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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14223

FusionGeneSummary for GABPA_OPCML

check button Fusion gene summary
Fusion gene informationFusion gene name: GABPA_OPCML
Fusion gene ID: 14223
HgeneTgene
Gene symbol

GABPA

OPCML

Gene ID

2551

4978

Gene nameGA binding protein transcription factor subunit alphaopioid binding protein/cell adhesion molecule like
SynonymsE4TF1-60|E4TF1A|NFT2|NRF2|NRF2A|RCH04A07IGLON1|OBCAM|OPCM
Cytomap

21q21.3

11q25

Type of geneprotein-codingprotein-coding
DescriptionGA-binding protein alpha chainGA binding protein transcription factor alpha subunit 60kDaGABP subunit alphahuman nuclear respiratory factor-2 subunit alphanuclear respiratory factor 2 alpha subunitnuclear respiratory factor 2 subunit alphatranscriptopioid-binding protein/cell adhesion moleculeIgLON family member 1opioid binding protein/cell adhesion molecule-like preprotein
Modification date2018052320180522
UniProtAcc

Q06546

Q14982

Ensembl transtripts involved in fusion geneENST00000354828, ENST00000400075, 
ENST00000487266, 
ENST00000524381, 
ENST00000529038, ENST00000331898, 
ENST00000374778, ENST00000541867, 
Fusion gene scores* DoF score3 X 3 X 2=185 X 4 X 5=100
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GABPA [Title/Abstract] AND OPCML [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGABPA

GO:0045944

positive regulation of transcription by RNA polymerase II

9857059|12750007|22306510|24501276


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA569674GABPAchr21

27143516

+OPCMLchr11

132286189

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000354828ENST00000524381GABPAchr21

27143516

+OPCMLchr11

132286189

-
3UTR-intronENST00000354828ENST00000529038GABPAchr21

27143516

+OPCMLchr11

132286189

-
3UTR-3UTRENST00000354828ENST00000331898GABPAchr21

27143516

+OPCMLchr11

132286189

-
3UTR-intronENST00000354828ENST00000374778GABPAchr21

27143516

+OPCMLchr11

132286189

-
3UTR-intronENST00000354828ENST00000541867GABPAchr21

27143516

+OPCMLchr11

132286189

-
3UTR-3UTRENST00000400075ENST00000524381GABPAchr21

27143516

+OPCMLchr11

132286189

-
3UTR-intronENST00000400075ENST00000529038GABPAchr21

27143516

+OPCMLchr11

132286189

-
3UTR-3UTRENST00000400075ENST00000331898GABPAchr21

27143516

+OPCMLchr11

132286189

-
3UTR-intronENST00000400075ENST00000374778GABPAchr21

27143516

+OPCMLchr11

132286189

-
3UTR-intronENST00000400075ENST00000541867GABPAchr21

27143516

+OPCMLchr11

132286189

-
intron-3UTRENST00000487266ENST00000524381GABPAchr21

27143516

+OPCMLchr11

132286189

-
intron-intronENST00000487266ENST00000529038GABPAchr21

27143516

+OPCMLchr11

132286189

-
intron-3UTRENST00000487266ENST00000331898GABPAchr21

27143516

+OPCMLchr11

132286189

-
intron-intronENST00000487266ENST00000374778GABPAchr21

27143516

+OPCMLchr11

132286189

-
intron-intronENST00000487266ENST00000541867GABPAchr21

27143516

+OPCMLchr11

132286189

-

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FusionProtFeatures for GABPA_OPCML


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GABPA

Q06546

OPCML

Q14982

Transcription factor capable of interacting with purinerich repeats (GA repeats). Necessary for the expression of theAdenovirus E4 gene. Binds opioids in the presence of acidic lipids; probablyinvolved in cell contact.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GABPA_OPCML


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GABPA_OPCML


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GABPA_OPCML


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GABPA_OPCML


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGABPAC0011581Depressive disorder1PSYGENET
HgeneGABPAC0015923Fetal Alcohol Syndrome1PSYGENET
HgeneGABPAC2985290Fetal Alcohol Spectrum Disorders1PSYGENET
TgeneOPCMLC0036341Schizophrenia1PSYGENET
TgeneOPCMLC1140680Malignant neoplasm of ovary1UNIPROT