTTGTGGCCTCT GAAGTTCCCTGGAAGTATGTCATCAACACCTGCGGGCAAGACTTTCCCCTGAAAACCAACAGGGAAATAGTTCAGTATCTGAAGGGATTT AAAGGGAAAAATATCACCCCCGGAGTGCTGCCTCCTGACCACGCTGTTGGACGGACTAAATACGTCCACCAAGAACTGTTAAACCACAAA AATTCCTACGTGATTAAAACAACAAAATTAAAAACTCCTCCTCCTCATGACATGGTGATTTACTTTGGCACGGCCTACGTGGCTCTCACA AGGGACTTTGCTAACTTCGTCCTCCAAGACCAGCTCGCACTTGACTTACTCTCCTGGTCCAAGGACACCTACAGCCCCGACGAACATTTC TGGGTGACACTCAACAGGATTCCCGGTCTGGTCCTTGCACTCCTGTTTCCAAGCATGGCGAGCATGGCGGCTATAGGCAGCTGCTCGAAA GAGTACCGCGTGCTCCTTGGCCAGCTCCAGAAGCAGACAGATCTCATGCAGGACACCAGCAGACTCCTGGACCCCTATATACGTATCCAA GGCCTGGATGTTCCTAAACTGAGAGAGCACTGCAGGGAGCGCCCCGGGGCCTTCCCCAGTGAGGAGACCCTGAGGGGGCTGGGCAGGCGG GGCTTCCTGCAGACCCTCAATGCCACACTGGGCTGCGTCCTGCACAGACTGGCCGACTTAGAGCAGCGCCTCCCCAAGGCCCAGGATTTG GAGAGGTCTGGGCTGAACATCGAGGACTTGGAGAAGCTGCAGATGGCGAGGCCGAACATCCTCGGGCTCAGGAACAACATCTACTGCATG GCCCAGCTGCTGGACAACTCAGACACGGCTGAGCCCACGAAGGCTGGCCGGGGGGCCTCTCAGCCGCCCACCCCCACCCCTGCCTCGGAT GCTTTTCAGCGCAAGCTGGAGGGCTGCAGGTTCCTGCATGGCTACCATCGCTTCATGCACTCAGTGGGGCGGGTCTTCAGCAAGTGGGGG GAGAGCCCGAACCGGAGCCGGAGACACAGCCCCCACCAGGCCCTGAGGAAGGGGGTGCGCAGGACCAGACCCTCCAGGAAAGGCAAGAGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GCNT2_ENST00000495262_chr6_10530069_+_OSM_ENST00000215781_chr22_30661133_-_3239nt AAACAGGCTTACTGTGTTCACTGCTGGACGCCTCTGGGCAATCTTACCCTCCTGGGAACTGAGAGAGACAATGCTAGGAGCCAGAAACAT GAGGAATACATGAGCTCGGCGCCAATGGAACATGCTTTCACACCGGGTGCAGCTAACCACCACATCATACAAAACTCGTCGCTGACGTTT TAGATGTATAATCTGATTGGCATGGACTCACAGAGGAGGGAGTAAGGGAAGAGTAAGAAGATTTCAAAGGAGAGACACAGGTTGCAGGTT AGCAGGAGAACAGGCAAGCCAAATGCAAAGGAGCCACTTCAGAAATGTGTCACAGAAAAGTGAAAATGCAACCTAGTGGTAAGTGAAGAG GGGAAGAAGAAAGAAAAAGGACCAGAACCGTGAACTGAAGGGACAGGGAACAGCCAGACGAGAGCTTCAGCCATCACGAGGATGATTTCG GAACCTGGAGAAAATGTAAGTTAAATATATCTACACTCTGATCCTATCTCAAGAGAGAGATATTTTACTCATTTCCTGGTTGTGAATGAT GGGCTCTTGGAAGCACTGTCTTTTTAGCGCGTCTCTTATCTCTGCCCTGATTTTTGTATTTGTTTACAATACTGAGTTATGGGAGAATAA ACGTTTTCTGAGGGCAGCTCTGTCCAATGCTTCACTGTTAGCAGAAGCCTGTCATCAGATTTTTGAGGGGAAAGTTTTTTACCCAACAGA AAATGCATTGAAAACTACCCTTGATGAAGCTACCTGCTATGAGTACATGGTTCGAAGCCACTATGTAACAGAAACACTCTCTGAAGAAGA GGCTGGGTTCCCTTTAGCTTACACAGTGACCATCCACAAAGACTTCGGCACTTTTGAGAGGCTCTTCAGGGCGATTTATATGCCCCAAAA TGTCTACTGTGTGCACCTGGATCAGAAGGCGACGGATGCCTTTAAAGGTGCAGTGAAACAGTTACTCAGCTGCTTCCCAAATGCTTTTCT GGCTTCCAAGAAGGAGTCGGTTGTCTATGGGGGGATCTCCAGGCTCCAGGCTGACCTGAACTGCCTGGAAGACCTTGTGGCCTCTGAAGT TCCCTGGAAGTATGTCATCAACACCTGCGGGCAAGACTTTCCCCTGAAAACCAACAGGGAAATAGTTCAGTATCTGAAGGGATTTAAAGG GAAAAATATCACCCCCGGAGTGCTGCCTCCTGACCACGCTGTTGGACGGACTAAATACGTCCACCAAGAACTGTTAAACCACAAAAATTC CTACGTGATTAAAACAACAAAATTAAAAACTCCTCCTCCTCATGACATGGTGATTTACTTTGGCACGGCCTACGTGGCTCTCACAAGGGA CTTTGCTAACTTCGTCCTCCAAGACCAGCTCGCACTTGACTTACTCTCCTGGTCCAAGGACACCTACAGCCCCGACGAACATTTCTGGGT GACACTCAACAGGATTCCCGGTCTGGTCCTTGCACTCCTGTTTCCAAGCATGGCGAGCATGGCGGCTATAGGCAGCTGCTCGAAAGAGTA CCGCGTGCTCCTTGGCCAGCTCCAGAAGCAGACAGATCTCATGCAGGACACCAGCAGACTCCTGGACCCCTATATACGTATCCAAGGCCT GGATGTTCCTAAACTGAGAGAGCACTGCAGGGAGCGCCCCGGGGCCTTCCCCAGTGAGGAGACCCTGAGGGGGCTGGGCAGGCGGGGCTT CCTGCAGACCCTCAATGCCACACTGGGCTGCGTCCTGCACAGACTGGCCGACTTAGAGCAGCGCCTCCCCAAGGCCCAGGATTTGGAGAG GTCTGGGCTGAACATCGAGGACTTGGAGAAGCTGCAGATGGCGAGGCCGAACATCCTCGGGCTCAGGAACAACATCTACTGCATGGCCCA GCTGCTGGACAACTCAGACACGGCTGAGCCCACGAAGGCTGGCCGGGGGGCCTCTCAGCCGCCCACCCCCACCCCTGCCTCGGATGCTTT TCAGCGCAAGCTGGAGGGCTGCAGGTTCCTGCATGGCTACCATCGCTTCATGCACTCAGTGGGGCGGGTCTTCAGCAAGTGGGGGGAGAG CCCGAACCGGAGCCGGAGACACAGCCCCCACCAGGCCCTGAGGAAGGGGGTGCGCAGGACCAGACCCTCCAGGAAAGGCAAGAGACTCAT GACCAGGGGACAGCTGCCCCGGTAGCCTCGAGAGCACCCCTTGCCGGTGAAGGATGCGGCAGGTGCTCTGTGGATGAGAGGAACCATCGC AGGATGACAGCTCCCGGGTCCCCAAACCTGTTCCCCTCTGCTACTAGCCACTGAGAAGTGCACTTTAAGAGGTGGGAGCTGGGCAGACCC CTCTACCTCCTCCAGGCTGGGAGACAGAGTCAGGCTGTTGCGCTCCCACCTCAGCCCCAAGTTCCCCAGGCCCAGTGGGGTGGCCGGGCG GGCCACGCGGGACCGACTTTCCATTGATTCAGGGGTCTGATGACACAGGCTGACTCATGGCCGGGCTGACTGCCCCCCTGCCTTGCTCCC CGAGGCCTGCCGGTCCTTCCCTCTCATGACTTGCAGGGCCGTTGCCCCCAGACTTCCTCCTTTCCGTGTTTCTGAAGGGGAGGTCACAGC CTGAGCTGGCCTCCTATGCCTCATCATGTCCCAAACCAGACACCTGGATGTCTGGGTGACCTCACTTTAGGCAGCTGTAACAGCGGCAGG GTGTCCCAGGAGCCCTGATCCGGGGGTCCAGGGAATGGAGCTCAGGTCCCAGGCCAGCCCCGAAGTCGCCACGTGGCCTGGGGCAGGTCA CTTTACCTCTGTGGACCTGTTTTCTCTTTGTGAAGCTAGGGAGTTAGAGGCTGTACAAGGCCCCCACTGCCTGTCGGTTGCTTGGATTCC CTGACGTAAGGTGGATATTAAAAATCTGTAAATCAGGACAGGTGGTGCAAATGGCGCTGGGAGGTGTACACGGAGGTCTCTGTAAAAGCA GACCCACCTCCCAGCGCCGGGAAGCCCGTCTTGGGTCCTCGCTGCTGGCTGCTCCCCCTGGTGGTGGATCCTGGAATTTTCTCACGCAGG