|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 14270 |
FusionGeneSummary for GAK_MEX3D |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GAK_MEX3D | Fusion gene ID: 14270 | Hgene | Tgene | Gene symbol | GAK | MEX3D | Gene ID | 2580 | 399664 |
| Gene name | cyclin G associated kinase | mex-3 RNA binding family member D | |
| Synonyms | DNAJ26|DNAJC26 | MEX-3D|MEX3|OK/SW-cl.4|RKHD1|RNF193|TINO | |
| Cytomap | 4p16.3 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cyclin-G-associated kinaseauxilin-2 | RNA-binding protein MEX3DRING finger and KH domain-containing protein 1RING finger protein 193bcl-2 ARE RNA binding proteinring finger (C3HC4 type) and KH domain containing 1ring finger and KH domain containing 1 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O14976 | Q86XN8 | |
| Ensembl transtripts involved in fusion gene | ENST00000314167, ENST00000511163, ENST00000509566, | ENST00000402693, ENST00000388824, | |
| Fusion gene scores | * DoF score | 7 X 8 X 4=224 | 4 X 2 X 3=24 |
| # samples | 7 | 4 | |
| ** MAII score | log2(7/224*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GAK [Title/Abstract] AND MEX3D [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GAK | GO:0010977 | negative regulation of neuron projection development | 24510904 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-YL-A9WL-01A | GAK | chr4 | 875695 | - | MEX3D | chr19 | 1556922 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000314167 | ENST00000402693 | GAK | chr4 | 875695 | - | MEX3D | chr19 | 1556922 | - |
| Frame-shift | ENST00000314167 | ENST00000388824 | GAK | chr4 | 875695 | - | MEX3D | chr19 | 1556922 | - |
| In-frame | ENST00000511163 | ENST00000402693 | GAK | chr4 | 875695 | - | MEX3D | chr19 | 1556922 | - |
| Frame-shift | ENST00000511163 | ENST00000388824 | GAK | chr4 | 875695 | - | MEX3D | chr19 | 1556922 | - |
| intron-3CDS | ENST00000509566 | ENST00000402693 | GAK | chr4 | 875695 | - | MEX3D | chr19 | 1556922 | - |
| intron-3CDS | ENST00000509566 | ENST00000388824 | GAK | chr4 | 875695 | - | MEX3D | chr19 | 1556922 | - |
Top |
FusionProtFeatures for GAK_MEX3D |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GAK | MEX3D |
| Associates with cyclin G and CDK5. Seems to act as anauxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expressionoscillates slightly during the cell cycle, peaking at G1.{ECO:0000269|PubMed:10625686}. | RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GAK | chr4:875695 | chr19:1556922 | ENST00000314167 | - | 15 | 28 | 347_350 | 553 | 1312 | Compositional bias | Note=Poly-Pro |
