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Fusion gene ID: 14223 |
FusionGeneSummary for GABPA_OPCML |
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Fusion gene information | Fusion gene name: GABPA_OPCML | Fusion gene ID: 14223 | Hgene | Tgene | Gene symbol | GABPA | OPCML | Gene ID | 2551 | 4978 |
Gene name | GA binding protein transcription factor subunit alpha | opioid binding protein/cell adhesion molecule like | |
Synonyms | E4TF1-60|E4TF1A|NFT2|NRF2|NRF2A|RCH04A07 | IGLON1|OBCAM|OPCM | |
Cytomap | 21q21.3 | 11q25 | |
Type of gene | protein-coding | protein-coding | |
Description | GA-binding protein alpha chainGA binding protein transcription factor alpha subunit 60kDaGABP subunit alphahuman nuclear respiratory factor-2 subunit alphanuclear respiratory factor 2 alpha subunitnuclear respiratory factor 2 subunit alphatranscript | opioid-binding protein/cell adhesion moleculeIgLON family member 1opioid binding protein/cell adhesion molecule-like preprotein | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q06546 | Q14982 | |
Ensembl transtripts involved in fusion gene | ENST00000354828, ENST00000400075, ENST00000487266, | ENST00000524381, ENST00000529038, ENST00000331898, ENST00000374778, ENST00000541867, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 5 X 4 X 5=100 |
# samples | 3 | 5 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GABPA [Title/Abstract] AND OPCML [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GABPA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9857059|12750007|22306510|24501276 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA569674 | GABPA | chr21 | 27143516 | + | OPCML | chr11 | 132286189 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000354828 | ENST00000524381 | GABPA | chr21 | 27143516 | + | OPCML | chr11 | 132286189 | - |
3UTR-intron | ENST00000354828 | ENST00000529038 | GABPA | chr21 | 27143516 | + | OPCML | chr11 | 132286189 | - |
3UTR-3UTR | ENST00000354828 | ENST00000331898 | GABPA | chr21 | 27143516 | + | OPCML | chr11 | 132286189 | - |
3UTR-intron | ENST00000354828 | ENST00000374778 | GABPA | chr21 | 27143516 | + | OPCML | chr11 | 132286189 | - |
3UTR-intron | ENST00000354828 | ENST00000541867 | GABPA | chr21 | 27143516 | + | OPCML | chr11 | 132286189 | - |
3UTR-3UTR | ENST00000400075 | ENST00000524381 | GABPA | chr21 | 27143516 | + | OPCML | chr11 | 132286189 | - |
3UTR-intron | ENST00000400075 | ENST00000529038 | GABPA | chr21 | 27143516 | + | OPCML | chr11 | 132286189 | - |
3UTR-3UTR | ENST00000400075 | ENST00000331898 | GABPA | chr21 | 27143516 | + | OPCML | chr11 | 132286189 | - |
3UTR-intron | ENST00000400075 | ENST00000374778 | GABPA | chr21 | 27143516 | + | OPCML | chr11 | 132286189 | - |
3UTR-intron | ENST00000400075 | ENST00000541867 | GABPA | chr21 | 27143516 | + | OPCML | chr11 | 132286189 | - |
intron-3UTR | ENST00000487266 | ENST00000524381 | GABPA | chr21 | 27143516 | + | OPCML | chr11 | 132286189 | - |
intron-intron | ENST00000487266 | ENST00000529038 | GABPA | chr21 | 27143516 | + | OPCML | chr11 | 132286189 | - |
intron-3UTR | ENST00000487266 | ENST00000331898 | GABPA | chr21 | 27143516 | + | OPCML | chr11 | 132286189 | - |
intron-intron | ENST00000487266 | ENST00000374778 | GABPA | chr21 | 27143516 | + | OPCML | chr11 | 132286189 | - |
intron-intron | ENST00000487266 | ENST00000541867 | GABPA | chr21 | 27143516 | + | OPCML | chr11 | 132286189 | - |
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FusionProtFeatures for GABPA_OPCML |
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Hgene | Tgene |
GABPA | OPCML |
Transcription factor capable of interacting with purinerich repeats (GA repeats). Necessary for the expression of theAdenovirus E4 gene. | Binds opioids in the presence of acidic lipids; probablyinvolved in cell contact. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GABPA_OPCML |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GABPA_OPCML |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GABPA_OPCML |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GABPA_OPCML |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GABPA | C0011581 | Depressive disorder | 1 | PSYGENET |
Hgene | GABPA | C0015923 | Fetal Alcohol Syndrome | 1 | PSYGENET |
Hgene | GABPA | C2985290 | Fetal Alcohol Spectrum Disorders | 1 | PSYGENET |
Tgene | OPCML | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | OPCML | C1140680 | Malignant neoplasm of ovary | 1 | UNIPROT |