	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 14440

FusionGeneSummary for GATAD2A_SSBP4

Fusion gene summary

Fusion gene information	Fusion gene name: GATAD2A_SSBP4
	Fusion gene ID: 14440
		Hgene	Tgene
	Gene symbol	GATAD2A	SSBP4
	Gene ID	54815	170463
	Gene name	GATA zinc finger domain containing 2A	single stranded DNA binding protein 4
	Synonyms	p66alpha	-
	Cytomap	19p13.11	19p13.11
	Type of gene	protein-coding	protein-coding
	Description	transcriptional repressor p66-alphaGATA zinc finger domain-containing protein 2A	single-stranded DNA-binding protein 4
	Modification date	20180523	20180523
	UniProtAcc	Q86YP4	Q9BWG4
	Ensembl transtripts involved in fusion gene	ENST00000252577, ENST00000360315, ENST00000537887, ENST00000404158, ENST00000358713, ENST00000429563, ENST00000473184,	ENST00000348495, ENST00000270061, ENST00000598159, ENST00000599699,
Fusion gene scores	* DoF score	13 X 8 X 9=936	3 X 1 X 3=9
	# samples	15	3
	** MAII score	log2(15/936*10)=-2.64154602908752 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: GATAD2A [Title/Abstract] AND SSBP4 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GATAD2A	GO:0045892	negative regulation of transcription, DNA-templated	12183469

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	UCEC	TCGA-BG-A3PP-01A	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000252577	ENST00000348495	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
5UTR-3CDS	ENST00000252577	ENST00000270061	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
5UTR-3UTR	ENST00000252577	ENST00000598159	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
5UTR-intron	ENST00000252577	ENST00000599699	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
5UTR-3CDS	ENST00000360315	ENST00000348495	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
5UTR-3CDS	ENST00000360315	ENST00000270061	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
5UTR-3UTR	ENST00000360315	ENST00000598159	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
5UTR-intron	ENST00000360315	ENST00000599699	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
5UTR-3CDS	ENST00000537887	ENST00000348495	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
5UTR-3CDS	ENST00000537887	ENST00000270061	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
5UTR-3UTR	ENST00000537887	ENST00000598159	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
5UTR-intron	ENST00000537887	ENST00000599699	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
intron-3CDS	ENST00000404158	ENST00000348495	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
intron-3CDS	ENST00000404158	ENST00000270061	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
intron-3UTR	ENST00000404158	ENST00000598159	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
intron-intron	ENST00000404158	ENST00000599699	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
intron-3CDS	ENST00000358713	ENST00000348495	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
intron-3CDS	ENST00000358713	ENST00000270061	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
intron-3UTR	ENST00000358713	ENST00000598159	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
intron-intron	ENST00000358713	ENST00000599699	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
intron-3CDS	ENST00000429563	ENST00000348495	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
intron-3CDS	ENST00000429563	ENST00000270061	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
intron-3UTR	ENST00000429563	ENST00000598159	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
intron-intron	ENST00000429563	ENST00000599699	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
intron-3CDS	ENST00000473184	ENST00000348495	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
intron-3CDS	ENST00000473184	ENST00000270061	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
intron-3UTR	ENST00000473184	ENST00000598159	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+
intron-intron	ENST00000473184	ENST00000599699	GATAD2A	chr19	19496947	+	SSBP4	chr19	18538161	+

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FusionProtFeatures for GATAD2A_SSBP4

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GATAD2A Q86YP4	SSBP4 Q9BWG4
Transcriptional repressor. Enhances MBD2-mediatedrepression. Efficient repression requires the presence of GATAD2B.{ECO:0000269\|PubMed:12183469, ECO:0000269\|PubMed:16415179}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for GATAD2A_SSBP4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GATAD2A_SSBP4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
GATAD2A	MBD2, MBD3, HDAC1, RBBP4, RBBP7, HIST2H2AC, HIST2H2BE, HIST1H3A, HIST1H4A, CHD4, SOX2, CHD7, ELAVL1, MTA2, HDAC2, CHD3, MTA3, KRT40, OBSL1, PSME3, ZNF219, PHF20L1, FAM219A, MBD3L1, ZBTB46, CHD5, GATAD2B, MTA1, RUVBL1, KRAS, HIST1H3E, KPNA1, TCF20, CDK2AP1, HMG20A, ZMYND8, ZNF687, NABP2, RBPJ, NFATC2, ZNF592, APPBP2, CPNE5, IKZF1, DLD, TRIM25, ZNF827	SSBP4	LDB1, IL36RN, ISL1, TFAP2B, LDB2, TRIM33, MOV10, LMX1B, IDI2, SSBP2, LHX1, MBNL1, ISL2, SSBP3, LHX8, LMO4, GM2A, LHX4, LHX9, LHX6, PIN1, LMO2

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for GATAD2A_SSBP4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for GATAD2A_SSBP4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 14440

FusionGeneSummary for GATAD2A_SSBP4

FusionProtFeatures for GATAD2A_SSBP4

FusionGeneSequence for GATAD2A_SSBP4

FusionGenePPI for GATAD2A_SSBP4

RelatedDrugs for GATAD2A_SSBP4

RelatedDiseases for GATAD2A_SSBP4