AGCCATTGCTCTCCTAGAGGGGGTCTCAGAAACTGCGAGGCCAGTTCCTTGGAGGGACATGACTAATTTATCGATTTTTATCAATTTTTA >In-frame_GCNT2_ENST00000379597_chr6_10530069_+_OSM_ENST00000215781_chr22_30661133_-_3260nt ATATCTCTCCAGGCAGTATTCACATGCTTTAAACTGAAGCTCGTAGCTTGGCAGTGCAGTTTAAGCAAATAAACTCAGGCTGTTGAACAC AATGATTAACAGGAAGCAGGGGAGGGGACATAGTTACTAGACTCTGGCCGGGACAAGAGGCTGAGGTTAAGGTCTTAGAGCCGATGACTT GCAGAATGGTCACCTCACCCACTTGTAATTTCATGGTGGGAACAGGTGGACCCCCTGGAATCAGAACCTCTCTGAGGACATCTGTTTTTG TGTAGACACAGGTTGCAGGTTAGCAGGAGAACAGGCAAGCCAAATGCAAAGGAGCCACTTCAGAAATGTGTCACAGAAAAGTGAAAATGC AACCTAGTGGTAAGTGAAGAGGGGAAGAAGAAAGAAAAAGGACCAGAACCGTGAACTGAAGGGACAGGGAACAGCCAGACGAGAGCTTCA GCCATCACGAGGATGATTTCGGAACCTGGAGAAAATGTAAGTTAAATATATCTACACTCTGATCCTATCTCAAGAGAGAGATATTTTACT CATTTCCTGGTTGTGAATGATGGGCTCTTGGAAGCACTGTCTTTTTAGCGCGTCTCTTATCTCTGCCCTGATTTTTGTATTTGTTTACAA TACTGAGTTATGGGAGAATAAACGTTTTCTGAGGGCAGCTCTGTCCAATGCTTCACTGTTAGCAGAAGCCTGTCATCAGATTTTTGAGGG GAAAGTTTTTTACCCAACAGAAAATGCATTGAAAACTACCCTTGATGAAGCTACCTGCTATGAGTACATGGTTCGAAGCCACTATGTAAC AGAAACACTCTCTGAAGAAGAGGCTGGGTTCCCTTTAGCTTACACAGTGACCATCCACAAAGACTTCGGCACTTTTGAGAGGCTCTTCAG GGCGATTTATATGCCCCAAAATGTCTACTGTGTGCACCTGGATCAGAAGGCGACGGATGCCTTTAAAGGTGCAGTGAAACAGTTACTCAG CTGCTTCCCAAATGCTTTTCTGGCTTCCAAGAAGGAGTCGGTTGTCTATGGGGGGATCTCCAGGCTCCAGGCTGACCTGAACTGCCTGGA AGACCTTGTGGCCTCTGAAGTTCCCTGGAAGTATGTCATCAACACCTGCGGGCAAGACTTTCCCCTGAAAACCAACAGGGAAATAGTTCA GTATCTGAAGGGATTTAAAGGGAAAAATATCACCCCCGGAGTGCTGCCTCCTGACCACGCTGTTGGACGGACTAAATACGTCCACCAAGA ACTGTTAAACCACAAAAATTCCTACGTGATTAAAACAACAAAATTAAAAACTCCTCCTCCTCATGACATGGTGATTTACTTTGGCACGGC CTACGTGGCTCTCACAAGGGACTTTGCTAACTTCGTCCTCCAAGACCAGCTCGCACTTGACTTACTCTCCTGGTCCAAGGACACCTACAG CCCCGACGAACATTTCTGGGTGACACTCAACAGGATTCCCGGTCTGGTCCTTGCACTCCTGTTTCCAAGCATGGCGAGCATGGCGGCTAT AGGCAGCTGCTCGAAAGAGTACCGCGTGCTCCTTGGCCAGCTCCAGAAGCAGACAGATCTCATGCAGGACACCAGCAGACTCCTGGACCC CTATATACGTATCCAAGGCCTGGATGTTCCTAAACTGAGAGAGCACTGCAGGGAGCGCCCCGGGGCCTTCCCCAGTGAGGAGACCCTGAG GGGGCTGGGCAGGCGGGGCTTCCTGCAGACCCTCAATGCCACACTGGGCTGCGTCCTGCACAGACTGGCCGACTTAGAGCAGCGCCTCCC CAAGGCCCAGGATTTGGAGAGGTCTGGGCTGAACATCGAGGACTTGGAGAAGCTGCAGATGGCGAGGCCGAACATCCTCGGGCTCAGGAA CAACATCTACTGCATGGCCCAGCTGCTGGACAACTCAGACACGGCTGAGCCCACGAAGGCTGGCCGGGGGGCCTCTCAGCCGCCCACCCC CACCCCTGCCTCGGATGCTTTTCAGCGCAAGCTGGAGGGCTGCAGGTTCCTGCATGGCTACCATCGCTTCATGCACTCAGTGGGGCGGGT CTTCAGCAAGTGGGGGGAGAGCCCGAACCGGAGCCGGAGACACAGCCCCCACCAGGCCCTGAGGAAGGGGGTGCGCAGGACCAGACCCTC CAGGAAAGGCAAGAGACTCATGACCAGGGGACAGCTGCCCCGGTAGCCTCGAGAGCACCCCTTGCCGGTGAAGGATGCGGCAGGTGCTCT GTGGATGAGAGGAACCATCGCAGGATGACAGCTCCCGGGTCCCCAAACCTGTTCCCCTCTGCTACTAGCCACTGAGAAGTGCACTTTAAG AGGTGGGAGCTGGGCAGACCCCTCTACCTCCTCCAGGCTGGGAGACAGAGTCAGGCTGTTGCGCTCCCACCTCAGCCCCAAGTTCCCCAG GCCCAGTGGGGTGGCCGGGCGGGCCACGCGGGACCGACTTTCCATTGATTCAGGGGTCTGATGACACAGGCTGACTCATGGCCGGGCTGA CTGCCCCCCTGCCTTGCTCCCCGAGGCCTGCCGGTCCTTCCCTCTCATGACTTGCAGGGCCGTTGCCCCCAGACTTCCTCCTTTCCGTGT TTCTGAAGGGGAGGTCACAGCCTGAGCTGGCCTCCTATGCCTCATCATGTCCCAAACCAGACACCTGGATGTCTGGGTGACCTCACTTTA GGCAGCTGTAACAGCGGCAGGGTGTCCCAGGAGCCCTGATCCGGGGGTCCAGGGAATGGAGCTCAGGTCCCAGGCCAGCCCCGAAGTCGC CACGTGGCCTGGGGCAGGTCACTTTACCTCTGTGGACCTGTTTTCTCTTTGTGAAGCTAGGGAGTTAGAGGCTGTACAAGGCCCCCACTG CCTGTCGGTTGCTTGGATTCCCTGACGTAAGGTGGATATTAAAAATCTGTAAATCAGGACAGGTGGTGCAAATGGCGCTGGGAGGTGTAC ACGGAGGTCTCTGTAAAAGCAGACCCACCTCCCAGCGCCGGGAAGCCCGTCTTGGGTCCTCGCTGCTGGCTGCTCCCCCTGGTGGTGGAT CCTGGAATTTTCTCACGCAGGAGCCATTGCTCTCCTAGAGGGGGTCTCAGAAACTGCGAGGCCAGTTCCTTGGAGGGACATGACTAATTT ATCGATTTTTATCAATTTTTATCAGTTTTATATTTATAAGCCTTATTTATGATGTATATTTAATGTTAATATTGTGCAAACTTATATTTA |
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FusionGenePPI for GCNT2_OSM |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GCNT2 | PARK2, ATP2A1, METTL9, GHITM, COL14A1, TRIM68, FAM3C, HLA-DPB1, TMEM79, TRIM25 | OSM | LIFR, TNNT1, APP, C1QBP, UBE2O, IL6ST, C5orf22, ZNF579, TRPM3, COL4A6, OSMR |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GCNT2_OSM |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GCNT2_OSM |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GCNT2 | C3805373 | CATARACT 13 WITH ADULT i PHENOTYPE | 1 | UNIPROT |
| Tgene | OSM | C0011616 | Contact Dermatitis | 1 | CTD_human |
| Tgene | OSM | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | OSM | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | OSM | C0263454 | Chloracne | 1 | CTD_human |
| Tgene | OSM | C3495559 | Juvenile arthritis | 1 | CTD_human |
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