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Fusion gene ID: 14462 |
FusionGeneSummary for GATAD2B_S100A4 |
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Fusion gene information | Fusion gene name: GATAD2B_S100A4 | Fusion gene ID: 14462 | Hgene | Tgene | Gene symbol | GATAD2B | S100A4 | Gene ID | 57459 | 6275 |
Gene name | GATA zinc finger domain containing 2B | S100 calcium binding protein A4 | |
Synonyms | MRD18|P66beta|p68 | 18A2|42A|CAPL|FSP1|MTS1|P9KA|PEL98 | |
Cytomap | 1q21.3 | 1q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | transcriptional repressor p66-betaGATA zinc finger domain-containing protein 2Btranscription repressor p66 beta component of the MeCP1 complex | protein S100-A4S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog)calcium placental proteinfibroblast-specific protein-1leukemia multidrug resistance associated proteinmalignant transformation suppress | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q8WXI9 | P26447 | |
Ensembl transtripts involved in fusion gene | ENST00000368655, | ENST00000368715, ENST00000481009, ENST00000354332, ENST00000368716, ENST00000368714, | |
Fusion gene scores | * DoF score | 23 X 6 X 12=1656 | 3 X 2 X 2=12 |
# samples | 25 | 3 | |
** MAII score | log2(25/1656*10)=-2.72770267283724 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: GATAD2B [Title/Abstract] AND S100A4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | S100A4 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 15033494 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SKCM | TCGA-FS-A1YW-06A | GATAD2B | chr1 | 153895209 | - | S100A4 | chr1 | 153517285 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-5UTR | ENST00000368655 | ENST00000368715 | GATAD2B | chr1 | 153895209 | - | S100A4 | chr1 | 153517285 | - |
5UTR-5UTR | ENST00000368655 | ENST00000481009 | GATAD2B | chr1 | 153895209 | - | S100A4 | chr1 | 153517285 | - |
5UTR-5UTR | ENST00000368655 | ENST00000354332 | GATAD2B | chr1 | 153895209 | - | S100A4 | chr1 | 153517285 | - |
5UTR-5UTR | ENST00000368655 | ENST00000368716 | GATAD2B | chr1 | 153895209 | - | S100A4 | chr1 | 153517285 | - |
5UTR-5UTR | ENST00000368655 | ENST00000368714 | GATAD2B | chr1 | 153895209 | - | S100A4 | chr1 | 153517285 | - |
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FusionProtFeatures for GATAD2B_S100A4 |
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Hgene | Tgene |
GATAD2B | S100A4 |
Transcriptional repressor. Enhances MBD2-mediatedrepression. Efficient repression requires the presence of GATAD2A.Targets MBD3 to discrete loci in the nucleus. May play a role insynapse development. {ECO:0000269|PubMed:12183469,ECO:0000269|PubMed:16415179}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GATAD2B_S100A4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GATAD2B_S100A4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GATAD2B | MBD2, MBD3, RBBP7, RBBP4, MTA2, HDAC1, HDAC2, FOXP1, FOXP2, HIST2H2AC, HIST2H2BE, HIST1H3A, HIST1H4A, PARK7, CHD4, SOX2, MTA1, NDUFA2, NDUFA7, NOTCH1, MTA3, SMAD2, ZBTB1, PRKAB2, GOLGA2, TRIM27, TRAF1, CALCOCO2, TEX11, RPGRIP1, CEP70, USHBP1, BRCA1, SUZ12, EED, RNF2, SUMO2, SIRT6, ZNF219, PHF20L1, CHD3, CHD5, KPNA5, CDK2AP1, ZBTB33, MBD3L1, ZBTB46, NTRK1, GATAD2A, RBPMS, HIST1H3E, KPNA1, TCF20, HMG20A, ZMYND8, NFATC1, FOXC1, FOXG1, FOXJ2, FOXQ1, FOXS1, NFATC2, CPNE5, ZBED1, TXNIP, MAGEE1, FAM219A, L3MBTL2, QPRT, TCF19, IKZF1, IKZF3, CROT, CDC16, PSME3, NCAPH2, MTNR1A, TRIM25, UHRF2, ZNF827 | S100A4 | S100A1, BAG6, UNC119, TP53, PPFIBP1, H2AFX, MDM2, SMAD3, SMAD2, IGBP1, TOM1L2, UNK, SUGT1, PSMA1, SELENBP1, SNRPF, TRIP13, ZZEF1, CEP76, S100B, MOV10, NXF1, EGFR, HSPB1, SRPK2, XIAP, IGHG3, NPAT, CDK2, NR2C2, PHF12, S100A6, SUV39H1, DYNLL1, DNAJA3, DNAJB6, POP4, CNTRL, KAT7, WDFY3, SYNE2, BRD1, UQCR10, BBX, CORO7, PTGR2, ESCO2, RHOU, RHOA, NOV |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GATAD2B_S100A4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | S100A4 | P26447 | DB00831 | Trifluoperazine | Protein S100-A4 | small molecule | approved|investigational |
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RelatedDiseases for GATAD2B_S100A4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | S100A4 | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
Tgene | S100A4 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Tgene | S100A4 | C0022116 | Ischemia | 1 | CTD_human |
Tgene | S100A4 | C0022548 | Keloid | 1 | CTD_human |
Tgene | S100A4 | C0025149 | Medulloblastoma | 1 | CTD_human |
Tgene | S100A4 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Tgene | S100A4 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | S100A4 | C0035222 | Respiratory Distress Syndrome, Adult | 1 | CTD_human |
Tgene | S100A4 | C0751895 | Vasospasm, Intracranial | 1 | CTD_human |