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Fusion gene ID: 1439 |
FusionGeneSummary for ALB_SERPING1 |
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Fusion gene information | Fusion gene name: ALB_SERPING1 | Fusion gene ID: 1439 | Hgene | Tgene | Gene symbol | ALB | SERPING1 | Gene ID | 213 | 710 |
Gene name | albumin | serpin family G member 1 | |
Synonyms | HSA|PRO0883|PRO0903|PRO1341 | C1IN|C1INH|C1NH|HAE1|HAE2 | |
Cytomap | 4q13.3 | 11q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | serum albumin | plasma protease C1 inhibitorC1 esterase inhibitorC1-inhibiting factorcomplement component 1 inhibitorserine/cysteine proteinase inhibitor clade G member 1serpin G1serpin peptidase inhibitor clade G member 1serpin peptidase inhibitor, clade G (C1 in | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P02768 | P05155 | |
Ensembl transtripts involved in fusion gene | ENST00000295897, ENST00000415165, ENST00000503124, ENST00000509063, ENST00000401494, ENST00000505649, | ENST00000278407, ENST00000340687, ENST00000378323, ENST00000378324, ENST00000403558, ENST00000531605, | |
Fusion gene scores | * DoF score | 19 X 15 X 3=855 | 6 X 6 X 2=72 |
# samples | 25 | 7 | |
** MAII score | log2(25/855*10)=-1.77399632511117 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ALB [Title/Abstract] AND SERPING1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ALB | GO:0009267 | cellular response to starvation | 16245148 |
Hgene | ALB | GO:0019836 | hemolysis by symbiont of host erythrocytes | 16394536 |
Hgene | ALB | GO:0043066 | negative regulation of apoptotic process | 16153637 |
Hgene | ALB | GO:0051659 | maintenance of mitochondrion location | 16153637 |
Tgene | SERPING1 | GO:0001869 | negative regulation of complement activation, lectin pathway | 10946292 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BP294362 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000295897 | ENST00000278407 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
In-frame | ENST00000295897 | ENST00000340687 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
Frame-shift | ENST00000295897 | ENST00000378323 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
Frame-shift | ENST00000295897 | ENST00000378324 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
Frame-shift | ENST00000295897 | ENST00000403558 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
5CDS-intron | ENST00000295897 | ENST00000531605 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
intron-3CDS | ENST00000415165 | ENST00000278407 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
intron-3CDS | ENST00000415165 | ENST00000340687 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
intron-3CDS | ENST00000415165 | ENST00000378323 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
intron-3CDS | ENST00000415165 | ENST00000378324 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
intron-3CDS | ENST00000415165 | ENST00000403558 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
intron-intron | ENST00000415165 | ENST00000531605 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
intron-3CDS | ENST00000503124 | ENST00000278407 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
intron-3CDS | ENST00000503124 | ENST00000340687 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
intron-3CDS | ENST00000503124 | ENST00000378323 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
intron-3CDS | ENST00000503124 | ENST00000378324 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
intron-3CDS | ENST00000503124 | ENST00000403558 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
intron-intron | ENST00000503124 | ENST00000531605 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
Frame-shift | ENST00000509063 | ENST00000278407 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
In-frame | ENST00000509063 | ENST00000340687 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
Frame-shift | ENST00000509063 | ENST00000378323 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
Frame-shift | ENST00000509063 | ENST00000378324 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
Frame-shift | ENST00000509063 | ENST00000403558 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
5CDS-intron | ENST00000509063 | ENST00000531605 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
intron-3CDS | ENST00000401494 | ENST00000278407 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
intron-3CDS | ENST00000401494 | ENST00000340687 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
intron-3CDS | ENST00000401494 | ENST00000378323 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
intron-3CDS | ENST00000401494 | ENST00000378324 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
intron-3CDS | ENST00000401494 | ENST00000403558 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
intron-intron | ENST00000401494 | ENST00000531605 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
3UTR-3CDS | ENST00000505649 | ENST00000278407 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
3UTR-3CDS | ENST00000505649 | ENST00000340687 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
3UTR-3CDS | ENST00000505649 | ENST00000378323 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
3UTR-3CDS | ENST00000505649 | ENST00000378324 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
3UTR-3CDS | ENST00000505649 | ENST00000403558 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
3UTR-intron | ENST00000505649 | ENST00000531605 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
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FusionProtFeatures for ALB_SERPING1 |
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Hgene | Tgene |
ALB | SERPING1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ALB_SERPING1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_ALB_ENST00000295897_chr4_74274476_+_SERPING1_ENST00000340687_chr11_57381845_+_0aa >In-frame_ALB_ENST00000509063_chr4_74274476_+_SERPING1_ENST00000340687_chr11_57381845_+_0aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_ALB_ENST00000295897_chr4_74274476_+_SERPING1_ENST00000340687_chr11_57381845_+_0nt >In-frame_ALB_ENST00000509063_chr4_74274476_+_SERPING1_ENST00000340687_chr11_57381845_+_0nt |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_ALB_ENST00000295897_chr4_74274476_+_SERPING1_ENST00000340687_chr11_57381845_+_0nt >In-frame_ALB_ENST00000509063_chr4_74274476_+_SERPING1_ENST00000340687_chr11_57381845_+_0nt |
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FusionGenePPI for ALB_SERPING1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ALB_SERPING1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | ALB | P02768 | DB00493 | Cefotaxime | Serum albumin | small molecule | approved |
Hgene | ALB | P02768 | DB01045 | Rifampicin | Serum albumin | small molecule | approved |
Hgene | ALB | P02768 | DB03255 | Phenol | Serum albumin | small molecule | approved|experimental |
Hgene | ALB | P02768 | DB00276 | Amsacrine | Serum albumin | small molecule | approved|investigational |
Hgene | ALB | P02768 | DB00545 | Pyridostigmine | Serum albumin | small molecule | approved|investigational |
Hgene | ALB | P02768 | DB06713 | Norelgestromin | Serum albumin | small molecule | approved|investigational |
Hgene | ALB | P02768 | DB11638 | Artenimol | Serum albumin | small molecule | approved|investigational |
Hgene | ALB | P02768 | DB00199 | Erythromycin | Serum albumin | small molecule | approved|investigational|vet_approved |
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RelatedDiseases for ALB_SERPING1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ALB | C0033687 | Proteinuria | 9 | CTD_human |
Hgene | ALB | C0017658 | Glomerulonephritis | 8 | CTD_human |
Hgene | ALB | C0022658 | Kidney Diseases | 8 | CTD_human |
Hgene | ALB | C0017665 | Membranous glomerulonephritis | 6 | CTD_human |
Hgene | ALB | C0027697 | Nephritis | 6 | CTD_human |
Hgene | ALB | C0027707 | Nephritis, Interstitial | 4 | CTD_human |
Hgene | ALB | C0038454 | Cerebrovascular accident | 4 | CTD_human |
Hgene | ALB | C0342185 | Hyperthyroxinemia, Familial Dysalbuminemic | 4 | CTD_human;UNIPROT |
Hgene | ALB | C0023893 | Liver Cirrhosis, Experimental | 3 | CTD_human |
Hgene | ALB | C0025290 | Aseptic Meningitis | 3 | CTD_human |
Hgene | ALB | C2609414 | Acute kidney injury | 3 | CTD_human |
Hgene | ALB | C0014544 | Epilepsy | 2 | CTD_human |
Hgene | ALB | C0020649 | Hypotension | 2 | CTD_human;HPO |
Hgene | ALB | C0023890 | Liver Cirrhosis | 2 | CTD_human |
Hgene | ALB | C0027726 | Nephrotic Syndrome | 2 | CTD_human |
Hgene | ALB | C0036830 | Serum Sickness | 2 | CTD_human |
Hgene | ALB | C0162557 | Liver Failure, Acute | 2 | CTD_human |
Hgene | ALB | C4277682 | Chemical and Drug Induced Liver Injury | 2 | CTD_human |
Hgene | ALB | C0002994 | Angioedema | 1 | CTD_human |
Hgene | ALB | C0003460 | Anuria | 1 | CTD_human |
Hgene | ALB | C0004509 | Azoospermia | 1 | CTD_human |
Hgene | ALB | C0006111 | Brain Diseases | 1 | CTD_human |
Hgene | ALB | C0007222 | Cardiovascular Diseases | 1 | CTD_human |
Hgene | ALB | C0007786 | Brain Ischemia | 1 | CTD_human |
Hgene | ALB | C0011581 | Depressive disorder | 1 | CTD_human |
Hgene | ALB | C0011875 | Diabetic Angiopathies | 1 | CTD_human |
Hgene | ALB | C0011881 | Diabetic Nephropathy | 1 | CTD_human |
Hgene | ALB | C0013502 | Echinococcosis | 1 | CTD_human |
Hgene | ALB | C0016059 | Fibrosis | 1 | CTD_human |
Hgene | ALB | C0017662 | Glomerulonephritis, Membranoproliferative | 1 | CTD_human |
Hgene | ALB | C0018799 | Heart Diseases | 1 | CTD_human |
Hgene | ALB | C0018801 | Heart failure | 1 | CTD_human |
Hgene | ALB | C0019061 | Hemolytic-Uremic Syndrome | 1 | CTD_human |
Hgene | ALB | C0019158 | Hepatitis | 1 | CTD_human |
Hgene | ALB | C0019693 | HIV Infections | 1 | CTD_human |
Hgene | ALB | C0019699 | HIV Seropositivity | 1 | CTD_human |
Hgene | ALB | C0020517 | Hypersensitivity | 1 | CTD_human |
Hgene | ALB | C0020522 | Delayed Hypersensitivity | 1 | CTD_human |
Hgene | ALB | C0020538 | Hypertensive disease | 1 | CTD_human |
Hgene | ALB | C0022548 | Keloid | 1 | CTD_human |
Hgene | ALB | C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
Hgene | ALB | C0026848 | Myopathy | 1 | CTD_human |
Hgene | ALB | C0027055 | Myocardial Reperfusion Injury | 1 | CTD_human |
Hgene | ALB | C0027720 | Nephrosis | 1 | CTD_human |
Hgene | ALB | C0028797 | Occupational Diseases | 1 | CTD_human |
Hgene | ALB | C0030193 | Pain | 1 | CTD_human |
Hgene | ALB | C0030286 | Pancreatic Diseases | 1 | CTD_human |
Hgene | ALB | C0030305 | Pancreatitis | 1 | CTD_human |
Hgene | ALB | C0035222 | Respiratory Distress Syndrome, Adult | 1 | CTD_human |
Hgene | ALB | C0035242 | Respiratory Tract Diseases | 1 | CTD_human |
Hgene | ALB | C0035457 | Rhinitis, Allergic, Perennial | 1 | CTD_human |
Hgene | ALB | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |
Hgene | ALB | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | ALB | C0040034 | Thrombocytopenia | 1 | CTD_human |
Hgene | ALB | C0041755 | Adverse reaction to drug | 1 | CTD_human |
Hgene | ALB | C0042109 | Urticaria | 1 | CTD_human |
Hgene | ALB | C0042164 | Uveitis | 1 | CTD_human |
Hgene | ALB | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Hgene | ALB | C0239981 | Hypoalbuminemia | 1 | CTD_human;HPO |
Hgene | ALB | C0993582 | Arthritis, Experimental | 1 | CTD_human |
Tgene | SERPING1 | C2717906 | Hereditary Angioedema Type I | 10 | ORPHANET;UNIPROT |
Tgene | SERPING1 | C0019243 | Angioedemas, Hereditary | 6 | CTD_human |
Tgene | SERPING1 | C2717905 | Hereditary Angioedema Types I and II | 3 | CTD_human |
Tgene | SERPING1 | C2931758 | Acquired angioedema | 2 | CTD_human |
Tgene | SERPING1 | C0021400 | Influenza | 1 | CTD_human |
Tgene | SERPING1 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Tgene | SERPING1 | C0024143 | Lupus Nephritis | 1 | CTD_human |
Tgene | SERPING1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |