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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14337

FusionGeneSummary for GALNT7_SAP30

check button Fusion gene summary
Fusion gene informationFusion gene name: GALNT7_SAP30
Fusion gene ID: 14337
HgeneTgene
Gene symbol

GALNT7

SAP30

Gene ID

117248

8819

Gene namepolypeptide N-acetylgalactosaminyltransferase 15Sin3A associated protein 30
SynonymsGALNACT15|GALNT13|GALNT7|GALNTL2|PIH5|pp-GalNAc-T15-
Cytomap

3p25.1

4q34.1

Type of geneprotein-codingprotein-coding
Descriptionpolypeptide N-acetylgalactosaminyltransferase 15UDP-GalNAc transferase T15UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15UDP-N-acetyl-alpha-D-gahistone deacetylase complex subunit SAP3030 kDa Sin3-associated polypeptideSin3 corepressor complex subunit SAP30Sin3-associated polypeptide, 30kDaSin3A-associated protein, 30kDasin3-associated polypeptide p30sin3-associated polypeptide, 30 kDa
Modification date2018052320180523
UniProtAcc

Q86SF2

O75446

Ensembl transtripts involved in fusion geneENST00000265000, ENST00000512285, 
ENST00000502407, 
ENST00000504618, 
ENST00000296504, 
Fusion gene scores* DoF score7 X 6 X 4=1681 X 1 X 2=2
# samples 103
** MAII scorelog2(10/168*10)=-0.748461233004036
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/2*10)=3.90689059560852
Context

PubMed: GALNT7 [Title/Abstract] AND SAP30 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSAP30

GO:0006355

regulation of transcription, DNA-templated

9651585


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A24R-01AGALNT7chr4

174090112

+SAP30chr4

174294541

+
TCGALDBRCATCGA-D8-A1JG-01BGALNT7chr4

174090112

+SAP30chr4

174294541

+
TCGALDLUSCTCGA-21-5783-01AGALNT7chr4

174090112

+SAP30chr4

174294541

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000265000ENST00000504618GALNT7chr4

174090112

+SAP30chr4

174294541

+
5CDS-intronENST00000265000ENST00000296504GALNT7chr4

174090112

+SAP30chr4

174294541

+
5CDS-intronENST00000512285ENST00000504618GALNT7chr4

174090112

+SAP30chr4

174294541

+
5CDS-intronENST00000512285ENST00000296504GALNT7chr4

174090112

+SAP30chr4

174294541

+
intron-intronENST00000502407ENST00000504618GALNT7chr4

174090112

+SAP30chr4

174294541

+
intron-intronENST00000502407ENST00000296504GALNT7chr4

174090112

+SAP30chr4

174294541

+

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FusionProtFeatures for GALNT7_SAP30


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GALNT7

Q86SF2

SAP30

O75446

Glycopeptide transferase involved in O-linkedoligosaccharide biosynthesis, which catalyzes the transfer of anN-acetyl-D-galactosamine residue to an already glycosylatedpeptide. In contrast to other proteins of the family, it does notact as a peptide transferase that transfers GalNAc onto serine orthreonine residue on the protein receptor, but instead requiresthe prior addition of a GalNAc on a peptide before addingadditional GalNAc moieties. Some peptide transferase activity ishowever not excluded, considering that its appropriate peptidesubstrate may remain unidentified. Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoRcorepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in acomplex) but inactive in deacetylating nucleosomal histones.{ECO:0000250|UniProtKB:O88574, ECO:0000269|PubMed:9651585}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GALNT7_SAP30


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GALNT7_SAP30


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GALNT7MAPK6, TAZ, ATP1B3, TNFSF11, ANTXR1, B3GNT3, DNASE2B, ART3, B3GNT2, PTCH1, SIAE, PLTP, SLC9A1, REEP5, TCTN2, ADPGK, GALNT12, MPPE1, MAN2A2, DEFA5, GALNT4, GAA, NCEH1, CLTCL1, RMND1, DKKL1, MMESAP30YY1, HDAC1, SIN3A, CIR1, RBBP4, RBBP7, HDAC2, SIN3B, MTA2, NCOR1, NCOR2, PHF12, ING1, MXD1, ING2, HIST2H2BE, ID3, PCBD1, HDAC3, RBP1, SAP25, SMARCA2, TAF6, ARID4A, CHD4, UBASH3B, ZNF395, SAMSN1, BRMS1L, DDB1, CUL4B, BRMS1, ARID4B, KMT2A, LYST, FOXK2, SMC1A, SRA1, EBP, ZCCHC17, GAR1, BAHCC1, FAM60A, SUDS3, SAP130, TNRC18, CMBL, FOXK1, GATAD1, ZNF704, MXD3, PHF23


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GALNT7_SAP30


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GALNT7_SAP30


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource