FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 1439

FusionGeneSummary for ALB_SERPING1

check button Fusion gene summary
Fusion gene informationFusion gene name: ALB_SERPING1
Fusion gene ID: 1439
HgeneTgene
Gene symbol

ALB

SERPING1

Gene ID

213

710

Gene namealbuminserpin family G member 1
SynonymsHSA|PRO0883|PRO0903|PRO1341C1IN|C1INH|C1NH|HAE1|HAE2
Cytomap

4q13.3

11q12.1

Type of geneprotein-codingprotein-coding
Descriptionserum albuminplasma protease C1 inhibitorC1 esterase inhibitorC1-inhibiting factorcomplement component 1 inhibitorserine/cysteine proteinase inhibitor clade G member 1serpin G1serpin peptidase inhibitor clade G member 1serpin peptidase inhibitor, clade G (C1 in
Modification date2018052220180523
UniProtAcc

P02768

P05155

Ensembl transtripts involved in fusion geneENST00000295897, ENST00000415165, 
ENST00000503124, ENST00000509063, 
ENST00000401494, ENST00000505649, 
ENST00000278407, ENST00000340687, 
ENST00000378323, ENST00000378324, 
ENST00000403558, ENST00000531605, 
Fusion gene scores* DoF score19 X 15 X 3=8556 X 6 X 2=72
# samples 257
** MAII scorelog2(25/855*10)=-1.77399632511117
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALB [Title/Abstract] AND SERPING1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneALB

GO:0009267

cellular response to starvation

16245148

HgeneALB

GO:0019836

hemolysis by symbiont of host erythrocytes

16394536

HgeneALB

GO:0043066

negative regulation of apoptotic process

16153637

HgeneALB

GO:0051659

maintenance of mitochondrion location

16153637

TgeneSERPING1

GO:0001869

negative regulation of complement activation, lectin pathway

10946292


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP294362ALBchr4

74274476

+SERPING1chr11

57381845

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000295897ENST00000278407ALBchr4

74274476

+SERPING1chr11

57381845

+
In-frameENST00000295897ENST00000340687ALBchr4

74274476

+SERPING1chr11

57381845

+
Frame-shiftENST00000295897ENST00000378323ALBchr4

74274476

+SERPING1chr11

57381845

+
Frame-shiftENST00000295897ENST00000378324ALBchr4

74274476

+SERPING1chr11

57381845

+
Frame-shiftENST00000295897ENST00000403558ALBchr4

74274476

+SERPING1chr11

57381845

+
5CDS-intronENST00000295897ENST00000531605ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000415165ENST00000278407ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000415165ENST00000340687ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000415165ENST00000378323ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000415165ENST00000378324ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000415165ENST00000403558ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-intronENST00000415165ENST00000531605ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000503124ENST00000278407ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000503124ENST00000340687ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000503124ENST00000378323ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000503124ENST00000378324ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000503124ENST00000403558ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-intronENST00000503124ENST00000531605ALBchr4

74274476

+SERPING1chr11

57381845

+
Frame-shiftENST00000509063ENST00000278407ALBchr4

74274476

+SERPING1chr11

57381845

+
In-frameENST00000509063ENST00000340687ALBchr4

74274476

+SERPING1chr11

57381845

+
Frame-shiftENST00000509063ENST00000378323ALBchr4

74274476

+SERPING1chr11

57381845

+
Frame-shiftENST00000509063ENST00000378324ALBchr4

74274476

+SERPING1chr11

57381845

+
Frame-shiftENST00000509063ENST00000403558ALBchr4

74274476

+SERPING1chr11

57381845

+
5CDS-intronENST00000509063ENST00000531605ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000401494ENST00000278407ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000401494ENST00000340687ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000401494ENST00000378323ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000401494ENST00000378324ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000401494ENST00000403558ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-intronENST00000401494ENST00000531605ALBchr4

74274476

+SERPING1chr11

57381845

+
3UTR-3CDSENST00000505649ENST00000278407ALBchr4

74274476

+SERPING1chr11

57381845

+
3UTR-3CDSENST00000505649ENST00000340687ALBchr4

74274476

+SERPING1chr11

57381845

+
3UTR-3CDSENST00000505649ENST00000378323ALBchr4

74274476

+SERPING1chr11

57381845

+
3UTR-3CDSENST00000505649ENST00000378324ALBchr4

74274476

+SERPING1chr11

57381845

+
3UTR-3CDSENST00000505649ENST00000403558ALBchr4

74274476

+SERPING1chr11

57381845

+
3UTR-intronENST00000505649ENST00000531605ALBchr4

74274476

+SERPING1chr11

57381845

+

Top

FusionProtFeatures for ALB_SERPING1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALB

P02768

SERPING1

P05155


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ALB_SERPING1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ALB_ENST00000295897_chr4_74274476_+_SERPING1_ENST00000340687_chr11_57381845_+_0aa

>In-frame_ALB_ENST00000509063_chr4_74274476_+_SERPING1_ENST00000340687_chr11_57381845_+_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ALB_ENST00000295897_chr4_74274476_+_SERPING1_ENST00000340687_chr11_57381845_+_0nt

>In-frame_ALB_ENST00000509063_chr4_74274476_+_SERPING1_ENST00000340687_chr11_57381845_+_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_ALB_ENST00000295897_chr4_74274476_+_SERPING1_ENST00000340687_chr11_57381845_+_0nt

>In-frame_ALB_ENST00000509063_chr4_74274476_+_SERPING1_ENST00000340687_chr11_57381845_+_0nt


Top

FusionGenePPI for ALB_SERPING1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ALB_SERPING1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneALBP02768DB00493CefotaximeSerum albuminsmall moleculeapproved
HgeneALBP02768DB01045RifampicinSerum albuminsmall moleculeapproved
HgeneALBP02768DB03255PhenolSerum albuminsmall moleculeapproved|experimental
HgeneALBP02768DB00276AmsacrineSerum albuminsmall moleculeapproved|investigational
HgeneALBP02768DB00545PyridostigmineSerum albuminsmall moleculeapproved|investigational
HgeneALBP02768DB06713NorelgestrominSerum albuminsmall moleculeapproved|investigational
HgeneALBP02768DB11638ArtenimolSerum albuminsmall moleculeapproved|investigational
HgeneALBP02768DB00199ErythromycinSerum albuminsmall moleculeapproved|investigational|vet_approved

Top

RelatedDiseases for ALB_SERPING1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALBC0033687Proteinuria9CTD_human
HgeneALBC0017658Glomerulonephritis8CTD_human
HgeneALBC0022658Kidney Diseases8CTD_human
HgeneALBC0017665Membranous glomerulonephritis6CTD_human
HgeneALBC0027697Nephritis6CTD_human
HgeneALBC0027707Nephritis, Interstitial4CTD_human
HgeneALBC0038454Cerebrovascular accident4CTD_human
HgeneALBC0342185Hyperthyroxinemia, Familial Dysalbuminemic4CTD_human;UNIPROT
HgeneALBC0023893Liver Cirrhosis, Experimental3CTD_human
HgeneALBC0025290Aseptic Meningitis3CTD_human
HgeneALBC2609414Acute kidney injury3CTD_human
HgeneALBC0014544Epilepsy2CTD_human
HgeneALBC0020649Hypotension2CTD_human;HPO
HgeneALBC0023890Liver Cirrhosis2CTD_human
HgeneALBC0027726Nephrotic Syndrome2CTD_human
HgeneALBC0036830Serum Sickness2CTD_human
HgeneALBC0162557Liver Failure, Acute2CTD_human
HgeneALBC4277682Chemical and Drug Induced Liver Injury2CTD_human
HgeneALBC0002994Angioedema1CTD_human
HgeneALBC0003460Anuria1CTD_human
HgeneALBC0004509Azoospermia1CTD_human
HgeneALBC0006111Brain Diseases1CTD_human
HgeneALBC0007222Cardiovascular Diseases1CTD_human
HgeneALBC0007786Brain Ischemia1CTD_human
HgeneALBC0011581Depressive disorder1CTD_human
HgeneALBC0011875Diabetic Angiopathies1CTD_human
HgeneALBC0011881Diabetic Nephropathy1CTD_human
HgeneALBC0013502Echinococcosis1CTD_human
HgeneALBC0016059Fibrosis1CTD_human
HgeneALBC0017662Glomerulonephritis, Membranoproliferative1CTD_human
HgeneALBC0018799Heart Diseases1CTD_human
HgeneALBC0018801Heart failure1CTD_human
HgeneALBC0019061Hemolytic-Uremic Syndrome1CTD_human
HgeneALBC0019158Hepatitis1CTD_human
HgeneALBC0019693HIV Infections1CTD_human
HgeneALBC0019699HIV Seropositivity1CTD_human
HgeneALBC0020517Hypersensitivity1CTD_human
HgeneALBC0020522Delayed Hypersensitivity1CTD_human
HgeneALBC0020538Hypertensive disease1CTD_human
HgeneALBC0022548Keloid1CTD_human
HgeneALBC0022661Kidney Failure, Chronic1CTD_human
HgeneALBC0026848Myopathy1CTD_human
HgeneALBC0027055Myocardial Reperfusion Injury1CTD_human
HgeneALBC0027720Nephrosis1CTD_human
HgeneALBC0028797Occupational Diseases1CTD_human
HgeneALBC0030193Pain1CTD_human
HgeneALBC0030286Pancreatic Diseases1CTD_human
HgeneALBC0030305Pancreatitis1CTD_human
HgeneALBC0035222Respiratory Distress Syndrome, Adult1CTD_human
HgeneALBC0035242Respiratory Tract Diseases1CTD_human
HgeneALBC0035457Rhinitis, Allergic, Perennial1CTD_human
HgeneALBC0038325Stevens-Johnson Syndrome1CTD_human
HgeneALBC0038356Stomach Neoplasms1CTD_human
HgeneALBC0040034Thrombocytopenia1CTD_human
HgeneALBC0041755Adverse reaction to drug1CTD_human
HgeneALBC0042109Urticaria1CTD_human
HgeneALBC0042164Uveitis1CTD_human
HgeneALBC0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneALBC0239981Hypoalbuminemia1CTD_human;HPO
HgeneALBC0993582Arthritis, Experimental1CTD_human
TgeneSERPING1C2717906Hereditary Angioedema Type I10ORPHANET;UNIPROT
TgeneSERPING1C0019243Angioedemas, Hereditary6CTD_human
TgeneSERPING1C2717905Hereditary Angioedema Types I and II3CTD_human
TgeneSERPING1C2931758Acquired angioedema2CTD_human
TgeneSERPING1C0021400Influenza1CTD_human
TgeneSERPING1C0023890Liver Cirrhosis1CTD_human
TgeneSERPING1C0024143Lupus Nephritis1CTD_human
TgeneSERPING1C4277682Chemical and Drug Induced Liver Injury1CTD_human