FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 14443

FusionGeneSummary for GATAD2A_ZNF93

check button Fusion gene summary
Fusion gene informationFusion gene name: GATAD2A_ZNF93
Fusion gene ID: 14443
HgeneTgene
Gene symbol

GATAD2A

ZNF93

Gene ID

54815

81931

Gene nameGATA zinc finger domain containing 2Azinc finger protein 93
Synonymsp66alphaHPF34|HTF34|TF34|ZNF505
Cytomap

19p13.11

19p12

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional repressor p66-alphaGATA zinc finger domain-containing protein 2Azinc finger protein 93zinc finger protein 505zinc finger protein HTF34
Modification date2018052320180522
UniProtAcc

Q86YP4

P35789

Ensembl transtripts involved in fusion geneENST00000252577, ENST00000360315, 
ENST00000537887, ENST00000404158, 
ENST00000358713, ENST00000429563, 
ENST00000473184, 
ENST00000592613, 
ENST00000591366, ENST00000592160, 
ENST00000343769, 
Fusion gene scores* DoF score13 X 8 X 9=9363 X 2 X 3=18
# samples 153
** MAII scorelog2(15/936*10)=-2.64154602908752
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GATAD2A [Title/Abstract] AND ZNF93 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGATAD2A

GO:0045892

negative regulation of transcription, DNA-templated

12183469

TgeneZNF93

GO:0045892

negative regulation of transcription, DNA-templated

25274305

TgeneZNF93

GO:0070895

negative regulation of transposon integration

25274305


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-09-1667-01CGATAD2Achr19

19516828

+ZNF93chr19

20043991

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000252577ENST00000592613GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000252577ENST00000591366GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000252577ENST00000592160GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000252577ENST00000343769GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000360315ENST00000592613GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000360315ENST00000591366GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000360315ENST00000592160GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000360315ENST00000343769GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000537887ENST00000592613GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000537887ENST00000591366GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000537887ENST00000592160GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000537887ENST00000343769GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000404158ENST00000592613GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000404158ENST00000591366GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000404158ENST00000592160GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000404158ENST00000343769GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000358713ENST00000592613GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000358713ENST00000591366GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000358713ENST00000592160GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000358713ENST00000343769GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000429563ENST00000592613GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000429563ENST00000591366GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000429563ENST00000592160GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000429563ENST00000343769GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000473184ENST00000592613GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000473184ENST00000591366GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000473184ENST00000592160GATAD2Achr19

19516828

+ZNF93chr19

20043991

+
intron-intronENST00000473184ENST00000343769GATAD2Achr19

19516828

+ZNF93chr19

20043991

+

Top

FusionProtFeatures for GATAD2A_ZNF93


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GATAD2A

Q86YP4

ZNF93

P35789

Transcriptional repressor. Enhances MBD2-mediatedrepression. Efficient repression requires the presence of GATAD2B.{ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179}. Transcription factor specifically required to represslong interspersed nuclear element 1 (L1) retrotransposons:recognizes and binds L1 sequences and repress their expression byrecruiting a repressive complex containing TRIM28/KAP1(PubMed:25274305). Not able to repress expression of all subtypesof L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or oldersubtypes nor at the most recently evolved L1PA2 and L1Hs. 50% ofL1PA3 elements have lost the ZNF93-binding site, explaining whyZNF93 is not able to repress their expression (PubMed:25274305).{ECO:0000269|PubMed:25274305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for GATAD2A_ZNF93


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for GATAD2A_ZNF93


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GATAD2AMBD2, MBD3, HDAC1, RBBP4, RBBP7, HIST2H2AC, HIST2H2BE, HIST1H3A, HIST1H4A, CHD4, SOX2, CHD7, ELAVL1, MTA2, HDAC2, CHD3, MTA3, KRT40, OBSL1, PSME3, ZNF219, PHF20L1, FAM219A, MBD3L1, ZBTB46, CHD5, GATAD2B, MTA1, RUVBL1, KRAS, HIST1H3E, KPNA1, TCF20, CDK2AP1, HMG20A, ZMYND8, ZNF687, NABP2, RBPJ, NFATC2, ZNF592, APPBP2, CPNE5, IKZF1, DLD, TRIM25, ZNF827ZNF93FBL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GATAD2A_ZNF93


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for GATAD2A_ZNF93


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource