FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 14407

FusionGeneSummary for GAS7_AFF1

check button Fusion gene summary
Fusion gene informationFusion gene name: GAS7_AFF1
Fusion gene ID: 14407
HgeneTgene
Gene symbol

GAS7

AFF1

Gene ID

8522

4299

Gene namegrowth arrest specific 7AF4/FMR2 family member 1
Synonyms-AF4|MLLT2|PBM1
Cytomap

17p13.1

4q21.3-q22.1

Type of geneprotein-codingprotein-coding
Descriptiongrowth arrest-specific protein 7AF4/FMR2 family member 1ALL1-fused gene from chromosome 4 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2pre-B-cell monocytic leukemia partner 1proto-oncogene AF4
Modification date2018052320180523
UniProtAcc

O60861

P51825

Ensembl transtripts involved in fusion geneENST00000437099, ENST00000323816, 
ENST00000432992, ENST00000540214, 
ENST00000585266, ENST00000580865, 
ENST00000583882, ENST00000542249, 
ENST00000396115, ENST00000579158, 
ENST00000578655, 		ENST00000395146, 
ENST00000307808, ENST00000544085, 
ENST00000511996, 
Fusion gene scores* DoF score10 X 7 X 6=42010 X 25 X 4=1000
# samples 1231
** MAII scorelog2(12/420*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(31/1000*10)=-1.68965987938785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GAS7 [Title/Abstract] AND AFF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF371439GAS7chr17

10100696

+AFF1chr4

87929375

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000437099ENST00000395146GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000437099ENST00000307808GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000437099ENST00000544085GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000437099ENST00000511996GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000323816ENST00000395146GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000323816ENST00000307808GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000323816ENST00000544085GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000323816ENST00000511996GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000432992ENST00000395146GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000432992ENST00000307808GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000432992ENST00000544085GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000432992ENST00000511996GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000540214ENST00000395146GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000540214ENST00000307808GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000540214ENST00000544085GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000540214ENST00000511996GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000585266ENST00000395146GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000585266ENST00000307808GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000585266ENST00000544085GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000585266ENST00000511996GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000580865ENST00000395146GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000580865ENST00000307808GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000580865ENST00000544085GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000580865ENST00000511996GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000583882ENST00000395146GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000583882ENST00000307808GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000583882ENST00000544085GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000583882ENST00000511996GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000542249ENST00000395146GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000542249ENST00000307808GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000542249ENST00000544085GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000542249ENST00000511996GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000396115ENST00000395146GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000396115ENST00000307808GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000396115ENST00000544085GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000396115ENST00000511996GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000579158ENST00000395146GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000579158ENST00000307808GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000579158ENST00000544085GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000579158ENST00000511996GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000578655ENST00000395146GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000578655ENST00000307808GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000578655ENST00000544085GAS7chr17

10100696

+AFF1chr4

87929375

-
intron-intronENST00000578655ENST00000511996GAS7chr17

10100696

+AFF1chr4

87929375

-

Top

FusionProtFeatures for GAS7_AFF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GAS7

O60861

AFF1

P51825

May play a role in promoting maturation andmorphological differentiation of cerebellar neurons.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for GAS7_AFF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for GAS7_AFF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GAS7_AFF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for GAS7_AFF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGAS7C0028754Obesity1CTD_human