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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1442

FusionGeneSummary for ALB_TF

check button Fusion gene summary
Fusion gene informationFusion gene name: ALB_TF
Fusion gene ID: 1442
HgeneTgene
Gene symbol

ALB

TF

Gene ID

213

7018

Gene namealbumintransferrin
SynonymsHSA|PRO0883|PRO0903|PRO1341HEL-S-71p|PRO1557|PRO2086|TFQTL1
Cytomap

4q13.3

3q22.1

Type of geneprotein-codingprotein-coding
Descriptionserum albuminserotransferrinbeta-1 metal-binding globulinepididymis secretory sperm binding protein Li 71psiderophilin
Modification date2018052220180523
UniProtAcc

P02768

P02787

Ensembl transtripts involved in fusion geneENST00000295897, ENST00000415165, 
ENST00000503124, ENST00000509063, 
ENST00000401494, ENST00000505649, 
ENST00000402696, ENST00000264998, 
ENST00000475382, 
Fusion gene scores* DoF score19 X 15 X 3=8558 X 7 X 3=168
# samples 259
** MAII scorelog2(25/855*10)=-1.77399632511117
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALB [Title/Abstract] AND TF [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneALB

GO:0009267

cellular response to starvation

16245148

HgeneALB

GO:0019836

hemolysis by symbiont of host erythrocytes

16394536

HgeneALB

GO:0043066

negative regulation of apoptotic process

16153637

HgeneALB

GO:0051659

maintenance of mitochondrion location

16153637

TgeneTF

GO:0048260

positive regulation of receptor-mediated endocytosis

12704209


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI065112ALBchr4

74283820

-TFchr3

133497528

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000295897ENST00000402696ALBchr4

74283820

-TFchr3

133497528

+
5CDS-3UTRENST00000295897ENST00000264998ALBchr4

74283820

-TFchr3

133497528

+
5CDS-intronENST00000295897ENST00000475382ALBchr4

74283820

-TFchr3

133497528

+
5CDS-3UTRENST00000415165ENST00000402696ALBchr4

74283820

-TFchr3

133497528

+
5CDS-3UTRENST00000415165ENST00000264998ALBchr4

74283820

-TFchr3

133497528

+
5CDS-intronENST00000415165ENST00000475382ALBchr4

74283820

-TFchr3

133497528

+
5CDS-3UTRENST00000503124ENST00000402696ALBchr4

74283820

-TFchr3

133497528

+
5CDS-3UTRENST00000503124ENST00000264998ALBchr4

74283820

-TFchr3

133497528

+
5CDS-intronENST00000503124ENST00000475382ALBchr4

74283820

-TFchr3

133497528

+
5CDS-3UTRENST00000509063ENST00000402696ALBchr4

74283820

-TFchr3

133497528

+
5CDS-3UTRENST00000509063ENST00000264998ALBchr4

74283820

-TFchr3

133497528

+
5CDS-intronENST00000509063ENST00000475382ALBchr4

74283820

-TFchr3

133497528

+
5CDS-3UTRENST00000401494ENST00000402696ALBchr4

74283820

-TFchr3

133497528

+
5CDS-3UTRENST00000401494ENST00000264998ALBchr4

74283820

-TFchr3

133497528

+
5CDS-intronENST00000401494ENST00000475382ALBchr4

74283820

-TFchr3

133497528

+
3UTR-3UTRENST00000505649ENST00000402696ALBchr4

74283820

-TFchr3

133497528

+
3UTR-3UTRENST00000505649ENST00000264998ALBchr4

74283820

-TFchr3

133497528

+
3UTR-intronENST00000505649ENST00000475382ALBchr4

74283820

-TFchr3

133497528

+

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FusionProtFeatures for ALB_TF


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALB

P02768

TF

P02787

Transferrins are iron binding transport proteins whichcan bind two Fe(3+) ions in association with the binding of ananion, usually bicarbonate. It is responsible for the transport ofiron from sites of absorption and heme degradation to those ofstorage and utilization. Serum transferrin may also have a furtherrole in stimulating cell proliferation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ALB_TF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ALB_TF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ALB_TF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneALBP02768DB00493CefotaximeSerum albuminsmall moleculeapproved
HgeneALBP02768DB01045RifampicinSerum albuminsmall moleculeapproved
HgeneALBP02768DB03255PhenolSerum albuminsmall moleculeapproved|experimental
HgeneALBP02768DB00276AmsacrineSerum albuminsmall moleculeapproved|investigational
HgeneALBP02768DB00545PyridostigmineSerum albuminsmall moleculeapproved|investigational
HgeneALBP02768DB06713NorelgestrominSerum albuminsmall moleculeapproved|investigational
HgeneALBP02768DB11638ArtenimolSerum albuminsmall moleculeapproved|investigational
HgeneALBP02768DB00199ErythromycinSerum albuminsmall moleculeapproved|investigational|vet_approved
TgeneTFP02787DB00515CisplatinSerotransferrinsmall moleculeapproved
TgeneTFP02787DB01592IronSerotransferrinsmall moleculeapproved
TgeneTFP02787DB01370AluminiumSerotransferrinsmall moleculeapproved|investigational
TgeneTFP02787DB01593ZincSerotransferrinsmall moleculeapproved|investigational

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RelatedDiseases for ALB_TF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALBC0033687Proteinuria9CTD_human
HgeneALBC0017658Glomerulonephritis8CTD_human
HgeneALBC0022658Kidney Diseases8CTD_human
HgeneALBC0017665Membranous glomerulonephritis6CTD_human
HgeneALBC0027697Nephritis6CTD_human
HgeneALBC0027707Nephritis, Interstitial4CTD_human
HgeneALBC0038454Cerebrovascular accident4CTD_human
HgeneALBC0342185Hyperthyroxinemia, Familial Dysalbuminemic4CTD_human;UNIPROT
HgeneALBC0023893Liver Cirrhosis, Experimental3CTD_human
HgeneALBC0025290Aseptic Meningitis3CTD_human
HgeneALBC2609414Acute kidney injury3CTD_human
HgeneALBC0014544Epilepsy2CTD_human
HgeneALBC0020649Hypotension2CTD_human;HPO
HgeneALBC0023890Liver Cirrhosis2CTD_human
HgeneALBC0027726Nephrotic Syndrome2CTD_human
HgeneALBC0036830Serum Sickness2CTD_human
HgeneALBC0162557Liver Failure, Acute2CTD_human
HgeneALBC4277682Chemical and Drug Induced Liver Injury2CTD_human
HgeneALBC0002994Angioedema1CTD_human
HgeneALBC0003460Anuria1CTD_human
HgeneALBC0004509Azoospermia1CTD_human
HgeneALBC0006111Brain Diseases1CTD_human
HgeneALBC0007222Cardiovascular Diseases1CTD_human
HgeneALBC0007786Brain Ischemia1CTD_human
HgeneALBC0011581Depressive disorder1CTD_human
HgeneALBC0011875Diabetic Angiopathies1CTD_human
HgeneALBC0011881Diabetic Nephropathy1CTD_human
HgeneALBC0013502Echinococcosis1CTD_human
HgeneALBC0016059Fibrosis1CTD_human
HgeneALBC0017662Glomerulonephritis, Membranoproliferative1CTD_human
HgeneALBC0018799Heart Diseases1CTD_human
HgeneALBC0018801Heart failure1CTD_human
HgeneALBC0019061Hemolytic-Uremic Syndrome1CTD_human
HgeneALBC0019158Hepatitis1CTD_human
HgeneALBC0019693HIV Infections1CTD_human
HgeneALBC0019699HIV Seropositivity1CTD_human
HgeneALBC0020517Hypersensitivity1CTD_human
HgeneALBC0020522Delayed Hypersensitivity1CTD_human
HgeneALBC0020538Hypertensive disease1CTD_human
HgeneALBC0022548Keloid1CTD_human
HgeneALBC0022661Kidney Failure, Chronic1CTD_human
HgeneALBC0026848Myopathy1CTD_human
HgeneALBC0027055Myocardial Reperfusion Injury1CTD_human
HgeneALBC0027720Nephrosis1CTD_human
HgeneALBC0028797Occupational Diseases1CTD_human
HgeneALBC0030193Pain1CTD_human
HgeneALBC0030286Pancreatic Diseases1CTD_human
HgeneALBC0030305Pancreatitis1CTD_human
HgeneALBC0035222Respiratory Distress Syndrome, Adult1CTD_human
HgeneALBC0035242Respiratory Tract Diseases1CTD_human
HgeneALBC0035457Rhinitis, Allergic, Perennial1CTD_human
HgeneALBC0038325Stevens-Johnson Syndrome1CTD_human
HgeneALBC0038356Stomach Neoplasms1CTD_human
HgeneALBC0040034Thrombocytopenia1CTD_human
HgeneALBC0041755Adverse reaction to drug1CTD_human
HgeneALBC0042109Urticaria1CTD_human
HgeneALBC0042164Uveitis1CTD_human
HgeneALBC0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneALBC0239981Hypoalbuminemia1CTD_human;HPO
HgeneALBC0993582Arthritis, Experimental1CTD_human
TgeneTFC0036341Schizophrenia3PSYGENET
TgeneTFC0521802Congenital atransferrinemia3CTD_human;HPO;ORPHANET;UNIPROT
TgeneTFC0001973Alcoholic Intoxication, Chronic2CTD_human
TgeneTFC0002395Alzheimer's Disease2CTD_human
TgeneTFC0015695Fatty Liver2CTD_human
TgeneTFC0024667Animal Mammary Neoplasms2CTD_human
TgeneTFC0024668Mammary Neoplasms, Experimental2CTD_human
TgeneTFC0004352Autistic Disorder1CTD_human
TgeneTFC0013502Echinococcosis1CTD_human
TgeneTFC0019158Hepatitis1CTD_human
TgeneTFC0021368Inflammation1CTD_human
TgeneTFC0027626Neoplasm Invasiveness1CTD_human
TgeneTFC0027726Nephrotic Syndrome1CTD_human
TgeneTFC0028754Obesity1CTD_human
TgeneTFC0030524Paratuberculosis1CTD_human
TgeneTFC0035258Restless Legs Syndrome1CTD_human
TgeneTFC0036337Schizoaffective Disorder1PSYGENET
TgeneTFC0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneTFC0271901Microcytic hypochromic anemia (disorder)1CTD_human
TgeneTFC0282193Iron Overload1CTD_human
TgeneTFC0345967Malignant mesothelioma1CTD_human
TgeneTFC4277682Chemical and Drug Induced Liver Injury1CTD_human