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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1429

FusionGeneSummary for ALB_APP

check button Fusion gene summary
Fusion gene informationFusion gene name: ALB_APP
Fusion gene ID: 1429
HgeneTgene
Gene symbol

ALB

APP

Gene ID

213

351

Gene namealbuminamyloid beta precursor protein
SynonymsHSA|PRO0883|PRO0903|PRO1341AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4
Cytomap

4q13.3

21q21.3

Type of geneprotein-codingprotein-coding
Descriptionserum albuminamyloid-beta A4 proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid beta A4 proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor proteincereb
Modification date2018052220180527
UniProtAcc

P02768

P05067

Ensembl transtripts involved in fusion geneENST00000295897, ENST00000415165, 
ENST00000503124, ENST00000509063, 
ENST00000401494, ENST00000505649, 
ENST00000346798, ENST00000354192, 
ENST00000348990, ENST00000357903, 
ENST00000358918, ENST00000359726, 
ENST00000448388, ENST00000440126, 
ENST00000439274, ENST00000474136, 
Fusion gene scores* DoF score19 X 15 X 3=85516 X 17 X 6=1632
# samples 2520
** MAII scorelog2(25/855*10)=-1.77399632511117
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/1632*10)=-3.02856915219677
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALB [Title/Abstract] AND APP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneALB

GO:0009267

cellular response to starvation

16245148

HgeneALB

GO:0019836

hemolysis by symbiont of host erythrocytes

16394536

HgeneALB

GO:0043066

negative regulation of apoptotic process

16153637

HgeneALB

GO:0051659

maintenance of mitochondrion location

16153637

TgeneAPP

GO:0001934

positive regulation of protein phosphorylation

11404397

TgeneAPP

GO:0008285

negative regulation of cell proliferation

22944668


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW072570ALBchr4

74286814

-APPchr21

27354655

+
ChiTaRS3.1AA884347ALBchr4

74286814

-APPchr21

27354655

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000295897ENST00000346798ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000295897ENST00000354192ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000295897ENST00000348990ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000295897ENST00000357903ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000295897ENST00000358918ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000295897ENST00000359726ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000295897ENST00000448388ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000295897ENST00000440126ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000295897ENST00000439274ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000295897ENST00000474136ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000415165ENST00000346798ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000415165ENST00000354192ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000415165ENST00000348990ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000415165ENST00000357903ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000415165ENST00000358918ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000415165ENST00000359726ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000415165ENST00000448388ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000415165ENST00000440126ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000415165ENST00000439274ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000415165ENST00000474136ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000503124ENST00000346798ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000503124ENST00000354192ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000503124ENST00000348990ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000503124ENST00000357903ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000503124ENST00000358918ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000503124ENST00000359726ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000503124ENST00000448388ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000503124ENST00000440126ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000503124ENST00000439274ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000503124ENST00000474136ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000509063ENST00000346798ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000509063ENST00000354192ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000509063ENST00000348990ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000509063ENST00000357903ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000509063ENST00000358918ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000509063ENST00000359726ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000509063ENST00000448388ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000509063ENST00000440126ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000509063ENST00000439274ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000509063ENST00000474136ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000401494ENST00000346798ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000401494ENST00000354192ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000401494ENST00000348990ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000401494ENST00000357903ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000401494ENST00000358918ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000401494ENST00000359726ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000401494ENST00000448388ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000401494ENST00000440126ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000401494ENST00000439274ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000401494ENST00000474136ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000505649ENST00000346798ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000505649ENST00000354192ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000505649ENST00000348990ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000505649ENST00000357903ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000505649ENST00000358918ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000505649ENST00000359726ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000505649ENST00000448388ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000505649ENST00000440126ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000505649ENST00000439274ALBchr4

74286814

-APPchr21

27354655

+
intron-intronENST00000505649ENST00000474136ALBchr4

74286814

-APPchr21

27354655

+

Top

FusionProtFeatures for ALB_APP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALB

P02768

APP

P05067


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ALB_APP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ALB_APP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ALB_APP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneALBP02768DB00493CefotaximeSerum albuminsmall moleculeapproved
HgeneALBP02768DB01045RifampicinSerum albuminsmall moleculeapproved
HgeneALBP02768DB03255PhenolSerum albuminsmall moleculeapproved|experimental
HgeneALBP02768DB00276AmsacrineSerum albuminsmall moleculeapproved|investigational
HgeneALBP02768DB00545PyridostigmineSerum albuminsmall moleculeapproved|investigational
HgeneALBP02768DB06713NorelgestrominSerum albuminsmall moleculeapproved|investigational
HgeneALBP02768DB11638ArtenimolSerum albuminsmall moleculeapproved|investigational
HgeneALBP02768DB00199ErythromycinSerum albuminsmall moleculeapproved|investigational|vet_approved
TgeneAPPP05067DB06782DimercaprolAmyloid-beta A4 proteinsmall moleculeapproved
TgeneAPPP05067DB09148Florbetaben (18F)Amyloid-beta A4 proteinsmall moleculeapproved
TgeneAPPP05067DB00746DeferoxamineAmyloid-beta A4 proteinsmall moleculeapproved|investigational
TgeneAPPP05067DB01370AluminiumAmyloid-beta A4 proteinsmall moleculeapproved|investigational
TgeneAPPP05067DB01593ZincAmyloid-beta A4 proteinsmall moleculeapproved|investigational
TgeneAPPP05067DB09149Florbetapir (18F)Amyloid-beta A4 proteinsmall moleculeapproved|investigational
TgeneAPPP05067DB09151Flutemetamol (18F)Amyloid-beta A4 proteinsmall moleculeapproved|investigational

Top

RelatedDiseases for ALB_APP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALBC0033687Proteinuria9CTD_human
HgeneALBC0017658Glomerulonephritis8CTD_human
HgeneALBC0022658Kidney Diseases8CTD_human
HgeneALBC0017665Membranous glomerulonephritis6CTD_human
HgeneALBC0027697Nephritis6CTD_human
HgeneALBC0027707Nephritis, Interstitial4CTD_human
HgeneALBC0038454Cerebrovascular accident4CTD_human
HgeneALBC0342185Hyperthyroxinemia, Familial Dysalbuminemic4CTD_human;UNIPROT
HgeneALBC0023893Liver Cirrhosis, Experimental3CTD_human
HgeneALBC0025290Aseptic Meningitis3CTD_human
HgeneALBC2609414Acute kidney injury3CTD_human
HgeneALBC0014544Epilepsy2CTD_human
HgeneALBC0020649Hypotension2CTD_human;HPO
HgeneALBC0023890Liver Cirrhosis2CTD_human
HgeneALBC0027726Nephrotic Syndrome2CTD_human
HgeneALBC0036830Serum Sickness2CTD_human
HgeneALBC0162557Liver Failure, Acute2CTD_human
HgeneALBC4277682Chemical and Drug Induced Liver Injury2CTD_human
HgeneALBC0002994Angioedema1CTD_human
HgeneALBC0003460Anuria1CTD_human
HgeneALBC0004509Azoospermia1CTD_human
HgeneALBC0006111Brain Diseases1CTD_human
HgeneALBC0007222Cardiovascular Diseases1CTD_human
HgeneALBC0007786Brain Ischemia1CTD_human
HgeneALBC0011581Depressive disorder1CTD_human
HgeneALBC0011875Diabetic Angiopathies1CTD_human
HgeneALBC0011881Diabetic Nephropathy1CTD_human
HgeneALBC0013502Echinococcosis1CTD_human
HgeneALBC0016059Fibrosis1CTD_human
HgeneALBC0017662Glomerulonephritis, Membranoproliferative1CTD_human
HgeneALBC0018799Heart Diseases1CTD_human
HgeneALBC0018801Heart failure1CTD_human
HgeneALBC0019061Hemolytic-Uremic Syndrome1CTD_human
HgeneALBC0019158Hepatitis1CTD_human
HgeneALBC0019693HIV Infections1CTD_human
HgeneALBC0019699HIV Seropositivity1CTD_human
HgeneALBC0020517Hypersensitivity1CTD_human
HgeneALBC0020522Delayed Hypersensitivity1CTD_human
HgeneALBC0020538Hypertensive disease1CTD_human
HgeneALBC0022548Keloid1CTD_human
HgeneALBC0022661Kidney Failure, Chronic1CTD_human
HgeneALBC0026848Myopathy1CTD_human
HgeneALBC0027055Myocardial Reperfusion Injury1CTD_human
HgeneALBC0027720Nephrosis1CTD_human
HgeneALBC0028797Occupational Diseases1CTD_human
HgeneALBC0030193Pain1CTD_human
HgeneALBC0030286Pancreatic Diseases1CTD_human
HgeneALBC0030305Pancreatitis1CTD_human
HgeneALBC0035222Respiratory Distress Syndrome, Adult1CTD_human
HgeneALBC0035242Respiratory Tract Diseases1CTD_human
HgeneALBC0035457Rhinitis, Allergic, Perennial1CTD_human
HgeneALBC0038325Stevens-Johnson Syndrome1CTD_human
HgeneALBC0038356Stomach Neoplasms1CTD_human
HgeneALBC0040034Thrombocytopenia1CTD_human
HgeneALBC0041755Adverse reaction to drug1CTD_human
HgeneALBC0042109Urticaria1CTD_human
HgeneALBC0042164Uveitis1CTD_human
HgeneALBC0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneALBC0239981Hypoalbuminemia1CTD_human;HPO
HgeneALBC0993582Arthritis, Experimental1CTD_human
TgeneAPPC0002395Alzheimer's Disease55CTD_human;HPO;ORPHANET;UNIPROT
TgeneAPPC0025261Memory Disorders12CTD_human
TgeneAPPC0027746Nerve Degeneration11CTD_human
TgeneAPPC0023186Learning Disorders6CTD_human
TgeneAPPC0011570Mental Depression5PSYGENET
TgeneAPPC0011581Depressive disorder5PSYGENET
TgeneAPPC2751536CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED5ORPHANET;UNIPROT
TgeneAPPC0009241Cognition Disorders4CTD_human
TgeneAPPC0522224Paralysed4CTD_human
TgeneAPPC0524851Neurodegenerative Disorders2CTD_human
TgeneAPPC0600467Neurogenic Inflammation2CTD_human
TgeneAPPC2931672Cerebral hemorrhage with amyloidosis, hereditary, Dutch type2CTD_human;ORPHANET
TgeneAPPC0002622Amnesia1CTD_human
TgeneAPPC0002726Amyloidosis1CTD_human
TgeneAPPC0003469Anxiety Disorders1CTD_human
TgeneAPPC0005586Bipolar Disorder1PSYGENET
TgeneAPPC0006111Brain Diseases1CTD_human
TgeneAPPC0011573Endogenous depression1PSYGENET
TgeneAPPC0016667Fragile X Syndrome1CTD_human
TgeneAPPC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneAPPC0027540Necrosis1CTD_human
TgeneAPPC0037928Spinal Cord Diseases1CTD_human
TgeneAPPC0038002Splenomegaly1CTD_human
TgeneAPPC0043094Weight Gain1CTD_human
TgeneAPPC0085220Cerebral Amyloid Angiopathy1CTD_human;HPO
TgeneAPPC0231341Premature aging syndrome1CTD_human
TgeneAPPC0338656Impaired cognition1CTD_human
TgeneAPPC0497327Dementia1CTD_human;HPO
TgeneAPPC2936349Plaque, Amyloid1CTD_human