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Fusion gene ID: 14337 |
FusionGeneSummary for GALNT7_SAP30 |
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Fusion gene information | Fusion gene name: GALNT7_SAP30 | Fusion gene ID: 14337 | Hgene | Tgene | Gene symbol | GALNT7 | SAP30 | Gene ID | 117248 | 8819 |
Gene name | polypeptide N-acetylgalactosaminyltransferase 15 | Sin3A associated protein 30 | |
Synonyms | GALNACT15|GALNT13|GALNT7|GALNTL2|PIH5|pp-GalNAc-T15 | - | |
Cytomap | 3p25.1 | 4q34.1 | |
Type of gene | protein-coding | protein-coding | |
Description | polypeptide N-acetylgalactosaminyltransferase 15UDP-GalNAc transferase T15UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15UDP-N-acetyl-alpha-D-ga | histone deacetylase complex subunit SAP3030 kDa Sin3-associated polypeptideSin3 corepressor complex subunit SAP30Sin3-associated polypeptide, 30kDaSin3A-associated protein, 30kDasin3-associated polypeptide p30sin3-associated polypeptide, 30 kDa | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q86SF2 | O75446 | |
Ensembl transtripts involved in fusion gene | ENST00000265000, ENST00000512285, ENST00000502407, | ENST00000504618, ENST00000296504, | |
Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 1 X 1 X 2=2 |
# samples | 10 | 3 | |
** MAII score | log2(10/168*10)=-0.748461233004036 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/2*10)=3.90689059560852 | |
Context | PubMed: GALNT7 [Title/Abstract] AND SAP30 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SAP30 | GO:0006355 | regulation of transcription, DNA-templated | 9651585 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AR-A24R-01A | GALNT7 | chr4 | 174090112 | + | SAP30 | chr4 | 174294541 | + |
TCGA | LD | BRCA | TCGA-D8-A1JG-01B | GALNT7 | chr4 | 174090112 | + | SAP30 | chr4 | 174294541 | + |
TCGA | LD | LUSC | TCGA-21-5783-01A | GALNT7 | chr4 | 174090112 | + | SAP30 | chr4 | 174294541 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000265000 | ENST00000504618 | GALNT7 | chr4 | 174090112 | + | SAP30 | chr4 | 174294541 | + |
5CDS-intron | ENST00000265000 | ENST00000296504 | GALNT7 | chr4 | 174090112 | + | SAP30 | chr4 | 174294541 | + |
5CDS-intron | ENST00000512285 | ENST00000504618 | GALNT7 | chr4 | 174090112 | + | SAP30 | chr4 | 174294541 | + |
5CDS-intron | ENST00000512285 | ENST00000296504 | GALNT7 | chr4 | 174090112 | + | SAP30 | chr4 | 174294541 | + |
intron-intron | ENST00000502407 | ENST00000504618 | GALNT7 | chr4 | 174090112 | + | SAP30 | chr4 | 174294541 | + |
intron-intron | ENST00000502407 | ENST00000296504 | GALNT7 | chr4 | 174090112 | + | SAP30 | chr4 | 174294541 | + |
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FusionProtFeatures for GALNT7_SAP30 |
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Hgene | Tgene |
GALNT7 | SAP30 |
Glycopeptide transferase involved in O-linkedoligosaccharide biosynthesis, which catalyzes the transfer of anN-acetyl-D-galactosamine residue to an already glycosylatedpeptide. In contrast to other proteins of the family, it does notact as a peptide transferase that transfers GalNAc onto serine orthreonine residue on the protein receptor, but instead requiresthe prior addition of a GalNAc on a peptide before addingadditional GalNAc moieties. Some peptide transferase activity ishowever not excluded, considering that its appropriate peptidesubstrate may remain unidentified. | Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoRcorepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in acomplex) but inactive in deacetylating nucleosomal histones.{ECO:0000250|UniProtKB:O88574, ECO:0000269|PubMed:9651585}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GALNT7_SAP30 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GALNT7_SAP30 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GALNT7 | MAPK6, TAZ, ATP1B3, TNFSF11, ANTXR1, B3GNT3, DNASE2B, ART3, B3GNT2, PTCH1, SIAE, PLTP, SLC9A1, REEP5, TCTN2, ADPGK, GALNT12, MPPE1, MAN2A2, DEFA5, GALNT4, GAA, NCEH1, CLTCL1, RMND1, DKKL1, MME | SAP30 | YY1, HDAC1, SIN3A, CIR1, RBBP4, RBBP7, HDAC2, SIN3B, MTA2, NCOR1, NCOR2, PHF12, ING1, MXD1, ING2, HIST2H2BE, ID3, PCBD1, HDAC3, RBP1, SAP25, SMARCA2, TAF6, ARID4A, CHD4, UBASH3B, ZNF395, SAMSN1, BRMS1L, DDB1, CUL4B, BRMS1, ARID4B, KMT2A, LYST, FOXK2, SMC1A, SRA1, EBP, ZCCHC17, GAR1, BAHCC1, FAM60A, SUDS3, SAP130, TNRC18, CMBL, FOXK1, GATAD1, ZNF704, MXD3, PHF23 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GALNT7_SAP30 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GALNT7_SAP30 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |