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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14164

FusionGeneSummary for FZD6_BAALC

check button Fusion gene summary
Fusion gene informationFusion gene name: FZD6_BAALC
Fusion gene ID: 14164
HgeneTgene
Gene symbol

FZD6

BAALC

Gene ID

8323

79870

Gene namefrizzled class receptor 6BAALC, MAP3K1 and KLF4 binding
SynonymsFZ-6|FZ6|HFZ6|NDNC10-
Cytomap

8q22.3

8q22.3

Type of geneprotein-codingprotein-coding
Descriptionfrizzled-6frizzled 6, seven transmembrane spanning receptorfrizzled family receptor 6frizzled homolog 6seven transmembrane helix receptorbrain and acute leukemia cytoplasmic proteinBAALC, MEKK1 and KLF4 bindingbrain and acute leukemia, cytoplasmic
Modification date2018052720180519
UniProtAcc

O60353

Q8WXS3

Ensembl transtripts involved in fusion geneENST00000522566, ENST00000358755, 
ENST00000523739, ENST00000540287, 
ENST00000309982, ENST00000438105, 
ENST00000297574, ENST00000330955, 
ENST00000306391, ENST00000523754, 
Fusion gene scores* DoF score3 X 2 X 3=186 X 2 X 5=60
# samples 37
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FZD6 [Title/Abstract] AND BAALC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFZD6

GO:0035567

non-canonical Wnt signaling pathway

14747478

HgeneFZD6

GO:0043433

negative regulation of DNA binding transcription factor activity

14747478


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-DS-A3LQ-01AFZD6chr8

104312512

+BAALCchr8

104240217

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000522566ENST00000309982FZD6chr8

104312512

+BAALCchr8

104240217

+
Frame-shiftENST00000522566ENST00000438105FZD6chr8

104312512

+BAALCchr8

104240217

+
Frame-shiftENST00000522566ENST00000297574FZD6chr8

104312512

+BAALCchr8

104240217

+
5CDS-intronENST00000522566ENST00000330955FZD6chr8

104312512

+BAALCchr8

104240217

+
5CDS-intronENST00000522566ENST00000306391FZD6chr8

104312512

+BAALCchr8

104240217

+
5CDS-3UTRENST00000522566ENST00000523754FZD6chr8

104312512

+BAALCchr8

104240217

+
In-frameENST00000358755ENST00000309982FZD6chr8

104312512

+BAALCchr8

104240217

+
Frame-shiftENST00000358755ENST00000438105FZD6chr8

104312512

+BAALCchr8

104240217

+
Frame-shiftENST00000358755ENST00000297574FZD6chr8

104312512

+BAALCchr8

104240217

+
5CDS-intronENST00000358755ENST00000330955FZD6chr8

104312512

+BAALCchr8

104240217

+
5CDS-intronENST00000358755ENST00000306391FZD6chr8

104312512

+BAALCchr8

104240217

+
5CDS-3UTRENST00000358755ENST00000523754FZD6chr8

104312512

+BAALCchr8

104240217

+
In-frameENST00000523739ENST00000309982FZD6chr8

104312512

+BAALCchr8

104240217

+
Frame-shiftENST00000523739ENST00000438105FZD6chr8

104312512

+BAALCchr8

104240217

+
Frame-shiftENST00000523739ENST00000297574FZD6chr8

104312512

+BAALCchr8

104240217

+
5CDS-intronENST00000523739ENST00000330955FZD6chr8

104312512

+BAALCchr8

104240217

+
5CDS-intronENST00000523739ENST00000306391FZD6chr8

104312512

+BAALCchr8

104240217

+
5CDS-3UTRENST00000523739ENST00000523754FZD6chr8

104312512

+BAALCchr8

104240217

+
Frame-shiftENST00000540287ENST00000309982FZD6chr8

104312512

+BAALCchr8

104240217

+
Frame-shiftENST00000540287ENST00000438105FZD6chr8

104312512

+BAALCchr8

104240217

+
Frame-shiftENST00000540287ENST00000297574FZD6chr8

104312512

+BAALCchr8

104240217

+
5CDS-intronENST00000540287ENST00000330955FZD6chr8

104312512

+BAALCchr8

104240217

+
5CDS-intronENST00000540287ENST00000306391FZD6chr8

104312512

+BAALCchr8

104240217

+
5CDS-3UTRENST00000540287ENST00000523754FZD6chr8

104312512

+BAALCchr8

104240217

+

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FusionProtFeatures for FZD6_BAALC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FZD6

O60353

BAALC

Q8WXS3

Receptor for Wnt proteins. Most of frizzled receptorsare coupled to the beta-catenin canonical signaling pathway, whichleads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation ofWnt target genes. A second signaling pathway involving PKC andcalcium fluxes has been seen for some family members, but it isnot yet clear if it represents a distinct pathway or if it can beintegrated in the canonical pathway, as PKC seems to be requiredfor Wnt-mediated inactivation of GSK-3 kinase. Both pathways seemto involve interactions with G-proteins. May be involved intransduction and intercellular transmission of polarityinformation during tissue morphogenesis and/or in differentiatedtissues. Together with FZD3, is involved in the neural tubeclosure and plays a role in the regulation of the establishment ofplanar cell polarity (PCP), particularly in the orientation ofasymmetric bundles of stereocilia on the apical faces of a subsetof auditory and vestibular sensory cells located in the inner ear(By similarity). {ECO:0000250|UniProtKB:Q61089}. May play a synaptic role at the postsynaptic lipid raftspossibly through interaction with CAMK2A.{ECO:0000250|UniProtKB:Q920K5}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFZD6chr8:104312512chr8:104240217ENST00000358755+2719_13259707DomainFZ
HgeneFZD6chr8:104312512chr8:104240217ENST00000522566+2719_13259707DomainFZ
HgeneFZD6chr8:104312512chr8:104240217ENST00000523739+3819_13227675DomainFZ
HgeneFZD6chr8:104312512chr8:104240217ENST00000358755+2719_20159707Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104240217ENST00000358755+27223_23359707Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104240217ENST00000358755+27255_28459707Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104240217ENST00000358755+27306_32459707Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104240217ENST00000358755+27346_37059707Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104240217ENST00000358755+27392_41659707Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104240217ENST00000358755+27438_47359707Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104240217ENST00000358755+27495_70659707Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104240217ENST00000522566+2719_20159707Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104240217ENST00000522566+27223_23359707Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104240217ENST00000522566+27255_28459707Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104240217ENST00000522566+27306_32459707Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104240217ENST00000522566+27346_37059707Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104240217ENST00000522566+27392_41659707Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104240217ENST00000522566+27438_47359707Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104240217ENST00000522566+27495_70659707Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104240217ENST00000523739+3819_20127675Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104240217ENST00000523739+38223_23327675Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104240217ENST00000523739+38255_28427675Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104240217ENST00000523739+38306_32427675Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104240217ENST00000523739+38346_37027675Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104240217ENST00000523739+38392_41627675Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104240217ENST00000523739+38438_47327675Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104240217ENST00000523739+38495_70627675Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104240217ENST00000358755+27202_22259707TransmembraneHelical%3B Name%3D1
HgeneFZD6chr8:104312512chr8:104240217ENST00000358755+27234_25459707TransmembraneHelical%3B Name%3D2
HgeneFZD6chr8:104312512chr8:104240217ENST00000358755+27285_30559707TransmembraneHelical%3B Name%3D3
HgeneFZD6chr8:104312512chr8:104240217ENST00000358755+27325_34559707TransmembraneHelical%3B Name%3D4
HgeneFZD6chr8:104312512chr8:104240217ENST00000358755+27371_39159707TransmembraneHelical%3B Name%3D5
HgeneFZD6chr8:104312512chr8:104240217ENST00000358755+27417_43759707TransmembraneHelical%3B Name%3D6
HgeneFZD6chr8:104312512chr8:104240217ENST00000358755+27474_49459707TransmembraneHelical%3B Name%3D7
HgeneFZD6chr8:104312512chr8:104240217ENST00000522566+27202_22259707TransmembraneHelical%3B Name%3D1
HgeneFZD6chr8:104312512chr8:104240217ENST00000522566+27234_25459707TransmembraneHelical%3B Name%3D2
HgeneFZD6chr8:104312512chr8:104240217ENST00000522566+27285_30559707TransmembraneHelical%3B Name%3D3
HgeneFZD6chr8:104312512chr8:104240217ENST00000522566+27325_34559707TransmembraneHelical%3B Name%3D4
HgeneFZD6chr8:104312512chr8:104240217ENST00000522566+27371_39159707TransmembraneHelical%3B Name%3D5
HgeneFZD6chr8:104312512chr8:104240217ENST00000522566+27417_43759707TransmembraneHelical%3B Name%3D6
HgeneFZD6chr8:104312512chr8:104240217ENST00000522566+27474_49459707TransmembraneHelical%3B Name%3D7
HgeneFZD6chr8:104312512chr8:104240217ENST00000523739+38202_22227675TransmembraneHelical%3B Name%3D1
HgeneFZD6chr8:104312512chr8:104240217ENST00000523739+38234_25427675TransmembraneHelical%3B Name%3D2
HgeneFZD6chr8:104312512chr8:104240217ENST00000523739+38285_30527675TransmembraneHelical%3B Name%3D3
HgeneFZD6chr8:104312512chr8:104240217ENST00000523739+38325_34527675TransmembraneHelical%3B Name%3D4
HgeneFZD6chr8:104312512chr8:104240217ENST00000523739+38371_39127675TransmembraneHelical%3B Name%3D5
HgeneFZD6chr8:104312512chr8:104240217ENST00000523739+38417_43727675TransmembraneHelical%3B Name%3D6
HgeneFZD6chr8:104312512chr8:104240217ENST00000523739+38474_49427675TransmembraneHelical%3B Name%3D7


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FusionGeneSequence for FZD6_BAALC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FZD6_BAALC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FZD6SFRP1, ELAVL1, KLRAP1, SYNE4, GABRE, TMEM17, TMEM216, TMEM132A, ZNRF4, VNN2, TMPRSS12, GPR114BAALCMDFI, ATXN1, CHEK2, MAP3K1, KLF4, ATP1B3, RNF2, CHD1L, CINP, OSBPL1A, AP1G1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneBAALCchr8:104312512chr8:104240217ENST00000306391+024_36081CAMK2A
TgeneBAALCchr8:104312512chr8:104240217ENST00000330955+024_36074CAMK2A


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneBAALCchr8:104312512chr8:104240217ENST00000297574+244_36144181CAMK2A
TgeneBAALCchr8:104312512chr8:104240217ENST00000309982+134_36109146CAMK2A
TgeneBAALCchr8:104312512chr8:104240217ENST00000438105+024_365355CAMK2A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FZD6_BAALC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FZD6_BAALC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFZD6C3279974NAIL DISORDER, NONSYNDROMIC CONGENITAL, 101ORPHANET;UNIPROT
TgeneBAALCC0023467Leukemia, Myelocytic, Acute1CTD_human