![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 1421 |
FusionGeneSummary for AKTIP_COTL1 |
![]() |
Fusion gene information | Fusion gene name: AKTIP_COTL1 | Fusion gene ID: 1421 | Hgene | Tgene | Gene symbol | AKTIP | COTL1 | Gene ID | 64400 | 23406 |
Gene name | AKT interacting protein | coactosin like F-actin binding protein 1 | |
Synonyms | FT1|FTS | CLP | |
Cytomap | 16q12.2 | 16q24.1 | |
Type of gene | protein-coding | protein-coding | |
Description | AKT-interacting proteinfused toes homolog | coactosin-like proteincoactosin-like 1 | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | Q9H8T0 | Q14019 | |
Ensembl transtripts involved in fusion gene | ENST00000394657, ENST00000300245, ENST00000570004, | ENST00000262428, ENST00000567278, ENST00000564057, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 3 X 3=36 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: AKTIP [Title/Abstract] AND COTL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | AKTIP | GO:0001934 | positive regulation of protein phosphorylation | 14749367 |
Hgene | AKTIP | GO:0032092 | positive regulation of protein binding | 14749367 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LGG | TCGA-S9-A7R7-01A | AKTIP | chr16 | 53537059 | - | COTL1 | chr16 | 84600561 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000394657 | ENST00000262428 | AKTIP | chr16 | 53537059 | - | COTL1 | chr16 | 84600561 | - |
5UTR-5UTR | ENST00000394657 | ENST00000567278 | AKTIP | chr16 | 53537059 | - | COTL1 | chr16 | 84600561 | - |
5UTR-5UTR | ENST00000394657 | ENST00000564057 | AKTIP | chr16 | 53537059 | - | COTL1 | chr16 | 84600561 | - |
5UTR-3CDS | ENST00000300245 | ENST00000262428 | AKTIP | chr16 | 53537059 | - | COTL1 | chr16 | 84600561 | - |
5UTR-5UTR | ENST00000300245 | ENST00000567278 | AKTIP | chr16 | 53537059 | - | COTL1 | chr16 | 84600561 | - |
5UTR-5UTR | ENST00000300245 | ENST00000564057 | AKTIP | chr16 | 53537059 | - | COTL1 | chr16 | 84600561 | - |
intron-3CDS | ENST00000570004 | ENST00000262428 | AKTIP | chr16 | 53537059 | - | COTL1 | chr16 | 84600561 | - |
intron-5UTR | ENST00000570004 | ENST00000567278 | AKTIP | chr16 | 53537059 | - | COTL1 | chr16 | 84600561 | - |
intron-5UTR | ENST00000570004 | ENST00000564057 | AKTIP | chr16 | 53537059 | - | COTL1 | chr16 | 84600561 | - |
Top |
FusionProtFeatures for AKTIP_COTL1 |
![]() |
Hgene | Tgene |
AKTIP | COTL1 |
Component of the FTS/Hook/FHIP complex (FHF complex).The FHF complex may function to promote vesicle trafficking and/orfusion via the homotypic vesicular protein sorting complex (theHOPS complex). Regulates apoptosis by enhancing phosphorylationand activation of AKT1. Increases release of TNFSF6 via theAKT1/GSK3B/NFATC1 signaling cascade. {ECO:0000269|PubMed:14749367,ECO:0000269|PubMed:18799622}. | Binds to F-actin in a calcium-independent manner. Has nodirect effect on actin depolymerization. Acts as a chaperone forALOX5 (5LO), influencing both its stability and activity inleukotrienes synthesis. {ECO:0000269|PubMed:11583571,ECO:0000269|PubMed:19807693}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for AKTIP_COTL1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for AKTIP_COTL1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
AKTIP | CTBP2, HOOK2, HOOK1, IARS, TIMM50, PDS5A, HDLBP, DCTN1, AKT1, EXOC7, C10orf2, ASS1, GTF3C1, IMMT, POLA2, RPA1, KIAA1377, UTP14A, DZIP3, MARCH5, TRIM23, TRIM41, HOOK3, FAM160A2, VPS16, VPS18, VPS41, TRIM32, NAB1, FAM160A1, TSC1, PGGT1B, TNFSF13B, EGFR, SSX2IP, TERF1, TERF2, PRKDC, TRIM35 | COTL1 | ALOX5, ACTA1, ELAVL1, TERF2IP, CD2BP2, ACTG1, ACTB, PDE6H, ARHGDIA, CFL1, FSCN1, HEBP1, TMTC3, CRIP1, DUT, HN1, MDH2, PCBP1, SH3BGRL, TAGLN2, TIAL1, TKT, UBE2M, MCM2 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for AKTIP_COTL1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for AKTIP_COTL1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | AKTIP | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | COTL1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | COTL1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |