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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14184

FusionGeneSummary for G3BP2_NAAA

check button Fusion gene summary
Fusion gene informationFusion gene name: G3BP2_NAAA
Fusion gene ID: 14184
HgeneTgene
Gene symbol

G3BP2

NAAA

Gene ID

9908

27163

Gene nameG3BP stress granule assembly factor 2N-acylethanolamine acid amidase
Synonyms-ASAHL|PLT
Cytomap

4q21.1

4q21.1

Type of geneprotein-codingprotein-coding
Descriptionras GTPase-activating protein-binding protein 2G3BP-2GAP SH3 domain-binding protein 2GTPase activating protein (SH3 domain) binding protein 2Ras-GTPase activating protein SH3 domain-binding protein 2N-acylethanolamine-hydrolyzing acid amidaseASAH-like proteinacid ceramidase-like protein
Modification date2018052320180529
UniProtAcc

Q9UN86

Q02083

Ensembl transtripts involved in fusion geneENST00000395719, ENST00000359707, 
ENST00000357854, ENST00000502654, 
ENST00000399497, ENST00000286733, 
ENST00000511606, ENST00000507956, 
ENST00000505594, ENST00000507187, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 3 X 2=12
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: G3BP2 [Title/Abstract] AND NAAA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-44-7660-01AG3BP2chr4

76598392

-NAAAchr4

76841128

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000395719ENST00000399497G3BP2chr4

76598392

-NAAAchr4

76841128

-
intron-3CDSENST00000395719ENST00000286733G3BP2chr4

76598392

-NAAAchr4

76841128

-
intron-5UTRENST00000395719ENST00000511606G3BP2chr4

76598392

-NAAAchr4

76841128

-
intron-5UTRENST00000395719ENST00000507956G3BP2chr4

76598392

-NAAAchr4

76841128

-
intron-5UTRENST00000395719ENST00000505594G3BP2chr4

76598392

-NAAAchr4

76841128

-
intron-intronENST00000395719ENST00000507187G3BP2chr4

76598392

-NAAAchr4

76841128

-
5UTR-3CDSENST00000359707ENST00000399497G3BP2chr4

76598392

-NAAAchr4

76841128

-
5UTR-3CDSENST00000359707ENST00000286733G3BP2chr4

76598392

-NAAAchr4

76841128

-
5UTR-5UTRENST00000359707ENST00000511606G3BP2chr4

76598392

-NAAAchr4

76841128

-
5UTR-5UTRENST00000359707ENST00000507956G3BP2chr4

76598392

-NAAAchr4

76841128

-
5UTR-5UTRENST00000359707ENST00000505594G3BP2chr4

76598392

-NAAAchr4

76841128

-
5UTR-intronENST00000359707ENST00000507187G3BP2chr4

76598392

-NAAAchr4

76841128

-
5UTR-3CDSENST00000357854ENST00000399497G3BP2chr4

76598392

-NAAAchr4

76841128

-
5UTR-3CDSENST00000357854ENST00000286733G3BP2chr4

76598392

-NAAAchr4

76841128

-
5UTR-5UTRENST00000357854ENST00000511606G3BP2chr4

76598392

-NAAAchr4

76841128

-
5UTR-5UTRENST00000357854ENST00000507956G3BP2chr4

76598392

-NAAAchr4

76841128

-
5UTR-5UTRENST00000357854ENST00000505594G3BP2chr4

76598392

-NAAAchr4

76841128

-
5UTR-intronENST00000357854ENST00000507187G3BP2chr4

76598392

-NAAAchr4

76841128

-
5UTR-3CDSENST00000502654ENST00000399497G3BP2chr4

76598392

-NAAAchr4

76841128

-
5UTR-3CDSENST00000502654ENST00000286733G3BP2chr4

76598392

-NAAAchr4

76841128

-
5UTR-5UTRENST00000502654ENST00000511606G3BP2chr4

76598392

-NAAAchr4

76841128

-
5UTR-5UTRENST00000502654ENST00000507956G3BP2chr4

76598392

-NAAAchr4

76841128

-
5UTR-5UTRENST00000502654ENST00000505594G3BP2chr4

76598392

-NAAAchr4

76841128

-
5UTR-intronENST00000502654ENST00000507187G3BP2chr4

76598392

-NAAAchr4

76841128

-

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FusionProtFeatures for G3BP2_NAAA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
G3BP2

Q9UN86

NAAA

Q02083

Probable scaffold protein that may be involved in mRNAtransport. {ECO:0000305}. Degrades bioactive fatty acid amides to theircorresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibitsweak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine.{ECO:0000269|PubMed:15655246}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for G3BP2_NAAA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for G3BP2_NAAA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
G3BP2STK24, NFKBIA, DDX10, RNH1, RPL3L, NUP214, USP10, FARS2, ASCC3, ATXN2L, NUP62, C3orf17, GNL2, UIMC1, UBAP2, DDX24, NUFIP2, RPF2, WDR36, RPL22L1, ING4, TERF2, TP53, MDM2, UBC, PTEN, ELAVL1, ARRB2, CUL3, CDK2, CUL1, COPS5, CAND1, ESR1, CA9, VCP, TARDBP, PIN1, DDX6, FXR2, IVNS1ABP, SUZ12, RNF2, BMI1, G3BP1, POM121, NUP153, NUP88, HNRNPA1, ADSL, IFI30, IGF2BP3, PABPC1, PABPC4, PRPF8, YARS, SFN, NTRK1, RPL10, NF2, SNW1, WWP2, TRIM25, KLHDC3, CYLD, LASP1, RPS6, CAPRIN1NAAAAPP, FBXO6, SIAE, TMEM2, TCTN2, TMEM132A, ENTPD6, POGLUT1, MANEAL, SLC38A10, ARSK, GALNS, OAF, EXT1, SYVN1, OS9, TTC17, SCARB1, P3H4, TUBA1A, UGDH, EDEM1, NAGLU, TUBB8, SULF2, NDST1, MAN2A1, SGSH, NHLRC3, NXPH4, CYB5R1, GLB1L2, ZNF507, SEC24D, CLN5, BMP7, NRP2, ARSB, CNTNAP3, SMG8, PCSK5, FUT11, DCBLD2, ERF, ITGA4, CHST12, PLTP, MAN2B2, EDEM2, WDR73, ITGAV, TCTN1, SEC23IP, TUBA4A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for G3BP2_NAAA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for G3BP2_NAAA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource