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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14424

FusionGeneSummary for GATA3_TAF3

check button Fusion gene summary
Fusion gene informationFusion gene name: GATA3_TAF3
Fusion gene ID: 14424
HgeneTgene
Gene symbol

GATA3

TAF3

Gene ID

2625

83860

Gene nameGATA binding protein 3TATA-box binding protein associated factor 3
SynonymsHDR|HDRSTAF140|TAFII-140|TAFII140
Cytomap

10p14

10p14

Type of geneprotein-codingprotein-coding
Descriptiontrans-acting T-cell-specific transcription factor GATA-3GATA-binding factor 3transcription initiation factor TFIID subunit 3140 kDa TATA box-binding protein-associated factorRNA polymerase II transcription factor TAFII140TAF(II)140TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDaTBP-associated f
Modification date2018052320180522
UniProtAcc

P23771

Q5VWG9

Ensembl transtripts involved in fusion geneENST00000379328, ENST00000346208, 
ENST00000461472, 		ENST00000344293, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 3 X 5=90
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GATA3 [Title/Abstract] AND TAF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGATA3

GO:0033600

negative regulation of mammary gland epithelial cell proliferation

19483726

HgeneGATA3

GO:0045893

positive regulation of transcription, DNA-templated

19723756|19805038

HgeneGATA3

GO:0045944

positive regulation of transcription by RNA polymerase II

19232384|20189993|20484083

HgeneGATA3

GO:0060231

mesenchymal to epithelial transition

20189993

HgeneGATA3

GO:0072676

lymphocyte migration

19805038

HgeneGATA3

GO:2000664

positive regulation of interleukin-5 secretion

20554961

HgeneGATA3

GO:2000667

positive regulation of interleukin-13 secretion

20554961

TgeneTAF3

GO:0000122

negative regulation of transcription by RNA polymerase II

18549481

TgeneTAF3

GO:0043433

negative regulation of DNA binding transcription factor activity

18549481

TgeneTAF3

GO:0051457

maintenance of protein location in nucleus

15870280


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AR-A1AP-01AGATA3chr10

8111561

+TAF3chr10

8055694

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000379328ENST00000344293GATA3chr10

8111561

+TAF3chr10

8055694

+
In-frameENST00000346208ENST00000344293GATA3chr10

8111561

+TAF3chr10

8055694

+
3UTR-3CDSENST00000461472ENST00000344293GATA3chr10

8111561

+TAF3chr10

8055694

+

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FusionProtFeatures for GATA3_TAF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GATA3

P23771

TAF3

Q5VWG9

Transcriptional activator which binds to the enhancer ofthe T-cell receptor alpha and delta genes. Binds to the consensussequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2)differentiation process following immune and inflammatoryresponses. {ECO:0000269|PubMed:23824597}. Transcription factor TFIID is one of the general factorsrequired for accurate and regulated initiation by RNA polymeraseII. TFIID is a multimeric protein complex that plays a centralrole in mediating promoter responses to various activators andrepressors. Required in complex with TBPL2 for the differentiationof myoblasts into myocytes. The complex replaces TFIID at specificpromoters at an early stage in the differentiation process.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGATA3chr10:8111561chr10:8055694ENST00000346208+56137_142349444Compositional biasNote=Poly-Ser
HgeneGATA3chr10:8111561chr10:8055694ENST00000346208+56322_326349444Compositional biasNote=Poly-Thr
HgeneGATA3chr10:8111561chr10:8055694ENST00000379328+56137_142350445Compositional biasNote=Poly-Ser
HgeneGATA3chr10:8111561chr10:8055694ENST00000379328+56322_326350445Compositional biasNote=Poly-Thr
HgeneGATA3chr10:8111561chr10:8055694ENST00000379328+56344_353350445MotifYxKxHxxxRP
HgeneGATA3chr10:8111561chr10:8055694ENST00000346208+56288_316349444RegionNote=Flexible linker
HgeneGATA3chr10:8111561chr10:8055694ENST00000379328+56288_316350445RegionNote=Flexible linker
HgeneGATA3chr10:8111561chr10:8055694ENST00000346208+56263_287349444Zinc fingerGATA-type 1
HgeneGATA3chr10:8111561chr10:8055694ENST00000346208+56317_341349444Zinc fingerGATA-type 2
HgeneGATA3chr10:8111561chr10:8055694ENST00000379328+56263_287350445Zinc fingerGATA-type 1
HgeneGATA3chr10:8111561chr10:8055694ENST00000379328+56317_341350445Zinc fingerGATA-type 2
TgeneTAF3chr10:8111561chr10:8055694ENST00000344293+47865_915856930Zinc fingerPHD-type

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGATA3chr10:8111561chr10:8055694ENST00000346208+56344_353349444MotifYxKxHxxxRP
TgeneTAF3chr10:8111561chr10:8055694ENST00000344293+47136_141856930Compositional biasNote=Poly-Glu
TgeneTAF3chr10:8111561chr10:8055694ENST00000344293+47163_168856930Compositional biasNote=Poly-Glu
TgeneTAF3chr10:8111561chr10:8055694ENST00000344293+47507_746856930Compositional biasNote=Lys-rich
TgeneTAF3chr10:8111561chr10:8055694ENST00000344293+47779_833856930Compositional biasNote=Pro-rich


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FusionGeneSequence for GATA3_TAF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GATA3_TAF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GATA3LMO1, LMO2, TAL1, BMI1, MDM2, HDAC3, HDAC5, TBX21, RARB, HDAC4, SP1, REPIN1, MYB, SPI1, BRCA1, USP21, FOXP3, PSMA3, CDK2, FBXW7, MAPK14, WEE1, FOXA1TAF3KHDRBS2, TAF10, TBP, TBPL2, KAT2A, TAF12, TAF13, SAP130, TAF7, CTCF, TAF5, TAF4, TAF6, TAF1, KPNA2, KPNB1, HIST3H3, HIST2H4A, MED26, NPM1, CDC23, NAP1L4, ANAPC10, CDC16, MZT1, TAF7L, TAF8, TAF11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneGATA3chr10:8111561chr10:8055694ENST00000346208+561_258349444TBX21
HgeneGATA3chr10:8111561chr10:8055694ENST00000379328+561_258350445TBX21


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GATA3_TAF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GATA3_TAF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGATA3C1840333Barakat syndrome3CTD_human;ORPHANET;UNIPROT
HgeneGATA3C0003873Rheumatoid Arthritis1CTD_human
HgeneGATA3C0019829Hodgkin Disease1CTD_human
HgeneGATA3C0021368Inflammation1CTD_human
HgeneGATA3C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
HgeneGATA3C0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
HgeneGATA3C0024667Animal Mammary Neoplasms1CTD_human
HgeneGATA3C0024668Mammary Neoplasms, Experimental1CTD_human