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Fusion gene ID: 14204 |
FusionGeneSummary for GAB2_PTPRT |
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Fusion gene information | Fusion gene name: GAB2_PTPRT | Fusion gene ID: 14204 | Hgene | Tgene | Gene symbol | GAB2 | PTPRT | Gene ID | 9846 | 11122 |
Gene name | GRB2 associated binding protein 2 | protein tyrosine phosphatase, receptor type T | |
Synonyms | - | RPTPrho | |
Cytomap | 11q14.1 | 20q12-q13.11 | |
Type of gene | protein-coding | protein-coding | |
Description | GRB2-associated-binding protein 2Grb2-associated binder 2growth factor receptor bound protein 2-associated protein 2pp100 | receptor-type tyrosine-protein phosphatase TR-PTP-TRPTP-rhoreceptor protein tyrosine phosphatasereceptor-type tyrosine-protein phosphatase rho | |
Modification date | 20180527 | 20180519 | |
UniProtAcc | Q9UQC2 | O14522 | |
Ensembl transtripts involved in fusion gene | ENST00000340149, ENST00000361507, ENST00000526030, | ENST00000373184, ENST00000373187, ENST00000356100, ENST00000373190, ENST00000373193, ENST00000373198, ENST00000373201, ENST00000485499, | |
Fusion gene scores | * DoF score | 16 X 10 X 5=800 | 10 X 8 X 6=480 |
# samples | 16 | 10 | |
** MAII score | log2(16/800*10)=-2.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/480*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GAB2 [Title/Abstract] AND PTPRT [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GAB2 | GO:0008284 | positive regulation of cell proliferation | 19172738 |
Tgene | PTPRT | GO:0006470 | protein dephosphorylation | 16973135 |
Tgene | PTPRT | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 18644975 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-YG-AA3P-06A | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000340149 | ENST00000373184 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
intron-3CDS | ENST00000340149 | ENST00000373187 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
intron-3CDS | ENST00000340149 | ENST00000356100 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
intron-3CDS | ENST00000340149 | ENST00000373190 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
intron-3CDS | ENST00000340149 | ENST00000373193 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
intron-3CDS | ENST00000340149 | ENST00000373198 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
intron-3CDS | ENST00000340149 | ENST00000373201 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
intron-intron | ENST00000340149 | ENST00000485499 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
Frame-shift | ENST00000361507 | ENST00000373184 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
Frame-shift | ENST00000361507 | ENST00000373187 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
Frame-shift | ENST00000361507 | ENST00000356100 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
Frame-shift | ENST00000361507 | ENST00000373190 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
Frame-shift | ENST00000361507 | ENST00000373193 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
Frame-shift | ENST00000361507 | ENST00000373198 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
Frame-shift | ENST00000361507 | ENST00000373201 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
5CDS-intron | ENST00000361507 | ENST00000485499 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
5UTR-3CDS | ENST00000526030 | ENST00000373184 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
5UTR-3CDS | ENST00000526030 | ENST00000373187 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
5UTR-3CDS | ENST00000526030 | ENST00000356100 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
5UTR-3CDS | ENST00000526030 | ENST00000373190 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
5UTR-3CDS | ENST00000526030 | ENST00000373193 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
5UTR-3CDS | ENST00000526030 | ENST00000373198 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
5UTR-3CDS | ENST00000526030 | ENST00000373201 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
5UTR-intron | ENST00000526030 | ENST00000485499 | GAB2 | chr11 | 78128692 | - | PTPRT | chr20 | 40828028 | - |
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FusionProtFeatures for GAB2_PTPRT |
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Hgene | Tgene |
GAB2 | PTPRT |
Adapter protein which acts downstream of severalmembrane receptors including cytokine, antigen, hormone, cellmatrix and growth factor receptors to regulate multiple signalingpathways. Regulates osteoclast differentiation mediating theTNFRSF11A/RANK signaling. In allergic response, it plays a role inmast cells activation and degranulation through PI-3-kinaseregulation. Also involved in the regulation of cell proliferationand hematopoiesis. {ECO:0000269|PubMed:15750601,ECO:0000269|PubMed:19172738}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GAB2_PTPRT |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GAB2_PTPRT |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GAB2 | BCR, GRB2, ETV6, ARHGAP32, LYN, PLCG2, PTPN11, SHC1, ZAP70, CD247, LAT, PTPN6, PIK3R1, AKT1, GRAP, SRC, NCK1, PLCG1, CRKL, MET, GRAP2, LRRK1, PIK3R2, CRK, PIK3CB, MAPK1, MAPK3, MARK2, GAB1, GAB2, YWHAE, NTRK1, XPO1, FRS2, TGM4, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, SRSF12, RTKN, MAST3, SYDE1, PPM1H, AGAP1, CDC25B, CDK16, FAM110B, USP21, ANKRD34A, FAM53C, CGN, FAM110A, DENND4C, HDAC4, MAPKAP1, TBC1D25, NF1, NADK, CBY1, RAB3IP | PTPRT | CUL3, EGFR, ERBB2, ERBB4, ATP2A2, PHKA1, PHKB |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GAB2_PTPRT |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GAB2_PTPRT |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GAB2 | C0025202 | melanoma | 1 | CTD_human |
Hgene | GAB2 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | GAB2 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |