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Fusion gene ID: 14338 |
FusionGeneSummary for GALNT7_SPCS3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GALNT7_SPCS3 | Fusion gene ID: 14338 | Hgene | Tgene | Gene symbol | GALNT7 | SPCS3 | Gene ID | 117248 | 60559 |
| Gene name | polypeptide N-acetylgalactosaminyltransferase 15 | signal peptidase complex subunit 3 | |
| Synonyms | GALNACT15|GALNT13|GALNT7|GALNTL2|PIH5|pp-GalNAc-T15 | PRO3567|SPC22/23|SPC3|YLR066W | |
| Cytomap | 3p25.1 | 4q34.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | polypeptide N-acetylgalactosaminyltransferase 15UDP-GalNAc transferase T15UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15UDP-N-acetyl-alpha-D-ga | signal peptidase complex subunit 3SPase 22 kDa subunitSPase 22/23 kDa subunitmicrosomal signal peptidase 22/23 kDa subunitmicrosomal signal peptidase 23 kDa subunitsignal peptidase complex subunit 3 homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q86SF2 | P61009 | |
| Ensembl transtripts involved in fusion gene | ENST00000265000, ENST00000512285, ENST00000502407, | ENST00000503362, ENST00000507001, | |
| Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 3 X 1 X 1=3 |
| # samples | 10 | 3 | |
| ** MAII score | log2(10/168*10)=-0.748461233004036 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/3*10)=3.32192809488736 | |
| Context | PubMed: GALNT7 [Title/Abstract] AND SPCS3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SPCS3 | GO:0006508 | proteolysis | 27499293 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-7123-01A | GALNT7 | chr4 | 174169591 | + | SPCS3 | chr4 | 177243321 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000265000 | ENST00000503362 | GALNT7 | chr4 | 174169591 | + | SPCS3 | chr4 | 177243321 | + |
| 5CDS-intron | ENST00000265000 | ENST00000507001 | GALNT7 | chr4 | 174169591 | + | SPCS3 | chr4 | 177243321 | + |
| In-frame | ENST00000512285 | ENST00000503362 | GALNT7 | chr4 | 174169591 | + | SPCS3 | chr4 | 177243321 | + |
| 5CDS-intron | ENST00000512285 | ENST00000507001 | GALNT7 | chr4 | 174169591 | + | SPCS3 | chr4 | 177243321 | + |
| intron-3CDS | ENST00000502407 | ENST00000503362 | GALNT7 | chr4 | 174169591 | + | SPCS3 | chr4 | 177243321 | + |
| intron-intron | ENST00000502407 | ENST00000507001 | GALNT7 | chr4 | 174169591 | + | SPCS3 | chr4 | 177243321 | + |
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FusionProtFeatures for GALNT7_SPCS3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GALNT7 | SPCS3 |
| Glycopeptide transferase involved in O-linkedoligosaccharide biosynthesis, which catalyzes the transfer of anN-acetyl-D-galactosamine residue to an already glycosylatedpeptide. In contrast to other proteins of the family, it does notact as a peptide transferase that transfers GalNAc onto serine orthreonine residue on the protein receptor, but instead requiresthe prior addition of a GalNAc on a peptide before addingadditional GalNAc moieties. Some peptide transferase activity ishowever not excluded, considering that its appropriate peptidesubstrate may remain unidentified. | Component of the microsomal signal peptidase complexwhich removes signal peptides and other N-terminal peptides fromnascent proteins as they are translocated into the lumen of theendoplasmic reticulum. {ECO:0000269|PubMed:27499293}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GALNT7 | chr4:174169591 | chr4:177243321 | ENST00000265000 | + | 2 | 12 | 1_6 | 195 | 658 | Topological domain | Cytoplasmic |
| Hgene | GALNT7 | chr4:174169591 | chr4:177243321 | ENST00000265000 | + | 2 | 12 | 7_29 | 195 | 658 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GALNT7 | chr4:174169591 | chr4:177243321 | ENST00000265000 | + | 2 | 12 | 532_652 | 195 | 658 | Domain | Ricin B-type lectin |
| Hgene | >GALNT7 | chr4:174169591 | chr4:177243321 | ENST00000265000 | + | 2 | 12 | 206_317 | 195 | 658 | Region | Note=Catalytic subdomain A |
| Hgene | >GALNT7 | chr4:174169591 | chr4:177243321 | ENST00000265000 | + | 2 | 12 | 381_443 | 195 | 658 | Region | Note=Catalytic subdomain B |
| Hgene | >GALNT7 | chr4:174169591 | chr4:177243321 | ENST00000265000 | + | 2 | 12 | 30_657 | 195 | 658 | Topological domain | Lumenal |
| Tgene | SPCS3 | chr4:174169591 | chr4:177243321 | ENST00000503362 | + | 0 | 5 | 1_11 | 47 | 181 | Topological domain | Cytoplasmic |
| Tgene | SPCS3 | chr4:174169591 | chr4:177243321 | ENST00000503362 | + | 0 | 5 | 33_180 | 47 | 181 | Topological domain | Lumenal |
