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Fusion gene ID: 1431 |
FusionGeneSummary for ALB_DDX21 |
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Fusion gene information | Fusion gene name: ALB_DDX21 | Fusion gene ID: 1431 | Hgene | Tgene | Gene symbol | ALB | DDX21 | Gene ID | 213 | 54606 |
Gene name | albumin | DEAD-box helicase 56 | |
Synonyms | HSA|PRO0883|PRO0903|PRO1341 | DDX21|DDX26|NOH61 | |
Cytomap | 4q13.3 | 7p13 | |
Type of gene | protein-coding | protein-coding | |
Description | serum albumin | probable ATP-dependent RNA helicase DDX5661-kd nucleolar helicaseATP-dependent 61 kDa nucleolar RNA helicaseDEAD (Asp-Glu-Ala-Asp) box helicase 56DEAD (Asp-Glu-Ala-Asp) box polypeptide 56DEAD box protein 21DEAD box protein 56DEAD-box RNA helicasen | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | P02768 | Q9NR30 | |
Ensembl transtripts involved in fusion gene | ENST00000295897, ENST00000415165, ENST00000503124, ENST00000509063, ENST00000401494, ENST00000505649, | ENST00000354185, | |
Fusion gene scores | * DoF score | 19 X 15 X 3=855 | 33 X 8 X 14=3696 |
# samples | 25 | 37 | |
** MAII score | log2(25/855*10)=-1.77399632511117 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(37/3696*10)=-3.32036758089975 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ALB [Title/Abstract] AND DDX21 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ALB | GO:0009267 | cellular response to starvation | 16245148 |
Hgene | ALB | GO:0019836 | hemolysis by symbiont of host erythrocytes | 16394536 |
Hgene | ALB | GO:0043066 | negative regulation of apoptotic process | 16153637 |
Hgene | ALB | GO:0051659 | maintenance of mitochondrion location | 16153637 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-DD-AADD-01A | ALB | chr4 | 74286971 | + | DDX21 | chr10 | 70723858 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000295897 | ENST00000354185 | ALB | chr4 | 74286971 | + | DDX21 | chr10 | 70723858 | + |
5CDS-intron | ENST00000415165 | ENST00000354185 | ALB | chr4 | 74286971 | + | DDX21 | chr10 | 70723858 | + |
intron-intron | ENST00000503124 | ENST00000354185 | ALB | chr4 | 74286971 | + | DDX21 | chr10 | 70723858 | + |
intron-intron | ENST00000509063 | ENST00000354185 | ALB | chr4 | 74286971 | + | DDX21 | chr10 | 70723858 | + |
intron-intron | ENST00000401494 | ENST00000354185 | ALB | chr4 | 74286971 | + | DDX21 | chr10 | 70723858 | + |
intron-intron | ENST00000505649 | ENST00000354185 | ALB | chr4 | 74286971 | + | DDX21 | chr10 | 70723858 | + |
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FusionProtFeatures for ALB_DDX21 |
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Hgene | Tgene |
ALB | DDX21 |
RNA helicase that acts as a sensor of thetranscriptional status of both RNA polymerase (Pol) I and II:promotes ribosomal RNA (rRNA) processing and transcription frompolymerase II (Pol II) (PubMed:25470060). Binds various RNAs, suchas rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs(PubMed:25470060). In the nucleolus, localizes to rDNA locus,where it directly binds rRNAs and snoRNAs, and promotes rRNAtranscription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes(PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SKRNA and is recruited to the promoters of Pol II-transcribed genes:acts by facilitating the release of P-TEFb from inhibitory 7SKsnRNP in a manner that is dependent on its helicase activity,thereby promoting transcription of its target genes(PubMed:25470060). Functions as cofactor for JUN-activatedtranscription: required for phosphorylation of JUN at 'Ser-77'(PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA(helicase) and can fold or introduce a secondary structure to asingle-stranded RNA (foldase) (PubMed:9461305). Involved in rRNAprocessing (PubMed:14559904, PubMed:18180292). May bind tospecific miRNA hairpins (PubMed:28431233).{ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904,ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534,ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391,ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:9461305}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ALB_DDX21 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ALB_DDX21 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ALB | LUC7L2, FCGRT, PRB3, AMBP, USP37, UIMC1, DMWD, PSMD4, NR5A2, YWHAG, PSMA3, TK1, IMMT, PFDN1, FBXO25, CRYAB, APP, EEF2K, ADRA1B, APOA1, APOC1, SETX, KCNMA1, PDE4B, CTSL, CDC45, GJC2, CDCP1, DDB1, FGA, FN1, GABBR1, HP, IGHG1, IGHG2, IGKV2-40, KRT10, KRT14, KRT9, KRT1, OR8D2, KLK3, ATM, OR2T6, TLN2, TTR, CACNA1I, ZNF232, PLAG1, RLF, AHSG, APOA4, APOC3, CRB1, EXOC6, SCAF1, GFAP, IGL, TSC22D1, IGKC, ITGB5, KRT6A, SERPING1, TTPAL, F2, AP1M1, AMPD3, APOA2, APOC2, CHKB, F7, C4A, CFB, CFD, CFH, CST3, DCD, ETF1, GSN, IGDCC4, HBA2, HPX, PHC3, ST13, DERL1, FAM71E2, QTRTD1, KIAA0232, ITIH1, KRT13, KRT16, KRT5, KRT6B, OBSL1, CTAGE5, AGA, NCOA3, OR3A2, PPBP, PF4V1, PCDH1, RANBP2, RYR2, SACS, SH3BP5, PLA2G4F, TIAM1, PRSS3, PRSS3P2, ZNF292, AP4E1, APOE, CABLES1, SLC25A13, NLRC4, CLCA2, DGKG, DMD, DICER1, GRAP2, TRAPPC11, SPATA31A7, PDZRN4, PALB2, LDB3, CEP44, ITGA2, JARID2, GCN1L1, CAMTA1, SLC9A8, CNOT1, LAT, MYL4, MYLK3, TTN, NPHS1, SLC1A5, PEG3, CROT, BBC3, RANBP3, SCN5A, SPAST, SLA2, THRAP3, SGOL2, PRSS1, DCC, SORBS3, IQCB1, PAN2, PARK2, FUS, CCDC8, LAMTOR5, CA8, GDPD1, PINX1, ZNF558, RPS6KB2, HNRNPA1, MED4, MED20, SOD1, LRP8, TIMM13, GAR1, FOXA3, FOXJ3, FOXP3, RC3H1, CDC73, CPS1, MAPK6, DDX31, SNX27, HSPA8, UPF3A, CCDC82, ADAMTS18, RALBP1, CYLD | DDX21 | LYAR, PSTPIP1, RTCA, SMNDC1, JUN, RRP1B, SRRM2, SRRM1, CTNNBL1, DOT1L, NPM1, NOP56, TOP1, CALM1, PCK1, HDGF, SIRT7, HNRNPA1, TERF1, TERF2, CUL3, CUL4A, CDK2, GRK5, RPL6, RPL7, RPL31, RPL37A, RPS11, RPS24, RPL5, RSL1D1, RPL19, RPS23, IK, RNPS1, SAP18, SRSF5, SRSF7, HNRNPR, SFPQ, EFTUD2, RBM39, PARP1, RRP7A, RRS1, THRAP3, SON, MYO1C, SSR3, FTSJ3, NFIA, NOP2, SMARCA1, PCDHA2, SUPT16H, PDS5A, LAMP2, LMNB1, S100A9, ESR1, APTX, H2AFX, SMURF1, YWHAE, VCAM1, FN1, CSNK2A1, IL7R, ITGA4, AICDA, PAN2, LYN, SRPK2, SRPK3, FBXO6, TARDBP, WWOX, ERG, LGR4, IVNS1ABP, STAU1, CEP250, HUWE1, PA2G4, KPNA3, CUL7, OBSL1, CCDC8, UBE2I, EED, SUMO2, ILK, MAST3, LUZP4, EBNA1BP2, RPL14, ZC3H3, THUMPD1, NTRK1, DDX50, SCARNA22, HIST1H3E, HNRNPU, RPL10, IBTK, MACROD1, MCM2, MCM5, CDC5L, U2AF2, C1orf131, ZNF746, RBM34, FGF8, WDR46, HIST1H1T, SYNCRIP, ZNF512, RPL30, CNBP, H2AFY2, MECP2, E4F1, GPATCH4, ZCRB1, RBM4, FGF3, NIFK, NCL, INO80B, COX15, DLST, DNM1L, VDAC1, G3BP1, BRCA1, LMNA, RNF168, TES, MTF1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ALB_DDX21 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | ALB | P02768 | DB00493 | Cefotaxime | Serum albumin | small molecule | approved |
Hgene | ALB | P02768 | DB01045 | Rifampicin | Serum albumin | small molecule | approved |
Hgene | ALB | P02768 | DB03255 | Phenol | Serum albumin | small molecule | approved|experimental |
Hgene | ALB | P02768 | DB00276 | Amsacrine | Serum albumin | small molecule | approved|investigational |
Hgene | ALB | P02768 | DB00545 | Pyridostigmine | Serum albumin | small molecule | approved|investigational |
Hgene | ALB | P02768 | DB06713 | Norelgestromin | Serum albumin | small molecule | approved|investigational |
Hgene | ALB | P02768 | DB11638 | Artenimol | Serum albumin | small molecule | approved|investigational |
Hgene | ALB | P02768 | DB00199 | Erythromycin | Serum albumin | small molecule | approved|investigational|vet_approved |
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RelatedDiseases for ALB_DDX21 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ALB | C0033687 | Proteinuria | 9 | CTD_human |
Hgene | ALB | C0017658 | Glomerulonephritis | 8 | CTD_human |
Hgene | ALB | C0022658 | Kidney Diseases | 8 | CTD_human |
Hgene | ALB | C0017665 | Membranous glomerulonephritis | 6 | CTD_human |
Hgene | ALB | C0027697 | Nephritis | 6 | CTD_human |
Hgene | ALB | C0027707 | Nephritis, Interstitial | 4 | CTD_human |
Hgene | ALB | C0038454 | Cerebrovascular accident | 4 | CTD_human |
Hgene | ALB | C0342185 | Hyperthyroxinemia, Familial Dysalbuminemic | 4 | CTD_human;UNIPROT |
Hgene | ALB | C0023893 | Liver Cirrhosis, Experimental | 3 | CTD_human |
Hgene | ALB | C0025290 | Aseptic Meningitis | 3 | CTD_human |
Hgene | ALB | C2609414 | Acute kidney injury | 3 | CTD_human |
Hgene | ALB | C0014544 | Epilepsy | 2 | CTD_human |
Hgene | ALB | C0020649 | Hypotension | 2 | CTD_human;HPO |
Hgene | ALB | C0023890 | Liver Cirrhosis | 2 | CTD_human |
Hgene | ALB | C0027726 | Nephrotic Syndrome | 2 | CTD_human |
Hgene | ALB | C0036830 | Serum Sickness | 2 | CTD_human |
Hgene | ALB | C0162557 | Liver Failure, Acute | 2 | CTD_human |
Hgene | ALB | C4277682 | Chemical and Drug Induced Liver Injury | 2 | CTD_human |
Hgene | ALB | C0002994 | Angioedema | 1 | CTD_human |
Hgene | ALB | C0003460 | Anuria | 1 | CTD_human |
Hgene | ALB | C0004509 | Azoospermia | 1 | CTD_human |
Hgene | ALB | C0006111 | Brain Diseases | 1 | CTD_human |
Hgene | ALB | C0007222 | Cardiovascular Diseases | 1 | CTD_human |
Hgene | ALB | C0007786 | Brain Ischemia | 1 | CTD_human |
Hgene | ALB | C0011581 | Depressive disorder | 1 | CTD_human |
Hgene | ALB | C0011875 | Diabetic Angiopathies | 1 | CTD_human |
Hgene | ALB | C0011881 | Diabetic Nephropathy | 1 | CTD_human |
Hgene | ALB | C0013502 | Echinococcosis | 1 | CTD_human |
Hgene | ALB | C0016059 | Fibrosis | 1 | CTD_human |
Hgene | ALB | C0017662 | Glomerulonephritis, Membranoproliferative | 1 | CTD_human |
Hgene | ALB | C0018799 | Heart Diseases | 1 | CTD_human |
Hgene | ALB | C0018801 | Heart failure | 1 | CTD_human |
Hgene | ALB | C0019061 | Hemolytic-Uremic Syndrome | 1 | CTD_human |
Hgene | ALB | C0019158 | Hepatitis | 1 | CTD_human |
Hgene | ALB | C0019693 | HIV Infections | 1 | CTD_human |
Hgene | ALB | C0019699 | HIV Seropositivity | 1 | CTD_human |
Hgene | ALB | C0020517 | Hypersensitivity | 1 | CTD_human |
Hgene | ALB | C0020522 | Delayed Hypersensitivity | 1 | CTD_human |
Hgene | ALB | C0020538 | Hypertensive disease | 1 | CTD_human |
Hgene | ALB | C0022548 | Keloid | 1 | CTD_human |
Hgene | ALB | C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
Hgene | ALB | C0026848 | Myopathy | 1 | CTD_human |
Hgene | ALB | C0027055 | Myocardial Reperfusion Injury | 1 | CTD_human |
Hgene | ALB | C0027720 | Nephrosis | 1 | CTD_human |
Hgene | ALB | C0028797 | Occupational Diseases | 1 | CTD_human |
Hgene | ALB | C0030193 | Pain | 1 | CTD_human |
Hgene | ALB | C0030286 | Pancreatic Diseases | 1 | CTD_human |
Hgene | ALB | C0030305 | Pancreatitis | 1 | CTD_human |
Hgene | ALB | C0035222 | Respiratory Distress Syndrome, Adult | 1 | CTD_human |
Hgene | ALB | C0035242 | Respiratory Tract Diseases | 1 | CTD_human |
Hgene | ALB | C0035457 | Rhinitis, Allergic, Perennial | 1 | CTD_human |
Hgene | ALB | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |
Hgene | ALB | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | ALB | C0040034 | Thrombocytopenia | 1 | CTD_human |
Hgene | ALB | C0041755 | Adverse reaction to drug | 1 | CTD_human |
Hgene | ALB | C0042109 | Urticaria | 1 | CTD_human |
Hgene | ALB | C0042164 | Uveitis | 1 | CTD_human |
Hgene | ALB | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Hgene | ALB | C0239981 | Hypoalbuminemia | 1 | CTD_human;HPO |
Hgene | ALB | C0993582 | Arthritis, Experimental | 1 | CTD_human |