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Fusion gene ID: 14353 |
FusionGeneSummary for GAPDH_ACTB |
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Fusion gene information | Fusion gene name: GAPDH_ACTB | Fusion gene ID: 14353 | Hgene | Tgene | Gene symbol | GAPDH | ACTB | Gene ID | 2597 | 60 |
Gene name | glyceraldehyde-3-phosphate dehydrogenase | actin beta | |
Synonyms | G3PD|GAPD|HEL-S-162eP | BRWS1|PS1TP5BP1 | |
Cytomap | 12p13.31 | 7p22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | glyceraldehyde-3-phosphate dehydrogenaseOCAS, p38 componentOct1 coactivator in S phase, 38 Kd componentaging-associated gene 9 proteinepididymis secretory sperm binding protein Li 162ePpeptidyl-cysteine S-nitrosylase GAPDH | actin, cytoplasmic 1I(2)-actinPS1TP5-binding protein 1beta cytoskeletal actin | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P04406 | P60709 | |
Ensembl transtripts involved in fusion gene | ENST00000229239, ENST00000396856, ENST00000396861, ENST00000396859, ENST00000396858, | ENST00000464611, ENST00000331789, | |
Fusion gene scores | * DoF score | 18 X 18 X 6=1944 | 10 X 10 X 3=300 |
# samples | 26 | 11 | |
** MAII score | log2(26/1944*10)=-2.90244469057733 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/300*10)=-1.44745897697122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GAPDH [Title/Abstract] AND ACTB [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GAPDH | GO:0010951 | negative regulation of endopeptidase activity | 22832495 |
Hgene | GAPDH | GO:0017148 | negative regulation of translation | 23071094 |
Hgene | GAPDH | GO:0031640 | killing of cells of other organism | 22832495 |
Hgene | GAPDH | GO:0050715 | positive regulation of cytokine secretion | 22832495 |
Hgene | GAPDH | GO:0050832 | defense response to fungus | 22832495 |
Hgene | GAPDH | GO:0051873 | killing by host of symbiont cells | 22832495 |
Hgene | GAPDH | GO:0052501 | positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction | 22832495 |
Hgene | GAPDH | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 22832495 |
Hgene | GAPDH | GO:0071346 | cellular response to interferon-gamma | 15479637 |
Tgene | ACTB | GO:0098974 | postsynaptic actin cytoskeleton organization | 18341992 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-66-2783-01A | GAPDH | chr12 | 6643735 | + | ACTB | chr7 | 5569294 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-intron | ENST00000229239 | ENST00000464611 | GAPDH | chr12 | 6643735 | + | ACTB | chr7 | 5569294 | - |
5UTR-5UTR | ENST00000229239 | ENST00000331789 | GAPDH | chr12 | 6643735 | + | ACTB | chr7 | 5569294 | - |
5UTR-intron | ENST00000396856 | ENST00000464611 | GAPDH | chr12 | 6643735 | + | ACTB | chr7 | 5569294 | - |
5UTR-5UTR | ENST00000396856 | ENST00000331789 | GAPDH | chr12 | 6643735 | + | ACTB | chr7 | 5569294 | - |
5UTR-intron | ENST00000396861 | ENST00000464611 | GAPDH | chr12 | 6643735 | + | ACTB | chr7 | 5569294 | - |
5UTR-5UTR | ENST00000396861 | ENST00000331789 | GAPDH | chr12 | 6643735 | + | ACTB | chr7 | 5569294 | - |
intron-intron | ENST00000396859 | ENST00000464611 | GAPDH | chr12 | 6643735 | + | ACTB | chr7 | 5569294 | - |
intron-5UTR | ENST00000396859 | ENST00000331789 | GAPDH | chr12 | 6643735 | + | ACTB | chr7 | 5569294 | - |
intron-intron | ENST00000396858 | ENST00000464611 | GAPDH | chr12 | 6643735 | + | ACTB | chr7 | 5569294 | - |
intron-5UTR | ENST00000396858 | ENST00000331789 | GAPDH | chr12 | 6643735 | + | ACTB | chr7 | 5569294 | - |
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FusionProtFeatures for GAPDH_ACTB |
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Hgene | Tgene |
GAPDH | ACTB |
Has both glyceraldehyde-3-phosphate dehydrogenase andnitrosylase activities, thereby playing a role in glycolysis andnuclear functions, respectively. Participates in nuclear eventsincluding transcription, RNA transport, DNA replication andapoptosis. Nuclear functions are probably due to the nitrosylaseactivity that mediates cysteine S-nitrosylation of nuclear targetproteins such as SIRT1, HDAC2 and PRKDC. Modulates theorganization and assembly of the cytoskeleton. Facilitates theCHP1-dependent microtubule and membrane associations through itsability to stimulate the binding of CHP1 to microtubules (Bysimilarity). Glyceraldehyde-3-phosphate dehydrogenase is a keyenzyme in glycolysis that catalyzes the first step of the pathwayby converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediatesinterferon-gamma-induced transcript-selective translationinhibition in inflammation processes. Upon interferon-gammatreatment assembles into the GAIT complex which binds to stemloop-containing GAIT elements in the 3'-UTR of diverseinflammatory mRNAs (such as ceruplasmin) and suppresses theirtranslation. {ECO:0000250, ECO:0000269|PubMed:11724794,ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:3170585}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GAPDH_ACTB |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GAPDH_ACTB |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GAPDH | QRICH2, TXN, POU2F1, POU2F2, STIP1, NPAT, PLD2, LAMTOR5, PRDX1, ARL15, BTBD2, LAMA4, PAFAH1B3, PCDHA4, PSMD11, SERPINB9, TK1, RPA2, PRKCI, ATXN1, AR, PDIA2, PTK2, USP25, CDKN1A, SET, CCNB1, CBL, PPP2R2A, POU5F1, CD4, NR1H4, HNF4G, SIRT1, PCNA, MAPK1, PSMA3, GSK3B, BID, RBM5, KARS, HES1, ACTC1, GOT2, NFYC, OSMR, OSTF1, YWHAE, SNCA, KCNE3, ANXA1, SMN1, ANXA7, GADD45A, ARRB2, SLC2A4, EP300, TP53, TERF1, TINF2, ACD, POT1, HTT, GAPDH, PARK2, SIAH1, CUL3, CUL4B, CUL2, CDK2, CUL1, COPS5, COPS6, CAND1, NEDD8, KAT5, ISG15, MYOC, MDM2, ATN1, AKT1, GRB2, AP2M1, NPM1, APP, PSEN1, PGK1, TPI1, PKM, ENO1, HSPD1, EEF1A1, CSTF3, PGAM1, OLA1, PABPN1, HNRNPA3, ESR1, LIG4, HSP90AA1, HSP90AB1, BTK, FN1, VCAM1, ATF2, IQCB1, ITGA4, CD81, ICAM1, MAPK7, RAD52, ADRB2, EGFR, CDK17, YWHAQ, FBXO6, TRAP1, CDKN2A, PRPF40A, GAS7, CAPNS1, ACOT7, CRYZ, DCPS, DFFA, FERMT2, GBP1, HSPA9, METAP2, PPIB, RAP1GDS1, TUBA1A, TUBA1C, TUBB, TUFM, TYMP, UBQLN1, HSPA1L, MAT2B, PPP5C, YWHAG, RPA3, RPA1, ASB15, ASB16, STAU1, HUWE1, FUS, CUL7, OBSL1, CCDC8, EED, SIRT6, BLK, PRKY, MAP3K5, GAPDHS, ASPSCR1, HNRNPA1, AKR1A1, ASS1, CTBP1, DPYD, DTNB, DUT, ENO2, ENO3, ALDOA, CFL1, HSPA8, NLRP2, NUDC, PSMD3, SOD1, TACO1, TKT, GDPGP1, GLOD4, GPD1L, MSRB3, PGAM2, PRDX2, PRDX5, SMEK1, TANGO2, NTRK1, HSPB2, EWSR1, PPME1, CASC5, MED8, ANKRD36, MCM2, MCM5, CDC5L, ESRRB, CDC73, RABGGTA, ZIC1, GRIA2, MTNR1A, CYLD, TRIM25, BRCA1, HDAC6 | ACTB | CFL1, CFL2, ACTB, DSTN, ACTG1, NCALD, RAB8B, MYC, SMARCA4, SMARCE1, SMARCC2, NCF1, RAC1, RAC2, PFN1, PCYT1B, CCT5, CCT2, SSH1, SSH2, SPTBN2, RUVBL2, MEPCE, RUVBL1, PSTPIP1, INO80, BCL7C, MGMT, CENPA, CARM1, EMD, MORF4L1, MORF4L2, MRGBP, ESR1, ACTR3, ACTR2, DMAP1, KAT5, CBL, UCHL5, SMN1, AGO4, SMAD3, TJP1, YWHAQ, PSMA3, BCL2L1, H2AFX, AIMP2, TK1, CDKN1A, FABP4, RCC1, TTR, ANXA7, HMMR, CTGF, POLR2A, TAF11, PCK1, VHL, PROM1, ATF3, HNRNPU, ELAVL1, ARRB2, ANGPTL4, DHX9, ERG, FBXO25, TINF2, ACD, POT1, PPP1CC, PPP1CA, CUL3, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, CAND1, NEDD8, OSTF1, SHBG, MYOC, MKL1, LRRK2, SLC6A2, SNCA, UBASH3B, GRB2, PIK3R2, SHC1, CRK, EPS15, AP2M1, CYBB, IQGAP1, NSMAF, AKT1, ABLIM1, FPR1, A2M, MYH11, CORO1C, FHOD1, MAGOH, EIF4A3, HNF1A, SMURF1, VCP, TRAF3IP1, ERBB2, POLR1B, ESR2, FN1, VCAM1, HCK, DAB2, IQCB1, OTUB1, SMAD9, UBL4A, ITGA4, SVIL, PHB, BBS4, MAP1A, MAP2, NOS3, SLC12A3, DTNA, PAN2, PLG, ICAM1, CD81, ICAM3, MAPK7, AR, MYH9, ACE, RAD52, ENC1, CAV1, EP300, CSNK2B, KHDRBS1, PROSER2, RPL10A, COTL1, HNRNPD, PARK2, CDKN2A, RPA1, RPA2, RPA3, ASB9, ASB12, ZBTB1, HSPA5, ERRFI1, LGR4, CORO7, IVNS1ABP, STAU1, AMOT, HAUS1, CEP250, LGALS3BP, NEDD1, TP53, TUBG1, TUBGCP2, TUBGCP3, FUS, PA2G4, HDAC6, EHHADH, CAP2, WDYHV1, ALK, KAT2B, MDM2, ADA, MAGEA10, TPST1, LMX1B, USP46, DUSP19, HOXB5, HOMER1, PRSS23, HSD17B3, PNMA1, SLC30A6, HNRNPA1, SAMHD1, UNK, CORO1B, CAD, EEF1A1, EEF1A2, YARS, SCARNA22, HSPB2, TCP1, SRPK2, FLNA, PPP1CB, RAB2A, SYNPO, LIMA1, MYO18A, TRIM15, UBE3A, SKI, SNW1, CDC5L, ERBB3, EGFR, EPC1, MBTD1, PTPN1, GC, PHACTR2, PFN2, THRB, TMOD3, REG3A, DBN1, NEXN, TMCC2, COBL, CAP1, TWF2, RNASE3, SFXN5, NPB, SLC25A11, RPL15, PLEKHG6, PPIAL4G, CDK10, SCGB1A1, POLH, RIC3, NUS1, ACP1, IL1RL2, DUSP10, NXF5, THAP4, ZNF695, HTR1E, LSP1, RPS27, MEIS2, FBXL5, DEFA6, CLEC2D, UQCRB, TPGS2, CTNNB1, MTNR1A, CYLD, CCND2, FAM107A, HEY1, TES |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GAPDH_ACTB |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | GAPDH | P04406 | DB11638 | Artenimol | Glyceraldehyde-3-phosphate dehydrogenase | small molecule | approved|investigational |
Hgene | GAPDH | P04406 | DB09092 | Xanthinol | Glyceraldehyde-3-phosphate dehydrogenase | small molecule | approved|withdrawn |
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RelatedDiseases for GAPDH_ACTB |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GAPDH | C2239176 | Liver carcinoma | 2 | CTD_human |
Hgene | GAPDH | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Hgene | GAPDH | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Hgene | GAPDH | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Hgene | GAPDH | C0026640 | Mouth Neoplasms | 1 | CTD_human |
Hgene | GAPDH | C0027540 | Necrosis | 1 | CTD_human |
Hgene | GAPDH | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Hgene | GAPDH | C0029456 | Osteoporosis | 1 | CTD_human |
Hgene | GAPDH | C0242184 | Hypoxia | 1 | CTD_human |
Hgene | GAPDH | C0948089 | Acute Coronary Syndrome | 1 | CTD_human |
Tgene | ACTB | C2239176 | Liver carcinoma | 2 | CTD_human |
Tgene | ACTB | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | ACTB | C0009363 | Congenital ocular coloboma (disorder) | 1 | CTD_human |
Tgene | ACTB | C0013393 | Dysostoses | 1 | CTD_human |
Tgene | ACTB | C0013421 | Dystonia | 1 | CTD_human |
Tgene | ACTB | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Tgene | ACTB | C0018784 | Sensorineural Hearing Loss (disorder) | 1 | CTD_human;HPO |
Tgene | ACTB | C0024121 | Lung Neoplasms | 1 | CTD_human |
Tgene | ACTB | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Tgene | ACTB | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Tgene | ACTB | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Tgene | ACTB | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | ACTB | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | ACTB | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | ACTB | C0242184 | Hypoxia | 1 | CTD_human |
Tgene | ACTB | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Tgene | ACTB | C0497552 | Congenital neurologic anomalies | 1 | CTD_human |
Tgene | ACTB | C1846331 | Juvenile-onset dystonia | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | ACTB | C1855722 | Iris Coloboma with Ptosis, Hypertelorism, and Mental Retardation | 1 | ORPHANET;UNIPROT |