| Tgene | SPCS3 | chr4:174169591 | chr4:177243321 | ENST00000503362 | + | 0 | 5 | 12_32 | 47 | 181 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for GALNT7_SPCS3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GALNT7_ENST00000265000_chr4_174169591_+_SPCS3_ENST00000503362_chr4_177243321_+_329aa MRLKIGFILRSLLVVGSFLGLVVLWSSLTPRPDDPSPLSRMREDRDVNDPMPNRGGNGLAPGEDRFKPVVPWPHVEGVEVDLESIRRINK AKNEQEHHAGGDSQKDIMQRQYLTFKPQTFTYHDPVLRPGILGNFEPKEPEPPGVVGGPGEKAKPLVLGPEFKQAIQASIKEFGFNMVAS DMISLDRSVNDLRQEEKNVEDFTGPRERSDLGFITFDITADLENIFDWNVKQLFLYLSAEYSTKNNALNQVVLWDKIVLRGDNPKLLLKD >In-frame_GALNT7_ENST00000512285_chr4_174169591_+_SPCS3_ENST00000503362_chr4_177243321_+_329aa MRLKIGFILRSLLVVGSFLGLVVLWSSLTPRPDDPSPLSRMREDRDVNDPMPNRGGNGLAPGEDRFKPVVPWPHVEGVEVDLESIRRINK AKNEQEHHAGGDSQKDIMQRQYLTFKPQTFTYHDPVLRPGILGNFEPKEPEPPGVVGGPGEKAKPLVLGPEFKQAIQASIKEFGFNMVAS DMISLDRSVNDLRQEEKNVEDFTGPRERSDLGFITFDITADLENIFDWNVKQLFLYLSAEYSTKNNALNQVVLWDKIVLRGDNPKLLLKD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GALNT7_ENST00000265000_chr4_174169591_+_SPCS3_ENST00000503362_chr4_177243321_+_987nt ATGAGGCTGAAGATTGGGTTCATCTTACGCAGTTTGCTGGTGGTGGGAAGCTTCCTGGGGCTAGTGGTCCTCTGGTCTTCCCTGACCCCG CGGCCGGACGACCCAAGCCCGCTGAGCAGGATGAGGGAAGACAGAGATGTCAATGACCCCATGCCCAACCGAGGCGGCAATGGACTAGCT CCTGGGGAGGACAGATTCAAACCTGTGGTACCATGGCCTCATGTTGAAGGAGTAGAAGTGGACTTAGAGTCTATTAGAAGAATAAACAAG GCCAAAAATGAACAAGAGCACCATGCTGGAGGAGATTCCCAGAAAGATATCATGCAGAGGCAGTATCTCACATTTAAGCCTCAGACATTC ACCTACCATGATCCTGTGCTTCGCCCAGGGATCCTCGGTAACTTTGAACCCAAAGAACCTGAGCCTCCTGGAGTGGTTGGTGGCCCTGGA GAGAAAGCCAAGCCATTGGTTTTGGGACCAGAATTCAAACAAGCAATTCAAGCCAGCATTAAAGAGTTTGGATTTAACATGGTGGCAAGT GACATGATCTCACTGGACCGCAGCGTCAATGACTTACGCCAAGAAGAAAAAAATGTAGAAGATTTCACTGGACCTAGAGAAAGAAGTGAT CTGGGATTTATCACATTTGATATAACTGCTGATCTAGAGAATATATTTGATTGGAATGTTAAGCAGTTGTTTCTTTATTTATCAGCAGAA TATTCAACAAAAAATAATGCTCTGAACCAAGTTGTCCTATGGGACAAGATTGTTTTGAGAGGTGATAATCCGAAGCTGCTGCTGAAAGAT ATGAAAACAAAATATTTTTTCTTTGACGATGGAAATGGTCTCAAGGGAAACAGGAATGTCACTTTGACCCTGTCTTGGAACGTCGTACCA >In-frame_GALNT7_ENST00000512285_chr4_174169591_+_SPCS3_ENST00000503362_chr4_177243321_+_987nt ATGAGGCTGAAGATTGGGTTCATCTTACGCAGTTTGCTGGTGGTGGGAAGCTTCCTGGGGCTAGTGGTCCTCTGGTCTTCCCTGACCCCG CGGCCGGACGACCCAAGCCCGCTGAGCAGGATGAGGGAAGACAGAGATGTCAATGACCCCATGCCCAACCGAGGCGGCAATGGACTAGCT CCTGGGGAGGACAGATTCAAACCTGTGGTACCATGGCCTCATGTTGAAGGAGTAGAAGTGGACTTAGAGTCTATTAGAAGAATAAACAAG GCCAAAAATGAACAAGAGCACCATGCTGGAGGAGATTCCCAGAAAGATATCATGCAGAGGCAGTATCTCACATTTAAGCCTCAGACATTC ACCTACCATGATCCTGTGCTTCGCCCAGGGATCCTCGGTAACTTTGAACCCAAAGAACCTGAGCCTCCTGGAGTGGTTGGTGGCCCTGGA GAGAAAGCCAAGCCATTGGTTTTGGGACCAGAATTCAAACAAGCAATTCAAGCCAGCATTAAAGAGTTTGGATTTAACATGGTGGCAAGT GACATGATCTCACTGGACCGCAGCGTCAATGACTTACGCCAAGAAGAAAAAAATGTAGAAGATTTCACTGGACCTAGAGAAAGAAGTGAT CTGGGATTTATCACATTTGATATAACTGCTGATCTAGAGAATATATTTGATTGGAATGTTAAGCAGTTGTTTCTTTATTTATCAGCAGAA TATTCAACAAAAAATAATGCTCTGAACCAAGTTGTCCTATGGGACAAGATTGTTTTGAGAGGTGATAATCCGAAGCTGCTGCTGAAAGAT ATGAAAACAAAATATTTTTTCTTTGACGATGGAAATGGTCTCAAGGGAAACAGGAATGTCACTTTGACCCTGTCTTGGAACGTCGTACCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GALNT7_ENST00000265000_chr4_174169591_+_SPCS3_ENST00000503362_chr4_177243321_+_4985nt AGAGCCGGAGGAGGGGGAAGGAGGGAGGGGAGAGCGGTGGCGGCGGCTGCGCCGGGCTGTGAGTCTCTCGCCGCCGGAGGAAGATGAGGC TGAAGATTGGGTTCATCTTACGCAGTTTGCTGGTGGTGGGAAGCTTCCTGGGGCTAGTGGTCCTCTGGTCTTCCCTGACCCCGCGGCCGG ACGACCCAAGCCCGCTGAGCAGGATGAGGGAAGACAGAGATGTCAATGACCCCATGCCCAACCGAGGCGGCAATGGACTAGCTCCTGGGG AGGACAGATTCAAACCTGTGGTACCATGGCCTCATGTTGAAGGAGTAGAAGTGGACTTAGAGTCTATTAGAAGAATAAACAAGGCCAAAA ATGAACAAGAGCACCATGCTGGAGGAGATTCCCAGAAAGATATCATGCAGAGGCAGTATCTCACATTTAAGCCTCAGACATTCACCTACC ATGATCCTGTGCTTCGCCCAGGGATCCTCGGTAACTTTGAACCCAAAGAACCTGAGCCTCCTGGAGTGGTTGGTGGCCCTGGAGAGAAAG CCAAGCCATTGGTTTTGGGACCAGAATTCAAACAAGCAATTCAAGCCAGCATTAAAGAGTTTGGATTTAACATGGTGGCAAGTGACATGA TCTCACTGGACCGCAGCGTCAATGACTTACGCCAAGAAGAAAAAAATGTAGAAGATTTCACTGGACCTAGAGAAAGAAGTGATCTGGGAT TTATCACATTTGATATAACTGCTGATCTAGAGAATATATTTGATTGGAATGTTAAGCAGTTGTTTCTTTATTTATCAGCAGAATATTCAA CAAAAAATAATGCTCTGAACCAAGTTGTCCTATGGGACAAGATTGTTTTGAGAGGTGATAATCCGAAGCTGCTGCTGAAAGATATGAAAA CAAAATATTTTTTCTTTGACGATGGAAATGGTCTCAAGGGAAACAGGAATGTCACTTTGACCCTGTCTTGGAACGTCGTACCAAATGCTG GAATTCTACCTCTTGTGACAGGATCAGGACACGTATCTGTCCCATTTCCAGATACATATGAAATAACGAAGAGTTATTAAATTATTCTGA ATTTGAAACAACATATTTTTATACTTAATGAATTGTATCTCATTAATCTCTTCCCTTACATCTTCATGTATTGTTGGTTTGTTTTTTGGT TTTGGGTTTTTTTTTTTTTTTTTTTGGTATAAGAACTAACATCAAAAGGCCTGTTTAAAGGGAAAGGTTAATGGGCTACTTAATATTATG AACAAAACAAAAAAACAAGGCTGCCACAGTGGAATATTATCTTACAAGAATAAGAACTACATAAAACAGATTTGTAAAAAATACATATTT GAAGTATTCCCTGTATTTCCATTATTCTTTATGGAATATAAAGTAAGCATGAAAGGTAGTTAAAACTTTCAGGTGCCTGTAGAGTCATAA TAACTGTATTTTATGCCTTGCATTCACGCAAATTCACATTGGATGTGATTTAAAAGTAGACATTCTCTTTTTCCTCTTTTAGGATATGTT TGATTACTGGAAAATTAATATGGTTATTTGTTAGAAGTCTGGTTTATAAAAAAGCCAAAAGTGATGGAATTTATTCCATTTGTCTTAGGA AGGCCCATAATACTTGTTTTTCTTACATGTGACTAGCAACTTTCTCCACTTAAAGACTAAATACCTCTTTATATGATGTAAATTATTCTA ATTCATTTTAAAATCTTTTAGGTCAGCAAAATGTGTGTCTTCAGTGCTTTCTCTAAAAACGTTCCTTTATAGCTTTGTACTTTTTTTTTT AGCGTTGCCATTGAAAGTTAAAATGTTTGCATGGTTTACCCTCTGAGTTATGTTTCTTCTAGTGAGCATGCCTGCTGTCACTAAGTGAAT TATTTACTACTTTTTGTAGGTCTATATTTTAATAATTATTGGGATAATAATAATTGTGGTATGCTTTCCATTTACAAACCACTCATATAC TTTAGTGTATGTCATCCTCAATAATCTAATGAGGTAAGTAGTATAAGTGTTAGCTCTTTGCAGATAAGAAACTGAAACCCAGAAGTTTAT TGAATTGCTTCATTGTTACCTAGCCAGCAAGGAGTGGAATTAAAACTTGAACTCAGATCTTCTAATTTTCTGAGCTCATCCTTTCTCTTA TACCTCAGATTGCAGACTAATCAAATTTTACTTAAAACCTTCCTGATATTTTTGTTACCCTGGACACCCTTTCTATTCTAGAAAAGGTTT CCCATTTTATATGGAAGTGACTAATTTTCAAGCTGCCAACAACTTATATCGAGGTAATATTTTATTCTCTGAATAAATTCATTTCACTTA TATTAAAAGCATAAGGAAATCTACATGTATGTAAAAATAACTTAGAAATTCAGTACATAATACATGATTGAATACATGATCGTATTTAAC ATGTTTTTTTTTTCTGCAGTGGACAAATAAACATCCTCAAAGTAGCAACTGCAAATCAGTTACCCTTAGAAAAGCAAGACCAAACACTGT AGTTACACTATTAGCAGTGACCAAAAAGGGCTAATATTTTCTAAGAATAGTTTAAATTACAGACATTTGTTATATTTACCTTATGTGAAA TACATCACTATTTAATTACATTAATTTTAACATCTGTTGTGTGGAGTTGTATAGTTCATGCAAAAGCCTGTGGGTATGGGTTTTTCAAAC CAGCAGAAAGGTCAAAGGTACCTGAATGCTAAACTGCCTGGCTCCCAGCTTTTTCATTAAACTTTTCAGGGTCTTGGTTTCTTTATCTGT AAAATGACAGAGTTGGACCAGTTAACTTTAATGGCCATCCTTTTACACCACACAAGTTGATAAAATTTATCTGTTCAGCAAAGAGATTGA ACAAAAAAGCACGTTAGTAATATGAAGACAGGAAAACGAATGAAAGTCTAACACATAACTCATATTGATTTACTTTATTTCTGTTAGATT TTACACTCTGAAAATTTCACCTCATTTAGTTTGTACAAATACTAGACATGGAAACTTAAAATGTGCAGGTGTCAAAGCTTAAAAATCAGG TGTGTCCTCTTTAAAGGCATGTGCGATAAGCCTGCAGTCTTAACCAGACCTGGTACCAGTTTAACAGTTCATGATACTTCTGTGATGAGT GGATCTGTTAGTCTGGTAGAGATTAATGTTGAAATTTACTTGAATTACAGTTATTTGACAAGCCCACTTTTTTTGGAGTTTGGTGAGGAA GATAAGTAAAAATGCCCAACTAGTACAATGTGGAGAAAGTTTTCTGTTTGCTTGACTAAGGGAAATTGCTCAGAAAAAGAATGCTCCAAC ATGGGAATAAGGACCTTCAGTCTCAGGAACTCATTTTTGGGTGCAGTTTCTACATTTAAAAAATTGACTTGTGTTCAGTTTGATAACCAG TTCATTTGCTTTAGTCTCAGTGTTTTAAAGAAGTCTCATAATGTTCTACAAAGACACAAAGCTTCAGGCTTATACAAAACTGAGTATGAT TAGAAATACCTGAGCCCAGAAATGATTCTGAGAAAAGAGAATAATTTGAAGACACTTATTTAAAAGTAATTATGGTTAGAAATGAATTAA TTTAAAAATGTGTTCACATATCCCTTTCTCTAACAGTTTAACCTAGACAAACATCTGTATCAGTATTTTTTTATTCCCCTGATTGATTAC ATTTGGTTTCTTTATTCTGAAAGGAAAATAACAAAAACTTCAGAAATTCCTAAGGGTGTAATAAGAAAGTGGGTTTTGAGTTTCCTTTCC TGGAATTATTTTACAGTTCTTTGGTGGGTCTCGTCAGCCAATTCATAGCTGGGCTTTAAGATTATCATCTTAGAGATGATAGATGGGCTT TTTAAAGATTTCATCTTAGAGATGAAAAGCTGGGCTTTTTCTCTAAGATGATAATCTTAAAGCCCAGCTATTAATTGATAATGAACATTT TTCACTATTTTTTTTTCTATCTGAAGCTTAGAGATCTAGAGCTTTGGATCTTTCGGGTATATGTCAATGGAGGTATTATTTTATAATACT TTGCATTGACATGAAGTGGGTTCATGGGGGAAAACCATGAGCTGTGAACATTGGTAGCAAACAAGCATATATTCATTTCAAAACTTTCCT TGCTTTTAGCAGAGAGAAGCCTGTATATGTTACATGTGTGACTTTCAGTAGTTTAAAGAGATGTTTCAAAAAATTGTTGCATGTTTTTGA TGCAATTTGGGAAATTGTTTACTTCACAATGTAGTCATTCATAAAAAAATTCATGAAAATACTGAACATATGTTTGAGGATTTTTCTTTT CCTTTTTAAATTTTTTTATTTTTTCTGAGACGGAGATCTGCTCTTACGCCCAGGCTAGAGTGAAGTGGCGCGATCTTGGCTTACTGCAAC CTCCACCCCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGATTACAGGCGCCCGCCACCACGTCCGGCTAATTTTT GTATTTTCAGTAGAGACGGGGTTTTGCTATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGTGATCCACCTGCCTCGGCCTCCCAA AGTGTTAGGATAACAGGTGTGAGCCACCGTGCCCGGCTGAAGATTTTTCTTAATTGCAATAAATATTCAGCATTTTTTCTAATGAAAATG AATTTTGTTTACCAGTAAAAGTATGCATTTTAAAAGACTTTCAGATTTATGCTTTTTACGTGAAGCTGCTAAACTAAAAGTAAATGGAAG AAACCAAGTCTAGTAGGTTTTTTCTTTTTTTTTGTGGGGGTGGGATGGGGGAGGTTAGTTACACTTAAAATATCTTCTCCAGAGACTGTA TGCTCCTATACTAGACTGTAAGCTCTTTGAGGGCAGTCTGTCAGATTTATCTTTGTATCTTCCCCAGCGCCTAGTGTAGTGCCTTGCACA >In-frame_GALNT7_ENST00000512285_chr4_174169591_+_SPCS3_ENST00000503362_chr4_177243321_+_4927nt GTGAGTCTCTCGCCGCCGGAGGAAGATGAGGCTGAAGATTGGGTTCATCTTACGCAGTTTGCTGGTGGTGGGAAGCTTCCTGGGGCTAGT GGTCCTCTGGTCTTCCCTGACCCCGCGGCCGGACGACCCAAGCCCGCTGAGCAGGATGAGGGAAGACAGAGATGTCAATGACCCCATGCC CAACCGAGGCGGCAATGGACTAGCTCCTGGGGAGGACAGATTCAAACCTGTGGTACCATGGCCTCATGTTGAAGGAGTAGAAGTGGACTT AGAGTCTATTAGAAGAATAAACAAGGCCAAAAATGAACAAGAGCACCATGCTGGAGGAGATTCCCAGAAAGATATCATGCAGAGGCAGTA TCTCACATTTAAGCCTCAGACATTCACCTACCATGATCCTGTGCTTCGCCCAGGGATCCTCGGTAACTTTGAACCCAAAGAACCTGAGCC TCCTGGAGTGGTTGGTGGCCCTGGAGAGAAAGCCAAGCCATTGGTTTTGGGACCAGAATTCAAACAAGCAATTCAAGCCAGCATTAAAGA GTTTGGATTTAACATGGTGGCAAGTGACATGATCTCACTGGACCGCAGCGTCAATGACTTACGCCAAGAAGAAAAAAATGTAGAAGATTT CACTGGACCTAGAGAAAGAAGTGATCTGGGATTTATCACATTTGATATAACTGCTGATCTAGAGAATATATTTGATTGGAATGTTAAGCA GTTGTTTCTTTATTTATCAGCAGAATATTCAACAAAAAATAATGCTCTGAACCAAGTTGTCCTATGGGACAAGATTGTTTTGAGAGGTGA TAATCCGAAGCTGCTGCTGAAAGATATGAAAACAAAATATTTTTTCTTTGACGATGGAAATGGTCTCAAGGGAAACAGGAATGTCACTTT GACCCTGTCTTGGAACGTCGTACCAAATGCTGGAATTCTACCTCTTGTGACAGGATCAGGACACGTATCTGTCCCATTTCCAGATACATA TGAAATAACGAAGAGTTATTAAATTATTCTGAATTTGAAACAACATATTTTTATACTTAATGAATTGTATCTCATTAATCTCTTCCCTTA CATCTTCATGTATTGTTGGTTTGTTTTTTGGTTTTGGGTTTTTTTTTTTTTTTTTTTGGTATAAGAACTAACATCAAAAGGCCTGTTTAA AGGGAAAGGTTAATGGGCTACTTAATATTATGAACAAAACAAAAAAACAAGGCTGCCACAGTGGAATATTATCTTACAAGAATAAGAACT ACATAAAACAGATTTGTAAAAAATACATATTTGAAGTATTCCCTGTATTTCCATTATTCTTTATGGAATATAAAGTAAGCATGAAAGGTA GTTAAAACTTTCAGGTGCCTGTAGAGTCATAATAACTGTATTTTATGCCTTGCATTCACGCAAATTCACATTGGATGTGATTTAAAAGTA GACATTCTCTTTTTCCTCTTTTAGGATATGTTTGATTACTGGAAAATTAATATGGTTATTTGTTAGAAGTCTGGTTTATAAAAAAGCCAA AAGTGATGGAATTTATTCCATTTGTCTTAGGAAGGCCCATAATACTTGTTTTTCTTACATGTGACTAGCAACTTTCTCCACTTAAAGACT AAATACCTCTTTATATGATGTAAATTATTCTAATTCATTTTAAAATCTTTTAGGTCAGCAAAATGTGTGTCTTCAGTGCTTTCTCTAAAA ACGTTCCTTTATAGCTTTGTACTTTTTTTTTTAGCGTTGCCATTGAAAGTTAAAATGTTTGCATGGTTTACCCTCTGAGTTATGTTTCTT CTAGTGAGCATGCCTGCTGTCACTAAGTGAATTATTTACTACTTTTTGTAGGTCTATATTTTAATAATTATTGGGATAATAATAATTGTG GTATGCTTTCCATTTACAAACCACTCATATACTTTAGTGTATGTCATCCTCAATAATCTAATGAGGTAAGTAGTATAAGTGTTAGCTCTT TGCAGATAAGAAACTGAAACCCAGAAGTTTATTGAATTGCTTCATTGTTACCTAGCCAGCAAGGAGTGGAATTAAAACTTGAACTCAGAT CTTCTAATTTTCTGAGCTCATCCTTTCTCTTATACCTCAGATTGCAGACTAATCAAATTTTACTTAAAACCTTCCTGATATTTTTGTTAC CCTGGACACCCTTTCTATTCTAGAAAAGGTTTCCCATTTTATATGGAAGTGACTAATTTTCAAGCTGCCAACAACTTATATCGAGGTAAT ATTTTATTCTCTGAATAAATTCATTTCACTTATATTAAAAGCATAAGGAAATCTACATGTATGTAAAAATAACTTAGAAATTCAGTACAT AATACATGATTGAATACATGATCGTATTTAACATGTTTTTTTTTTCTGCAGTGGACAAATAAACATCCTCAAAGTAGCAACTGCAAATCA GTTACCCTTAGAAAAGCAAGACCAAACACTGTAGTTACACTATTAGCAGTGACCAAAAAGGGCTAATATTTTCTAAGAATAGTTTAAATT ACAGACATTTGTTATATTTACCTTATGTGAAATACATCACTATTTAATTACATTAATTTTAACATCTGTTGTGTGGAGTTGTATAGTTCA TGCAAAAGCCTGTGGGTATGGGTTTTTCAAACCAGCAGAAAGGTCAAAGGTACCTGAATGCTAAACTGCCTGGCTCCCAGCTTTTTCATT AAACTTTTCAGGGTCTTGGTTTCTTTATCTGTAAAATGACAGAGTTGGACCAGTTAACTTTAATGGCCATCCTTTTACACCACACAAGTT GATAAAATTTATCTGTTCAGCAAAGAGATTGAACAAAAAAGCACGTTAGTAATATGAAGACAGGAAAACGAATGAAAGTCTAACACATAA CTCATATTGATTTACTTTATTTCTGTTAGATTTTACACTCTGAAAATTTCACCTCATTTAGTTTGTACAAATACTAGACATGGAAACTTA AAATGTGCAGGTGTCAAAGCTTAAAAATCAGGTGTGTCCTCTTTAAAGGCATGTGCGATAAGCCTGCAGTCTTAACCAGACCTGGTACCA GTTTAACAGTTCATGATACTTCTGTGATGAGTGGATCTGTTAGTCTGGTAGAGATTAATGTTGAAATTTACTTGAATTACAGTTATTTGA CAAGCCCACTTTTTTTGGAGTTTGGTGAGGAAGATAAGTAAAAATGCCCAACTAGTACAATGTGGAGAAAGTTTTCTGTTTGCTTGACTA AGGGAAATTGCTCAGAAAAAGAATGCTCCAACATGGGAATAAGGACCTTCAGTCTCAGGAACTCATTTTTGGGTGCAGTTTCTACATTTA AAAAATTGACTTGTGTTCAGTTTGATAACCAGTTCATTTGCTTTAGTCTCAGTGTTTTAAAGAAGTCTCATAATGTTCTACAAAGACACA AAGCTTCAGGCTTATACAAAACTGAGTATGATTAGAAATACCTGAGCCCAGAAATGATTCTGAGAAAAGAGAATAATTTGAAGACACTTA TTTAAAAGTAATTATGGTTAGAAATGAATTAATTTAAAAATGTGTTCACATATCCCTTTCTCTAACAGTTTAACCTAGACAAACATCTGT ATCAGTATTTTTTTATTCCCCTGATTGATTACATTTGGTTTCTTTATTCTGAAAGGAAAATAACAAAAACTTCAGAAATTCCTAAGGGTG TAATAAGAAAGTGGGTTTTGAGTTTCCTTTCCTGGAATTATTTTACAGTTCTTTGGTGGGTCTCGTCAGCCAATTCATAGCTGGGCTTTA AGATTATCATCTTAGAGATGATAGATGGGCTTTTTAAAGATTTCATCTTAGAGATGAAAAGCTGGGCTTTTTCTCTAAGATGATAATCTT AAAGCCCAGCTATTAATTGATAATGAACATTTTTCACTATTTTTTTTTCTATCTGAAGCTTAGAGATCTAGAGCTTTGGATCTTTCGGGT ATATGTCAATGGAGGTATTATTTTATAATACTTTGCATTGACATGAAGTGGGTTCATGGGGGAAAACCATGAGCTGTGAACATTGGTAGC AAACAAGCATATATTCATTTCAAAACTTTCCTTGCTTTTAGCAGAGAGAAGCCTGTATATGTTACATGTGTGACTTTCAGTAGTTTAAAG AGATGTTTCAAAAAATTGTTGCATGTTTTTGATGCAATTTGGGAAATTGTTTACTTCACAATGTAGTCATTCATAAAAAAATTCATGAAA ATACTGAACATATGTTTGAGGATTTTTCTTTTCCTTTTTAAATTTTTTTATTTTTTCTGAGACGGAGATCTGCTCTTACGCCCAGGCTAG AGTGAAGTGGCGCGATCTTGGCTTACTGCAACCTCCACCCCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGATTA CAGGCGCCCGCCACCACGTCCGGCTAATTTTTGTATTTTCAGTAGAGACGGGGTTTTGCTATGTTGGCCAGGCTGGTCTCAAACTCCTGA CCTCAAGTGATCCACCTGCCTCGGCCTCCCAAAGTGTTAGGATAACAGGTGTGAGCCACCGTGCCCGGCTGAAGATTTTTCTTAATTGCA ATAAATATTCAGCATTTTTTCTAATGAAAATGAATTTTGTTTACCAGTAAAAGTATGCATTTTAAAAGACTTTCAGATTTATGCTTTTTA CGTGAAGCTGCTAAACTAAAAGTAAATGGAAGAAACCAAGTCTAGTAGGTTTTTTCTTTTTTTTTGTGGGGGTGGGATGGGGGAGGTTAG TTACACTTAAAATATCTTCTCCAGAGACTGTATGCTCCTATACTAGACTGTAAGCTCTTTGAGGGCAGTCTGTCAGATTTATCTTTGTAT |
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FusionGenePPI for GALNT7_SPCS3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GALNT7 | MAPK6, TAZ, ATP1B3, TNFSF11, ANTXR1, B3GNT3, DNASE2B, ART3, B3GNT2, PTCH1, SIAE, PLTP, SLC9A1, REEP5, TCTN2, ADPGK, GALNT12, MPPE1, MAN2A2, DEFA5, GALNT4, GAA, NCEH1, CLTCL1, RMND1, DKKL1, MME | SPCS3 | FBXO6, TCTN2, TCTN3, EVC2, TCTN1, TMEM17, TMEM216, TMEM67, MCM2, SEC11C, PTPRO, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GALNT7_SPCS3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GALNT7_SPCS3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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