| Hgene | GAK | chr4:875695 | chr19:1556922 | ENST00000314167 | - | 15 | 28 | 40_314 | 553 | 1312 | Domain | Protein kinase |
| Tgene | >MEX3D | chr4:875695 | chr19:1556922 | ENST00000388824 | - | 0 | 3 | 273_334 | 198 | 667 | Domain | KH 2 |
| Tgene | >MEX3D | chr4:875695 | chr19:1556922 | ENST00000402693 | - | 0 | 2 | 273_334 | 198 | 652 | Domain | KH 2 |
| Tgene | >MEX3D | chr4:875695 | chr19:1556922 | ENST00000388824 | - | 0 | 3 | 600_640 | 198 | 667 | Zinc finger | RING-type |
| Tgene | >MEX3D | chr4:875695 | chr19:1556922 | ENST00000402693 | - | 0 | 2 | 600_640 | 198 | 652 | Zinc finger | RING-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GAK | chr4:875695 | chr19:1556922 | ENST00000314167 | - | 15 | 28 | 1247_1311 | 553 | 1312 | Domain | J |
| Hgene | >GAK | chr4:875695 | chr19:1556922 | ENST00000314167 | - | 15 | 28 | 399_566 | 553 | 1312 | Domain | Phosphatase tensin-type |
| Hgene | >GAK | chr4:875695 | chr19:1556922 | ENST00000314167 | - | 15 | 28 | 572_710 | 553 | 1312 | Domain | C2 tensin-type |
| Tgene | MEX3D | chr4:875695 | chr19:1556922 | ENST00000388824 | - | 0 | 3 | 179_240 | 198 | 667 | Domain | KH 1 |
| Tgene | MEX3D | chr4:875695 | chr19:1556922 | ENST00000402693 | - | 0 | 2 | 179_240 | 198 | 652 | Domain | KH 1 |
Top |
FusionGeneSequence for GAK_MEX3D |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GAK_ENST00000314167_chr4_875695_-_MEX3D_ENST00000402693_chr19_1556922_-_1007aa MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMK KLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLL LSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLR IVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVNPKSPITELLEQNGGYGSATLSRGPPPPVGPAGSGYSG GLALAEYDQPYGGFLDILRGGTERLFTNLKDTSSKVIQSVANYAKGDLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHY AVYNLSPRTYRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCFCRLFSTAEAAVYMFS MKRCPPGIWPSHKRLQDQGPAGQDKHLHQDPSAGRGAGLHRDRPEGGRGDGQAXDPVGGRTLLHHPRHAQQGRGSARRRPGPAQPSRTDH HPGARALPGGGAGGGAQGRHHQAHPAADAHLHRDARARQGAGVRGHWDARERGPRARGDRGAHHAAHWRLHRRGPRQRLPRQRHRRLPGP ARGGRQPLGQDPQPGTTAPHGHGRPPRGHGPGRPQRPRGLLRGQPRRPLRAGPRPRQPLQRLRQRGLRLRRGGSRCPGGDGRPRRLRLRL RLRLPGAGPDRARRGHHLGAFXARRPLARLQRLLHGQRSPGTSRRRRPAQQWGRDPPPLAHAARARRPPPGAPAVSPWRPGPGGRAVLAT PAGPRILPRRRRLLHGHLAAQQPRGRRLRPPGLRRLREQPQAPFGVLGPGPGARVRGVRRGRGDGCAGPLRPQPLLHGLRRPHLRQERAR >In-frame_GAK_ENST00000511163_chr4_875695_-_MEX3D_ENST00000402693_chr19_1556922_-_928aa MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPI IHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFR QHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVNPKSPITELLEQNGGYGSATLSRGPPP PVGPAGSGYSGGLALAEYDQPYGGFLDILRGGTERLFTNLKDTSSKVIQSVANYAKGDLDISYITSRIAVMSFPAEGVESALKNNIEDVR LFLDSKHPGHYAVYNLSPRTYRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCFCRLF STAEAAVYMFSMKRCPPGIWPSHKRLQDQGPAGQDKHLHQDPSAGRGAGLHRDRPEGGRGDGQAXDPVGGRTLLHHPRHAQQGRGSARRR PGPAQPSRTDHHPGARALPGGGAGGGAQGRHHQAHPAADAHLHRDARARQGAGVRGHWDARERGPRARGDRGAHHAAHWRLHRRGPRQRL PRQRHRRLPGPARGGRQPLGQDPQPGTTAPHGHGRPPRGHGPGRPQRPRGLLRGQPRRPLRAGPRPRQPLQRLRQRGLRLRRGGSRCPGG DGRPRRLRLRLRLRLPGAGPDRARRGHHLGAFXARRPLARLQRLLHGQRSPGTSRRRRPAQQWGRDPPPLAHAARARRPPPGAPAVSPWR PGPGGRAVLATPAGPRILPRRRRLLHGHLAAQQPRGRRLRPPGLRRLREQPQAPFGVLGPGPGARVRGVRRGRGDGCAGPLRPQPLLHGL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GAK_ENST00000314167_chr4_875695_-_MEX3D_ENST00000402693_chr19_1556922_-_3022nt ATGTCGCTGCTGCAGTCGGCGCTCGACTTCTTGGCGGGTCCAGGCTCCCTGGGCGGTGCTTCCGGCCGCGACCAGAGTGACTTCGTGGGG CAGACGGTGGAACTGGGCGAGCTGCGGCTGCGGGTGCGGCGGGTCCTGGCCGAAGGAGGGTTTGCATTTGTGTATGAAGCTCAAGATGTG GGGAGTGGCAGAGAGTATGCATTAAAGAGGCTATTATCCAATGAAGAGGAAAAGAACAGAGCCATCATTCAAGAAGTTTGCTTCATGAAA AAGCTTTCCGGCCACCCGAACATTGTCCAGTTTTGTTCTGCAGCGTCTATAGGAAAAGAGGAGTCAGACACGGGGCAGGCTGAGTTCCTC TTGCTCACAGAGCTCTGTAAAGGGCAGCTGGTGGAATTTTTGAAGAAAATGGAATCTCGAGGCCCCCTTTCGTGCGACACGGTTCTGAAG ATCTTCTACCAGACGTGCCGCGCCGTGCAGCACATGCACCGGCAGAAGCCGCCCATCATCCACAGGGACCTCAAGGTTGAGAACTTGTTG CTTAGTAACCAAGGGACCATTAAGCTGTGTGACTTTGGCAGTGCCACGACCATCTCGCACTACCCTGACTACAGCTGGAGCGCCCAGAGG CGAGCCCTGGTGGAGGAAGAGATCACGAGGAATACAACACCAATGTATAGAACACCAGAAATCATAGACTTGTATTCCAACTTCCCGATC GGCGAGAAGCAGGATATCTGGGCCCTGGGCTGCATCTTGTACCTGCTGTGCTTCCGGCAGCACCCTTTTGAGGATGGAGCGAAACTTCGA ATAGTCAATGGGAAGTACTCGATCCCCCCGCACGACACGCAGTACACGGTCTTCCACAGCCTCATCCGCGCCATGCTGCAGGTGAACCCG GAGGAGCGGCTGTCCATCGCCGAGGTGGTGCACCAGCTGCAGGAGATCGCGGCCGCCCGCAACGTGAACCCCAAGTCTCCCATCACAGAG CTCCTGGAGCAGAATGGAGGCTACGGGAGCGCCACACTGTCCCGAGGGCCACCCCCTCCCGTGGGCCCCGCTGGCAGTGGCTACAGTGGA GGCCTGGCGCTGGCGGAGTACGACCAGCCGTATGGCGGCTTCCTGGACATTCTGCGGGGTGGGACAGAGCGGCTCTTCACCAACCTCAAG GACACCTCCTCCAAGGTCATCCAGTCCGTCGCTAATTATGCAAAGGGTGACCTGGACATATCTTACATCACATCCAGAATTGCAGTGATG TCATTCCCAGCAGAAGGTGTGGAGTCAGCGCTCAAAAACAACATCGAAGATGTGCGGTTGTTCCTGGACTCCAAGCACCCAGGGCACTAT GCCGTCTACAACCTGTCCCCGAGGACCTACCGGCCCTCCAGGTTCCACAACCGGGTCTCCGAGTGTGGCTGGGCAGCACGGCGGGCCCCA CACCTGCACACCCTGTACAACATCTGCAGGAACATGCACGCCTGGCTGCGGCAGGACCACAAGAACGTCTGCGTCGTGCACTGCATGGAC GGGAGAGCCGCGTCTGCTGTGGCCGTCTGCTCCTTCCTGTGCTTCTGCCGTCTCTTCAGCACCGCGGAGGCCGCCGTGTACATGTTCAGC ATGAAGCGCTGCCCACCAGGCATCTGGCCATCCCACAAAAGGCTGCAAGATCAAGGCCCTGCGGGCCAAGACAAACACCTACATCAAGAC CCCAGTGCGGGGCGAGGAGCCGGTCTTCATCGTGACCGGCCGGAAGGAGGACGTGGAGATGGCCAAGCGTGAGATCCTGTCGGCGGCCGA ACACTTCTCCATCATCCGCGCCACGCGCAGCAAGGCCGGGGGTCTGCCCGGCGCCGCCCAGGGCCCGCCCAACCTTCCCGGACAGACCAC CATCCAGGTGCGCGTGCCCTACCGGGTGGTGGGGCTGGTGGTGGGGCCCAAGGGCGCCACCATCAAGCGCATCCAGCAGCGGACGCACAC CTACATCGTGACGCCCGGGCGCGACAAGGAGCCGGTGTTCGCGGTCACTGGGATGCCCGAGAACGTGGACCGCGCGCGCGAGGAGATCGA GGCGCACATCACGCTGCGCACTGGCGCCTTCACCGACGCGGGCCCCGACAGCGACTTCCACGCCAACGGCACCGACGTCTGCCTGGACCT GCTCGGGGCGGCCGCCAGCCTCTGGGCCAAGACCCCCAACCAGGGACGACGGCCCCCCACGGCCACGGCCGGCCTCCGCGGGGACACGGC CCTGGGCGCCCCCAGCGCCCCCGAGGCCTTCTACGCGGGCAGCCGCGGCGGCCCCTCCGTGCCGGACCCAGGCCCCGCCAGCCCCTACAG CGGCTCCGGCAACGGGGGCTTCGCCTTCGGCGCGGAGGGTCCCGGTGCCCCGGTGGGGACGGCCGCCCCCGACGACTGCGACTTCGGCTT CGACTTCGACTTCCTGGCGCTGGACCTGACCGTGCCCGCCGCGGCCACCATCTGGGCGCCTTTTGAGCGCGCCGCCCCCTTGCCCGCCTT CAGCGGCTGCTCCACGGTCAACGGAGCCCCGGGACCTCCCGCCGCCGGCGCCCGGCGCAGCAGTGGGGCCGGGACCCCCCGCCACTCGCC CACGCTGCCCGAGCCCGGCGGCCTCCGCCTGGAGCTCCCGCTGTCTCGCCGTGGCGCCCCGGACCCGGTGGGCGCGCTGTCCTGGCGACC CCCGCAGGGCCCCGTATCCTTCCCAGGCGGCGCCGCCTTCTCCACGGCCACCTCGCTGCCCAGCAGCCCCGCGGCCGCCGCCTGCGCCCC CCTGGACTCCGGCGCCTCCGAGAACAGCCGCAAGCCCCCTTCGGCGTCCTCGGCCCCGGCCCTGGCGCGAGAGTGCGTGGTGTGCGCCGA GGGCGAGGTGATGGCTGCGCTGGTCCCCTGCGGCCACAACCTCTTCTGCATGGACTGCGCCGTCCGCATCTGCGGCAAGAGCGAGCCCGA >In-frame_GAK_ENST00000511163_chr4_875695_-_MEX3D_ENST00000402693_chr19_1556922_-_2785nt ATGTCGCTGCTGCAGTCGGCGCTCGACTTCTTGGCGGGTCCAGGCTCCCTGGGCGGTGCTTCCGGCCGCGACCAGAGTGACTTCGTGGGG CAGACGGTGGAACTGGGCGAGCTGCGGCTGCGGGTGCGGCGGGTCCTGGCCGAAGGGCAGCTGGTGGAATTTTTGAAGAAAATGGAATCT CGAGGCCCCCTTTCGTGCGACACGGTTCTGAAGATCTTCTACCAGACGTGCCGCGCCGTGCAGCACATGCACCGGCAGAAGCCGCCCATC ATCCACAGGGACCTCAAGGTTGAGAACTTGTTGCTTAGTAACCAAGGGACCATTAAGCTGTGTGACTTTGGCAGTGCCACGACCATCTCG CACTACCCTGACTACAGCTGGAGCGCCCAGAGGCGAGCCCTGGTGGAGGAAGAGATCACGAGGAATACAACACCAATGTATAGAACACCA GAAATCATAGACTTGTATTCCAACTTCCCGATCGGCGAGAAGCAGGATATCTGGGCCCTGGGCTGCATCTTGTACCTGCTGTGCTTCCGG CAGCACCCTTTTGAGGATGGAGCGAAACTTCGAATAGTCAATGGGAAGTACTCGATCCCCCCGCACGACACGCAGTACACGGTCTTCCAC AGCCTCATCCGCGCCATGCTGCAGGTGAACCCGGAGGAGCGGCTGTCCATCGCCGAGGTGGTGCACCAGCTGCAGGAGATCGCGGCCGCC CGCAACGTGAACCCCAAGTCTCCCATCACAGAGCTCCTGGAGCAGAATGGAGGCTACGGGAGCGCCACACTGTCCCGAGGGCCACCCCCT CCCGTGGGCCCCGCTGGCAGTGGCTACAGTGGAGGCCTGGCGCTGGCGGAGTACGACCAGCCGTATGGCGGCTTCCTGGACATTCTGCGG GGTGGGACAGAGCGGCTCTTCACCAACCTCAAGGACACCTCCTCCAAGGTCATCCAGTCCGTCGCTAATTATGCAAAGGGTGACCTGGAC ATATCTTACATCACATCCAGAATTGCAGTGATGTCATTCCCAGCAGAAGGTGTGGAGTCAGCGCTCAAAAACAACATCGAAGATGTGCGG TTGTTCCTGGACTCCAAGCACCCAGGGCACTATGCCGTCTACAACCTGTCCCCGAGGACCTACCGGCCCTCCAGGTTCCACAACCGGGTC TCCGAGTGTGGCTGGGCAGCACGGCGGGCCCCACACCTGCACACCCTGTACAACATCTGCAGGAACATGCACGCCTGGCTGCGGCAGGAC CACAAGAACGTCTGCGTCGTGCACTGCATGGACGGGAGAGCCGCGTCTGCTGTGGCCGTCTGCTCCTTCCTGTGCTTCTGCCGTCTCTTC AGCACCGCGGAGGCCGCCGTGTACATGTTCAGCATGAAGCGCTGCCCACCAGGCATCTGGCCATCCCACAAAAGGCTGCAAGATCAAGGC CCTGCGGGCCAAGACAAACACCTACATCAAGACCCCAGTGCGGGGCGAGGAGCCGGTCTTCATCGTGACCGGCCGGAAGGAGGACGTGGA GATGGCCAAGCGTGAGATCCTGTCGGCGGCCGAACACTTCTCCATCATCCGCGCCACGCGCAGCAAGGCCGGGGGTCTGCCCGGCGCCGC CCAGGGCCCGCCCAACCTTCCCGGACAGACCACCATCCAGGTGCGCGTGCCCTACCGGGTGGTGGGGCTGGTGGTGGGGCCCAAGGGCGC CACCATCAAGCGCATCCAGCAGCGGACGCACACCTACATCGTGACGCCCGGGCGCGACAAGGAGCCGGTGTTCGCGGTCACTGGGATGCC CGAGAACGTGGACCGCGCGCGCGAGGAGATCGAGGCGCACATCACGCTGCGCACTGGCGCCTTCACCGACGCGGGCCCCGACAGCGACTT CCACGCCAACGGCACCGACGTCTGCCTGGACCTGCTCGGGGCGGCCGCCAGCCTCTGGGCCAAGACCCCCAACCAGGGACGACGGCCCCC CACGGCCACGGCCGGCCTCCGCGGGGACACGGCCCTGGGCGCCCCCAGCGCCCCCGAGGCCTTCTACGCGGGCAGCCGCGGCGGCCCCTC CGTGCCGGACCCAGGCCCCGCCAGCCCCTACAGCGGCTCCGGCAACGGGGGCTTCGCCTTCGGCGCGGAGGGTCCCGGTGCCCCGGTGGG GACGGCCGCCCCCGACGACTGCGACTTCGGCTTCGACTTCGACTTCCTGGCGCTGGACCTGACCGTGCCCGCCGCGGCCACCATCTGGGC GCCTTTTGAGCGCGCCGCCCCCTTGCCCGCCTTCAGCGGCTGCTCCACGGTCAACGGAGCCCCGGGACCTCCCGCCGCCGGCGCCCGGCG CAGCAGTGGGGCCGGGACCCCCCGCCACTCGCCCACGCTGCCCGAGCCCGGCGGCCTCCGCCTGGAGCTCCCGCTGTCTCGCCGTGGCGC CCCGGACCCGGTGGGCGCGCTGTCCTGGCGACCCCCGCAGGGCCCCGTATCCTTCCCAGGCGGCGCCGCCTTCTCCACGGCCACCTCGCT GCCCAGCAGCCCCGCGGCCGCCGCCTGCGCCCCCCTGGACTCCGGCGCCTCCGAGAACAGCCGCAAGCCCCCTTCGGCGTCCTCGGCCCC GGCCCTGGCGCGAGAGTGCGTGGTGTGCGCCGAGGGCGAGGTGATGGCTGCGCTGGTCCCCTGCGGCCACAACCTCTTCTGCATGGACTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GAK_ENST00000314167_chr4_875695_-_MEX3D_ENST00000402693_chr19_1556922_-_4027nt GAAGATGGTGCACCTCCGGGCCGGCGGTTGCTGAGCTGACCCGGACGGCGAGGGAGCGGGAGCCCGAGCCCGACCACTCCGGCTGCCGCG GGGTGCGGCGCAGCCACCGCCATGTCGCTGCTGCAGTCGGCGCTCGACTTCTTGGCGGGTCCAGGCTCCCTGGGCGGTGCTTCCGGCCGC GACCAGAGTGACTTCGTGGGGCAGACGGTGGAACTGGGCGAGCTGCGGCTGCGGGTGCGGCGGGTCCTGGCCGAAGGAGGGTTTGCATTT GTGTATGAAGCTCAAGATGTGGGGAGTGGCAGAGAGTATGCATTAAAGAGGCTATTATCCAATGAAGAGGAAAAGAACAGAGCCATCATT CAAGAAGTTTGCTTCATGAAAAAGCTTTCCGGCCACCCGAACATTGTCCAGTTTTGTTCTGCAGCGTCTATAGGAAAAGAGGAGTCAGAC ACGGGGCAGGCTGAGTTCCTCTTGCTCACAGAGCTCTGTAAAGGGCAGCTGGTGGAATTTTTGAAGAAAATGGAATCTCGAGGCCCCCTT TCGTGCGACACGGTTCTGAAGATCTTCTACCAGACGTGCCGCGCCGTGCAGCACATGCACCGGCAGAAGCCGCCCATCATCCACAGGGAC CTCAAGGTTGAGAACTTGTTGCTTAGTAACCAAGGGACCATTAAGCTGTGTGACTTTGGCAGTGCCACGACCATCTCGCACTACCCTGAC TACAGCTGGAGCGCCCAGAGGCGAGCCCTGGTGGAGGAAGAGATCACGAGGAATACAACACCAATGTATAGAACACCAGAAATCATAGAC TTGTATTCCAACTTCCCGATCGGCGAGAAGCAGGATATCTGGGCCCTGGGCTGCATCTTGTACCTGCTGTGCTTCCGGCAGCACCCTTTT GAGGATGGAGCGAAACTTCGAATAGTCAATGGGAAGTACTCGATCCCCCCGCACGACACGCAGTACACGGTCTTCCACAGCCTCATCCGC GCCATGCTGCAGGTGAACCCGGAGGAGCGGCTGTCCATCGCCGAGGTGGTGCACCAGCTGCAGGAGATCGCGGCCGCCCGCAACGTGAAC CCCAAGTCTCCCATCACAGAGCTCCTGGAGCAGAATGGAGGCTACGGGAGCGCCACACTGTCCCGAGGGCCACCCCCTCCCGTGGGCCCC GCTGGCAGTGGCTACAGTGGAGGCCTGGCGCTGGCGGAGTACGACCAGCCGTATGGCGGCTTCCTGGACATTCTGCGGGGTGGGACAGAG CGGCTCTTCACCAACCTCAAGGACACCTCCTCCAAGGTCATCCAGTCCGTCGCTAATTATGCAAAGGGTGACCTGGACATATCTTACATC ACATCCAGAATTGCAGTGATGTCATTCCCAGCAGAAGGTGTGGAGTCAGCGCTCAAAAACAACATCGAAGATGTGCGGTTGTTCCTGGAC TCCAAGCACCCAGGGCACTATGCCGTCTACAACCTGTCCCCGAGGACCTACCGGCCCTCCAGGTTCCACAACCGGGTCTCCGAGTGTGGC TGGGCAGCACGGCGGGCCCCACACCTGCACACCCTGTACAACATCTGCAGGAACATGCACGCCTGGCTGCGGCAGGACCACAAGAACGTC TGCGTCGTGCACTGCATGGACGGGAGAGCCGCGTCTGCTGTGGCCGTCTGCTCCTTCCTGTGCTTCTGCCGTCTCTTCAGCACCGCGGAG GCCGCCGTGTACATGTTCAGCATGAAGCGCTGCCCACCAGGCATCTGGCCATCCCACAAAAGGCTGCAAGATCAAGGCCCTGCGGGCCAA GACAAACACCTACATCAAGACCCCAGTGCGGGGCGAGGAGCCGGTCTTCATCGTGACCGGCCGGAAGGAGGACGTGGAGATGGCCAAGCG TGAGATCCTGTCGGCGGCCGAACACTTCTCCATCATCCGCGCCACGCGCAGCAAGGCCGGGGGTCTGCCCGGCGCCGCCCAGGGCCCGCC CAACCTTCCCGGACAGACCACCATCCAGGTGCGCGTGCCCTACCGGGTGGTGGGGCTGGTGGTGGGGCCCAAGGGCGCCACCATCAAGCG CATCCAGCAGCGGACGCACACCTACATCGTGACGCCCGGGCGCGACAAGGAGCCGGTGTTCGCGGTCACTGGGATGCCCGAGAACGTGGA CCGCGCGCGCGAGGAGATCGAGGCGCACATCACGCTGCGCACTGGCGCCTTCACCGACGCGGGCCCCGACAGCGACTTCCACGCCAACGG CACCGACGTCTGCCTGGACCTGCTCGGGGCGGCCGCCAGCCTCTGGGCCAAGACCCCCAACCAGGGACGACGGCCCCCCACGGCCACGGC CGGCCTCCGCGGGGACACGGCCCTGGGCGCCCCCAGCGCCCCCGAGGCCTTCTACGCGGGCAGCCGCGGCGGCCCCTCCGTGCCGGACCC AGGCCCCGCCAGCCCCTACAGCGGCTCCGGCAACGGGGGCTTCGCCTTCGGCGCGGAGGGTCCCGGTGCCCCGGTGGGGACGGCCGCCCC CGACGACTGCGACTTCGGCTTCGACTTCGACTTCCTGGCGCTGGACCTGACCGTGCCCGCCGCGGCCACCATCTGGGCGCCTTTTGAGCG CGCCGCCCCCTTGCCCGCCTTCAGCGGCTGCTCCACGGTCAACGGAGCCCCGGGACCTCCCGCCGCCGGCGCCCGGCGCAGCAGTGGGGC CGGGACCCCCCGCCACTCGCCCACGCTGCCCGAGCCCGGCGGCCTCCGCCTGGAGCTCCCGCTGTCTCGCCGTGGCGCCCCGGACCCGGT GGGCGCGCTGTCCTGGCGACCCCCGCAGGGCCCCGTATCCTTCCCAGGCGGCGCCGCCTTCTCCACGGCCACCTCGCTGCCCAGCAGCCC CGCGGCCGCCGCCTGCGCCCCCCTGGACTCCGGCGCCTCCGAGAACAGCCGCAAGCCCCCTTCGGCGTCCTCGGCCCCGGCCCTGGCGCG AGAGTGCGTGGTGTGCGCCGAGGGCGAGGTGATGGCTGCGCTGGTCCCCTGCGGCCACAACCTCTTCTGCATGGACTGCGCCGTCCGCAT CTGCGGCAAGAGCGAGCCCGAGTGTCCCGCCTGCCGCACGCCGGCCACCCAGGCCATTCATATCTTTTCCTAGAGCGCGGACCACCACGT GGCCGGGGCCATCTGCGGGGGCCAGGGGTGGGCGCGGGAGACGGGGCGGGACCCGGGGTGGGAGAGGGACGGGGAGGGGGCGAGGGGCGG AGGCCGAGGGGGCAGGGGGGTGGGCGGCGGCCAGTGTTTACAGATGAGCTTTAACTGCCGCCTCAGGCGTGGAGACGGAGACCCCGCAGC CCGGCGGCGCCTCAGCCCTTCAACGACAGTATTGAGTGGTCAGGTTACAATAAACCGGAGAGAAAAGGTCCGCTTGCACTTTTTTTAGTT TTCTTATTTTTAGACACCCCTCCCCTCCAGGGTGATCTTTAAAAAAGCAAAACAAAAAACACGACTTTTCCAGCGCTCAGCGTTTTTTCC TTTCGTCCGAAGCCGTTTTCTGATTTGACTTTTCTCGCCGGCCGGTCTCAGGCCGCACAGACGTTCCAGAGGAGGAGGGTGACATTTTTA CTCCCTTTTTGGGGCTAACCATTTATGCTTTTGTACATCAACCGTGCGCGGCCGGAGGGGGCAGGGGGGCGGGGGCGAGGGGCGTTCCAA TCAAATTTCTAACTTTCTGTTAATTATTAATCCCCTTTTTACTGCGGTTTCTGTTGTCATTTTTAAAATTTTTTTAATTTTTTTTTTTTT TTACTTTTACTTTTTACCTCTTGTGTATATGTAGGGAATTTATAGGGAAATATGTACTTTATGGAATAAATTTTAAGAACTAAAATATAT TTTATTTTAAATAAAGTAATGGACCTTTAATCTTACACAGCTAAATTACTGATTATATATTTGCTGAGCTGATTTAAGGGTTAAAAAAAT >In-frame_GAK_ENST00000511163_chr4_875695_-_MEX3D_ENST00000402693_chr19_1556922_-_3865nt AGGGGACGGGGCTAGGCCGGGTCGCCGCCTGACGCGACGCGTCCTCACGGGCGCCTACGTCACGGCGTCGAGGCGGAAGATGGTGCACCT CCGGGCCGGCGGTTGCTGAGCTGACCCGGACGGCGAGGGAGCGGGAGCCCGAGCCCGACCACTCCGGCTGCCGCGGGGTGCGGCGCAGCC ACCGCCATGTCGCTGCTGCAGTCGGCGCTCGACTTCTTGGCGGGTCCAGGCTCCCTGGGCGGTGCTTCCGGCCGCGACCAGAGTGACTTC GTGGGGCAGACGGTGGAACTGGGCGAGCTGCGGCTGCGGGTGCGGCGGGTCCTGGCCGAAGGGCAGCTGGTGGAATTTTTGAAGAAAATG GAATCTCGAGGCCCCCTTTCGTGCGACACGGTTCTGAAGATCTTCTACCAGACGTGCCGCGCCGTGCAGCACATGCACCGGCAGAAGCCG CCCATCATCCACAGGGACCTCAAGGTTGAGAACTTGTTGCTTAGTAACCAAGGGACCATTAAGCTGTGTGACTTTGGCAGTGCCACGACC ATCTCGCACTACCCTGACTACAGCTGGAGCGCCCAGAGGCGAGCCCTGGTGGAGGAAGAGATCACGAGGAATACAACACCAATGTATAGA ACACCAGAAATCATAGACTTGTATTCCAACTTCCCGATCGGCGAGAAGCAGGATATCTGGGCCCTGGGCTGCATCTTGTACCTGCTGTGC TTCCGGCAGCACCCTTTTGAGGATGGAGCGAAACTTCGAATAGTCAATGGGAAGTACTCGATCCCCCCGCACGACACGCAGTACACGGTC TTCCACAGCCTCATCCGCGCCATGCTGCAGGTGAACCCGGAGGAGCGGCTGTCCATCGCCGAGGTGGTGCACCAGCTGCAGGAGATCGCG GCCGCCCGCAACGTGAACCCCAAGTCTCCCATCACAGAGCTCCTGGAGCAGAATGGAGGCTACGGGAGCGCCACACTGTCCCGAGGGCCA CCCCCTCCCGTGGGCCCCGCTGGCAGTGGCTACAGTGGAGGCCTGGCGCTGGCGGAGTACGACCAGCCGTATGGCGGCTTCCTGGACATT CTGCGGGGTGGGACAGAGCGGCTCTTCACCAACCTCAAGGACACCTCCTCCAAGGTCATCCAGTCCGTCGCTAATTATGCAAAGGGTGAC CTGGACATATCTTACATCACATCCAGAATTGCAGTGATGTCATTCCCAGCAGAAGGTGTGGAGTCAGCGCTCAAAAACAACATCGAAGAT GTGCGGTTGTTCCTGGACTCCAAGCACCCAGGGCACTATGCCGTCTACAACCTGTCCCCGAGGACCTACCGGCCCTCCAGGTTCCACAAC CGGGTCTCCGAGTGTGGCTGGGCAGCACGGCGGGCCCCACACCTGCACACCCTGTACAACATCTGCAGGAACATGCACGCCTGGCTGCGG CAGGACCACAAGAACGTCTGCGTCGTGCACTGCATGGACGGGAGAGCCGCGTCTGCTGTGGCCGTCTGCTCCTTCCTGTGCTTCTGCCGT CTCTTCAGCACCGCGGAGGCCGCCGTGTACATGTTCAGCATGAAGCGCTGCCCACCAGGCATCTGGCCATCCCACAAAAGGCTGCAAGAT CAAGGCCCTGCGGGCCAAGACAAACACCTACATCAAGACCCCAGTGCGGGGCGAGGAGCCGGTCTTCATCGTGACCGGCCGGAAGGAGGA CGTGGAGATGGCCAAGCGTGAGATCCTGTCGGCGGCCGAACACTTCTCCATCATCCGCGCCACGCGCAGCAAGGCCGGGGGTCTGCCCGG CGCCGCCCAGGGCCCGCCCAACCTTCCCGGACAGACCACCATCCAGGTGCGCGTGCCCTACCGGGTGGTGGGGCTGGTGGTGGGGCCCAA GGGCGCCACCATCAAGCGCATCCAGCAGCGGACGCACACCTACATCGTGACGCCCGGGCGCGACAAGGAGCCGGTGTTCGCGGTCACTGG GATGCCCGAGAACGTGGACCGCGCGCGCGAGGAGATCGAGGCGCACATCACGCTGCGCACTGGCGCCTTCACCGACGCGGGCCCCGACAG CGACTTCCACGCCAACGGCACCGACGTCTGCCTGGACCTGCTCGGGGCGGCCGCCAGCCTCTGGGCCAAGACCCCCAACCAGGGACGACG GCCCCCCACGGCCACGGCCGGCCTCCGCGGGGACACGGCCCTGGGCGCCCCCAGCGCCCCCGAGGCCTTCTACGCGGGCAGCCGCGGCGG CCCCTCCGTGCCGGACCCAGGCCCCGCCAGCCCCTACAGCGGCTCCGGCAACGGGGGCTTCGCCTTCGGCGCGGAGGGTCCCGGTGCCCC GGTGGGGACGGCCGCCCCCGACGACTGCGACTTCGGCTTCGACTTCGACTTCCTGGCGCTGGACCTGACCGTGCCCGCCGCGGCCACCAT CTGGGCGCCTTTTGAGCGCGCCGCCCCCTTGCCCGCCTTCAGCGGCTGCTCCACGGTCAACGGAGCCCCGGGACCTCCCGCCGCCGGCGC CCGGCGCAGCAGTGGGGCCGGGACCCCCCGCCACTCGCCCACGCTGCCCGAGCCCGGCGGCCTCCGCCTGGAGCTCCCGCTGTCTCGCCG TGGCGCCCCGGACCCGGTGGGCGCGCTGTCCTGGCGACCCCCGCAGGGCCCCGTATCCTTCCCAGGCGGCGCCGCCTTCTCCACGGCCAC CTCGCTGCCCAGCAGCCCCGCGGCCGCCGCCTGCGCCCCCCTGGACTCCGGCGCCTCCGAGAACAGCCGCAAGCCCCCTTCGGCGTCCTC GGCCCCGGCCCTGGCGCGAGAGTGCGTGGTGTGCGCCGAGGGCGAGGTGATGGCTGCGCTGGTCCCCTGCGGCCACAACCTCTTCTGCAT GGACTGCGCCGTCCGCATCTGCGGCAAGAGCGAGCCCGAGTGTCCCGCCTGCCGCACGCCGGCCACCCAGGCCATTCATATCTTTTCCTA GAGCGCGGACCACCACGTGGCCGGGGCCATCTGCGGGGGCCAGGGGTGGGCGCGGGAGACGGGGCGGGACCCGGGGTGGGAGAGGGACGG GGAGGGGGCGAGGGGCGGAGGCCGAGGGGGCAGGGGGGTGGGCGGCGGCCAGTGTTTACAGATGAGCTTTAACTGCCGCCTCAGGCGTGG AGACGGAGACCCCGCAGCCCGGCGGCGCCTCAGCCCTTCAACGACAGTATTGAGTGGTCAGGTTACAATAAACCGGAGAGAAAAGGTCCG CTTGCACTTTTTTTAGTTTTCTTATTTTTAGACACCCCTCCCCTCCAGGGTGATCTTTAAAAAAGCAAAACAAAAAACACGACTTTTCCA GCGCTCAGCGTTTTTTCCTTTCGTCCGAAGCCGTTTTCTGATTTGACTTTTCTCGCCGGCCGGTCTCAGGCCGCACAGACGTTCCAGAGG AGGAGGGTGACATTTTTACTCCCTTTTTGGGGCTAACCATTTATGCTTTTGTACATCAACCGTGCGCGGCCGGAGGGGGCAGGGGGGCGG GGGCGAGGGGCGTTCCAATCAAATTTCTAACTTTCTGTTAATTATTAATCCCCTTTTTACTGCGGTTTCTGTTGTCATTTTTAAAATTTT TTTAATTTTTTTTTTTTTTTACTTTTACTTTTTACCTCTTGTGTATATGTAGGGAATTTATAGGGAAATATGTACTTTATGGAATAAATT TTAAGAACTAAAATATATTTTATTTTAAATAAAGTAATGGACCTTTAATCTTACACAGCTAAATTACTGATTATATATTTGCTGAGCTGA |
Top |
FusionGenePPI for GAK_MEX3D |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GAK | USO1, AXIN1, CDK5, CCNG1, ALK, ATP13A2, APP, LGR4, DMWD, STAMBP, NTRK1, PPM1B, AP2A1, AP2A2, AP2B1, CALM1, CALML3, CAPZB, AP2M1, CLTA, CLTB, CLTC, CPM, DAB2, DBN1, EPS15, PHKG2, PICALM, SEC16A, GTSE1, GOLGB1, HIP1, MYO1C, MYO6, PIK3C2A, PSMA5, SEC13, SP1, SPTAN1, CLTCL1, NUMB, TNK1, HIP1R, XPR1, SEC24C, CLINT1, FEM1B, TNK2, RBM14, KIF3A, SYNPO, CEP162, AAK1, EDRF1, PHGDH, CHMP4A, LIMA1, PLXNA3, BMP2K, KIDINS220, STAMBPL1, DENND1A, AFAP1, ZNF106, INF2, WNK1, CPSF7, PUS7L, PARP10, STON2, MISP, ACTRT1, FAM83B, FAM83H, FBXW7, GPX7, HSPA8, RABGEF1, HSPBP1, C5AR2, IARS2, CBLC, CLASRP, MPP5, FAM174A, TRIM25 | MEX3D | ELAVL1, BCL2, AGO2, AGO1, YWHAH, NXF1, XPO1, LMO2, PLOD1, PSMC3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for GAK_MEX3D |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for GAK_MEX3D |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GAK | C0030567 | Parkinson Disease | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|