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Fusion gene ID: 14185 |
FusionGeneSummary for G3BP2_PTPN1 |
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Fusion gene information | Fusion gene name: G3BP2_PTPN1 | Fusion gene ID: 14185 | Hgene | Tgene | Gene symbol | G3BP2 | PTPN1 | Gene ID | 9908 | 5770 |
Gene name | G3BP stress granule assembly factor 2 | protein tyrosine phosphatase, non-receptor type 1 | |
Synonyms | - | PTP1B | |
Cytomap | 4q21.1 | 20q13.13 | |
Type of gene | protein-coding | protein-coding | |
Description | ras GTPase-activating protein-binding protein 2G3BP-2GAP SH3 domain-binding protein 2GTPase activating protein (SH3 domain) binding protein 2Ras-GTPase activating protein SH3 domain-binding protein 2 | tyrosine-protein phosphatase non-receptor type 1protein tyrosine phosphatase, placentalprotein-tyrosine phosphatase 1B | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q9UN86 | P18031 | |
Ensembl transtripts involved in fusion gene | ENST00000395719, ENST00000359707, ENST00000357854, ENST00000502654, | ENST00000371621, ENST00000541713, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 7 X 5 X 5=175 |
# samples | 2 | 10 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(10/175*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: G3BP2 [Title/Abstract] AND PTPN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PTPN1 | GO:0030100 | regulation of endocytosis | 21135139 |
Tgene | PTPN1 | GO:0030968 | endoplasmic reticulum unfolded protein response | 22169477 |
Tgene | PTPN1 | GO:0035335 | peptidyl-tyrosine dephosphorylation | 21135139 |
Tgene | PTPN1 | GO:0061098 | positive regulation of protein tyrosine kinase activity | 21216966 |
Tgene | PTPN1 | GO:1903898 | negative regulation of PERK-mediated unfolded protein response | 21216966 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-3C-AAAU-01A | G3BP2 | chr4 | 76649460 | - | PTPN1 | chr20 | 49177900 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000395719 | ENST00000371621 | G3BP2 | chr4 | 76649460 | - | PTPN1 | chr20 | 49177900 | + |
intron-intron | ENST00000395719 | ENST00000541713 | G3BP2 | chr4 | 76649460 | - | PTPN1 | chr20 | 49177900 | + |
intron-3CDS | ENST00000359707 | ENST00000371621 | G3BP2 | chr4 | 76649460 | - | PTPN1 | chr20 | 49177900 | + |
intron-intron | ENST00000359707 | ENST00000541713 | G3BP2 | chr4 | 76649460 | - | PTPN1 | chr20 | 49177900 | + |
intron-3CDS | ENST00000357854 | ENST00000371621 | G3BP2 | chr4 | 76649460 | - | PTPN1 | chr20 | 49177900 | + |
intron-intron | ENST00000357854 | ENST00000541713 | G3BP2 | chr4 | 76649460 | - | PTPN1 | chr20 | 49177900 | + |
intron-3CDS | ENST00000502654 | ENST00000371621 | G3BP2 | chr4 | 76649460 | - | PTPN1 | chr20 | 49177900 | + |
intron-intron | ENST00000502654 | ENST00000541713 | G3BP2 | chr4 | 76649460 | - | PTPN1 | chr20 | 49177900 | + |
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FusionProtFeatures for G3BP2_PTPN1 |
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Hgene | Tgene |
G3BP2 | PTPN1 |
