|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 14160 |
FusionGeneSummary for FZD1_FZD1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FZD1_FZD1 | Fusion gene ID: 14160 | Hgene | Tgene | Gene symbol | FZD1 | FZD1 | Gene ID | 8321 | 8321 |
| Gene name | frizzled class receptor 1 | frizzled class receptor 1 | |
| Synonyms | - | - | |
| Cytomap | 7q21.13 | 7q21.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | frizzled-1Wnt receptorfrizzled 1, seven transmembrane spanning receptorfrizzled family receptor 1frizzled homolog 1frizzled, Drosophila, homolog of, 1fz-1fzE1hFz1 | frizzled-1Wnt receptorfrizzled 1, seven transmembrane spanning receptorfrizzled family receptor 1frizzled homolog 1frizzled, Drosophila, homolog of, 1fz-1fzE1hFz1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UP38 | Q9UP38 | |
| Ensembl transtripts involved in fusion gene | ENST00000287934, | ENST00000287934, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: FZD1 [Title/Abstract] AND FZD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FZD1 | GO:0007267 | cell-cell signaling | 10557084 |
| Hgene | FZD1 | GO:0035425 | autocrine signaling | 10557084 |
| Hgene | FZD1 | GO:0045893 | positive regulation of transcription, DNA-templated | 18929644 |
| Hgene | FZD1 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 10557084|14739301 |
| Hgene | FZD1 | GO:0060070 | canonical Wnt signaling pathway | 10557084|14739301|28733458 |
| Tgene | FZD1 | GO:0007267 | cell-cell signaling | 10557084 |
| Tgene | FZD1 | GO:0035425 | autocrine signaling | 10557084 |
| Tgene | FZD1 | GO:0045893 | positive regulation of transcription, DNA-templated | 18929644 |
| Tgene | FZD1 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 10557084|14739301 |
| Tgene | FZD1 | GO:0060070 | canonical Wnt signaling pathway | 10557084|14739301|28733458 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | W01830 | FZD1 | chr7 | 90896865 | + | FZD1 | chr7 | 90895977 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000287934 | ENST00000287934 | FZD1 | chr7 | 90896865 | + | FZD1 | chr7 | 90895977 | + |
Top |
FusionProtFeatures for FZD1_FZD1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FZD1 | FZD1 |
| Receptor for Wnt proteins (PubMed:10557084). Activatedby WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparentlynot by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084).Contradictory results showing activation by WNT7B have beendescribed for mouse (By similarity). Functions in the canonicalWnt/beta-catenin signaling pathway (PubMed:10557084). Thecanonical Wnt/beta-catenin signaling pathway leads to theactivation of disheveled proteins, inhibition of GSK-3 kinase,nuclear accumulation of beta-catenin and activation of Wnt targetgenes (PubMed:10557084). A second signaling pathway involving PKCand calcium fluxes has been seen for some family members, but itis not yet clear if it represents a distinct pathway or if it canbe integrated in the canonical pathway, as PKC seems to berequired for Wnt-mediated inactivation of GSK-3 kinase. Bothpathways seem to involve interactions with G-proteins. May beinvolved in transduction and intercellular transmission ofpolarity information during tissue morphogenesis and/or indifferentiated tissues (Probable). {ECO:0000250|UniProtKB:O70421,ECO:0000269|PubMed:10557084, ECO:0000305}. | Receptor for Wnt proteins (PubMed:10557084). Activatedby WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparentlynot by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084).Contradictory results showing activation by WNT7B have beendescribed for mouse (By similarity). Functions in the canonicalWnt/beta-catenin signaling pathway (PubMed:10557084). Thecanonical Wnt/beta-catenin signaling pathway leads to theactivation of disheveled proteins, inhibition of GSK-3 kinase,nuclear accumulation of beta-catenin and activation of Wnt targetgenes (PubMed:10557084). A second signaling pathway involving PKCand calcium fluxes has been seen for some family members, but itis not yet clear if it represents a distinct pathway or if it canbe integrated in the canonical pathway, as PKC seems to berequired for Wnt-mediated inactivation of GSK-3 kinase. Bothpathways seem to involve interactions with G-proteins. May beinvolved in transduction and intercellular transmission ofpolarity information during tissue morphogenesis and/or indifferentiated tissues (Probable). {ECO:0000250|UniProtKB:O70421,ECO:0000269|PubMed:10557084, ECO:0000305}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for FZD1_FZD1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for FZD1_FZD1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for FZD1_FZD1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for FZD1_FZD1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|