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Fusion gene ID: 14337 |
FusionGeneSummary for GALNT7_SAP30 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GALNT7_SAP30 | Fusion gene ID: 14337 | Hgene | Tgene | Gene symbol | GALNT7 | SAP30 | Gene ID | 117248 | 8819 |
| Gene name | polypeptide N-acetylgalactosaminyltransferase 15 | Sin3A associated protein 30 | |
| Synonyms | GALNACT15|GALNT13|GALNT7|GALNTL2|PIH5|pp-GalNAc-T15 | - | |
| Cytomap | 3p25.1 | 4q34.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | polypeptide N-acetylgalactosaminyltransferase 15UDP-GalNAc transferase T15UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15UDP-N-acetyl-alpha-D-ga | histone deacetylase complex subunit SAP3030 kDa Sin3-associated polypeptideSin3 corepressor complex subunit SAP30Sin3-associated polypeptide, 30kDaSin3A-associated protein, 30kDasin3-associated polypeptide p30sin3-associated polypeptide, 30 kDa | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q86SF2 | O75446 | |
| Ensembl transtripts involved in fusion gene | ENST00000265000, ENST00000512285, ENST00000502407, | ENST00000504618, ENST00000296504, | |
| Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 1 X 1 X 2=2 |
| # samples | 10 | 3 | |
| ** MAII score | log2(10/168*10)=-0.748461233004036 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/2*10)=3.90689059560852 | |
| Context | PubMed: GALNT7 [Title/Abstract] AND SAP30 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SAP30 | GO:0006355 | regulation of transcription, DNA-templated | 9651585 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AR-A24R-01A | GALNT7 | chr4 | 174090112 | + | SAP30 | chr4 | 174294541 | + |
| TCGA | LD | BRCA | TCGA-D8-A1JG-01B | GALNT7 | chr4 | 174090112 | + | SAP30 | chr4 | 174294541 | + |
| TCGA | LD | LUSC | TCGA-21-5783-01A | GALNT7 | chr4 | 174090112 | + | SAP30 | chr4 | 174294541 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000265000 | ENST00000504618 | GALNT7 | chr4 | 174090112 | + | SAP30 | chr4 | 174294541 | + |
| 5CDS-intron | ENST00000265000 | ENST00000296504 | GALNT7 | chr4 | 174090112 | + | SAP30 | chr4 | 174294541 | + |
| 5CDS-intron | ENST00000512285 | ENST00000504618 | GALNT7 | chr4 | 174090112 | + | SAP30 | chr4 | 174294541 | + |
| 5CDS-intron | ENST00000512285 | ENST00000296504 | GALNT7 | chr4 | 174090112 | + | SAP30 | chr4 | 174294541 | + |
| intron-intron | ENST00000502407 | ENST00000504618 | GALNT7 | chr4 | 174090112 | + | SAP30 | chr4 | 174294541 | + |
| intron-intron | ENST00000502407 | ENST00000296504 | GALNT7 | chr4 | 174090112 | + | SAP30 | chr4 | 174294541 | + |
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FusionProtFeatures for GALNT7_SAP30 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GALNT7 | SAP30 |
| Glycopeptide transferase involved in O-linkedoligosaccharide biosynthesis, which catalyzes the transfer of anN-acetyl-D-galactosamine residue to an already glycosylatedpeptide. In contrast to other proteins of the family, it does notact as a peptide transferase that transfers GalNAc onto serine orthreonine residue on the protein receptor, but instead requiresthe prior addition of a GalNAc on a peptide before addingadditional GalNAc moieties. Some peptide transferase activity ishowever not excluded, considering that its appropriate peptidesubstrate may remain unidentified. | Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoRcorepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in acomplex) but inactive in deacetylating nucleosomal histones.{ECO:0000250|UniProtKB:O88574, ECO:0000269|PubMed:9651585}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GALNT7_SAP30 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GALNT7_SAP30 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GALNT7 | MAPK6, TAZ, ATP1B3, TNFSF11, ANTXR1, B3GNT3, DNASE2B, ART3, B3GNT2, PTCH1, SIAE, PLTP, SLC9A1, REEP5, TCTN2, ADPGK, GALNT12, MPPE1, MAN2A2, DEFA5, GALNT4, GAA, NCEH1, CLTCL1, RMND1, DKKL1, MME | SAP30 | YY1, HDAC1, SIN3A, CIR1, RBBP4, RBBP7, HDAC2, SIN3B, MTA2, NCOR1, NCOR2, PHF12, ING1, MXD1, ING2, HIST2H2BE, ID3, PCBD1, HDAC3, RBP1, SAP25, SMARCA2, TAF6, ARID4A, CHD4, UBASH3B, ZNF395, SAMSN1, BRMS1L, DDB1, CUL4B, BRMS1, ARID4B, KMT2A, LYST, FOXK2, SMC1A, SRA1, EBP, ZCCHC17, GAR1, BAHCC1, FAM60A, SUDS3, SAP130, TNRC18, CMBL, FOXK1, GATAD1, ZNF704, MXD3, PHF23 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GALNT7_SAP30 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GALNT7_SAP30 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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