Probable scaffold protein that may be involved in mRNAtransport. {ECO:0000305}. | Tyrosine-protein phosphatase which acts as a regulatorof endoplasmic reticulum unfolded protein response. Mediatesdephosphorylation of EIF2AK3/PERK; inactivating the protein kinaseactivity of EIF2AK3/PERK. May play an important role in CKII- andp60c-src-induced signal transduction cascades. May regulate theEFNA5-EPHA3 signaling pathway which modulates cell reorganizationand cell-cell repulsion. May also regulate the hepatocyte growthfactor receptor signaling pathway through dephosphorylation ofMET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139,ECO:0000269|PubMed:22169477}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for G3BP2_PTPN1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for G3BP2_PTPN1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
G3BP2 | STK24, NFKBIA, DDX10, RNH1, RPL3L, NUP214, USP10, FARS2, ASCC3, ATXN2L, NUP62, C3orf17, GNL2, UIMC1, UBAP2, DDX24, NUFIP2, RPF2, WDR36, RPL22L1, ING4, TERF2, TP53, MDM2, UBC, PTEN, ELAVL1, ARRB2, CUL3, CDK2, CUL1, COPS5, CAND1, ESR1, CA9, VCP, TARDBP, PIN1, DDX6, FXR2, IVNS1ABP, SUZ12, RNF2, BMI1, G3BP1, POM121, NUP153, NUP88, HNRNPA1, ADSL, IFI30, IGF2BP3, PABPC1, PABPC4, PRPF8, YARS, SFN, NTRK1, RPL10, NF2, SNW1, WWP2, TRIM25, KLHDC3, CYLD, LASP1, RPS6, CAPRIN1 | PTPN1 | GSK3B, GRB2, IRS1, CAV1, EGFR, CRK, BCAR1, CTNNB1, STAT5A, STAT5B, NTRK1, NTRK2, NTRK3, LTK, TYK2, JAK2, INSR, IGF1R, GHR, STAM2, ILF3, SLC25A3, MCAT, MARCKSL1, LAMTOR3, HNRNPU, ZMPSTE24, STAT3, ATF2, CSNK2A1, SRC, ATP4A, ASS1, RFWD2, IL1B, ASGR2, HMOX2, SLC39A4, LYPD3, ENPP6, ZACN, PLTP, LYPD6, KRAS, AGR3, BCAS3, CASC3, CASZ1, CCL5, CDH13, DIRAS3, FAM84B, KLK7, MRC2, RHOBTB2, SNAI1, THRSP, VPS45, HERC2, TCTN2, TCTN3, EVC2, TMEM17, TMEM216, ATP6V1B2, ATP6V0A1, COL5A1, STOM, FLOT2, GALNT2, MSN, PHB, ABCD3, SMARCD2, ATP6V0D1, GOSR1, MVP, FLOT1, PHB2, LTN1, GOLIM4, BCOR, WRAP53, MREG, PCNP, KIDINS220, RNF213, ARHGAP39, PTRF, CDH1, ACTB, APLP2, CASC4, SNRPD2, TOMM70A, CTDNEP1, C5AR2, TMEM63A, C3AR1, GPR21, GHITM, SLCO6A1, TMPRSS3, AMTN, MRAP2, GPR114, KIAA1467, SLC39A12, APLNR, DUSP1, DCUN1D5, PISD, COX11, NDUFAF4, NARS, PTRH2, TBC1D15, NPPC, PFN2, ARL1, DHCR24, AIP, RAB5C, PGRMC1, SEC61A1, CDIPT, SLC27A4, ILVBL, DHCR7, TRIP13, ARF4, HEATR3, PCMT1, ARF1, CCDC47, CDK4, FLAD1, RMDN3, CLK2, LAT |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for G3BP2_PTPN1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | PTPN1 | P18031 | DB01133 | Tiludronic acid | Tyrosine-protein phosphatase non-receptor type 1 | small molecule | approved|investigational|vet_approved |
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RelatedDiseases for G3BP2_PTPN1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PTPN1 | C0019829 | Hodgkin Disease | 1 | CTD_human |
Tgene | PTPN1 | C0021655 | Insulin Resistance | 1 | CTD_human |
Tgene | PTPN1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | PTPN1 | C0025063 | Mediastinal Neoplasms | 1 | CTD_human |
Tgene | PTPN1 | C0028754 | Obesity | 1 | CTD_human |
Tgene | PTPN1 | C0035372 | Rett Syndrome | 1 | CTD_human |
Tgene | PTPN1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | PTPN1 | C0079731 | B-Cell Lymphomas | 1 | CTD_human |