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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14299

FusionGeneSummary for GALNT13_USP34

check button Fusion gene summary
Fusion gene informationFusion gene name: GALNT13_USP34
Fusion gene ID: 14299
HgeneTgene
Gene symbol

GALNT13

USP34

Gene ID

117248

9736

Gene namepolypeptide N-acetylgalactosaminyltransferase 15ubiquitin specific peptidase 34
SynonymsGALNACT15|GALNT13|GALNT7|GALNTL2|PIH5|pp-GalNAc-T15-
Cytomap

3p25.1

2p15

Type of geneprotein-codingprotein-coding
Descriptionpolypeptide N-acetylgalactosaminyltransferase 15UDP-GalNAc transferase T15UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15UDP-N-acetyl-alpha-D-gaubiquitin carboxyl-terminal hydrolase 34deubiquitinating enzyme 34ubiquitin specific protease 34ubiquitin thioesterase 34ubiquitin thiolesterase 34ubiquitin-specific-processing protease 34
Modification date2018052320180523
UniProtAcc

Q8IUC8

Q70CQ2

Ensembl transtripts involved in fusion geneENST00000392825, ENST00000409237, 
ENST00000487047, 
ENST00000398571, 
ENST00000472689, 
Fusion gene scores* DoF score3 X 3 X 2=186 X 7 X 2=84
# samples 37
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GALNT13 [Title/Abstract] AND USP34 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUSP34

GO:0016579

protein deubiquitination

14715245

TgeneUSP34

GO:0071108

protein K48-linked deubiquitination

21383061

TgeneUSP34

GO:0090263

positive regulation of canonical Wnt signaling pathway

21383061


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1Z97017GALNT13chr2

155153258

-USP34chr2

61479516

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000392825ENST00000398571GALNT13chr2

155153258

-USP34chr2

61479516

+
intron-intronENST00000392825ENST00000472689GALNT13chr2

155153258

-USP34chr2

61479516

+
intron-intronENST00000409237ENST00000398571GALNT13chr2

155153258

-USP34chr2

61479516

+
intron-intronENST00000409237ENST00000472689GALNT13chr2

155153258

-USP34chr2

61479516

+
intron-intronENST00000487047ENST00000398571GALNT13chr2

155153258

-USP34chr2

61479516

+
intron-intronENST00000487047ENST00000472689GALNT13chr2

155153258

-USP34chr2

61479516

+

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FusionProtFeatures for GALNT13_USP34


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GALNT13

Q8IUC8

USP34

Q70CQ2

Catalyzes the initial reaction in O-linkedoligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on theprotein receptor. Has a much stronger activity than GALNT1 totransfer GalNAc to mucin peptides, such as Muc5Ac and Muc7. Ableto glycosylate SDC3. May be responsible for the synthesis of Tnantigen in neuronal cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GALNT13_USP34


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GALNT13_USP34


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GALNT13_USP34


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GALNT13_USP34


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource