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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14211

FusionGeneSummary for GABARAP_GABARAP

check button Fusion gene summary
Fusion gene informationFusion gene name: GABARAP_GABARAP
Fusion gene ID: 14211
HgeneTgene
Gene symbol

GABARAP

GABARAP

Gene ID

11337

11337

Gene nameGABA type A receptor-associated proteinGABA type A receptor-associated protein
SynonymsATG8A|GABARAP-a|MM46ATG8A|GABARAP-a|MM46
Cytomap

17p13.1

17p13.1

Type of geneprotein-codingprotein-coding
Descriptiongamma-aminobutyric acid receptor-associated proteinGABA(A) receptor-associated proteingamma-aminobutyric acid receptor-associated proteinGABA(A) receptor-associated protein
Modification date2018052320180523
UniProtAcc

O95166

O95166

Ensembl transtripts involved in fusion geneENST00000302386, ENST00000577035, 
ENST00000571129, ENST00000571253, 
ENST00000573928, 		ENST00000302386, 
ENST00000577035, ENST00000571129, 
ENST00000571253, ENST00000573928, 
Fusion gene scores* DoF score4 X 4 X 4=642 X 2 X 1=4
# samples 42
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: GABARAP [Title/Abstract] AND GABARAP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGABARAP

GO:0008625

extrinsic apoptotic signaling pathway via death domain receptors

15977068

TgeneGABARAP

GO:0008625

extrinsic apoptotic signaling pathway via death domain receptors

15977068


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA455489GABARAPchr17

7143884

-GABARAPchr17

7143747

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000302386ENST00000302386GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-3UTRENST00000302386ENST00000577035GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-intronENST00000302386ENST00000571129GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-intronENST00000302386ENST00000571253GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-intronENST00000302386ENST00000573928GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-3UTRENST00000577035ENST00000302386GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-3UTRENST00000577035ENST00000577035GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-intronENST00000577035ENST00000571129GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-intronENST00000577035ENST00000571253GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-intronENST00000577035ENST00000573928GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-3UTRENST00000571129ENST00000302386GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-3UTRENST00000571129ENST00000577035GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-intronENST00000571129ENST00000571129GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-intronENST00000571129ENST00000571253GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-intronENST00000571129ENST00000573928GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-3UTRENST00000571253ENST00000302386GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-3UTRENST00000571253ENST00000577035GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-intronENST00000571253ENST00000571129GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-intronENST00000571253ENST00000571253GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-intronENST00000571253ENST00000573928GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-3UTRENST00000573928ENST00000302386GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-3UTRENST00000573928ENST00000577035GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-intronENST00000573928ENST00000571129GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-intronENST00000573928ENST00000571253GABARAPchr17

7143884

-GABARAPchr17

7143747

+
intron-intronENST00000573928ENST00000573928GABARAPchr17

7143884

-GABARAPchr17

7143747

+

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FusionProtFeatures for GABARAP_GABARAP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GABARAP

O95166

GABARAP

O95166

Ubiquitin-like modifier that plays a role inintracellular transport of GABA(A) receptors and its interactionwith the cytoskeleton. Involved in apoptosis. Involved inautophagy. Whereas LC3s are involved in elongation of thephagophore membrane, the GABARAP/GATE-16 subfamily is essentialfor a later stage in autophagosome maturation.{ECO:0000269|PubMed:15977068}. Ubiquitin-like modifier that plays a role inintracellular transport of GABA(A) receptors and its interactionwith the cytoskeleton. Involved in apoptosis. Involved inautophagy. Whereas LC3s are involved in elongation of thephagophore membrane, the GABARAP/GATE-16 subfamily is essentialfor a later stage in autophagosome maturation.{ECO:0000269|PubMed:15977068}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GABARAP_GABARAP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GABARAP_GABARAP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GABARAP_GABARAP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GABARAP_GABARAP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGABARAPC0036341Schizophrenia1PSYGENET
TgeneGABARAPC0036341Schizophrenia1PSYGENET