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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14279

FusionGeneSummary for GALNS_CCNG2

check button Fusion gene summary
Fusion gene informationFusion gene name: GALNS_CCNG2
Fusion gene ID: 14279
HgeneTgene
Gene symbol

GALNS

CCNG2

Gene ID

2588

901

Gene namegalactosamine (N-acetyl)-6-sulfatasecyclin G2
SynonymsGALNAC6S|GAS|GalN6S|MPS4A-
Cytomap

16q24.3

4q21.1

Type of geneprotein-codingprotein-coding
DescriptionN-acetylgalactosamine-6-sulfataseN-acetylgalactosamine-6-sulfate sulfatasechondroitinasechondroitinsulfatasegalNAc6S sulfatasegalactosamine (N-acetyl)-6-sulfate sulfatasegalactose-6-sulfate sulfatasecyclin-G2
Modification date2018052220180523
UniProtAcc

P34059

Q16589

Ensembl transtripts involved in fusion geneENST00000268695, ENST00000542788, 
ENST00000565364, ENST00000568311, 
ENST00000569433, 
ENST00000497512, 
ENST00000316355, ENST00000354403, 
ENST00000502280, ENST00000395640, 
ENST00000509972, 
Fusion gene scores* DoF score2 X 1 X 2=43 X 2 X 2=12
# samples 23
** MAII scorelog2(2/4*10)=2.32192809488736log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GALNS [Title/Abstract] AND CCNG2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DN998848GALNSchr16

88923166

-CCNG2chr4

78079686

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000268695ENST00000497512GALNSchr16

88923166

-CCNG2chr4

78079686

+
5CDS-3UTRENST00000268695ENST00000316355GALNSchr16

88923166

-CCNG2chr4

78079686

+
5CDS-3UTRENST00000268695ENST00000354403GALNSchr16

88923166

-CCNG2chr4

78079686

+
5CDS-3UTRENST00000268695ENST00000502280GALNSchr16

88923166

-CCNG2chr4

78079686

+
5CDS-3UTRENST00000268695ENST00000395640GALNSchr16

88923166

-CCNG2chr4

78079686

+
5CDS-3UTRENST00000268695ENST00000509972GALNSchr16

88923166

-CCNG2chr4

78079686

+
intron-3UTRENST00000542788ENST00000497512GALNSchr16

88923166

-CCNG2chr4

78079686

+
intron-3UTRENST00000542788ENST00000316355GALNSchr16

88923166

-CCNG2chr4

78079686

+
intron-3UTRENST00000542788ENST00000354403GALNSchr16

88923166

-CCNG2chr4

78079686

+
intron-3UTRENST00000542788ENST00000502280GALNSchr16

88923166

-CCNG2chr4

78079686

+
intron-3UTRENST00000542788ENST00000395640GALNSchr16

88923166

-CCNG2chr4

78079686

+
intron-3UTRENST00000542788ENST00000509972GALNSchr16

88923166

-CCNG2chr4

78079686

+
5UTR-3UTRENST00000565364ENST00000497512GALNSchr16

88923166

-CCNG2chr4

78079686

+
5UTR-3UTRENST00000565364ENST00000316355GALNSchr16

88923166

-CCNG2chr4

78079686

+
5UTR-3UTRENST00000565364ENST00000354403GALNSchr16

88923166

-CCNG2chr4

78079686

+
5UTR-3UTRENST00000565364ENST00000502280GALNSchr16

88923166

-CCNG2chr4

78079686

+
5UTR-3UTRENST00000565364ENST00000395640GALNSchr16

88923166

-CCNG2chr4

78079686

+
5UTR-3UTRENST00000565364ENST00000509972GALNSchr16

88923166

-CCNG2chr4

78079686

+
5CDS-3UTRENST00000568311ENST00000497512GALNSchr16

88923166

-CCNG2chr4

78079686

+
5CDS-3UTRENST00000568311ENST00000316355GALNSchr16

88923166

-CCNG2chr4

78079686

+
5CDS-3UTRENST00000568311ENST00000354403GALNSchr16

88923166

-CCNG2chr4

78079686

+
5CDS-3UTRENST00000568311ENST00000502280GALNSchr16

88923166

-CCNG2chr4

78079686

+
5CDS-3UTRENST00000568311ENST00000395640GALNSchr16

88923166

-CCNG2chr4

78079686

+
5CDS-3UTRENST00000568311ENST00000509972GALNSchr16

88923166

-CCNG2chr4

78079686

+
5CDS-3UTRENST00000569433ENST00000497512GALNSchr16

88923166

-CCNG2chr4

78079686

+
5CDS-3UTRENST00000569433ENST00000316355GALNSchr16

88923166

-CCNG2chr4

78079686

+
5CDS-3UTRENST00000569433ENST00000354403GALNSchr16

88923166

-CCNG2chr4

78079686

+
5CDS-3UTRENST00000569433ENST00000502280GALNSchr16

88923166

-CCNG2chr4

78079686

+
5CDS-3UTRENST00000569433ENST00000395640GALNSchr16

88923166

-CCNG2chr4

78079686

+
5CDS-3UTRENST00000569433ENST00000509972GALNSchr16

88923166

-CCNG2chr4

78079686

+

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FusionProtFeatures for GALNS_CCNG2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GALNS

P34059

CCNG2

Q16589

May play a role in growth regulation and in negativeregulation of cell cycle progression.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GALNS_CCNG2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GALNS_CCNG2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GALNSNEU1, TAZ, IDS, PLAUR, DNASE2B, PTPRK, DPEP2, ISLR, NAAA, ARSA, ATXN2L, PRG3, LYZL1, P2RX5, LYPD4, LYZL2, WNT16, OLFM2, INSL5, SLAMF1, ALPPL2, TPSB2, ERLIN2, DEFA1, SIAE, TDGF1, PSG8, PRG2, SPACA4, MTNR1ACCNG2PPP2R5B, PPP2R5C, PPP2CA, SKP1, SKP2, NRIP2, FAM208B, EFHC2, PPP2R5D, NME2, PPP2R5E


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GALNS_CCNG2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GALNS_CCNG2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGALNSC0086651Mucopolysaccharidosis, MPS-IV-A8ORPHANET;UNIPROT
HgeneGALNSC0021368Inflammation1CTD_human