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Fusion gene ID: 14476 |
FusionGeneSummary for GBAP1_CABIN1 |
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Fusion gene information | Fusion gene name: GBAP1_CABIN1 | Fusion gene ID: 14476 | Hgene | Tgene | Gene symbol | GBAP1 | CABIN1 | Gene ID | 2630 | 23523 |
Gene name | glucosylceramidase beta pseudogene 1 | calcineurin binding protein 1 | |
Synonyms | GBAP | CAIN|KB-318B8.7|PPP3IN | |
Cytomap | 1q22 | 22q11.23 | |
Type of gene | pseudo | protein-coding | |
Description | glucosidase, beta, acid pseudogene 1glucosidase, beta; acid, pseudogeneglucosylceramidase-like protein | calcineurin-binding protein cabin-1calcineurin binding protein cabin 1calcineurin inhibitor | |
Modification date | 20180329 | 20180523 | |
UniProtAcc | Q9Y6J0 | ||
Ensembl transtripts involved in fusion gene | ENST00000486869, | ENST00000263119, ENST00000405822, ENST00000398319, ENST00000337989, ENST00000485008, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 7 X 5 X 4=140 |
# samples | 1 | 6 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/140*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GBAP1 [Title/Abstract] AND CABIN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CABIN1 | GO:0006336 | DNA replication-independent nucleosome assembly | 14718166 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | GBM | TCGA-06-0141-01A | GBAP1 | chr1 | 155186175 | - | CABIN1 | chr22 | 24574329 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3UTR | ENST00000486869 | ENST00000263119 | GBAP1 | chr1 | 155186175 | - | CABIN1 | chr22 | 24574329 | + |
5UTR-3UTR | ENST00000486869 | ENST00000405822 | GBAP1 | chr1 | 155186175 | - | CABIN1 | chr22 | 24574329 | + |
5UTR-3UTR | ENST00000486869 | ENST00000398319 | GBAP1 | chr1 | 155186175 | - | CABIN1 | chr22 | 24574329 | + |
5UTR-3UTR | ENST00000486869 | ENST00000337989 | GBAP1 | chr1 | 155186175 | - | CABIN1 | chr22 | 24574329 | + |
5UTR-intron | ENST00000486869 | ENST00000485008 | GBAP1 | chr1 | 155186175 | - | CABIN1 | chr22 | 24574329 | + |
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FusionProtFeatures for GBAP1_CABIN1 |
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Hgene | Tgene |
GBAP1 | CABIN1 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | May be required for replication-independent chromatinassembly. May serve as a negative regulator of T-cell receptor(TCR) signaling via inhibition of calcineurin. Inhibition ofactivated calcineurin is dependent on both PKC and calciumsignals. Acts as a negative regulator of p53/TP53 by keeping p53in an inactive state on chromatin at promoters of a subset of it'starget genes. {ECO:0000269|PubMed:14718166,ECO:0000269|PubMed:9655484}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GBAP1_CABIN1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GBAP1_CABIN1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GBAP1 | CABIN1 | MEF2BNB-MEF2B, HDAC1, HDAC2, SIN3A, MEF2D, DNM1, AMPH, AP1B1, PPP3CA, SUV39H1, HIRA, CAMK4, YWHAQ, H3F3A, UBN1, POLR2A, TFAP4, HECW2, MEF2B, EAF1, HIST1H3A, ASF1A, MEF2A, NFATC2, ASF1B, CDX1, XAGE1B, TLK2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GBAP1_CABIN1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GBAP1_CABIN1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CABIN1 | C0018800 | Cardiomegaly | 1 | CTD_human |
Tgene | CABIN1 | C0036341 | Schizophrenia | 1 | PSYGENET |