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Fusion gene ID: 14184 |
FusionGeneSummary for G3BP2_NAAA |
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Fusion gene information | Fusion gene name: G3BP2_NAAA | Fusion gene ID: 14184 | Hgene | Tgene | Gene symbol | G3BP2 | NAAA | Gene ID | 9908 | 27163 |
Gene name | G3BP stress granule assembly factor 2 | N-acylethanolamine acid amidase | |
Synonyms | - | ASAHL|PLT | |
Cytomap | 4q21.1 | 4q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | ras GTPase-activating protein-binding protein 2G3BP-2GAP SH3 domain-binding protein 2GTPase activating protein (SH3 domain) binding protein 2Ras-GTPase activating protein SH3 domain-binding protein 2 | N-acylethanolamine-hydrolyzing acid amidaseASAH-like proteinacid ceramidase-like protein | |
Modification date | 20180523 | 20180529 | |
UniProtAcc | Q9UN86 | Q02083 | |
Ensembl transtripts involved in fusion gene | ENST00000395719, ENST00000359707, ENST00000357854, ENST00000502654, | ENST00000399497, ENST00000286733, ENST00000511606, ENST00000507956, ENST00000505594, ENST00000507187, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 3 X 2=12 |
# samples | 2 | 3 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: G3BP2 [Title/Abstract] AND NAAA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-44-7660-01A | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000395719 | ENST00000399497 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
intron-3CDS | ENST00000395719 | ENST00000286733 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
intron-5UTR | ENST00000395719 | ENST00000511606 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
intron-5UTR | ENST00000395719 | ENST00000507956 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
intron-5UTR | ENST00000395719 | ENST00000505594 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
intron-intron | ENST00000395719 | ENST00000507187 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
5UTR-3CDS | ENST00000359707 | ENST00000399497 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
5UTR-3CDS | ENST00000359707 | ENST00000286733 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
5UTR-5UTR | ENST00000359707 | ENST00000511606 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
5UTR-5UTR | ENST00000359707 | ENST00000507956 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
5UTR-5UTR | ENST00000359707 | ENST00000505594 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
5UTR-intron | ENST00000359707 | ENST00000507187 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
5UTR-3CDS | ENST00000357854 | ENST00000399497 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
5UTR-3CDS | ENST00000357854 | ENST00000286733 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
5UTR-5UTR | ENST00000357854 | ENST00000511606 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
5UTR-5UTR | ENST00000357854 | ENST00000507956 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
5UTR-5UTR | ENST00000357854 | ENST00000505594 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
5UTR-intron | ENST00000357854 | ENST00000507187 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
5UTR-3CDS | ENST00000502654 | ENST00000399497 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
5UTR-3CDS | ENST00000502654 | ENST00000286733 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
5UTR-5UTR | ENST00000502654 | ENST00000511606 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
5UTR-5UTR | ENST00000502654 | ENST00000507956 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
5UTR-5UTR | ENST00000502654 | ENST00000505594 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
5UTR-intron | ENST00000502654 | ENST00000507187 | G3BP2 | chr4 | 76598392 | - | NAAA | chr4 | 76841128 | - |
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FusionProtFeatures for G3BP2_NAAA |
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Hgene | Tgene |
G3BP2 | NAAA |
Probable scaffold protein that may be involved in mRNAtransport. {ECO:0000305}. | Degrades bioactive fatty acid amides to theircorresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibitsweak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine.{ECO:0000269|PubMed:15655246}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for G3BP2_NAAA |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for G3BP2_NAAA |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
G3BP2 | STK24, NFKBIA, DDX10, RNH1, RPL3L, NUP214, USP10, FARS2, ASCC3, ATXN2L, NUP62, C3orf17, GNL2, UIMC1, UBAP2, DDX24, NUFIP2, RPF2, WDR36, RPL22L1, ING4, TERF2, TP53, MDM2, UBC, PTEN, ELAVL1, ARRB2, CUL3, CDK2, CUL1, COPS5, CAND1, ESR1, CA9, VCP, TARDBP, PIN1, DDX6, FXR2, IVNS1ABP, SUZ12, RNF2, BMI1, G3BP1, POM121, NUP153, NUP88, HNRNPA1, ADSL, IFI30, IGF2BP3, PABPC1, PABPC4, PRPF8, YARS, SFN, NTRK1, RPL10, NF2, SNW1, WWP2, TRIM25, KLHDC3, CYLD, LASP1, RPS6, CAPRIN1 | NAAA | APP, FBXO6, SIAE, TMEM2, TCTN2, TMEM132A, ENTPD6, POGLUT1, MANEAL, SLC38A10, ARSK, GALNS, OAF, EXT1, SYVN1, OS9, TTC17, SCARB1, P3H4, TUBA1A, UGDH, EDEM1, NAGLU, TUBB8, SULF2, NDST1, MAN2A1, SGSH, NHLRC3, NXPH4, CYB5R1, GLB1L2, ZNF507, SEC24D, CLN5, BMP7, NRP2, ARSB, CNTNAP3, SMG8, PCSK5, FUT11, DCBLD2, ERF, ITGA4, CHST12, PLTP, MAN2B2, EDEM2, WDR73, ITGAV, TCTN1, SEC23IP, TUBA4A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for G3BP2_NAAA |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for G3BP2_NAAA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |