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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14133

FusionGeneSummary for FXYD5_HNRNPUL1

check button Fusion gene summary
Fusion gene informationFusion gene name: FXYD5_HNRNPUL1
Fusion gene ID: 14133
HgeneTgene
Gene symbol

FXYD5

HNRNPUL1

Gene ID

53827

11100

Gene nameFXYD domain containing ion transport regulator 5heterogeneous nuclear ribonucleoprotein U like 1
SynonymsDYSAD|HSPC113|IWU1|KCT1|OIT2|PRO6241|RICE1B-AP5|E1BAP5|HNRPUL1
Cytomap

19q13.12

19q13.2

Type of geneprotein-codingprotein-coding
DescriptionFXYD domain-containing ion transport regulator 5dysadherinkeratinocytes associated transmembrane protein 1heterogeneous nuclear ribonucleoprotein U-like protein 1E1B 55kDa associated protein 5E1B-55 kDa-associated protein 5adenovirus early region 1B-associated protein 5
Modification date2018052320180522
UniProtAcc

Q96DB9

Q9BUJ2

Ensembl transtripts involved in fusion geneENST00000543307, ENST00000392219, 
ENST00000541435, ENST00000590686, 
ENST00000342879, ENST00000588699, 
ENST00000423817, ENST00000392218, 
ENST00000591716, ENST00000392217, 
ENST00000352456, ENST00000595018, 
ENST00000392006, ENST00000378215, 
ENST00000602130, ENST00000593587, 
ENST00000263367, ENST00000594207, 
Fusion gene scores* DoF score3 X 3 X 4=3613 X 12 X 5=780
# samples 414
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(14/780*10)=-2.47804729680464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FXYD5 [Title/Abstract] AND HNRNPUL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-25-1877-01AFXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000543307ENST00000352456FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000543307ENST00000595018FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000543307ENST00000392006FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000543307ENST00000378215FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000543307ENST00000602130FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000543307ENST00000593587FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000543307ENST00000263367FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-3UTRENST00000543307ENST00000594207FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000392219ENST00000352456FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000392219ENST00000595018FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000392219ENST00000392006FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000392219ENST00000378215FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000392219ENST00000602130FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000392219ENST00000593587FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000392219ENST00000263367FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-3UTRENST00000392219ENST00000594207FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000541435ENST00000352456FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000541435ENST00000595018FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000541435ENST00000392006FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000541435ENST00000378215FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000541435ENST00000602130FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000541435ENST00000593587FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000541435ENST00000263367FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-3UTRENST00000541435ENST00000594207FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000590686ENST00000352456FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000590686ENST00000595018FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000590686ENST00000392006FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000590686ENST00000378215FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000590686ENST00000602130FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000590686ENST00000593587FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000590686ENST00000263367FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-3UTRENST00000590686ENST00000594207FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000342879ENST00000352456FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000342879ENST00000595018FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000342879ENST00000392006FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000342879ENST00000378215FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000342879ENST00000602130FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000342879ENST00000593587FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000342879ENST00000263367FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-3UTRENST00000342879ENST00000594207FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000588699ENST00000352456FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000588699ENST00000595018FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000588699ENST00000392006FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000588699ENST00000378215FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000588699ENST00000602130FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000588699ENST00000593587FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000588699ENST00000263367FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-3UTRENST00000588699ENST00000594207FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000423817ENST00000352456FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000423817ENST00000595018FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000423817ENST00000392006FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000423817ENST00000378215FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000423817ENST00000602130FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000423817ENST00000593587FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000423817ENST00000263367FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-3UTRENST00000423817ENST00000594207FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000392218ENST00000352456FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000392218ENST00000595018FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000392218ENST00000392006FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000392218ENST00000378215FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000392218ENST00000602130FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000392218ENST00000593587FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000392218ENST00000263367FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
5CDS-3UTRENST00000392218ENST00000594207FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
intron-5UTRENST00000591716ENST00000352456FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
intron-5UTRENST00000591716ENST00000595018FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
intron-5UTRENST00000591716ENST00000392006FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
intron-5UTRENST00000591716ENST00000378215FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
intron-5UTRENST00000591716ENST00000602130FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
intron-5UTRENST00000591716ENST00000593587FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
intron-5UTRENST00000591716ENST00000263367FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
intron-3UTRENST00000591716ENST00000594207FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
intron-5UTRENST00000392217ENST00000352456FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
intron-5UTRENST00000392217ENST00000595018FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
intron-5UTRENST00000392217ENST00000392006FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
intron-5UTRENST00000392217ENST00000378215FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
intron-5UTRENST00000392217ENST00000602130FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
intron-5UTRENST00000392217ENST00000593587FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
intron-5UTRENST00000392217ENST00000263367FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+
intron-3UTRENST00000392217ENST00000594207FXYD5chr19

35648404

+HNRNPUL1chr19

41774128

+

Top

FusionProtFeatures for FXYD5_HNRNPUL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FXYD5

Q96DB9

HNRNPUL1

Q9BUJ2

Involved in down-regulation of E-cadherin which resultsin reduced cell adhesion. Promotes metastasis.{ECO:0000269|PubMed:11756660}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FXYD5_HNRNPUL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FXYD5_HNRNPUL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FXYD5HNRNPUL1POLR1E, CNBP, BRD7, C14orf1, MED31, CRMP1, PRPF40A, PRMT1, PRMT2, MEPCE, TLX3, ATM, ATRIP, RPA1, RPA2, PCM1, ELAVL1, SF3A2, SIRT7, TSG101, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, NXF1, HNRNPH1, HNRNPF, RBMX, EEF1A1, HNRNPA0, ILF2, HNRNPDL, HSPA5, RAB11B, ATP6V1H, DES, HNRNPH3, ZMPSTE24, TMEM179B, HNRNPUL2, EPB41L1, DBN1, ECH1, SAMM50, BARD1, SNRPC, SNRPB2, SF3B4, SF1, SRSF9, RBM22, PPIL1, ZNF207, HNRNPUL1, RBM4, SMN1, HNRNPH2, RAE1, NUP98, IL7R, BAG3, EP300, EWSR1, TGM2, GIT2, PIAS4, TARDBP, ITCH, NEDD4, APEX1, OSGEP, PEG10, TES, SERPINE2, RPA3, WWOX, ERG, IVNS1ABP, SMN2, TP53BP2, DZIP3, SORBS3, WWP2, ROPN1, VPS37C, RBM4B, MAPK1IP1L, CUL7, OBSL1, EED, RNF2, HNRNPA1, FBXW11, NTRK1, PDCD6, SAFB, SAFB2, TMED2, DMRTB1, MATR3, SYNCRIP, DGCR8, PCIF1, MCM2, SENP3, CFAP20, CYLD, CD2BP2, COX15, FOXA1, TRIM25, G3BP1, UBE2A, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FXYD5_HNRNPUL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FXYD5_HNRNPUL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFXYD5C0023893Liver Cirrhosis, Experimental1CTD_human