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Fusion gene ID: 14400 |
FusionGeneSummary for GAS5_RPL36A-HNRNPH2 |
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Fusion gene information | Fusion gene name: GAS5_RPL36A-HNRNPH2 | Fusion gene ID: 14400 | Hgene | Tgene | Gene symbol | GAS5 | RPL36A-HNRNPH2 | Gene ID | 60674 | 100529097 |
Gene name | growth arrest specific 5 | RPL36A-HNRNPH2 readthrough | |
Synonyms | NCRNA00030|SNHG2 | - | |
Cytomap | 1q25.1 | Xq22.1 | |
Type of gene | ncRNA | protein-coding | |
Description | growth arrest specific 5 (non-protein coding)growth arrest specific transcript 5small nucleolar RNA host gene (non-protein coding) 2 | RPL36A-HNRNPH2 protein | |
Modification date | 20180519 | 20180329 | |
UniProtAcc | |||
Ensembl transtripts involved in fusion gene | ENST00000363840, ENST00000365524, ENST00000364822, ENST00000363859, ENST00000385578, ENST00000363146, ENST00000364084, | ENST00000409170, | |
Fusion gene scores | * DoF score | 13 X 13 X 2=338 | 2 X 2 X 1=4 |
# samples | 14 | 2 | |
** MAII score | log2(14/338*10)=-1.27159641933722 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: GAS5 [Title/Abstract] AND RPL36A-HNRNPH2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AV757482 | GAS5 | chr1 | 173834509 | - | RPL36A-HNRNPH2 | chrX | 100656487 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000363840 | ENST00000409170 | GAS5 | chr1 | 173834509 | - | RPL36A-HNRNPH2 | chrX | 100656487 | - |
intron-intron | ENST00000365524 | ENST00000409170 | GAS5 | chr1 | 173834509 | - | RPL36A-HNRNPH2 | chrX | 100656487 | - |
intron-intron | ENST00000364822 | ENST00000409170 | GAS5 | chr1 | 173834509 | - | RPL36A-HNRNPH2 | chrX | 100656487 | - |
intron-intron | ENST00000363859 | ENST00000409170 | GAS5 | chr1 | 173834509 | - | RPL36A-HNRNPH2 | chrX | 100656487 | - |
intron-intron | ENST00000385578 | ENST00000409170 | GAS5 | chr1 | 173834509 | - | RPL36A-HNRNPH2 | chrX | 100656487 | - |
intron-intron | ENST00000363146 | ENST00000409170 | GAS5 | chr1 | 173834509 | - | RPL36A-HNRNPH2 | chrX | 100656487 | - |
intron-intron | ENST00000364084 | ENST00000409170 | GAS5 | chr1 | 173834509 | - | RPL36A-HNRNPH2 | chrX | 100656487 | - |
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FusionProtFeatures for GAS5_RPL36A-HNRNPH2 |
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Hgene | Tgene |
GAS5 | RPL36A-HNRNPH2 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GAS5_RPL36A-HNRNPH2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GAS5_RPL36A-HNRNPH2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GAS5_RPL36A-HNRNPH2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GAS5_RPL36A-HNRNPH2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GAS5 | C0151744 | Myocardial Ischemia | 1 | CTD_human |