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Fusion gene ID: 14404 |
FusionGeneSummary for GAS6_GAS6 |
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Fusion gene information | Fusion gene name: GAS6_GAS6 | Fusion gene ID: 14404 | Hgene | Tgene | Gene symbol | GAS6 | GAS6 | Gene ID | 2621 | 2621 |
Gene name | growth arrest specific 6 | growth arrest specific 6 | |
Synonyms | AXLLG|AXSF | AXLLG|AXSF | |
Cytomap | 13q34 | 13q34 | |
Type of gene | protein-coding | protein-coding | |
Description | growth arrest-specific protein 6AXL receptor tyrosine kinase ligandAXL stimulatory factor | growth arrest-specific protein 6AXL receptor tyrosine kinase ligandAXL stimulatory factor | |
Modification date | 20180527 | 20180527 | |
UniProtAcc | Q14393 | Q14393 | |
Ensembl transtripts involved in fusion gene | ENST00000357389, ENST00000327773, ENST00000476291, ENST00000418959, ENST00000450766, ENST00000355761, | ENST00000357389, ENST00000327773, ENST00000476291, ENST00000418959, ENST00000450766, ENST00000355761, | |
Fusion gene scores | * DoF score | 4 X 5 X 3=60 | 3 X 5 X 2=30 |
# samples | 5 | 4 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/30*10)=0.415037499278844 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: GAS6 [Title/Abstract] AND GAS6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GAS6 | GO:0001934 | positive regulation of protein phosphorylation | 7854420|16723520|20103767 |
Hgene | GAS6 | GO:0006468 | protein phosphorylation | 16359517 |
Hgene | GAS6 | GO:0006909 | phagocytosis | 21501828 |
Hgene | GAS6 | GO:0007165 | signal transduction | 7854420|18680538 |
Hgene | GAS6 | GO:0010628 | positive regulation of gene expression | 19657094 |
Hgene | GAS6 | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway | 19657094 |
Hgene | GAS6 | GO:0018105 | peptidyl-serine phosphorylation | 18680538|20103767 |
Hgene | GAS6 | GO:0019064 | fusion of virus membrane with host plasma membrane | 21501828 |
Hgene | GAS6 | GO:0019079 | viral genome replication | 21501828 |
Hgene | GAS6 | GO:0032689 | negative regulation of interferon-gamma production | 18840707 |
Hgene | GAS6 | GO:0032715 | negative regulation of interleukin-6 production | 19657094 |
Hgene | GAS6 | GO:0032720 | negative regulation of tumor necrosis factor production | 19657094|20103767 |
Hgene | GAS6 | GO:0032825 | positive regulation of natural killer cell differentiation | 18840707 |
Hgene | GAS6 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 16723520 |
Hgene | GAS6 | GO:0033159 | negative regulation of protein import into nucleus, translocation | 20103767 |
Hgene | GAS6 | GO:0035457 | cellular response to interferon-alpha | 19657094 |
Hgene | GAS6 | GO:0035690 | cellular response to drug | 16359517 |
Hgene | GAS6 | GO:0035754 | B cell chemotaxis | 19922767 |
Hgene | GAS6 | GO:0043066 | negative regulation of apoptotic process | 19922767 |
Hgene | GAS6 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 16723520 |
Hgene | GAS6 | GO:0043277 | apoptotic cell clearance | 21501828 |
Hgene | GAS6 | GO:0043433 | negative regulation of DNA binding transcription factor activity | 18680538 |
Hgene | GAS6 | GO:0043491 | protein kinase B signaling | 16723520|20103767 |
Hgene | GAS6 | GO:0045860 | positive regulation of protein kinase activity | 7854420 |
Hgene | GAS6 | GO:0045892 | negative regulation of transcription, DNA-templated | 18680538 |
Hgene | GAS6 | GO:0046718 | viral entry into host cell | 21501828 |
Hgene | GAS6 | GO:0046813 | receptor-mediated virion attachment to host cell | 21501828 |
Hgene | GAS6 | GO:0046827 | positive regulation of protein export from nucleus | 18680538 |
Hgene | GAS6 | GO:0048146 | positive regulation of fibroblast proliferation | 7854420|15184064 |
Hgene | GAS6 | GO:0050711 | negative regulation of interleukin-1 secretion | 20103767 |
Hgene | GAS6 | GO:0050766 | positive regulation of phagocytosis | 18395422 |
Hgene | GAS6 | GO:0051897 | positive regulation of protein kinase B signaling | 16359517|16723520|18680538 |
Hgene | GAS6 | GO:0061098 | positive regulation of protein tyrosine kinase activity | 20103767 |
Hgene | GAS6 | GO:0070168 | negative regulation of biomineral tissue development | 20048160 |
Hgene | GAS6 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 15184064 |
Hgene | GAS6 | GO:0070588 | calcium ion transmembrane transport | 18395422 |
Hgene | GAS6 | GO:0071307 | cellular response to vitamin K | 16359517 |
Hgene | GAS6 | GO:0072659 | protein localization to plasma membrane | 16359517 |
Hgene | GAS6 | GO:0097241 | hematopoietic stem cell migration to bone marrow | 19922767 |
Hgene | GAS6 | GO:1900142 | negative regulation of oligodendrocyte apoptotic process | 16723520 |
Hgene | GAS6 | GO:1900165 | negative regulation of interleukin-6 secretion | 20103767 |
Hgene | GAS6 | GO:2000270 | negative regulation of fibroblast apoptotic process | 16359517 |
Hgene | GAS6 | GO:2000352 | negative regulation of endothelial cell apoptotic process | 16359517|18680538|18760998 |
Hgene | GAS6 | GO:2000510 | positive regulation of dendritic cell chemotaxis | 19657094 |
Hgene | GAS6 | GO:2000669 | negative regulation of dendritic cell apoptotic process | 19657094 |
Tgene | GAS6 | GO:0001934 | positive regulation of protein phosphorylation | 7854420|16723520|20103767 |
Tgene | GAS6 | GO:0006468 | protein phosphorylation | 16359517 |
Tgene | GAS6 | GO:0006909 | phagocytosis | 21501828 |
Tgene | GAS6 | GO:0007165 | signal transduction | 7854420|18680538 |
Tgene | GAS6 | GO:0010628 | positive regulation of gene expression | 19657094 |
Tgene | GAS6 | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway | 19657094 |
Tgene | GAS6 | GO:0018105 | peptidyl-serine phosphorylation | 18680538|20103767 |
Tgene | GAS6 | GO:0019064 | fusion of virus membrane with host plasma membrane | 21501828 |
Tgene | GAS6 | GO:0019079 | viral genome replication | 21501828 |
Tgene | GAS6 | GO:0032689 | negative regulation of interferon-gamma production | 18840707 |
Tgene | GAS6 | GO:0032715 | negative regulation of interleukin-6 production | 19657094 |
Tgene | GAS6 | GO:0032720 | negative regulation of tumor necrosis factor production | 19657094|20103767 |
Tgene | GAS6 | GO:0032825 | positive regulation of natural killer cell differentiation | 18840707 |
Tgene | GAS6 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 16723520 |
Tgene | GAS6 | GO:0033159 | negative regulation of protein import into nucleus, translocation | 20103767 |
Tgene | GAS6 | GO:0035457 | cellular response to interferon-alpha | 19657094 |
Tgene | GAS6 | GO:0035690 | cellular response to drug | 16359517 |
Tgene | GAS6 | GO:0035754 | B cell chemotaxis | 19922767 |
Tgene | GAS6 | GO:0043066 | negative regulation of apoptotic process | 19922767 |
Tgene | GAS6 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 16723520 |
Tgene | GAS6 | GO:0043277 | apoptotic cell clearance | 21501828 |
Tgene | GAS6 | GO:0043433 | negative regulation of DNA binding transcription factor activity | 18680538 |
Tgene | GAS6 | GO:0043491 | protein kinase B signaling | 16723520|20103767 |
Tgene | GAS6 | GO:0045860 | positive regulation of protein kinase activity | 7854420 |
Tgene | GAS6 | GO:0045892 | negative regulation of transcription, DNA-templated | 18680538 |
Tgene | GAS6 | GO:0046718 | viral entry into host cell | 21501828 |
Tgene | GAS6 | GO:0046813 | receptor-mediated virion attachment to host cell | 21501828 |
Tgene | GAS6 | GO:0046827 | positive regulation of protein export from nucleus | 18680538 |
Tgene | GAS6 | GO:0048146 | positive regulation of fibroblast proliferation | 7854420|15184064 |
Tgene | GAS6 | GO:0050711 | negative regulation of interleukin-1 secretion | 20103767 |
Tgene | GAS6 | GO:0050766 | positive regulation of phagocytosis | 18395422 |
Tgene | GAS6 | GO:0051897 | positive regulation of protein kinase B signaling | 16359517|16723520|18680538 |
Tgene | GAS6 | GO:0061098 | positive regulation of protein tyrosine kinase activity | 20103767 |
Tgene | GAS6 | GO:0070168 | negative regulation of biomineral tissue development | 20048160 |
Tgene | GAS6 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 15184064 |
Tgene | GAS6 | GO:0070588 | calcium ion transmembrane transport | 18395422 |
Tgene | GAS6 | GO:0071307 | cellular response to vitamin K | 16359517 |
Tgene | GAS6 | GO:0072659 | protein localization to plasma membrane | 16359517 |
Tgene | GAS6 | GO:0097241 | hematopoietic stem cell migration to bone marrow | 19922767 |
Tgene | GAS6 | GO:1900142 | negative regulation of oligodendrocyte apoptotic process | 16723520 |
Tgene | GAS6 | GO:1900165 | negative regulation of interleukin-6 secretion | 20103767 |
Tgene | GAS6 | GO:2000270 | negative regulation of fibroblast apoptotic process | 16359517 |
Tgene | GAS6 | GO:2000352 | negative regulation of endothelial cell apoptotic process | 16359517|18680538|18760998 |
Tgene | GAS6 | GO:2000510 | positive regulation of dendritic cell chemotaxis | 19657094 |
Tgene | GAS6 | GO:2000669 | negative regulation of dendritic cell apoptotic process | 19657094 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF755561 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - | ||
ChiTaRS3.1 | AA057674 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000357389 | ENST00000357389 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000357389 | ENST00000327773 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000357389 | ENST00000476291 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000357389 | ENST00000418959 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000357389 | ENST00000450766 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000357389 | ENST00000355761 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000327773 | ENST00000357389 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000327773 | ENST00000327773 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000327773 | ENST00000476291 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000327773 | ENST00000418959 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000327773 | ENST00000450766 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000327773 | ENST00000355761 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000476291 | ENST00000357389 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000476291 | ENST00000327773 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000476291 | ENST00000476291 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000476291 | ENST00000418959 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000476291 | ENST00000450766 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000476291 | ENST00000355761 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000418959 | ENST00000357389 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000418959 | ENST00000327773 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000418959 | ENST00000476291 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000418959 | ENST00000418959 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000418959 | ENST00000450766 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000418959 | ENST00000355761 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000450766 | ENST00000357389 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000450766 | ENST00000327773 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000450766 | ENST00000476291 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000450766 | ENST00000418959 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000450766 | ENST00000450766 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000450766 | ENST00000355761 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000355761 | ENST00000357389 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000355761 | ENST00000327773 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000355761 | ENST00000476291 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000355761 | ENST00000418959 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000355761 | ENST00000450766 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-intron | ENST00000355761 | ENST00000355761 | GAS6 | chr13 | 114534547 | - | GAS6 | chr13 | 114535216 | - |
intron-3UTR | ENST00000357389 | ENST00000357389 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000357389 | ENST00000327773 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-intron | ENST00000357389 | ENST00000476291 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000357389 | ENST00000418959 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000357389 | ENST00000450766 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000357389 | ENST00000355761 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000327773 | ENST00000357389 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000327773 | ENST00000327773 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-intron | ENST00000327773 | ENST00000476291 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000327773 | ENST00000418959 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000327773 | ENST00000450766 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000327773 | ENST00000355761 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000476291 | ENST00000357389 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000476291 | ENST00000327773 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-intron | ENST00000476291 | ENST00000476291 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000476291 | ENST00000418959 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000476291 | ENST00000450766 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000476291 | ENST00000355761 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000418959 | ENST00000357389 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000418959 | ENST00000327773 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-intron | ENST00000418959 | ENST00000476291 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000418959 | ENST00000418959 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000418959 | ENST00000450766 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000418959 | ENST00000355761 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000450766 | ENST00000357389 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000450766 | ENST00000327773 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-intron | ENST00000450766 | ENST00000476291 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000450766 | ENST00000418959 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000450766 | ENST00000450766 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000450766 | ENST00000355761 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000355761 | ENST00000357389 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000355761 | ENST00000327773 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-intron | ENST00000355761 | ENST00000476291 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000355761 | ENST00000418959 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000355761 | ENST00000450766 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
intron-3UTR | ENST00000355761 | ENST00000355761 | GAS6 | chr13 | 114523763 | + | GAS6 | chr13 | 114523834 | - |
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FusionProtFeatures for GAS6_GAS6 |
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Hgene | Tgene |
GAS6 | GAS6 |
Ligand for tyrosine-protein kinase receptors AXL, TYRO3and MER whose signaling is implicated in cell growth and survival,cell adhesion and cell migration. GAS6/AXL signaling plays a rolein various processes such as endothelial cell survival duringacidification by preventing apoptosis, optimal cytokine signalingduring human natural killer cell development, hepaticregeneration, gonadotropin-releasing hormone neuron survival andmigration, platelet activation, or regulation of thromboticresponses. {ECO:0000269|PubMed:12364394,ECO:0000269|PubMed:18840707}. (Microbial infection) Can bridges virus envelopephosphatidylserine to the TAM receptor tyrosine kinase Axl tomediate viral entry by apoptotic mimicry (PubMed:21501828). Playsa role in Dengue cell entry by apoptotic mimicry(PubMed:23084921). Plays a role in Vaccinia virus cell entry byapoptotic mimicry (PubMed:21501828). Plays a role in ebolavirusand marburgvirus cell entry by apoptotic mimicry(PubMed:17005688). {ECO:0000269|PubMed:17005688,ECO:0000269|PubMed:21501828, ECO:0000269|PubMed:23084921}. | Ligand for tyrosine-protein kinase receptors AXL, TYRO3and MER whose signaling is implicated in cell growth and survival,cell adhesion and cell migration. GAS6/AXL signaling plays a rolein various processes such as endothelial cell survival duringacidification by preventing apoptosis, optimal cytokine signalingduring human natural killer cell development, hepaticregeneration, gonadotropin-releasing hormone neuron survival andmigration, platelet activation, or regulation of thromboticresponses. {ECO:0000269|PubMed:12364394,ECO:0000269|PubMed:18840707}. (Microbial infection) Can bridges virus envelopephosphatidylserine to the TAM receptor tyrosine kinase Axl tomediate viral entry by apoptotic mimicry (PubMed:21501828). Playsa role in Dengue cell entry by apoptotic mimicry(PubMed:23084921). Plays a role in Vaccinia virus cell entry byapoptotic mimicry (PubMed:21501828). Plays a role in ebolavirusand marburgvirus cell entry by apoptotic mimicry(PubMed:17005688). {ECO:0000269|PubMed:17005688,ECO:0000269|PubMed:21501828, ECO:0000269|PubMed:23084921}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GAS6_GAS6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GAS6_GAS6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GAS6_GAS6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GAS6_GAS6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GAS6 | C0040053 | Thrombosis | 4 | CTD_human |
Hgene | GAS6 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Hgene | GAS6 | C0011881 | Diabetic Nephropathy | 1 | CTD_human |
Hgene | GAS6 | C0018800 | Cardiomegaly | 1 | CTD_human |
Hgene | GAS6 | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |
Hgene | GAS6 | C0040038 | Thromboembolism | 1 | CTD_human |
Hgene | GAS6 | C2609414 | Acute kidney injury | 1 | CTD_human |
Tgene | GAS6 | C0040053 | Thrombosis | 4 | CTD_human |
Tgene | GAS6 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Tgene | GAS6 | C0011881 | Diabetic Nephropathy | 1 | CTD_human |
Tgene | GAS6 | C0018800 | Cardiomegaly | 1 | CTD_human |
Tgene | GAS6 | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |
Tgene | GAS6 | C0040038 | Thromboembolism | 1 | CTD_human |
Tgene | GAS6 | C2609414 | Acute kidney injury | 1 | CTD_human |