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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 14251

FusionGeneSummary for GABRG3_OCA2

check button Fusion gene summary
Fusion gene informationFusion gene name: GABRG3_OCA2
Fusion gene ID: 14251
HgeneTgene
Gene symbol

GABRG3

OCA2

Gene ID

2567

4948

Gene namegamma-aminobutyric acid type A receptor gamma3 subunitOCA2 melanosomal transmembrane protein
Synonyms-BEY|BEY1|BEY2|BOCA|D15S12|EYCL|EYCL2|EYCL3|HCL3|P|PED|SHEP1
Cytomap

15q12

15q12-q13.1

Type of geneprotein-codingprotein-coding
Descriptiongamma-aminobutyric acid receptor subunit gamma-3GABA(A) receptor subunit gamma-3GABA(G) receptor, gamma 3gamma-aminobutyric acid (GABA) A receptor, gamma 3P proteinP-proteineye color 2 (central brown)eye color 3 (brown)hair color 3 (brown)melanocyte-specific transporter proteinoculocutaneous albinism II (pink-eye dilution homolog, mouse)pink-eyed dilution protein homologtotal brown iris pigmentation
Modification date2018052320180519
UniProtAcc

Q99928

Q04671

Ensembl transtripts involved in fusion geneENST00000333743, ENST00000555083, 
ENST00000554786, 		ENST00000353809, 
ENST00000354638, ENST00000382996, 
Fusion gene scores* DoF score4 X 3 X 4=486 X 7 X 7=294
# samples 57
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GABRG3 [Title/Abstract] AND OCA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E9-A22G-01AGABRG3chr15

27271968

+OCA2chr15

28211968

-
TCGARVLUSCTCGA-22-5489-01AGABRG3chr15

27271968

+OCA2chr15

28000618

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000333743ENST00000353809GABRG3chr15

27271968

+OCA2chr15

28211968

-
In-frameENST00000333743ENST00000354638GABRG3chr15

27271968

+OCA2chr15

28211968

-
In-frameENST00000333743ENST00000382996GABRG3chr15

27271968

+OCA2chr15

28211968

-
In-frameENST00000555083ENST00000353809GABRG3chr15

27271968

+OCA2chr15

28211968

-
In-frameENST00000555083ENST00000354638GABRG3chr15

27271968

+OCA2chr15

28211968

-
In-frameENST00000555083ENST00000382996GABRG3chr15

27271968

+OCA2chr15

28211968

-
intron-3CDSENST00000554786ENST00000353809GABRG3chr15

27271968

+OCA2chr15

28211968

-
intron-3CDSENST00000554786ENST00000354638GABRG3chr15

27271968

+OCA2chr15

28211968

-
intron-3CDSENST00000554786ENST00000382996GABRG3chr15

27271968

+OCA2chr15

28211968

-
Frame-shiftENST00000333743ENST00000353809GABRG3chr15

27271968

+OCA2chr15

28000618

-
In-frameENST00000333743ENST00000354638GABRG3chr15

27271968

+OCA2chr15

28000618

-
5CDS-intronENST00000333743ENST00000382996GABRG3chr15

27271968

+OCA2chr15

28000618

-
Frame-shiftENST00000555083ENST00000353809GABRG3chr15

27271968

+OCA2chr15

28000618

-
In-frameENST00000555083ENST00000354638GABRG3chr15

27271968

+OCA2chr15

28000618

-
5CDS-intronENST00000555083ENST00000382996GABRG3chr15

27271968

+OCA2chr15

28000618

-
intron-3CDSENST00000554786ENST00000353809GABRG3chr15

27271968

+OCA2chr15

28000618

-
intron-3CDSENST00000554786ENST00000354638GABRG3chr15

27271968

+OCA2chr15

28000618

-
intron-intronENST00000554786ENST00000382996GABRG3chr15

27271968

+OCA2chr15

28000618

-

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FusionProtFeatures for GABRG3_OCA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GABRG3

Q99928

OCA2

Q04671

GABA, the major inhibitory neurotransmitter in thevertebrate brain, mediates neuronal inhibition by binding to theGABA/benzodiazepine receptor and opening an integral chloridechannel. Could be involved in the transport of tyrosine, theprecursor to melanin synthesis, within the melanocyte. Regulatesthe pH of melanosome and the melanosome maturation. One of thecomponents of the mammalian pigmentary system. Seems to regulatethe post-translational processing of tyrosinase, which catalyzesthe limiting reaction in melanin synthesis. May serve as a keycontrol point at which ethnic skin color variation is determined.Major determinant of brown and/or blue eye color.{ECO:0000269|PubMed:11310796, ECO:0000269|PubMed:15262401,ECO:0000269|PubMed:18252222, ECO:0000269|PubMed:22234890,ECO:0000269|PubMed:7601462}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223531_620477815Topological domainCytoplasmic
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223638_647477815Topological domainExtracellular
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223665_679477815Topological domainCytoplasmic
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223697_720477815Topological domainExtracellular
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223738_760477815Topological domainCytoplasmic
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223778_817477815Topological domainExtracellular
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223835_838477815Topological domainCytoplasmic
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324531_620501839Topological domainCytoplasmic
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324638_647501839Topological domainExtracellular
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324665_679501839Topological domainCytoplasmic
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324697_720501839Topological domainExtracellular
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324738_760501839Topological domainCytoplasmic
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324778_817501839Topological domainExtracellular
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324835_838501839Topological domainCytoplasmic
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319531_620501669Topological domainCytoplasmic
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319638_647501669Topological domainExtracellular
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319665_679501669Topological domainCytoplasmic
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319697_720501669Topological domainExtracellular
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319738_760501669Topological domainCytoplasmic
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319778_817501669Topological domainExtracellular
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319835_838501669Topological domainCytoplasmic
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223514_530477815TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223621_637477815TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223648_664477815TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223680_696477815TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223721_737477815TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223761_777477815TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223818_834477815TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324514_530501839TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324621_637501839TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324648_664501839TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324680_696501839TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324721_737501839TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324761_777501839TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324818_834501839TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319514_530501669TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319621_637501669TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319648_664501669TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319680_696501669TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319721_737501669TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319761_777501669TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319818_834501669TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGABRG3chr15:27271968chr15:28211968ENST00000333743+31018_25490468Topological domainExtracellular
HgeneGABRG3chr15:27271968chr15:28211968ENST00000333743+310338_44390468Topological domainCytoplasmic
HgeneGABRG3chr15:27271968chr15:28211968ENST00000555083+3618_25490254Topological domainExtracellular
HgeneGABRG3chr15:27271968chr15:28211968ENST00000555083+36338_44390254Topological domainCytoplasmic
HgeneGABRG3chr15:27271968chr15:28211968ENST00000333743+310255_27790468TransmembraneHelical
HgeneGABRG3chr15:27271968chr15:28211968ENST00000333743+310281_30390468TransmembraneHelical
HgeneGABRG3chr15:27271968chr15:28211968ENST00000333743+310315_33790468TransmembraneHelical
HgeneGABRG3chr15:27271968chr15:28211968ENST00000333743+310444_46790468TransmembraneHelical
HgeneGABRG3chr15:27271968chr15:28211968ENST00000555083+36255_27790254TransmembraneHelical
HgeneGABRG3chr15:27271968chr15:28211968ENST00000555083+36281_30390254TransmembraneHelical
HgeneGABRG3chr15:27271968chr15:28211968ENST00000555083+36315_33790254TransmembraneHelical
HgeneGABRG3chr15:27271968chr15:28211968ENST00000555083+36444_46790254TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223198_330477815Topological domainExtracellular
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-12231_179477815Topological domainCytoplasmic
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223348_353477815Topological domainCytoplasmic
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223371_384477815Topological domainExtracellular
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223402_423477815Topological domainCytoplasmic
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223441_513477815Topological domainExtracellular
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324198_330501839Topological domainExtracellular
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-13241_179501839Topological domainCytoplasmic
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324348_353501839Topological domainCytoplasmic
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324371_384501839Topological domainExtracellular
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324402_423501839Topological domainCytoplasmic
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324441_513501839Topological domainExtracellular
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319198_330501669Topological domainExtracellular
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-13191_179501669Topological domainCytoplasmic
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319348_353501669Topological domainCytoplasmic
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319371_384501669Topological domainExtracellular
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319402_423501669Topological domainCytoplasmic
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319441_513501669Topological domainExtracellular
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223180_197477815TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223331_347477815TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223354_370477815TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223385_401477815TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000353809-1223424_440477815TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324180_197501839TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324331_347501839TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324354_370501839TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324385_401501839TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000354638-1324424_440501839TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319180_197501669TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319331_347501669TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319354_370501669TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319385_401501669TransmembraneHelical
TgeneOCA2chr15:27271968chr15:28211968ENST00000382996-1319424_440501669TransmembraneHelical


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FusionGeneSequence for GABRG3_OCA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_GABRG3_ENST00000333743_chr15_27271968_+_OCA2_ENST00000353809_chr15_28211968_-_428aa
MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINM
GLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIVELKHEIHVWRLTAQRISPASREETAVRRLLLGKVLALEHLLARRLH
TFHRQISQEDKNWETNIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVPGIHLDLGWIAILGAIWLLILADIHDFEIILHRVEWAT
LLFFAALFVLMEALAHLHLIEYVGEQTALLIKMVPEEQRLIAAIVLVVWVSALASSLIDNIPFTATMIPVLLNLSHDPEVGLPAPPLMYA

>In-frame_GABRG3_ENST00000333743_chr15_27271968_+_OCA2_ENST00000354638_chr15_28211968_-_428aa
MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINM
GLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIVELKHEIHVWRLTAQRISPASREETAVRRLLLGKVLALEHLLARRLH
TFHRQISQEDKNWETNIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVPGIHLDLGWIAILGAIWLLILADIHDFEIILHRVEWAT
LLFFAALFVLMEALAHLHLIEYVGEQTALLIKMVPEEQRLIAAIVLVVWVSALASSLIDNIPFTATMIPVLLNLSHDPEVGLPAPPLMYA

>In-frame_GABRG3_ENST00000333743_chr15_27271968_+_OCA2_ENST00000382996_chr15_28211968_-_258aa
MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINM
GLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIVELKHEIHVWRLTAQRISPASREETAVRRLLLGKVLALEHLLARRLH

>In-frame_GABRG3_ENST00000555083_chr15_27271968_+_OCA2_ENST00000353809_chr15_28211968_-_428aa
MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINM
GLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIVELKHEIHVWRLTAQRISPASREETAVRRLLLGKVLALEHLLARRLH
TFHRQISQEDKNWETNIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVPGIHLDLGWIAILGAIWLLILADIHDFEIILHRVEWAT
LLFFAALFVLMEALAHLHLIEYVGEQTALLIKMVPEEQRLIAAIVLVVWVSALASSLIDNIPFTATMIPVLLNLSHDPEVGLPAPPLMYA

>In-frame_GABRG3_ENST00000555083_chr15_27271968_+_OCA2_ENST00000354638_chr15_28211968_-_428aa
MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINM
GLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIVELKHEIHVWRLTAQRISPASREETAVRRLLLGKVLALEHLLARRLH
TFHRQISQEDKNWETNIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVPGIHLDLGWIAILGAIWLLILADIHDFEIILHRVEWAT
LLFFAALFVLMEALAHLHLIEYVGEQTALLIKMVPEEQRLIAAIVLVVWVSALASSLIDNIPFTATMIPVLLNLSHDPEVGLPAPPLMYA

>In-frame_GABRG3_ENST00000555083_chr15_27271968_+_OCA2_ENST00000382996_chr15_28211968_-_258aa
MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINM
GLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIVELKHEIHVWRLTAQRISPASREETAVRRLLLGKVLALEHLLARRLH

>In-frame_GABRG3_ENST00000333743_chr15_27271968_+_OCA2_ENST00000354638_chr15_28000618_-_118aa
MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINM

>In-frame_GABRG3_ENST00000555083_chr15_27271968_+_OCA2_ENST00000354638_chr15_28000618_-_118aa
MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINM


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_GABRG3_ENST00000333743_chr15_27271968_+_OCA2_ENST00000353809_chr15_28211968_-_1284nt
ATGGCCCCGAAGCTGCTGCTCCTCCTCTGCCTGTTCTCGGGCTTGCACGCGCGGTCCAGAAAGGTGGAAGAGGATGAATATGAAGATTCA
TCATCAAACCAAAAGTGGGTCTTGGCTCCAAAATCCCAAGACACCGACGTGACTCTTATTCTCAACAAGTTGCTAAGAGAATATGATAAA
AAGCTGAGGCCAGATATTGGAATAAAACCGACCGTAATTGACGTTGACATTTATGTTAACAGCATTGGTCCTGTGTCATCAATAAACATG
GGCCTGGACTTTGCCGGATTCACTGCACACATGTTCATTGGGATTTGCCTTGTTCTCCTGGTCTGCTTTCCGCTCCTCAGACTCCTTTAC
TGGAACAGAAAGCTTTATAACAAGGAACCCAGTGAGATTGTTGAACTGAAGCACGAGATTCACGTCTGGCGCCTGACTGCTCAGCGCATC
AGCCCGGCCAGCCGCGAGGAGACAGCTGTGCGCCGCCTGCTGCTGGGGAAGGTGCTGGCACTGGAGCACCTGCTCGCCCGGAGGCTGCAC
ACCTTCCACAGACAGATCTCACAGGAGGACAAAAATTGGGAGACCAATATCCAAGAACTCCAAAAAAAGCATAGGATATCTGACGGGATT
CTGCTCGCCAAATGCCTGACAGTGTTGGGATTTGTTATCTTCATGTTTTTCCTCAATTCGTTTGTCCCTGGCATTCATCTTGATCTTGGA
TGGATTGCTATTCTGGGTGCCATCTGGTTGCTAATTTTAGCTGATATTCATGATTTTGAGATAATTCTACACAGAGTGGAATGGGCAACC
CTTCTGTTTTTTGCAGCGCTCTTTGTTCTGATGGAGGCATTGGCACATCTCCACTTAATAGAATATGTTGGAGAACAAACTGCTTTGCTA
ATAAAGATGGTCCCAGAGGAGCAGCGCCTCATAGCCGCCATTGTCCTGGTGGTGTGGGTCTCAGCCCTGGCGTCGTCCCTGATTGACAAC
ATCCCGTTCACTGCTACCATGATTCCCGTGCTCCTGAACCTGAGCCACGACCCTGAGGTTGGCCTGCCCGCACCGCCGCTCATGTATGCC
CTGGCCTTCGGTGCTTGCCTGGGAGGTAACGGGACACTGATTGGCGCGTCGGCAAACGTCGTGTGTGCAGGGATTGCAGAACAGCATGGA
TATGGGTTCTCCTTCATGGAATTTTTCAGGCTGGGCTTCCCAATGATGGTTGTGTCCTGCACTGTTGGGATGTGTTATCTCCTTGTGGCT

>In-frame_GABRG3_ENST00000333743_chr15_27271968_+_OCA2_ENST00000354638_chr15_28211968_-_1284nt
ATGGCCCCGAAGCTGCTGCTCCTCCTCTGCCTGTTCTCGGGCTTGCACGCGCGGTCCAGAAAGGTGGAAGAGGATGAATATGAAGATTCA
TCATCAAACCAAAAGTGGGTCTTGGCTCCAAAATCCCAAGACACCGACGTGACTCTTATTCTCAACAAGTTGCTAAGAGAATATGATAAA
AAGCTGAGGCCAGATATTGGAATAAAACCGACCGTAATTGACGTTGACATTTATGTTAACAGCATTGGTCCTGTGTCATCAATAAACATG
GGCCTGGACTTTGCCGGATTCACTGCACACATGTTCATTGGGATTTGCCTTGTTCTCCTGGTCTGCTTTCCGCTCCTCAGACTCCTTTAC
TGGAACAGAAAGCTTTATAACAAGGAACCCAGTGAGATTGTTGAACTGAAGCACGAGATTCACGTCTGGCGCCTGACTGCTCAGCGCATC
AGCCCGGCCAGCCGCGAGGAGACAGCTGTGCGCCGCCTGCTGCTGGGGAAGGTGCTGGCACTGGAGCACCTGCTCGCCCGGAGGCTGCAC
ACCTTCCACAGACAGATCTCACAGGAGGACAAAAATTGGGAGACCAATATCCAAGAACTCCAAAAAAAGCATAGGATATCTGACGGGATT
CTGCTCGCCAAATGCCTGACAGTGTTGGGATTTGTTATCTTCATGTTTTTCCTCAATTCGTTTGTCCCTGGCATTCATCTTGATCTTGGA
TGGATTGCTATTCTGGGTGCCATCTGGTTGCTAATTTTAGCTGATATTCATGATTTTGAGATAATTCTACACAGAGTGGAATGGGCAACC
CTTCTGTTTTTTGCAGCGCTCTTTGTTCTGATGGAGGCATTGGCACATCTCCACTTAATAGAATATGTTGGAGAACAAACTGCTTTGCTA
ATAAAGATGGTCCCAGAGGAGCAGCGCCTCATAGCCGCCATTGTCCTGGTGGTGTGGGTCTCAGCCCTGGCGTCGTCCCTGATTGACAAC
ATCCCGTTCACTGCTACCATGATTCCCGTGCTCCTGAACCTGAGCCACGACCCTGAGGTTGGCCTGCCCGCACCGCCGCTCATGTATGCC
CTGGCCTTCGGTGCTTGCCTGGGAGGTAACGGGACACTGATTGGCGCGTCGGCAAACGTCGTGTGTGCAGGGATTGCAGAACAGCATGGA
TATGGGTTCTCCTTCATGGAATTTTTCAGGCTGGGCTTCCCAATGATGGTTGTGTCCTGCACTGTTGGGATGTGTTATCTCCTTGTGGCT

>In-frame_GABRG3_ENST00000333743_chr15_27271968_+_OCA2_ENST00000382996_chr15_28211968_-_774nt
ATGGCCCCGAAGCTGCTGCTCCTCCTCTGCCTGTTCTCGGGCTTGCACGCGCGGTCCAGAAAGGTGGAAGAGGATGAATATGAAGATTCA
TCATCAAACCAAAAGTGGGTCTTGGCTCCAAAATCCCAAGACACCGACGTGACTCTTATTCTCAACAAGTTGCTAAGAGAATATGATAAA
AAGCTGAGGCCAGATATTGGAATAAAACCGACCGTAATTGACGTTGACATTTATGTTAACAGCATTGGTCCTGTGTCATCAATAAACATG
GGCCTGGACTTTGCCGGATTCACTGCACACATGTTCATTGGGATTTGCCTTGTTCTCCTGGTCTGCTTTCCGCTCCTCAGACTCCTTTAC
TGGAACAGAAAGCTTTATAACAAGGAACCCAGTGAGATTGTTGAACTGAAGCACGAGATTCACGTCTGGCGCCTGACTGCTCAGCGCATC
AGCCCGGCCAGCCGCGAGGAGACAGCTGTGCGCCGCCTGCTGCTGGGGAAGGTGCTGGCACTGGAGCACCTGCTCGCCCGGAGGCTGCAC
ACCTTCCACAGACAGATCTCACAGGAGGACAAAAATTGGGAGACCAATATCCAAGAACTCCAAAAAAAGCATAGGATATCTGACGGGATT
CTGCTCGCCAAATGCCTGACAGTGTTGGGATTTGTTATCTTCATGTTTTTCCTCAATTCGTTTGTCCCTGGCATTCATCTTGATCTTGGT

>In-frame_GABRG3_ENST00000555083_chr15_27271968_+_OCA2_ENST00000353809_chr15_28211968_-_1284nt
ATGGCCCCGAAGCTGCTGCTCCTCCTCTGCCTGTTCTCGGGCTTGCACGCGCGGTCCAGAAAGGTGGAAGAGGATGAATATGAAGATTCA
TCATCAAACCAAAAGTGGGTCTTGGCTCCAAAATCCCAAGACACCGACGTGACTCTTATTCTCAACAAGTTGCTAAGAGAATATGATAAA
AAGCTGAGGCCAGATATTGGAATAAAACCGACCGTAATTGACGTTGACATTTATGTTAACAGCATTGGTCCTGTGTCATCAATAAACATG
GGCCTGGACTTTGCCGGATTCACTGCACACATGTTCATTGGGATTTGCCTTGTTCTCCTGGTCTGCTTTCCGCTCCTCAGACTCCTTTAC
TGGAACAGAAAGCTTTATAACAAGGAACCCAGTGAGATTGTTGAACTGAAGCACGAGATTCACGTCTGGCGCCTGACTGCTCAGCGCATC
AGCCCGGCCAGCCGCGAGGAGACAGCTGTGCGCCGCCTGCTGCTGGGGAAGGTGCTGGCACTGGAGCACCTGCTCGCCCGGAGGCTGCAC
ACCTTCCACAGACAGATCTCACAGGAGGACAAAAATTGGGAGACCAATATCCAAGAACTCCAAAAAAAGCATAGGATATCTGACGGGATT
CTGCTCGCCAAATGCCTGACAGTGTTGGGATTTGTTATCTTCATGTTTTTCCTCAATTCGTTTGTCCCTGGCATTCATCTTGATCTTGGA
TGGATTGCTATTCTGGGTGCCATCTGGTTGCTAATTTTAGCTGATATTCATGATTTTGAGATAATTCTACACAGAGTGGAATGGGCAACC
CTTCTGTTTTTTGCAGCGCTCTTTGTTCTGATGGAGGCATTGGCACATCTCCACTTAATAGAATATGTTGGAGAACAAACTGCTTTGCTA
ATAAAGATGGTCCCAGAGGAGCAGCGCCTCATAGCCGCCATTGTCCTGGTGGTGTGGGTCTCAGCCCTGGCGTCGTCCCTGATTGACAAC
ATCCCGTTCACTGCTACCATGATTCCCGTGCTCCTGAACCTGAGCCACGACCCTGAGGTTGGCCTGCCCGCACCGCCGCTCATGTATGCC
CTGGCCTTCGGTGCTTGCCTGGGAGGTAACGGGACACTGATTGGCGCGTCGGCAAACGTCGTGTGTGCAGGGATTGCAGAACAGCATGGA
TATGGGTTCTCCTTCATGGAATTTTTCAGGCTGGGCTTCCCAATGATGGTTGTGTCCTGCACTGTTGGGATGTGTTATCTCCTTGTGGCT

>In-frame_GABRG3_ENST00000555083_chr15_27271968_+_OCA2_ENST00000354638_chr15_28211968_-_1284nt
ATGGCCCCGAAGCTGCTGCTCCTCCTCTGCCTGTTCTCGGGCTTGCACGCGCGGTCCAGAAAGGTGGAAGAGGATGAATATGAAGATTCA
TCATCAAACCAAAAGTGGGTCTTGGCTCCAAAATCCCAAGACACCGACGTGACTCTTATTCTCAACAAGTTGCTAAGAGAATATGATAAA
AAGCTGAGGCCAGATATTGGAATAAAACCGACCGTAATTGACGTTGACATTTATGTTAACAGCATTGGTCCTGTGTCATCAATAAACATG
GGCCTGGACTTTGCCGGATTCACTGCACACATGTTCATTGGGATTTGCCTTGTTCTCCTGGTCTGCTTTCCGCTCCTCAGACTCCTTTAC
TGGAACAGAAAGCTTTATAACAAGGAACCCAGTGAGATTGTTGAACTGAAGCACGAGATTCACGTCTGGCGCCTGACTGCTCAGCGCATC
AGCCCGGCCAGCCGCGAGGAGACAGCTGTGCGCCGCCTGCTGCTGGGGAAGGTGCTGGCACTGGAGCACCTGCTCGCCCGGAGGCTGCAC
ACCTTCCACAGACAGATCTCACAGGAGGACAAAAATTGGGAGACCAATATCCAAGAACTCCAAAAAAAGCATAGGATATCTGACGGGATT
CTGCTCGCCAAATGCCTGACAGTGTTGGGATTTGTTATCTTCATGTTTTTCCTCAATTCGTTTGTCCCTGGCATTCATCTTGATCTTGGA
TGGATTGCTATTCTGGGTGCCATCTGGTTGCTAATTTTAGCTGATATTCATGATTTTGAGATAATTCTACACAGAGTGGAATGGGCAACC
CTTCTGTTTTTTGCAGCGCTCTTTGTTCTGATGGAGGCATTGGCACATCTCCACTTAATAGAATATGTTGGAGAACAAACTGCTTTGCTA
ATAAAGATGGTCCCAGAGGAGCAGCGCCTCATAGCCGCCATTGTCCTGGTGGTGTGGGTCTCAGCCCTGGCGTCGTCCCTGATTGACAAC
ATCCCGTTCACTGCTACCATGATTCCCGTGCTCCTGAACCTGAGCCACGACCCTGAGGTTGGCCTGCCCGCACCGCCGCTCATGTATGCC
CTGGCCTTCGGTGCTTGCCTGGGAGGTAACGGGACACTGATTGGCGCGTCGGCAAACGTCGTGTGTGCAGGGATTGCAGAACAGCATGGA
TATGGGTTCTCCTTCATGGAATTTTTCAGGCTGGGCTTCCCAATGATGGTTGTGTCCTGCACTGTTGGGATGTGTTATCTCCTTGTGGCT

>In-frame_GABRG3_ENST00000555083_chr15_27271968_+_OCA2_ENST00000382996_chr15_28211968_-_774nt
ATGGCCCCGAAGCTGCTGCTCCTCCTCTGCCTGTTCTCGGGCTTGCACGCGCGGTCCAGAAAGGTGGAAGAGGATGAATATGAAGATTCA
TCATCAAACCAAAAGTGGGTCTTGGCTCCAAAATCCCAAGACACCGACGTGACTCTTATTCTCAACAAGTTGCTAAGAGAATATGATAAA
AAGCTGAGGCCAGATATTGGAATAAAACCGACCGTAATTGACGTTGACATTTATGTTAACAGCATTGGTCCTGTGTCATCAATAAACATG
GGCCTGGACTTTGCCGGATTCACTGCACACATGTTCATTGGGATTTGCCTTGTTCTCCTGGTCTGCTTTCCGCTCCTCAGACTCCTTTAC
TGGAACAGAAAGCTTTATAACAAGGAACCCAGTGAGATTGTTGAACTGAAGCACGAGATTCACGTCTGGCGCCTGACTGCTCAGCGCATC
AGCCCGGCCAGCCGCGAGGAGACAGCTGTGCGCCGCCTGCTGCTGGGGAAGGTGCTGGCACTGGAGCACCTGCTCGCCCGGAGGCTGCAC
ACCTTCCACAGACAGATCTCACAGGAGGACAAAAATTGGGAGACCAATATCCAAGAACTCCAAAAAAAGCATAGGATATCTGACGGGATT
CTGCTCGCCAAATGCCTGACAGTGTTGGGATTTGTTATCTTCATGTTTTTCCTCAATTCGTTTGTCCCTGGCATTCATCTTGATCTTGGT

>In-frame_GABRG3_ENST00000333743_chr15_27271968_+_OCA2_ENST00000354638_chr15_28000618_-_355nt
ATGGCCCCGAAGCTGCTGCTCCTCCTCTGCCTGTTCTCGGGCTTGCACGCGCGGTCCAGAAAGGTGGAAGAGGATGAATATGAAGATTCA
TCATCAAACCAAAAGTGGGTCTTGGCTCCAAAATCCCAAGACACCGACGTGACTCTTATTCTCAACAAGTTGCTAAGAGAATATGATAAA
AAGCTGAGGCCAGATATTGGAATAAAACCGACCGTAATTGACGTTGACATTTATGTTAACAGCATTGGTCCTGTGTCATCAATAAACATG

>In-frame_GABRG3_ENST00000555083_chr15_27271968_+_OCA2_ENST00000354638_chr15_28000618_-_355nt
ATGGCCCCGAAGCTGCTGCTCCTCCTCTGCCTGTTCTCGGGCTTGCACGCGCGGTCCAGAAAGGTGGAAGAGGATGAATATGAAGATTCA
TCATCAAACCAAAAGTGGGTCTTGGCTCCAAAATCCCAAGACACCGACGTGACTCTTATTCTCAACAAGTTGCTAAGAGAATATGATAAA
AAGCTGAGGCCAGATATTGGAATAAAACCGACCGTAATTGACGTTGACATTTATGTTAACAGCATTGGTCCTGTGTCATCAATAAACATG


* Fusion transcript sequences (Full-length transcript).
>In-frame_GABRG3_ENST00000333743_chr15_27271968_+_OCA2_ENST00000353809_chr15_28211968_-_2051nt
GCCGCCCGGTTGCGCGGACCGGCGCTAGTGCGCGGGTGGGGGCGGCGCGCCGCGGTGGCCCGGCGTCCCGTGTGCGTCCAGTGTGCGCCC
CGCGGGGGCGCGGCCAGCGCCAGAGTAGATACCTGTCCCGCCCGCCGCGGCCAGCAGCCTCGGAGGAAGCCAGGGCAAAGAGGGCCGGCG
GAGACCAGGTCCGCGCCGGAGGAAGCCGCGCCCGGCCGAGGCCCCGGACCCTGCGCCCCGAGCTCCACGGCACCATGGCCCCGAAGCTGC
TGCTCCTCCTCTGCCTGTTCTCGGGCTTGCACGCGCGGTCCAGAAAGGTGGAAGAGGATGAATATGAAGATTCATCATCAAACCAAAAGT
GGGTCTTGGCTCCAAAATCCCAAGACACCGACGTGACTCTTATTCTCAACAAGTTGCTAAGAGAATATGATAAAAAGCTGAGGCCAGATA
TTGGAATAAAACCGACCGTAATTGACGTTGACATTTATGTTAACAGCATTGGTCCTGTGTCATCAATAAACATGGGCCTGGACTTTGCCG
GATTCACTGCACACATGTTCATTGGGATTTGCCTTGTTCTCCTGGTCTGCTTTCCGCTCCTCAGACTCCTTTACTGGAACAGAAAGCTTT
ATAACAAGGAACCCAGTGAGATTGTTGAACTGAAGCACGAGATTCACGTCTGGCGCCTGACTGCTCAGCGCATCAGCCCGGCCAGCCGCG
AGGAGACAGCTGTGCGCCGCCTGCTGCTGGGGAAGGTGCTGGCACTGGAGCACCTGCTCGCCCGGAGGCTGCACACCTTCCACAGACAGA
TCTCACAGGAGGACAAAAATTGGGAGACCAATATCCAAGAACTCCAAAAAAAGCATAGGATATCTGACGGGATTCTGCTCGCCAAATGCC
TGACAGTGTTGGGATTTGTTATCTTCATGTTTTTCCTCAATTCGTTTGTCCCTGGCATTCATCTTGATCTTGGATGGATTGCTATTCTGG
GTGCCATCTGGTTGCTAATTTTAGCTGATATTCATGATTTTGAGATAATTCTACACAGAGTGGAATGGGCAACCCTTCTGTTTTTTGCAG
CGCTCTTTGTTCTGATGGAGGCATTGGCACATCTCCACTTAATAGAATATGTTGGAGAACAAACTGCTTTGCTAATAAAGATGGTCCCAG
AGGAGCAGCGCCTCATAGCCGCCATTGTCCTGGTGGTGTGGGTCTCAGCCCTGGCGTCGTCCCTGATTGACAACATCCCGTTCACTGCTA
CCATGATTCCCGTGCTCCTGAACCTGAGCCACGACCCTGAGGTTGGCCTGCCCGCACCGCCGCTCATGTATGCCCTGGCCTTCGGTGCTT
GCCTGGGAGGTAACGGGACACTGATTGGCGCGTCGGCAAACGTCGTGTGTGCAGGGATTGCAGAACAGCATGGATATGGGTTCTCCTTCA
TGGAATTTTTCAGGCTGGGCTTCCCAATGATGGTTGTGTCCTGCACTGTTGGGATGTGTTATCTCCTTGTGGCTCATGTGGTGGTGGGAT
GGAATTAATAGACATCCATCTATTGCTCGAAGACTAAAGGAAACTTCATCCATCACAACCCATTAGTCATAAAACTACCCTGACCCCACT
GTTTGAAGAAGAAAAGGTGCTTACCCTGGAGATGCTACAGAGACACAGTGGAATAGACCTTGACACTAACACTCTAATTCAAGCGAATGT
TGGAACACCATGACCTCCTCTGTGTGTCCTTTCTCCCCAAGGACAAAATGTAGAAAGATGTGAGATAACTTACTCAAGATTCCCCTCCAG
AAAAATACGTATGTTTAAAAACCCTTCCTGCTATACATAGGAAAAGACACACATCCACCTAAAATTGACTGTACTGTTTAACTGTCAATT
CTCCTGAGGCTAAACACAGTTTGTTTTTCTTGTAATCACTTTTCATGTTAAAATAATCAGCATTCAAATTGTATGCTTTCTGAATATAGA

>In-frame_GABRG3_ENST00000333743_chr15_27271968_+_OCA2_ENST00000354638_chr15_28211968_-_2051nt
GCCGCCCGGTTGCGCGGACCGGCGCTAGTGCGCGGGTGGGGGCGGCGCGCCGCGGTGGCCCGGCGTCCCGTGTGCGTCCAGTGTGCGCCC
CGCGGGGGCGCGGCCAGCGCCAGAGTAGATACCTGTCCCGCCCGCCGCGGCCAGCAGCCTCGGAGGAAGCCAGGGCAAAGAGGGCCGGCG
GAGACCAGGTCCGCGCCGGAGGAAGCCGCGCCCGGCCGAGGCCCCGGACCCTGCGCCCCGAGCTCCACGGCACCATGGCCCCGAAGCTGC
TGCTCCTCCTCTGCCTGTTCTCGGGCTTGCACGCGCGGTCCAGAAAGGTGGAAGAGGATGAATATGAAGATTCATCATCAAACCAAAAGT
GGGTCTTGGCTCCAAAATCCCAAGACACCGACGTGACTCTTATTCTCAACAAGTTGCTAAGAGAATATGATAAAAAGCTGAGGCCAGATA
TTGGAATAAAACCGACCGTAATTGACGTTGACATTTATGTTAACAGCATTGGTCCTGTGTCATCAATAAACATGGGCCTGGACTTTGCCG
GATTCACTGCACACATGTTCATTGGGATTTGCCTTGTTCTCCTGGTCTGCTTTCCGCTCCTCAGACTCCTTTACTGGAACAGAAAGCTTT
ATAACAAGGAACCCAGTGAGATTGTTGAACTGAAGCACGAGATTCACGTCTGGCGCCTGACTGCTCAGCGCATCAGCCCGGCCAGCCGCG
AGGAGACAGCTGTGCGCCGCCTGCTGCTGGGGAAGGTGCTGGCACTGGAGCACCTGCTCGCCCGGAGGCTGCACACCTTCCACAGACAGA
TCTCACAGGAGGACAAAAATTGGGAGACCAATATCCAAGAACTCCAAAAAAAGCATAGGATATCTGACGGGATTCTGCTCGCCAAATGCC
TGACAGTGTTGGGATTTGTTATCTTCATGTTTTTCCTCAATTCGTTTGTCCCTGGCATTCATCTTGATCTTGGATGGATTGCTATTCTGG
GTGCCATCTGGTTGCTAATTTTAGCTGATATTCATGATTTTGAGATAATTCTACACAGAGTGGAATGGGCAACCCTTCTGTTTTTTGCAG
CGCTCTTTGTTCTGATGGAGGCATTGGCACATCTCCACTTAATAGAATATGTTGGAGAACAAACTGCTTTGCTAATAAAGATGGTCCCAG
AGGAGCAGCGCCTCATAGCCGCCATTGTCCTGGTGGTGTGGGTCTCAGCCCTGGCGTCGTCCCTGATTGACAACATCCCGTTCACTGCTA
CCATGATTCCCGTGCTCCTGAACCTGAGCCACGACCCTGAGGTTGGCCTGCCCGCACCGCCGCTCATGTATGCCCTGGCCTTCGGTGCTT
GCCTGGGAGGTAACGGGACACTGATTGGCGCGTCGGCAAACGTCGTGTGTGCAGGGATTGCAGAACAGCATGGATATGGGTTCTCCTTCA
TGGAATTTTTCAGGCTGGGCTTCCCAATGATGGTTGTGTCCTGCACTGTTGGGATGTGTTATCTCCTTGTGGCTCATGTGGTGGTGGGAT
GGAATTAATAGACATCCATCTATTGCTCGAAGACTAAAGGAAACTTCATCCATCACAACCCATTAGTCATAAAACTACCCTGACCCCACT
GTTTGAAGAAGAAAAGGTGCTTACCCTGGAGATGCTACAGAGACACAGTGGAATAGACCTTGACACTAACACTCTAATTCAAGCGAATGT
TGGAACACCATGACCTCCTCTGTGTGTCCTTTCTCCCCAAGGACAAAATGTAGAAAGATGTGAGATAACTTACTCAAGATTCCCCTCCAG
AAAAATACGTATGTTTAAAAACCCTTCCTGCTATACATAGGAAAAGACACACATCCACCTAAAATTGACTGTACTGTTTAACTGTCAATT
CTCCTGAGGCTAAACACAGTTTGTTTTTCTTGTAATCACTTTTCATGTTAAAATAATCAGCATTCAAATTGTATGCTTTCTGAATATAGA

>In-frame_GABRG3_ENST00000333743_chr15_27271968_+_OCA2_ENST00000382996_chr15_28211968_-_1028nt
GCCGCCCGGTTGCGCGGACCGGCGCTAGTGCGCGGGTGGGGGCGGCGCGCCGCGGTGGCCCGGCGTCCCGTGTGCGTCCAGTGTGCGCCC
CGCGGGGGCGCGGCCAGCGCCAGAGTAGATACCTGTCCCGCCCGCCGCGGCCAGCAGCCTCGGAGGAAGCCAGGGCAAAGAGGGCCGGCG
GAGACCAGGTCCGCGCCGGAGGAAGCCGCGCCCGGCCGAGGCCCCGGACCCTGCGCCCCGAGCTCCACGGCACCATGGCCCCGAAGCTGC
TGCTCCTCCTCTGCCTGTTCTCGGGCTTGCACGCGCGGTCCAGAAAGGTGGAAGAGGATGAATATGAAGATTCATCATCAAACCAAAAGT
GGGTCTTGGCTCCAAAATCCCAAGACACCGACGTGACTCTTATTCTCAACAAGTTGCTAAGAGAATATGATAAAAAGCTGAGGCCAGATA
TTGGAATAAAACCGACCGTAATTGACGTTGACATTTATGTTAACAGCATTGGTCCTGTGTCATCAATAAACATGGGCCTGGACTTTGCCG
GATTCACTGCACACATGTTCATTGGGATTTGCCTTGTTCTCCTGGTCTGCTTTCCGCTCCTCAGACTCCTTTACTGGAACAGAAAGCTTT
ATAACAAGGAACCCAGTGAGATTGTTGAACTGAAGCACGAGATTCACGTCTGGCGCCTGACTGCTCAGCGCATCAGCCCGGCCAGCCGCG
AGGAGACAGCTGTGCGCCGCCTGCTGCTGGGGAAGGTGCTGGCACTGGAGCACCTGCTCGCCCGGAGGCTGCACACCTTCCACAGACAGA
TCTCACAGGAGGACAAAAATTGGGAGACCAATATCCAAGAACTCCAAAAAAAGCATAGGATATCTGACGGGATTCTGCTCGCCAAATGCC
TGACAGTGTTGGGATTTGTTATCTTCATGTTTTTCCTCAATTCGTTTGTCCCTGGCATTCATCTTGATCTTGGTGGCCTGGGCTTGGTTC

>In-frame_GABRG3_ENST00000555083_chr15_27271968_+_OCA2_ENST00000353809_chr15_28211968_-_1940nt
AGAGTAGATACCTGTCCCGCCCGCCGCGGCCAGCAGCCTCGGAGGAAGCCAGGGCAAAGAGGGCCGGCGGAGACCAGGTCCGCGCCGGAG
GAAGCCGCGCCCGGCCGAGGCCCCGGACCCTGCGCCCCGAGCTCCACGGCACCATGGCCCCGAAGCTGCTGCTCCTCCTCTGCCTGTTCT
CGGGCTTGCACGCGCGGTCCAGAAAGGTGGAAGAGGATGAATATGAAGATTCATCATCAAACCAAAAGTGGGTCTTGGCTCCAAAATCCC
AAGACACCGACGTGACTCTTATTCTCAACAAGTTGCTAAGAGAATATGATAAAAAGCTGAGGCCAGATATTGGAATAAAACCGACCGTAA
TTGACGTTGACATTTATGTTAACAGCATTGGTCCTGTGTCATCAATAAACATGGGCCTGGACTTTGCCGGATTCACTGCACACATGTTCA
TTGGGATTTGCCTTGTTCTCCTGGTCTGCTTTCCGCTCCTCAGACTCCTTTACTGGAACAGAAAGCTTTATAACAAGGAACCCAGTGAGA
TTGTTGAACTGAAGCACGAGATTCACGTCTGGCGCCTGACTGCTCAGCGCATCAGCCCGGCCAGCCGCGAGGAGACAGCTGTGCGCCGCC
TGCTGCTGGGGAAGGTGCTGGCACTGGAGCACCTGCTCGCCCGGAGGCTGCACACCTTCCACAGACAGATCTCACAGGAGGACAAAAATT
GGGAGACCAATATCCAAGAACTCCAAAAAAAGCATAGGATATCTGACGGGATTCTGCTCGCCAAATGCCTGACAGTGTTGGGATTTGTTA
TCTTCATGTTTTTCCTCAATTCGTTTGTCCCTGGCATTCATCTTGATCTTGGATGGATTGCTATTCTGGGTGCCATCTGGTTGCTAATTT
TAGCTGATATTCATGATTTTGAGATAATTCTACACAGAGTGGAATGGGCAACCCTTCTGTTTTTTGCAGCGCTCTTTGTTCTGATGGAGG
CATTGGCACATCTCCACTTAATAGAATATGTTGGAGAACAAACTGCTTTGCTAATAAAGATGGTCCCAGAGGAGCAGCGCCTCATAGCCG
CCATTGTCCTGGTGGTGTGGGTCTCAGCCCTGGCGTCGTCCCTGATTGACAACATCCCGTTCACTGCTACCATGATTCCCGTGCTCCTGA
ACCTGAGCCACGACCCTGAGGTTGGCCTGCCCGCACCGCCGCTCATGTATGCCCTGGCCTTCGGTGCTTGCCTGGGAGGTAACGGGACAC
TGATTGGCGCGTCGGCAAACGTCGTGTGTGCAGGGATTGCAGAACAGCATGGATATGGGTTCTCCTTCATGGAATTTTTCAGGCTGGGCT
TCCCAATGATGGTTGTGTCCTGCACTGTTGGGATGTGTTATCTCCTTGTGGCTCATGTGGTGGTGGGATGGAATTAATAGACATCCATCT
ATTGCTCGAAGACTAAAGGAAACTTCATCCATCACAACCCATTAGTCATAAAACTACCCTGACCCCACTGTTTGAAGAAGAAAAGGTGCT
TACCCTGGAGATGCTACAGAGACACAGTGGAATAGACCTTGACACTAACACTCTAATTCAAGCGAATGTTGGAACACCATGACCTCCTCT
GTGTGTCCTTTCTCCCCAAGGACAAAATGTAGAAAGATGTGAGATAACTTACTCAAGATTCCCCTCCAGAAAAATACGTATGTTTAAAAA
CCCTTCCTGCTATACATAGGAAAAGACACACATCCACCTAAAATTGACTGTACTGTTTAACTGTCAATTCTCCTGAGGCTAAACACAGTT
TGTTTTTCTTGTAATCACTTTTCATGTTAAAATAATCAGCATTCAAATTGTATGCTTTCTGAATATAGACTTTCTGGGAAAAGGTTTACT

>In-frame_GABRG3_ENST00000555083_chr15_27271968_+_OCA2_ENST00000354638_chr15_28211968_-_1940nt
AGAGTAGATACCTGTCCCGCCCGCCGCGGCCAGCAGCCTCGGAGGAAGCCAGGGCAAAGAGGGCCGGCGGAGACCAGGTCCGCGCCGGAG
GAAGCCGCGCCCGGCCGAGGCCCCGGACCCTGCGCCCCGAGCTCCACGGCACCATGGCCCCGAAGCTGCTGCTCCTCCTCTGCCTGTTCT
CGGGCTTGCACGCGCGGTCCAGAAAGGTGGAAGAGGATGAATATGAAGATTCATCATCAAACCAAAAGTGGGTCTTGGCTCCAAAATCCC
AAGACACCGACGTGACTCTTATTCTCAACAAGTTGCTAAGAGAATATGATAAAAAGCTGAGGCCAGATATTGGAATAAAACCGACCGTAA
TTGACGTTGACATTTATGTTAACAGCATTGGTCCTGTGTCATCAATAAACATGGGCCTGGACTTTGCCGGATTCACTGCACACATGTTCA
TTGGGATTTGCCTTGTTCTCCTGGTCTGCTTTCCGCTCCTCAGACTCCTTTACTGGAACAGAAAGCTTTATAACAAGGAACCCAGTGAGA
TTGTTGAACTGAAGCACGAGATTCACGTCTGGCGCCTGACTGCTCAGCGCATCAGCCCGGCCAGCCGCGAGGAGACAGCTGTGCGCCGCC
TGCTGCTGGGGAAGGTGCTGGCACTGGAGCACCTGCTCGCCCGGAGGCTGCACACCTTCCACAGACAGATCTCACAGGAGGACAAAAATT
GGGAGACCAATATCCAAGAACTCCAAAAAAAGCATAGGATATCTGACGGGATTCTGCTCGCCAAATGCCTGACAGTGTTGGGATTTGTTA
TCTTCATGTTTTTCCTCAATTCGTTTGTCCCTGGCATTCATCTTGATCTTGGATGGATTGCTATTCTGGGTGCCATCTGGTTGCTAATTT
TAGCTGATATTCATGATTTTGAGATAATTCTACACAGAGTGGAATGGGCAACCCTTCTGTTTTTTGCAGCGCTCTTTGTTCTGATGGAGG
CATTGGCACATCTCCACTTAATAGAATATGTTGGAGAACAAACTGCTTTGCTAATAAAGATGGTCCCAGAGGAGCAGCGCCTCATAGCCG
CCATTGTCCTGGTGGTGTGGGTCTCAGCCCTGGCGTCGTCCCTGATTGACAACATCCCGTTCACTGCTACCATGATTCCCGTGCTCCTGA
ACCTGAGCCACGACCCTGAGGTTGGCCTGCCCGCACCGCCGCTCATGTATGCCCTGGCCTTCGGTGCTTGCCTGGGAGGTAACGGGACAC
TGATTGGCGCGTCGGCAAACGTCGTGTGTGCAGGGATTGCAGAACAGCATGGATATGGGTTCTCCTTCATGGAATTTTTCAGGCTGGGCT
TCCCAATGATGGTTGTGTCCTGCACTGTTGGGATGTGTTATCTCCTTGTGGCTCATGTGGTGGTGGGATGGAATTAATAGACATCCATCT
ATTGCTCGAAGACTAAAGGAAACTTCATCCATCACAACCCATTAGTCATAAAACTACCCTGACCCCACTGTTTGAAGAAGAAAAGGTGCT
TACCCTGGAGATGCTACAGAGACACAGTGGAATAGACCTTGACACTAACACTCTAATTCAAGCGAATGTTGGAACACCATGACCTCCTCT
GTGTGTCCTTTCTCCCCAAGGACAAAATGTAGAAAGATGTGAGATAACTTACTCAAGATTCCCCTCCAGAAAAATACGTATGTTTAAAAA
CCCTTCCTGCTATACATAGGAAAAGACACACATCCACCTAAAATTGACTGTACTGTTTAACTGTCAATTCTCCTGAGGCTAAACACAGTT
TGTTTTTCTTGTAATCACTTTTCATGTTAAAATAATCAGCATTCAAATTGTATGCTTTCTGAATATAGACTTTCTGGGAAAAGGTTTACT

>In-frame_GABRG3_ENST00000555083_chr15_27271968_+_OCA2_ENST00000382996_chr15_28211968_-_917nt
AGAGTAGATACCTGTCCCGCCCGCCGCGGCCAGCAGCCTCGGAGGAAGCCAGGGCAAAGAGGGCCGGCGGAGACCAGGTCCGCGCCGGAG
GAAGCCGCGCCCGGCCGAGGCCCCGGACCCTGCGCCCCGAGCTCCACGGCACCATGGCCCCGAAGCTGCTGCTCCTCCTCTGCCTGTTCT
CGGGCTTGCACGCGCGGTCCAGAAAGGTGGAAGAGGATGAATATGAAGATTCATCATCAAACCAAAAGTGGGTCTTGGCTCCAAAATCCC
AAGACACCGACGTGACTCTTATTCTCAACAAGTTGCTAAGAGAATATGATAAAAAGCTGAGGCCAGATATTGGAATAAAACCGACCGTAA
TTGACGTTGACATTTATGTTAACAGCATTGGTCCTGTGTCATCAATAAACATGGGCCTGGACTTTGCCGGATTCACTGCACACATGTTCA
TTGGGATTTGCCTTGTTCTCCTGGTCTGCTTTCCGCTCCTCAGACTCCTTTACTGGAACAGAAAGCTTTATAACAAGGAACCCAGTGAGA
TTGTTGAACTGAAGCACGAGATTCACGTCTGGCGCCTGACTGCTCAGCGCATCAGCCCGGCCAGCCGCGAGGAGACAGCTGTGCGCCGCC
TGCTGCTGGGGAAGGTGCTGGCACTGGAGCACCTGCTCGCCCGGAGGCTGCACACCTTCCACAGACAGATCTCACAGGAGGACAAAAATT
GGGAGACCAATATCCAAGAACTCCAAAAAAAGCATAGGATATCTGACGGGATTCTGCTCGCCAAATGCCTGACAGTGTTGGGATTTGTTA
TCTTCATGTTTTTCCTCAATTCGTTTGTCCCTGGCATTCATCTTGATCTTGGTGGCCTGGGCTTGGTTCAAGCTGGCAGGTATTATTTAT

>In-frame_GABRG3_ENST00000333743_chr15_27271968_+_OCA2_ENST00000354638_chr15_28000618_-_1122nt
GCCGCCCGGTTGCGCGGACCGGCGCTAGTGCGCGGGTGGGGGCGGCGCGCCGCGGTGGCCCGGCGTCCCGTGTGCGTCCAGTGTGCGCCC
CGCGGGGGCGCGGCCAGCGCCAGAGTAGATACCTGTCCCGCCCGCCGCGGCCAGCAGCCTCGGAGGAAGCCAGGGCAAAGAGGGCCGGCG
GAGACCAGGTCCGCGCCGGAGGAAGCCGCGCCCGGCCGAGGCCCCGGACCCTGCGCCCCGAGCTCCACGGCACCATGGCCCCGAAGCTGC
TGCTCCTCCTCTGCCTGTTCTCGGGCTTGCACGCGCGGTCCAGAAAGGTGGAAGAGGATGAATATGAAGATTCATCATCAAACCAAAAGT
GGGTCTTGGCTCCAAAATCCCAAGACACCGACGTGACTCTTATTCTCAACAAGTTGCTAAGAGAATATGATAAAAAGCTGAGGCCAGATA
TTGGAATAAAACCGACCGTAATTGACGTTGACATTTATGTTAACAGCATTGGTCCTGTGTCATCAATAAACATGGCTGGGCTTCCCAATG
ATGGTTGTGTCCTGCACTGTTGGGATGTGTTATCTCCTTGTGGCTCATGTGGTGGTGGGATGGAATTAATAGACATCCATCTATTGCTCG
AAGACTAAAGGAAACTTCATCCATCACAACCCATTAGTCATAAAACTACCCTGACCCCACTGTTTGAAGAAGAAAAGGTGCTTACCCTGG
AGATGCTACAGAGACACAGTGGAATAGACCTTGACACTAACACTCTAATTCAAGCGAATGTTGGAACACCATGACCTCCTCTGTGTGTCC
TTTCTCCCCAAGGACAAAATGTAGAAAGATGTGAGATAACTTACTCAAGATTCCCCTCCAGAAAAATACGTATGTTTAAAAACCCTTCCT
GCTATACATAGGAAAAGACACACATCCACCTAAAATTGACTGTACTGTTTAACTGTCAATTCTCCTGAGGCTAAACACAGTTTGTTTTTC
TTGTAATCACTTTTCATGTTAAAATAATCAGCATTCAAATTGTATGCTTTCTGAATATAGACTTTCTGGGAAAAGGTTTACTGCTCGTAA

>In-frame_GABRG3_ENST00000555083_chr15_27271968_+_OCA2_ENST00000354638_chr15_28000618_-_1011nt
AGAGTAGATACCTGTCCCGCCCGCCGCGGCCAGCAGCCTCGGAGGAAGCCAGGGCAAAGAGGGCCGGCGGAGACCAGGTCCGCGCCGGAG
GAAGCCGCGCCCGGCCGAGGCCCCGGACCCTGCGCCCCGAGCTCCACGGCACCATGGCCCCGAAGCTGCTGCTCCTCCTCTGCCTGTTCT
CGGGCTTGCACGCGCGGTCCAGAAAGGTGGAAGAGGATGAATATGAAGATTCATCATCAAACCAAAAGTGGGTCTTGGCTCCAAAATCCC
AAGACACCGACGTGACTCTTATTCTCAACAAGTTGCTAAGAGAATATGATAAAAAGCTGAGGCCAGATATTGGAATAAAACCGACCGTAA
TTGACGTTGACATTTATGTTAACAGCATTGGTCCTGTGTCATCAATAAACATGGCTGGGCTTCCCAATGATGGTTGTGTCCTGCACTGTT
GGGATGTGTTATCTCCTTGTGGCTCATGTGGTGGTGGGATGGAATTAATAGACATCCATCTATTGCTCGAAGACTAAAGGAAACTTCATC
CATCACAACCCATTAGTCATAAAACTACCCTGACCCCACTGTTTGAAGAAGAAAAGGTGCTTACCCTGGAGATGCTACAGAGACACAGTG
GAATAGACCTTGACACTAACACTCTAATTCAAGCGAATGTTGGAACACCATGACCTCCTCTGTGTGTCCTTTCTCCCCAAGGACAAAATG
TAGAAAGATGTGAGATAACTTACTCAAGATTCCCCTCCAGAAAAATACGTATGTTTAAAAACCCTTCCTGCTATACATAGGAAAAGACAC
ACATCCACCTAAAATTGACTGTACTGTTTAACTGTCAATTCTCCTGAGGCTAAACACAGTTTGTTTTTCTTGTAATCACTTTTCATGTTA
AAATAATCAGCATTCAAATTGTATGCTTTCTGAATATAGACTTTCTGGGAAAAGGTTTACTGCTCGTAAGGAAACATTTTATGTATTAAA


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FusionGenePPI for GABRG3_OCA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GABRG3TP53OCA2ATP13A2, HTR3A, CHRND


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GABRG3_OCA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGABRG3Q99928DB00546AdinazolamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved
HgeneGABRG3Q99928DB00842OxazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved
HgeneGABRG3Q99928DB00898EthanolGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved
HgeneGABRG3Q99928DB01594CinolazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved
HgeneGABRG3Q99928DB01595NitrazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved
HgeneGABRG3Q99928DB00683MidazolamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit
HgeneGABRG3Q99928DB01215EstazolamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit
HgeneGABRG3Q99928DB01559ClotiazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit
HgeneGABRG3Q99928DB01567FludiazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit
HgeneGABRG3Q99928DB01588PrazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit
HgeneGABRG3Q99928DB01589QuazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit
HgeneGABRG3Q99928DB00690FlurazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit|investigational
HgeneGABRG3Q99928DB01558BromazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit|investigational
HgeneGABRG3Q99928DB00829DiazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit|investigational|vet_approved
HgeneGABRG3Q99928DB00801HalazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit|withdrawn
HgeneGABRG3Q99928DB00231TemazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|investigational
HgeneGABRG3Q99928DB00897TriazolamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|investigational

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RelatedDiseases for GABRG3_OCA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGABRG3C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneGABRG3C3711376Isodicentric Chromosome 15 Syndrome1CTD_human
TgeneOCA2C0268495Oculocutaneous albinism type 28CTD_human;ORPHANET;UNIPROT