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Fusion gene ID: 14407 |
FusionGeneSummary for GAS7_AFF1 |
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Fusion gene information | Fusion gene name: GAS7_AFF1 | Fusion gene ID: 14407 | Hgene | Tgene | Gene symbol | GAS7 | AFF1 | Gene ID | 8522 | 4299 |
Gene name | growth arrest specific 7 | AF4/FMR2 family member 1 | |
Synonyms | - | AF4|MLLT2|PBM1 | |
Cytomap | 17p13.1 | 4q21.3-q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | growth arrest-specific protein 7 | AF4/FMR2 family member 1ALL1-fused gene from chromosome 4 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2pre-B-cell monocytic leukemia partner 1proto-oncogene AF4 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O60861 | P51825 | |
Ensembl transtripts involved in fusion gene | ENST00000437099, ENST00000323816, ENST00000432992, ENST00000540214, ENST00000585266, ENST00000580865, ENST00000583882, ENST00000542249, ENST00000396115, ENST00000579158, ENST00000578655, | ENST00000395146, ENST00000307808, ENST00000544085, ENST00000511996, | |
Fusion gene scores | * DoF score | 10 X 7 X 6=420 | 10 X 25 X 4=1000 |
# samples | 12 | 31 | |
** MAII score | log2(12/420*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(31/1000*10)=-1.68965987938785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GAS7 [Title/Abstract] AND AFF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF371439 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000437099 | ENST00000395146 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000437099 | ENST00000307808 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000437099 | ENST00000544085 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000437099 | ENST00000511996 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000323816 | ENST00000395146 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000323816 | ENST00000307808 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000323816 | ENST00000544085 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000323816 | ENST00000511996 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000432992 | ENST00000395146 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000432992 | ENST00000307808 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000432992 | ENST00000544085 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000432992 | ENST00000511996 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000540214 | ENST00000395146 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000540214 | ENST00000307808 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000540214 | ENST00000544085 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000540214 | ENST00000511996 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000585266 | ENST00000395146 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000585266 | ENST00000307808 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000585266 | ENST00000544085 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000585266 | ENST00000511996 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000580865 | ENST00000395146 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000580865 | ENST00000307808 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000580865 | ENST00000544085 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000580865 | ENST00000511996 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000583882 | ENST00000395146 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000583882 | ENST00000307808 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000583882 | ENST00000544085 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000583882 | ENST00000511996 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000542249 | ENST00000395146 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000542249 | ENST00000307808 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000542249 | ENST00000544085 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000542249 | ENST00000511996 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000396115 | ENST00000395146 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000396115 | ENST00000307808 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000396115 | ENST00000544085 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000396115 | ENST00000511996 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000579158 | ENST00000395146 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000579158 | ENST00000307808 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000579158 | ENST00000544085 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000579158 | ENST00000511996 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000578655 | ENST00000395146 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000578655 | ENST00000307808 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000578655 | ENST00000544085 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
intron-intron | ENST00000578655 | ENST00000511996 | GAS7 | chr17 | 10100696 | + | AFF1 | chr4 | 87929375 | - |
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FusionProtFeatures for GAS7_AFF1 |
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Hgene | Tgene |
GAS7 | AFF1 |
May play a role in promoting maturation andmorphological differentiation of cerebellar neurons. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GAS7_AFF1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GAS7_AFF1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GAS7_AFF1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GAS7_AFF1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GAS7 | C0028754 | Obesity | 1 | CTD_human |