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Fusion gene ID: 14140 |
FusionGeneSummary for FYCO1_ATG7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FYCO1_ATG7 | Fusion gene ID: 14140 | Hgene | Tgene | Gene symbol | FYCO1 | ATG7 | Gene ID | 79443 | 10533 |
| Gene name | FYVE and coiled-coil domain containing 1 | autophagy related 7 | |
| Synonyms | CATC2|CTRCT18|RUFY3|ZFYVE7 | APG7-LIKE|APG7L|GSA7 | |
| Cytomap | 3p21.31 | 3p25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | FYVE and coiled-coil domain-containing protein 1RUN and FYVE domain containing 3zinc finger FYVE domain-containing protein 7 | ubiquitin-like modifier-activating enzyme ATG7APG7 autophagy 7-likeATG12-activating enzyme E1 ATG7hAGP7ubiquitin-activating enzyme E1-like protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9BQS8 | O95352 | |
| Ensembl transtripts involved in fusion gene | ENST00000296137, ENST00000535325, ENST00000438446, | ENST00000446450, ENST00000354956, ENST00000354449, ENST00000469654, | |
| Fusion gene scores | * DoF score | 6 X 6 X 3=108 | 11 X 11 X 7=847 |
| # samples | 6 | 15 | |
| ** MAII score | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/847*10)=-2.49739946883632 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FYCO1 [Title/Abstract] AND ATG7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ATG7 | GO:0006497 | protein lipidation | 12890687 |
| Tgene | ATG7 | GO:0009267 | cellular response to starvation | 20543840 |
| Tgene | ATG7 | GO:0031401 | positive regulation of protein modification process | 12890687 |
| Tgene | ATG7 | GO:0071455 | cellular response to hyperoxia | 20543840 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-MP-A4TK-01A | FYCO1 | chr3 | 46021197 | - | ATG7 | chr3 | 11421446 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000296137 | ENST00000446450 | FYCO1 | chr3 | 46021197 | - | ATG7 | chr3 | 11421446 | + |
| 5CDS-intron | ENST00000296137 | ENST00000354956 | FYCO1 | chr3 | 46021197 | - | ATG7 | chr3 | 11421446 | + |
| 5CDS-intron | ENST00000296137 | ENST00000354449 | FYCO1 | chr3 | 46021197 | - | ATG7 | chr3 | 11421446 | + |
| 5CDS-intron | ENST00000296137 | ENST00000469654 | FYCO1 | chr3 | 46021197 | - | ATG7 | chr3 | 11421446 | + |
| In-frame | ENST00000535325 | ENST00000446450 | FYCO1 | chr3 | 46021197 | - | ATG7 | chr3 | 11421446 | + |
| 5CDS-intron | ENST00000535325 | ENST00000354956 | FYCO1 | chr3 | 46021197 | - | ATG7 | chr3 | 11421446 | + |
| 5CDS-intron | ENST00000535325 | ENST00000354449 | FYCO1 | chr3 | 46021197 | - | ATG7 | chr3 | 11421446 | + |
| 5CDS-intron | ENST00000535325 | ENST00000469654 | FYCO1 | chr3 | 46021197 | - | ATG7 | chr3 | 11421446 | + |
| intron-3CDS | ENST00000438446 | ENST00000446450 | FYCO1 | chr3 | 46021197 | - | ATG7 | chr3 | 11421446 | + |
| intron-intron | ENST00000438446 | ENST00000354956 | FYCO1 | chr3 | 46021197 | - | ATG7 | chr3 | 11421446 | + |
| intron-intron | ENST00000438446 | ENST00000354449 | FYCO1 | chr3 | 46021197 | - | ATG7 | chr3 | 11421446 | + |
| intron-intron | ENST00000438446 | ENST00000469654 | FYCO1 | chr3 | 46021197 | - | ATG7 | chr3 | 11421446 | + |
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FusionProtFeatures for FYCO1_ATG7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FYCO1 | ATG7 |
| May mediate microtubule plus end-directed vesicletransport. {ECO:0000269|PubMed:20100911}. | E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) andautophagy. Activates ATG12 for its conjugation with ATG5 as wellas the ATG8 family proteins for their conjugation withphosphatidylethanolamine. Both systems are needed for the ATG8association to Cvt vesicles and autophagosomes membranes. Requiredfor autophagic death induced by caspase-8 inhibition. Required formitophagy which contributes to regulate mitochondrial quantity andquality by eliminating the mitochondria to a basal level tofulfill cellular energy requirements and preventing excess ROSproduction. Modulates p53/TP53 activity to regulate cell cycle andsurvival during metabolic stress. Plays also a key role in themaintenance of axonal homeostasis, the prevention of axonaldegeneration, the maintenance of hematopoietic stem cells, theformation of Paneth cell granules, as well as in adiposedifferentiation. {ECO:0000269|PubMed:11096062,ECO:0000269|PubMed:16303767, ECO:0000269|PubMed:22170151}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FYCO1_ATG7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FYCO1_ENST00000535325_chr3_46021197_-_ATG7_ENST00000446450_chr3_11421446_+_134aa MASTNAESQLQRIIRDLQDAVTELSKEFQEAGEPITDDSTSLHKFSYKLEYLLQFDQKEKATLLGNKKDYWDYFCACLAKVKGANDGIRF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FYCO1_ENST00000535325_chr3_46021197_-_ATG7_ENST00000446450_chr3_11421446_+_402nt ATGGCCTCCACCAATGCAGAGAGCCAGCTCCAGAGAATCATCCGAGACTTGCAAGATGCTGTGACAGAACTAAGCAAAGAATTTCAGGAA GCAGGGGAACCCATCACGGATGACAGCACCAGCTTGCATAAATTTTCTTATAAACTTGAGTATCTCCTGCAATTTGATCAGAAAGAGAAG GCCACCCTCCTGGGCAACAAGAAGGACTACTGGGATTACTTCTGTGCCTGCCTGGCCAAGGTGAAAGGAGCCAATGATGGGATCCGCTTT GTCAAGTCTATCTCAGAGATCCGGGGATTTCTTTCACGGTTTGATAATGTCCTTCCCGTCAGCCTGGCATTTGACAAATGTACAGCTTGT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FYCO1_ENST00000535325_chr3_46021197_-_ATG7_ENST00000446450_chr3_11421446_+_632nt GAGCAGACAGCCACCGAGGGCCGAAATTCTGAGCCTTCCTCTGGACCCAGGCAGGAGACATACAGACAAGAAAGGCAAACTCACCATGGC CTCCACCAATGCAGAGAGCCAGCTCCAGAGAATCATCCGAGACTTGCAAGATGCTGTGACAGAACTAAGCAAAGAATTTCAGGAAGCAGG GGAACCCATCACGGATGACAGCACCAGCTTGCATAAATTTTCTTATAAACTTGAGTATCTCCTGCAATTTGATCAGAAAGAGAAGGCCAC CCTCCTGGGCAACAAGAAGGACTACTGGGATTACTTCTGTGCCTGCCTGGCCAAGGTGAAAGGAGCCAATGATGGGATCCGCTTTGTCAA GTCTATCTCAGAGATCCGGGGATTTCTTTCACGGTTTGATAATGTCCTTCCCGTCAGCCTGGCATTTGACAAATGTACAGCTTGTTCTTC CAAAATCTGGGACATGAGCGATGATGAGACCATCTGAGATGGCCCCGCTGTGGGGCTGACTTCTCCCCGGCCGCCTGCTGAGGAGCTCTC CATCGCCAGAGCAGGACTGCTGACCCCAGGCCTGGTGATTCTGGGCCCCTCCTCCATACCCCGAGGTCTGGGATTCCCCCCTCTGCTGCC |
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FusionGenePPI for FYCO1_ATG7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FYCO1 | C18orf8, CCZ1, MAP4, MON1B, LMNA, RPA2, TMPO, RPA1, SEC23B, SEC24B, CCAR1, FOXK1, RPA3, EMD, KIF5B, KIF23, MAP1LC3A, MAP1LC3B, APP, IQCB1, KDM1A, PRMT6, RAF1, MOV10, CCT7, CCT6B, CCT6A, CCT2, CCT3, DTNA, TCP1, MLYCD, SASS6, CCDC101, TRUB2, CCDC68, C17orf59, XPO1, PPL, DDX60, GOPC, PAX6, NOL9, POLDIP3, ADO, RFT1, HIF1AN, TCP10L, CYLD, TRIM25 | ATG7 | ATG3, ATG10, ATG12, GABARAPL2, GABARAP, MAP1LC3C, GABARAPL1, CLN3, MAP1LC3A, MAP1LC3B, PIK3C2A, FOXO1, IRF2, SIRT1, SQSTM1, APP, EP300, BAG3, EEF1D, ANP32E, ATP6V1C1, MAN2B1, PPP2CB, VPS36, WDR92, CTTN, GSPT1, GSPT2, GTF2A1, MAT2B, NASP, PPP3CB, RDX, SARS, SHMT2, SNX1, SNX2, SNX6, STAT1, TBCD, UGDH, KIAA0930, UROS, RWDD2A, LGMN, PSG1, ARHGAP25, UBA3, UBA6, NTRK1, XRCC6BP1, TXLNB, KHDRBS2, RIPK1, STXBP6, KCNJ5, NAA40, MICU2, GFER, TRIP6, DNLZ, FKBP5, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FYCO1_ATG7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FYCO1_ATG7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FYCO1 | C1864908 | Cataract, autosomal recessive congenital 2 | 1 | UNIPROT |
| Tgene | ATG7 | C0002871 | Anemia | 1 | CTD_human |
| Tgene | ATG7 | C0023380 | Lethargy | 1 | CTD_human |
| Tgene | ATG7 | C0024312 | Lymphopenia | 1 | CTD_human |
| Tgene | ATG7 | C0027540 | Necrosis | 1 | CTD_human |
| Tgene | ATG7 | C1262477 | Weight decreased | 1 | CTD_human |
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