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Fusion gene ID: 14161 |
FusionGeneSummary for FZD3_CTBP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FZD3_CTBP1 | Fusion gene ID: 14161 | Hgene | Tgene | Gene symbol | FZD3 | CTBP1 | Gene ID | 7976 | 1487 |
| Gene name | frizzled class receptor 3 | C-terminal binding protein 1 | |
| Synonyms | Fz-3 | BARS|HADDTS | |
| Cytomap | 8p21.1 | 4p16.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | frizzled-3frizzled 3, seven transmembrane spanning receptorfrizzled family receptor 3frizzled homolog 3 | C-terminal-binding protein 1brefeldin A-ribosylated substrate | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9NPG1 | Q13363 | |
| Ensembl transtripts involved in fusion gene | ENST00000537916, ENST00000240093, ENST00000517911, | ENST00000382952, ENST00000290921, ENST00000510568, ENST00000515690, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 8 X 7 X 8=448 |
| # samples | 2 | 12 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(12/448*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FZD3 [Title/Abstract] AND CTBP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FZD3 | GO:0060070 | canonical Wnt signaling pathway | 20802536 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DB495584 | FZD3 | chr8 | 28351860 | + | CTBP1 | chr4 | 1235309 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-5UTR | ENST00000537916 | ENST00000382952 | FZD3 | chr8 | 28351860 | + | CTBP1 | chr4 | 1235309 | - |
| 5UTR-intron | ENST00000537916 | ENST00000290921 | FZD3 | chr8 | 28351860 | + | CTBP1 | chr4 | 1235309 | - |
| 5UTR-5UTR | ENST00000537916 | ENST00000510568 | FZD3 | chr8 | 28351860 | + | CTBP1 | chr4 | 1235309 | - |
| 5UTR-intron | ENST00000537916 | ENST00000515690 | FZD3 | chr8 | 28351860 | + | CTBP1 | chr4 | 1235309 | - |
| 5UTR-5UTR | ENST00000240093 | ENST00000382952 | FZD3 | chr8 | 28351860 | + | CTBP1 | chr4 | 1235309 | - |
| 5UTR-intron | ENST00000240093 | ENST00000290921 | FZD3 | chr8 | 28351860 | + | CTBP1 | chr4 | 1235309 | - |
| 5UTR-5UTR | ENST00000240093 | ENST00000510568 | FZD3 | chr8 | 28351860 | + | CTBP1 | chr4 | 1235309 | - |
| 5UTR-intron | ENST00000240093 | ENST00000515690 | FZD3 | chr8 | 28351860 | + | CTBP1 | chr4 | 1235309 | - |
| intron-5UTR | ENST00000517911 | ENST00000382952 | FZD3 | chr8 | 28351860 | + | CTBP1 | chr4 | 1235309 | - |
| intron-intron | ENST00000517911 | ENST00000290921 | FZD3 | chr8 | 28351860 | + | CTBP1 | chr4 | 1235309 | - |
| intron-5UTR | ENST00000517911 | ENST00000510568 | FZD3 | chr8 | 28351860 | + | CTBP1 | chr4 | 1235309 | - |
| intron-intron | ENST00000517911 | ENST00000515690 | FZD3 | chr8 | 28351860 | + | CTBP1 | chr4 | 1235309 | - |
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FusionProtFeatures for FZD3_CTBP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FZD3 | CTBP1 |
| Receptor for Wnt proteins. Most of frizzled receptorsare coupled to the beta-catenin canonical signaling pathway, whichleads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation ofWnt target genes. A second signaling pathway involving PKC andcalcium fluxes has been seen for some family members, but it isnot yet clear if it represents a distinct pathway or if it can beintegrated in the canonical pathway, as PKC seems to be requiredfor Wnt-mediated inactivation of GSK-3 kinase. Both pathways seemto involve interactions with G-proteins. Activation by Wnt5Astimulates PKC activity via a G-protein-dependent mechanism.Involved in transduction and intercellular transmission ofpolarity information during tissue morphogenesis and/or indifferentiated tissues. Plays a role in controlling early axongrowth and guidance processes necessary for the formation of asubset of central and peripheral major fiber tracts. Required forthe development of major fiber tracts in the central nervoussystem, including: the anterior commissure, the corpus callosum,the thalamocortical, corticothalamic and nigrostriatal tracts, thecorticospinal tract, the fasciculus retroflexus, themammillothalamic tract, the medial lemniscus, and ascending fibertracts from the spinal cord to the brain. In the peripheralnervous system, controls axon growth in distinct populations ofcranial and spinal motor neurons, including the facialbranchimotor nerve, the hypoglossal nerve, the phrenic nerve, andmotor nerves innervating dorsal limbs. Involved in the migrationof cranial neural crest cells. May also be implicated in thetransmission of sensory information from the trunk and limbs tothe brain. Controls commissural sensory axons guidance aftermidline crossing along the anterior-posterior axis in thedeveloping spinal cord in a Wnt-dependent signaling pathway.Together with FZD6, is involved in the neural tube closure andplays a role in the regulation of the establishment of planar cellpolarity (PCP), particularly in the orientation of asymmetricbundles of stereocilia on the apical faces of a subset of auditoryand vestibular sensory cells located in the inner ear. Promotesneurogenesis by maintaining sympathetic neuroblasts within thecell cycle in a beta-catenin-dependent manner (By similarity).{ECO:0000250|UniProtKB:Q61086}. | Corepressor targeting diverse transcription regulatorssuch as GLIS2 or BCL6. Has dehydrogenase activity. Involved incontrolling the equilibrium between tubular and stacked structuresin the Golgi complex. Functions in brown adipose tissue (BAT)differentiation. {ECO:0000269|PubMed:12419229,ECO:0000269|PubMed:15542832, ECO:0000269|PubMed:18212045,ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:9858600}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FZD3_CTBP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FZD3_CTBP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FZD3 | SYNE4, VNN2, XAGE1B, UPK1A, GPR21, GPR114, ZBBX | CTBP1 | PNN, IKZF1, SMAD6, RBBP8, TGIF1, NRIP1, MDM2, HDAC1, HDAC3, HDAC4, HDAC5, HDAC9, BRCA1, HDAC2, KAT2B, GEMIN2, TBP, GTF2B, FOXP1, FOXP2, KMT2A, CBX4, MECOM, IKZF4, CTBP2, ZEB1, ACTL6B, HTT, TBL1X, ZNF217, RCOR1, SATB1, CTBP1, TCF4, LCOR, TP53, HIC1, EHMT2, EHMT1, WIZ, APC, PLK1, TUBG1, HSD11B2, TCF7L2, KDM1A, CREBBP, EP300, KAT2A, SP1, RREB1, CDYL, UBE2I, BCORL1, SERPINH1, BCL3, AKT1, HIST3H3, SPEN, ZBP1, SOBP, ZNF219, LCORL, CHD3, RBBP5, CTNNA1, SOX2, ELAVL1, ZEB2, TERF2IP, TERF2, TFAP4, ATXN1L, BCL6, NCOR2, ECT2, CTNNB1, KLF4, DNMT1, RUNX1, BAG3, THAP11, HEMGN, NME2, ORC4, ARNT2, NOL4L, KLF12, MARCH10, CDC23, FUNDC1, IKZF2, KLF3, LNX1, PIAS2, RAI2, RNF111, ZBTB18, CEP68, NOL4, DGCR6, SNRPN, CRY2, HOXB5, PRKAA1, MAPK9, PLCB1, BCAS3, TSHZ3, DMRTB1, EGFR, HIC2, PRDM2, ZNF516, DYRK1A, TRPS1, C10orf12, BCOR, FBXO11, RCOR2, RCOR3, C2orf44, RBL1, INA, RB1, E2F7, TRMT61B, FOXK1, C15orf39, AMPD2, TOR2A, ADSS, ATIC, CARM1, CTH, ECHS1, FKBP1A, GAPDH, DUT, HYI, SSNA1, WDR1, NTRK1, MED23, OFD1, FBF1, KCNIP3, KLF8, NFATC1, NFATC2, MTMR7, RBM14-RBM4, IGFBP1, CHD4, NISCH, KIAA0430, HELZ, PCGF5, SOWAHA, PAN2, EIF4ENIF1, FANCC, FANCA, FANCF, FANCG, FANCL, FANCE, FANCD2, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FZD3_CTBP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FZD3_CTBP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FZD3 | C0036341 | Schizophrenia | 5 | PSYGENET |
| Hgene | FZD3 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Hgene | FZD3 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
| Hgene | FZD3 | C0525045 | Mood Disorders | 1 | PSYGENET |
| Tgene | CTBP1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
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