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Fusion gene ID: 14299 |
FusionGeneSummary for GALNT13_USP34 |
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Fusion gene information | Fusion gene name: GALNT13_USP34 | Fusion gene ID: 14299 | Hgene | Tgene | Gene symbol | GALNT13 | USP34 | Gene ID | 117248 | 9736 |
Gene name | polypeptide N-acetylgalactosaminyltransferase 15 | ubiquitin specific peptidase 34 | |
Synonyms | GALNACT15|GALNT13|GALNT7|GALNTL2|PIH5|pp-GalNAc-T15 | - | |
Cytomap | 3p25.1 | 2p15 | |
Type of gene | protein-coding | protein-coding | |
Description | polypeptide N-acetylgalactosaminyltransferase 15UDP-GalNAc transferase T15UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15UDP-N-acetyl-alpha-D-ga | ubiquitin carboxyl-terminal hydrolase 34deubiquitinating enzyme 34ubiquitin specific protease 34ubiquitin thioesterase 34ubiquitin thiolesterase 34ubiquitin-specific-processing protease 34 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8IUC8 | Q70CQ2 | |
Ensembl transtripts involved in fusion gene | ENST00000392825, ENST00000409237, ENST00000487047, | ENST00000398571, ENST00000472689, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 6 X 7 X 2=84 |
# samples | 3 | 7 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GALNT13 [Title/Abstract] AND USP34 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | USP34 | GO:0016579 | protein deubiquitination | 14715245 |
Tgene | USP34 | GO:0071108 | protein K48-linked deubiquitination | 21383061 |
Tgene | USP34 | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 21383061 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | Z97017 | GALNT13 | chr2 | 155153258 | - | USP34 | chr2 | 61479516 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000392825 | ENST00000398571 | GALNT13 | chr2 | 155153258 | - | USP34 | chr2 | 61479516 | + |
intron-intron | ENST00000392825 | ENST00000472689 | GALNT13 | chr2 | 155153258 | - | USP34 | chr2 | 61479516 | + |
intron-intron | ENST00000409237 | ENST00000398571 | GALNT13 | chr2 | 155153258 | - | USP34 | chr2 | 61479516 | + |
intron-intron | ENST00000409237 | ENST00000472689 | GALNT13 | chr2 | 155153258 | - | USP34 | chr2 | 61479516 | + |
intron-intron | ENST00000487047 | ENST00000398571 | GALNT13 | chr2 | 155153258 | - | USP34 | chr2 | 61479516 | + |
intron-intron | ENST00000487047 | ENST00000472689 | GALNT13 | chr2 | 155153258 | - | USP34 | chr2 | 61479516 | + |
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FusionProtFeatures for GALNT13_USP34 |
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Hgene | Tgene |
GALNT13 | USP34 |
Catalyzes the initial reaction in O-linkedoligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on theprotein receptor. Has a much stronger activity than GALNT1 totransfer GalNAc to mucin peptides, such as Muc5Ac and Muc7. Ableto glycosylate SDC3. May be responsible for the synthesis of Tnantigen in neuronal cells. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GALNT13_USP34 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GALNT13_USP34 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GALNT13_USP34 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GALNT13_USP34 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |