	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 14252

FusionGeneSummary for GABRG3_SNHG14

Fusion gene summary

Fusion gene information	Fusion gene name: GABRG3_SNHG14
	Fusion gene ID: 14252
		Hgene	Tgene
	Gene symbol	GABRG3	SNHG14
	Gene ID	2567	104472715
	Gene name	gamma-aminobutyric acid type A receptor gamma3 subunit	small nucleolar RNA host gene 14
	Synonyms	-	115HG\|IC-SNURF-SNRPN\|LNCAT\|NCRNA00214\|U-UBE3A-ATS\|UBE3A-AS\|UBE3A-AS1\|UBE3AATS
	Cytomap	15q12	15q11.2
	Type of gene	protein-coding	ncRNA
	Description	gamma-aminobutyric acid receptor subunit gamma-3GABA(A) receptor subunit gamma-3GABA(G) receptor, gamma 3gamma-aminobutyric acid (GABA) A receptor, gamma 3	UBE3A antisense RNA 1 (non-protein coding)UBE3A antisense transcriptlarge noncoding antisense transcriptsmall nucleolar RNA host gene 14 (non-protein coding)
	Modification date	20180523	20180329
	UniProtAcc	Q99928
	Ensembl transtripts involved in fusion gene	ENST00000333743, ENST00000555083, ENST00000554786,	ENST00000549804, ENST00000547292, ENST00000424208, ENST00000452731, ENST00000554726, ENST00000551631, ENST00000459433, ENST00000551361, ENST00000553134, ENST00000551938, ENST00000384733, ENST00000551077, ENST00000546682, ENST00000553108, ENST00000384430, ENST00000516123, ENST00000553149, ENST00000441592, ENST00000365306, ENST00000414175, ENST00000456576, ENST00000363358, ENST00000424333, ENST00000450809, ENST00000453082, ENST00000365067, ENST00000390982, ENST00000580438,
Fusion gene scores	* DoF score	4 X 3 X 4=48	3 X 3 X 2=18
	# samples	5	3
	** MAII score	log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: GABRG3 [Title/Abstract] AND SNHG14 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	PRAD	TCGA-HC-8265-01A	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000333743	ENST00000549804	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000547292	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000424208	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-3UTR	ENST00000333743	ENST00000452731	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000554726	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000551631	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000459433	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000551361	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000553134	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000551938	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000384733	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000551077	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000546682	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000553108	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000384430	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000516123	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000553149	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000441592	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000365306	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000414175	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000456576	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000363358	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000424333	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000450809	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000453082	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000365067	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000390982	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000333743	ENST00000580438	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000549804	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000547292	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000424208	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-3UTR	ENST00000555083	ENST00000452731	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000554726	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000551631	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000459433	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000551361	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000553134	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000551938	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000384733	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000551077	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000546682	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000553108	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000384430	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000516123	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000553149	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000441592	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000365306	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000414175	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000456576	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000363358	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000424333	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000450809	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000453082	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000365067	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000390982	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
5CDS-intron	ENST00000555083	ENST00000580438	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000549804	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000547292	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000424208	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-3UTR	ENST00000554786	ENST00000452731	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000554726	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000551631	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000459433	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000551361	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000553134	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000551938	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000384733	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000551077	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000546682	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000553108	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000384430	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000516123	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000553149	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000441592	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000365306	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000414175	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000456576	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000363358	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000424333	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000450809	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000453082	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000365067	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000390982	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+
intron-intron	ENST00000554786	ENST00000580438	GABRG3	chr15	27271968	+	SNHG14	chr15	25583158	+

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FusionProtFeatures for GABRG3_SNHG14

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GABRG3 Q99928	SNHG14
GABA, the major inhibitory neurotransmitter in thevertebrate brain, mediates neuronal inhibition by binding to theGABA/benzodiazepine receptor and opening an integral chloridechannel.	Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269\|PubMed:10224141, ECO:0000269\|PubMed:28301481}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for GABRG3_SNHG14

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GABRG3_SNHG14

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
GABRG3	TP53	SNHG14

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for GABRG3_SNHG14

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	GABRG3	Q99928	DB00546	Adinazolam	Gamma-aminobutyric acid receptor subunit gamma-3	small molecule	approved
Hgene	GABRG3	Q99928	DB00842	Oxazepam	Gamma-aminobutyric acid receptor subunit gamma-3	small molecule	approved
Hgene	GABRG3	Q99928	DB00898	Ethanol	Gamma-aminobutyric acid receptor subunit gamma-3	small molecule	approved
Hgene	GABRG3	Q99928	DB01594	Cinolazepam	Gamma-aminobutyric acid receptor subunit gamma-3	small molecule	approved
Hgene	GABRG3	Q99928	DB01595	Nitrazepam	Gamma-aminobutyric acid receptor subunit gamma-3	small molecule	approved
Hgene	GABRG3	Q99928	DB00683	Midazolam	Gamma-aminobutyric acid receptor subunit gamma-3	small molecule	approved\|illicit
Hgene	GABRG3	Q99928	DB01215	Estazolam	Gamma-aminobutyric acid receptor subunit gamma-3	small molecule	approved\|illicit
Hgene	GABRG3	Q99928	DB01559	Clotiazepam	Gamma-aminobutyric acid receptor subunit gamma-3	small molecule	approved\|illicit
Hgene	GABRG3	Q99928	DB01567	Fludiazepam	Gamma-aminobutyric acid receptor subunit gamma-3	small molecule	approved\|illicit
Hgene	GABRG3	Q99928	DB01588	Prazepam	Gamma-aminobutyric acid receptor subunit gamma-3	small molecule	approved\|illicit
Hgene	GABRG3	Q99928	DB01589	Quazepam	Gamma-aminobutyric acid receptor subunit gamma-3	small molecule	approved\|illicit
Hgene	GABRG3	Q99928	DB00690	Flurazepam	Gamma-aminobutyric acid receptor subunit gamma-3	small molecule	approved\|illicit\|investigational
Hgene	GABRG3	Q99928	DB01558	Bromazepam	Gamma-aminobutyric acid receptor subunit gamma-3	small molecule	approved\|illicit\|investigational
Hgene	GABRG3	Q99928	DB00829	Diazepam	Gamma-aminobutyric acid receptor subunit gamma-3	small molecule	approved\|illicit\|investigational\|vet_approved
Hgene	GABRG3	Q99928	DB00801	Halazepam	Gamma-aminobutyric acid receptor subunit gamma-3	small molecule	approved\|illicit\|withdrawn
Hgene	GABRG3	Q99928	DB00231	Temazepam	Gamma-aminobutyric acid receptor subunit gamma-3	small molecule	approved\|investigational
Hgene	GABRG3	Q99928	DB00897	Triazolam	Gamma-aminobutyric acid receptor subunit gamma-3	small molecule	approved\|investigational

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RelatedDiseases for GABRG3_SNHG14

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	GABRG3	C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
Hgene	GABRG3	C3711376	Isodicentric Chromosome 15 Syndrome	1	CTD_human

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Fusion gene ID: 14252

FusionGeneSummary for GABRG3_SNHG14

FusionProtFeatures for GABRG3_SNHG14

FusionGeneSequence for GABRG3_SNHG14

FusionGenePPI for GABRG3_SNHG14

RelatedDrugs for GABRG3_SNHG14

RelatedDiseases for GABRG3_SNHG14