|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 1413 |
FusionGeneSummary for AKT3_ADSS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AKT3_ADSS | Fusion gene ID: 1413 | Hgene | Tgene | Gene symbol | AKT3 | ADSS | Gene ID | 10000 | 159 |
| Gene name | AKT serine/threonine kinase 3 | adenylosuccinate synthase | |
| Synonyms | MPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2 | ADEH|ADSS 2 | |
| Cytomap | 1q43-q44 | 1q44 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RAC-gamma serine/threonine-protein kinasePKB gammaRAC-gamma serine/threonine protein kinasev-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | adenylosuccinate synthetase isozyme 2AMPSase 2IMP--aspartate ligase 2L-type adenylosuccinate synthetaseadSS 2adenylosuccinate synthetase (Ade(-)H-complementing)adenylosuccinate synthetase, acidic isozymeadenylosuccinate synthetase, liver isozyme | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y243 | P30520 | |
| Ensembl transtripts involved in fusion gene | ENST00000336199, ENST00000366540, ENST00000366539, ENST00000263826, ENST00000492957, | ENST00000366535, ENST00000462358, | |
| Fusion gene scores | * DoF score | 8 X 5 X 5=200 | 3 X 1 X 3=9 |
| # samples | 9 | 3 | |
| ** MAII score | log2(9/200*10)=-1.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: AKT3 [Title/Abstract] AND ADSS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AKT3 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 28254819 |
| Hgene | AKT3 | GO:1905564 | positive regulation of vascular endothelial cell proliferation | 28254819 |
| Tgene | ADSS | GO:0006167 | AMP biosynthetic process | 2004783 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-ZG-A9KY-01A | AKT3 | chr1 | 244006427 | - | ADSS | chr1 | 244601070 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000336199 | ENST00000366535 | AKT3 | chr1 | 244006427 | - | ADSS | chr1 | 244601070 | - |
| 5CDS-intron | ENST00000336199 | ENST00000462358 | AKT3 | chr1 | 244006427 | - | ADSS | chr1 | 244601070 | - |
| Frame-shit | ENST00000366540 | ENST00000366535 | AKT3 | chr1 | 244006427 | - | ADSS | chr1 | 244601070 | - |
| 5CDS-intron | ENST00000366540 | ENST00000462358 | AKT3 | chr1 | 244006427 | - | ADSS | chr1 | 244601070 | - |
| In-frame | ENST00000366539 | ENST00000366535 | AKT3 | chr1 | 244006427 | - | ADSS | chr1 | 244601070 | - |
| 5CDS-intron | ENST00000366539 | ENST00000462358 | AKT3 | chr1 | 244006427 | - | ADSS | chr1 | 244601070 | - |
| In-frame | ENST00000263826 | ENST00000366535 | AKT3 | chr1 | 244006427 | - | ADSS | chr1 | 244601070 | - |
| 5CDS-intron | ENST00000263826 | ENST00000462358 | AKT3 | chr1 | 244006427 | - | ADSS | chr1 | 244601070 | - |
| intron-3CDS | ENST00000492957 | ENST00000366535 | AKT3 | chr1 | 244006427 | - | ADSS | chr1 | 244601070 | - |
| intron-intron | ENST00000492957 | ENST00000462358 | AKT3 | chr1 | 244006427 | - | ADSS | chr1 | 244601070 | - |
Top |
FusionProtFeatures for AKT3_ADSS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AKT3 | ADSS |
| AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, andwhich regulate many processes including metabolism, proliferation,cell survival, growth and angiogenesis. This is mediated throughserine and/or threonine phosphorylation of a range of downstreamsubstrates. Over 100 substrate candidates have been reported sofar, but for most of them, no isoform specificity has beenreported. AKT3 is the least studied AKT isoform. It plays animportant role in brain development and is crucial for theviability of malignant glioma cells. AKT3 isoform may also be thekey molecule in up-regulation and down-regulation of MMP13 viaIL13. Required for the coordination of mitochondrial biogenesiswith growth factor-induced increases in cellular energy demands.Down-regulation by RNA interference reduces the expression of thephosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. {ECO:0000269|PubMed:18524868,ECO:0000269|PubMed:21191416}. | Plays an important role in the de novo pathway and inthe salvage pathway of purine nucleotide biosynthesis. Catalyzesthe first committed step in the biosynthesis of AMP from IMP. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ADSS | chr1:244006427 | chr1:244601070 | ENST00000366535 | - | 0 | 13 | 362_364 | 61 | 457 | Nucleotide binding | Note=GTP |
| Tgene | >ADSS | chr1:244006427 | chr1:244601070 | ENST00000366535 | - | 0 | 13 | 444_447 | 61 | 457 | Nucleotide binding | Note=GTP |
| Tgene | >ADSS | chr1:244006427 | chr1:244601070 | ENST00000366535 | - | 0 | 13 | 67_69 | 61 | 457 | Nucleotide binding | Note=GTP |
| Tgene | >ADSS | chr1:244006427 | chr1:244601070 | ENST00000366535 | - | 0 | 13 | 330_336 | 61 | 457 | Region | Substrate binding |
| Tgene | >ADSS | chr1:244006427 | chr1:244601070 | ENST00000366535 | - | 0 | 13 | 65_68 | 61 | 457 | Region | IMP binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >AKT3 | chr1:244006427 | chr1:244601070 | ENST00000263826 | - | 1 | 13 | 148_405 | 15 | 480 | Domain | Protein kinase |
| Hgene | >AKT3 | chr1:244006427 | chr1:244601070 | ENST00000263826 | - | 1 | 13 | 406_479 | 15 | 480 | Domain | Note=AGC-kinase C-terminal |
| Hgene | >AKT3 | chr1:244006427 | chr1:244601070 | ENST00000263826 | - | 1 | 13 | 5_107 | 15 | 480 | Domain | PH |
| Hgene | >AKT3 | chr1:244006427 | chr1:244601070 | ENST00000336199 | - | 1 | 14 | 148_405 | 15 | 476 | Domain | Protein kinase |
| Hgene | >AKT3 | chr1:244006427 | chr1:244601070 | ENST00000336199 | - | 1 | 14 | 406_479 | 15 | 476 | Domain | Note=AGC-kinase C-terminal |
| Hgene | >AKT3 | chr1:244006427 | chr1:244601070 | ENST00000336199 | - | 1 | 14 | 5_107 | 15 | 476 | Domain | PH |
| Hgene | >AKT3 | chr1:244006427 | chr1:244601070 | ENST00000366539 | - | 2 | 14 | 148_405 | 15 | 480 | Domain | Protein kinase |
| Hgene | >AKT3 | chr1:244006427 | chr1:244601070 | ENST00000366539 | - | 2 | 14 | 406_479 | 15 | 480 | Domain | Note=AGC-kinase C-terminal |
| Hgene | >AKT3 | chr1:244006427 | chr1:244601070 | ENST00000366539 | - | 2 | 14 | 5_107 | 15 | 480 | Domain | PH |
| Hgene | >AKT3 | chr1:244006427 | chr1:244601070 | ENST00000366540 | - | 2 | 14 | 148_405 | 15 | 466 | Domain | Protein kinase |
| Hgene | >AKT3 | chr1:244006427 | chr1:244601070 | ENST00000366540 | - | 2 | 14 | 406_479 | 15 | 466 | Domain | Note=AGC-kinase C-terminal |
| Hgene | >AKT3 | chr1:244006427 | chr1:244601070 | ENST00000366540 | - | 2 | 14 | 5_107 | 15 | 466 | Domain | PH |
| Hgene | >AKT3 | chr1:244006427 | chr1:244601070 | ENST00000263826 | - | 1 | 13 | 154_162 | 15 | 480 | Nucleotide binding | ATP |
| Hgene | >AKT3 | chr1:244006427 | chr1:244601070 | ENST00000336199 | - | 1 | 14 | 154_162 | 15 | 476 | Nucleotide binding | ATP |
| Hgene | >AKT3 | chr1:244006427 | chr1:244601070 | ENST00000366539 | - | 2 | 14 | 154_162 | 15 | 480 | Nucleotide binding | ATP |
| Hgene | >AKT3 | chr1:244006427 | chr1:244601070 | ENST00000366540 | - | 2 | 14 | 154_162 | 15 | 466 | Nucleotide binding | ATP |
| Tgene | ADSS | chr1:244006427 | chr1:244601070 | ENST00000366535 | - | 0 | 13 | 39_45 | 61 | 457 | Nucleotide binding | Note=GTP |
| Tgene | ADSS | chr1:244006427 | chr1:244601070 | ENST00000366535 | - | 0 | 13 | 40_43 | 61 | 457 | Region | IMP binding |
Top |
FusionGeneSequence for AKT3_ADSS |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_AKT3_ENST00000336199_chr1_244006427_-_ADSS_ENST00000366535_chr1_244601070_-_411aa MSDVTIVKEGWVQKRGRKXCWPYSCCGFCGIXFSSLTQWNNXSKCHCIHWKWCGNSSTWIVXRSREKCSKRKRTRRLGKKAYYIXQSSYC IXFSSSSXWYPGTTETRTSRKKFGYNKKGHWPSLFVQSCSEWTQDVRPCFXLXWLLXEVXSSSXPIQIYIPHFGNRHXRXITKTQGLYGK DXTNGERWSLFSIXGPTWTTKENLGRRCKCSTIRYXFWDLPFCNLFKLYCWRCLYWFGYATSKCWRSVWSCESLYNXSWYWCLSYRARQX NWRIITNKGXRVWCNYWKEKKMWLVGPRFAQICSYDQWIYCVGTYQVGYFGHVYGNQSWSCLQVRWXNHTSYPSKPRSLKXSXSSIXDSP >In-frame_AKT3_ENST00000366539_chr1_244006427_-_ADSS_ENST00000366535_chr1_244601070_-_411aa MSDVTIVKEGWVQKRGRKXCWPYSCCGFCGIXFSSLTQWNNXSKCHCIHWKWCGNSSTWIVXRSREKCSKRKRTRRLGKKAYYIXQSSYC IXFSSSSXWYPGTTETRTSRKKFGYNKKGHWPSLFVQSCSEWTQDVRPCFXLXWLLXEVXSSSXPIQIYIPHFGNRHXRXITKTQGLYGK DXTNGERWSLFSIXGPTWTTKENLGRRCKCSTIRYXFWDLPFCNLFKLYCWRCLYWFGYATSKCWRSVWSCESLYNXSWYWCLSYRARQX NWRIITNKGXRVWCNYWKEKKMWLVGPRFAQICSYDQWIYCVGTYQVGYFGHVYGNQSWSCLQVRWXNHTSYPSKPRSLKXSXSSIXDSP >In-frame_AKT3_ENST00000263826_chr1_244006427_-_ADSS_ENST00000366535_chr1_244601070_-_411aa MSDVTIVKEGWVQKRGRKXCWPYSCCGFCGIXFSSLTQWNNXSKCHCIHWKWCGNSSTWIVXRSREKCSKRKRTRRLGKKAYYIXQSSYC IXFSSSSXWYPGTTETRTSRKKFGYNKKGHWPSLFVQSCSEWTQDVRPCFXLXWLLXEVXSSSXPIQIYIPHFGNRHXRXITKTQGLYGK DXTNGERWSLFSIXGPTWTTKENLGRRCKCSTIRYXFWDLPFCNLFKLYCWRCLYWFGYATSKCWRSVWSCESLYNXSWYWCLSYRARQX NWRIITNKGXRVWCNYWKEKKMWLVGPRFAQICSYDQWIYCVGTYQVGYFGHVYGNQSWSCLQVRWXNHTSYPSKPRSLKXSXSSIXDSP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_AKT3_ENST00000336199_chr1_244006427_-_ADSS_ENST00000366535_chr1_244601070_-_1234nt ATGAGCGATGTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGGGAGGAAATAATGCTGGCCATACAGTTGTTGTGGATTCTGTGGA ATATGATTTTCATCTCTTACCCAGTGGAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGTGGTAATTCATCTACCTGGATT GTTTGAAGAAGCAGAGAAAAATGTTCAAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTATATCTGACAGAGCTCATATTGT ATTTGATTTTCATCAAGCAGCTGATGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTTGGGTACAACAAAAAAGGGCAT TGGCCCAGTTTATTCGTCCAAAGCTGCTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGATGGCTTCTCTGAGAGGTTTAA AGTTCTAGCTAACCAATACAAATCTATATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAAACTCAAGGGTTATATGGAAAA GATTAAACCAATGGTGAGAGATGGAGTTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAATCTTGGTAGAAGGTGCAAATGC AGCACTATTAGATATTGATTTTGGGACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGTTTGTACTGGTTTGGGTATGCC ACCTCAAAATGTTGGAGAAGTGTATGGAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTTTCCTACAGAGCAAGACAATGA AATTGGAGAATTATTACAAACAAGGGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGGCTGGTTGGACCTCGTTTTGCT CAAATATGCTCATATGATCAATGGATTTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTTTACGGAAATCAAAGTTGGAGT TGCTTACAAGTTAGATGGTGAAATCATACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGAAGTTCAATATAAGACTCTCCC AGGATGGAACACAGACATATCAAATGCAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGTTCGATTTATTGAAGATGAGCT >In-frame_AKT3_ENST00000366539_chr1_244006427_-_ADSS_ENST00000366535_chr1_244601070_-_1234nt ATGAGCGATGTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGGGAGGAAATAATGCTGGCCATACAGTTGTTGTGGATTCTGTGGA ATATGATTTTCATCTCTTACCCAGTGGAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGTGGTAATTCATCTACCTGGATT GTTTGAAGAAGCAGAGAAAAATGTTCAAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTATATCTGACAGAGCTCATATTGT ATTTGATTTTCATCAAGCAGCTGATGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTTGGGTACAACAAAAAAGGGCAT TGGCCCAGTTTATTCGTCCAAAGCTGCTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGATGGCTTCTCTGAGAGGTTTAA AGTTCTAGCTAACCAATACAAATCTATATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAAACTCAAGGGTTATATGGAAAA GATTAAACCAATGGTGAGAGATGGAGTTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAATCTTGGTAGAAGGTGCAAATGC AGCACTATTAGATATTGATTTTGGGACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGTTTGTACTGGTTTGGGTATGCC ACCTCAAAATGTTGGAGAAGTGTATGGAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTTTCCTACAGAGCAAGACAATGA AATTGGAGAATTATTACAAACAAGGGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGGCTGGTTGGACCTCGTTTTGCT CAAATATGCTCATATGATCAATGGATTTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTTTACGGAAATCAAAGTTGGAGT TGCTTACAAGTTAGATGGTGAAATCATACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGAAGTTCAATATAAGACTCTCCC AGGATGGAACACAGACATATCAAATGCAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGTTCGATTTATTGAAGATGAGCT >In-frame_AKT3_ENST00000263826_chr1_244006427_-_ADSS_ENST00000366535_chr1_244601070_-_1234nt ATGAGCGATGTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGGGAGGAAATAATGCTGGCCATACAGTTGTTGTGGATTCTGTGGA ATATGATTTTCATCTCTTACCCAGTGGAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGTGGTAATTCATCTACCTGGATT GTTTGAAGAAGCAGAGAAAAATGTTCAAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTATATCTGACAGAGCTCATATTGT ATTTGATTTTCATCAAGCAGCTGATGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTTGGGTACAACAAAAAAGGGCAT TGGCCCAGTTTATTCGTCCAAAGCTGCTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGATGGCTTCTCTGAGAGGTTTAA AGTTCTAGCTAACCAATACAAATCTATATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAAACTCAAGGGTTATATGGAAAA GATTAAACCAATGGTGAGAGATGGAGTTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAATCTTGGTAGAAGGTGCAAATGC AGCACTATTAGATATTGATTTTGGGACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGTTTGTACTGGTTTGGGTATGCC ACCTCAAAATGTTGGAGAAGTGTATGGAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTTTCCTACAGAGCAAGACAATGA AATTGGAGAATTATTACAAACAAGGGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGGCTGGTTGGACCTCGTTTTGCT CAAATATGCTCATATGATCAATGGATTTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTTTACGGAAATCAAAGTTGGAGT TGCTTACAAGTTAGATGGTGAAATCATACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGAAGTTCAATATAAGACTCTCCC AGGATGGAACACAGACATATCAAATGCAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGTTCGATTTATTGAAGATGAGCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_AKT3_ENST00000336199_chr1_244006427_-_ADSS_ENST00000366535_chr1_244601070_-_2392nt CCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAA GAAGGTTGGGTTCAGAAGAGGGGGAGGAAATAATGCTGGCCATACAGTTGTTGTGGATTCTGTGGAATATGATTTTCATCTCTTACCCAG TGGAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGTGGTAATTCATCTACCTGGATTGTTTGAAGAAGCAGAGAAAAATGT TCAAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTATATCTGACAGAGCTCATATTGTATTTGATTTTCATCAAGCAGCTGA TGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTTGGGTACAACAAAAAAGGGCATTGGCCCAGTTTATTCGTCCAAAGC TGCTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGATGGCTTCTCTGAGAGGTTTAAAGTTCTAGCTAACCAATACAAATC TATATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAAACTCAAGGGTTATATGGAAAAGATTAAACCAATGGTGAGAGATGG AGTTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAATCTTGGTAGAAGGTGCAAATGCAGCACTATTAGATATTGATTTTGG GACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGTTTGTACTGGTTTGGGTATGCCACCTCAAAATGTTGGAGAAGTGTA TGGAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTTTCCTACAGAGCAAGACAATGAAATTGGAGAATTATTACAAACAAG GGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGGCTGGTTGGACCTCGTTTTGCTCAAATATGCTCATATGATCAATGG ATTTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTTTACGGAAATCAAAGTTGGAGTTGCTTACAAGTTAGATGGTGAAAT CATACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGAAGTTCAATATAAGACTCTCCCAGGATGGAACACAGACATATCAAA TGCAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGTTCGATTTATTGAAGATGAGCTTCAAATTCCAGTTAAGTGGATTGG TGTTGGTAAATCCAGAGAATCTATGATTCAACTCTTTTAATGATTGCCAGTAATGCAAGAAACACTCCTTGAGAGGGAGGGGAAAAGACT TTCTTAAATATTTCATTTATGACCTGCAAATTCAAGAATAAAGACACTGAAGTAAGTTTGAAGCCCTACAGTTGTTTCCAGTCTTTTCAG ATGGATGCCTACTGTGGAGATTAACTTTGGCATATTCCAGTGTCAGCTTTCTTTAGCTGGAATTGCCAAATCATTTGTTGCTCCTGCTGC TCTCATGGTGCCACGTTTTTTTTTTCAATGTTTAGTAATAGTATAATCCATGTTGTTTGATATCAAAAGTAGAATTACTTTTAATGTAGT TTTTCTTCATTATTGTCATTGCGTGTTCTTAAGTTTTACCCCTATTAGATGGTAAGAACAATTAATGCAGTTTTGCACAAATATTTTTAC ATTCTGATCATTCAGTTCTGTCATTGTAATCTTTGTTGTTAGAAACAAATGATGAAAACATAGGGGTTCTGTAAACTTTTGTAATGCTAT GAATTCTGTTTAAATTTTGGGCTGTCTATTTTCTGCTGAAACCATGCAAAATTGAGCTTTGGTGGGGCTGGGAGGGGGTTATGTATTCAT GGGACCTTTAATTTGTACAGAACACAGAACTTATTTCTGTCAGTTATTTAATACATTGAAAATTTAGTGAAATGTTCAAAGAGAATAGAT GTTTCCCAAAACAACAATCTTTATGTTAAAAATAGTCATTAAAAGATCTGTTGTAATATATGGTGGATATTTTTCTTTAATTTCAAACAT TACCTCTGAAATGTGTATCTTTTCTTTTTTATCTTACCATTAATTTTAAATCTAGTGGATTGGTTTTCAACATCGTGCCTGCCGATATGC CTACAGAATCATCTGTAAGTGTCAAAATGAACCCACGTTGTTAGCCATAATTTTGATTATGCCTTTATTTCTCCTTTCTTGAAAAAAAAA AGGTGTTATTTTGACAATTAGGCATAACATTGTTTTGTAGATTATCTTTTAATGAACTATTTTAAATGTTAAATTAGGTGCCACTTAAAT >In-frame_AKT3_ENST00000366539_chr1_244006427_-_ADSS_ENST00000366535_chr1_244601070_-_2527nt CCCTCTCCTCCCCCCGCCCCCCCCCGGCTCCATCCTCCGCCGCCGCCCGAGCAGCTGCGGGGCCGCCACCGCCGCCGCCGCCGTTGCAGG CTGAGTCATCACTAGAGAGTGGGAAGGGCAGCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTG GGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGGGAGGAAATAATGCTGGCCATAC AGTTGTTGTGGATTCTGTGGAATATGATTTTCATCTCTTACCCAGTGGAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGT GGTAATTCATCTACCTGGATTGTTTGAAGAAGCAGAGAAAAATGTTCAAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTAT ATCTGACAGAGCTCATATTGTATTTGATTTTCATCAAGCAGCTGATGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTT GGGTACAACAAAAAAGGGCATTGGCCCAGTTTATTCGTCCAAAGCTGCTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGA TGGCTTCTCTGAGAGGTTTAAAGTTCTAGCTAACCAATACAAATCTATATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAA ACTCAAGGGTTATATGGAAAAGATTAAACCAATGGTGAGAGATGGAGTTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAAT CTTGGTAGAAGGTGCAAATGCAGCACTATTAGATATTGATTTTGGGACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGT TTGTACTGGTTTGGGTATGCCACCTCAAAATGTTGGAGAAGTGTATGGAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTT TCCTACAGAGCAAGACAATGAAATTGGAGAATTATTACAAACAAGGGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGG CTGGTTGGACCTCGTTTTGCTCAAATATGCTCATATGATCAATGGATTTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTT TACGGAAATCAAAGTTGGAGTTGCTTACAAGTTAGATGGTGAAATCATACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGA AGTTCAATATAAGACTCTCCCAGGATGGAACACAGACATATCAAATGCAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGT TCGATTTATTGAAGATGAGCTTCAAATTCCAGTTAAGTGGATTGGTGTTGGTAAATCCAGAGAATCTATGATTCAACTCTTTTAATGATT GCCAGTAATGCAAGAAACACTCCTTGAGAGGGAGGGGAAAAGACTTTCTTAAATATTTCATTTATGACCTGCAAATTCAAGAATAAAGAC ACTGAAGTAAGTTTGAAGCCCTACAGTTGTTTCCAGTCTTTTCAGATGGATGCCTACTGTGGAGATTAACTTTGGCATATTCCAGTGTCA GCTTTCTTTAGCTGGAATTGCCAAATCATTTGTTGCTCCTGCTGCTCTCATGGTGCCACGTTTTTTTTTTCAATGTTTAGTAATAGTATA ATCCATGTTGTTTGATATCAAAAGTAGAATTACTTTTAATGTAGTTTTTCTTCATTATTGTCATTGCGTGTTCTTAAGTTTTACCCCTAT TAGATGGTAAGAACAATTAATGCAGTTTTGCACAAATATTTTTACATTCTGATCATTCAGTTCTGTCATTGTAATCTTTGTTGTTAGAAA CAAATGATGAAAACATAGGGGTTCTGTAAACTTTTGTAATGCTATGAATTCTGTTTAAATTTTGGGCTGTCTATTTTCTGCTGAAACCAT GCAAAATTGAGCTTTGGTGGGGCTGGGAGGGGGTTATGTATTCATGGGACCTTTAATTTGTACAGAACACAGAACTTATTTCTGTCAGTT ATTTAATACATTGAAAATTTAGTGAAATGTTCAAAGAGAATAGATGTTTCCCAAAACAACAATCTTTATGTTAAAAATAGTCATTAAAAG ATCTGTTGTAATATATGGTGGATATTTTTCTTTAATTTCAAACATTACCTCTGAAATGTGTATCTTTTCTTTTTTATCTTACCATTAATT TTAAATCTAGTGGATTGGTTTTCAACATCGTGCCTGCCGATATGCCTACAGAATCATCTGTAAGTGTCAAAATGAACCCACGTTGTTAGC CATAATTTTGATTATGCCTTTATTTCTCCTTTCTTGAAAAAAAAAAGGTGTTATTTTGACAATTAGGCATAACATTGTTTTGTAGATTAT CTTTTAATGAACTATTTTAAATGTTAAATTAGGTGCCACTTAAATTTATTTTATTACACCATGAATAGCTGATTAAAAGAACCAAATATT >In-frame_AKT3_ENST00000263826_chr1_244006427_-_ADSS_ENST00000366535_chr1_244601070_-_2407nt GCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGAT GTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGGGAGGAAATAATGCTGGCCATACAGTTGTTGTGGATTCTGTGGAATATGATTT TCATCTCTTACCCAGTGGAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGTGGTAATTCATCTACCTGGATTGTTTGAAGA AGCAGAGAAAAATGTTCAAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTATATCTGACAGAGCTCATATTGTATTTGATTT TCATCAAGCAGCTGATGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTTGGGTACAACAAAAAAGGGCATTGGCCCAGT TTATTCGTCCAAAGCTGCTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGATGGCTTCTCTGAGAGGTTTAAAGTTCTAGC TAACCAATACAAATCTATATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAAACTCAAGGGTTATATGGAAAAGATTAAACC AATGGTGAGAGATGGAGTTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAATCTTGGTAGAAGGTGCAAATGCAGCACTATT AGATATTGATTTTGGGACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGTTTGTACTGGTTTGGGTATGCCACCTCAAAA TGTTGGAGAAGTGTATGGAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTTTCCTACAGAGCAAGACAATGAAATTGGAGA ATTATTACAAACAAGGGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGGCTGGTTGGACCTCGTTTTGCTCAAATATGC TCATATGATCAATGGATTTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTTTACGGAAATCAAAGTTGGAGTTGCTTACAA GTTAGATGGTGAAATCATACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGAAGTTCAATATAAGACTCTCCCAGGATGGAA CACAGACATATCAAATGCAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGTTCGATTTATTGAAGATGAGCTTCAAATTCC AGTTAAGTGGATTGGTGTTGGTAAATCCAGAGAATCTATGATTCAACTCTTTTAATGATTGCCAGTAATGCAAGAAACACTCCTTGAGAG GGAGGGGAAAAGACTTTCTTAAATATTTCATTTATGACCTGCAAATTCAAGAATAAAGACACTGAAGTAAGTTTGAAGCCCTACAGTTGT TTCCAGTCTTTTCAGATGGATGCCTACTGTGGAGATTAACTTTGGCATATTCCAGTGTCAGCTTTCTTTAGCTGGAATTGCCAAATCATT TGTTGCTCCTGCTGCTCTCATGGTGCCACGTTTTTTTTTTCAATGTTTAGTAATAGTATAATCCATGTTGTTTGATATCAAAAGTAGAAT TACTTTTAATGTAGTTTTTCTTCATTATTGTCATTGCGTGTTCTTAAGTTTTACCCCTATTAGATGGTAAGAACAATTAATGCAGTTTTG CACAAATATTTTTACATTCTGATCATTCAGTTCTGTCATTGTAATCTTTGTTGTTAGAAACAAATGATGAAAACATAGGGGTTCTGTAAA CTTTTGTAATGCTATGAATTCTGTTTAAATTTTGGGCTGTCTATTTTCTGCTGAAACCATGCAAAATTGAGCTTTGGTGGGGCTGGGAGG GGGTTATGTATTCATGGGACCTTTAATTTGTACAGAACACAGAACTTATTTCTGTCAGTTATTTAATACATTGAAAATTTAGTGAAATGT TCAAAGAGAATAGATGTTTCCCAAAACAACAATCTTTATGTTAAAAATAGTCATTAAAAGATCTGTTGTAATATATGGTGGATATTTTTC TTTAATTTCAAACATTACCTCTGAAATGTGTATCTTTTCTTTTTTATCTTACCATTAATTTTAAATCTAGTGGATTGGTTTTCAACATCG TGCCTGCCGATATGCCTACAGAATCATCTGTAAGTGTCAAAATGAACCCACGTTGTTAGCCATAATTTTGATTATGCCTTTATTTCTCCT TTCTTGAAAAAAAAAAGGTGTTATTTTGACAATTAGGCATAACATTGTTTTGTAGATTATCTTTTAATGAACTATTTTAAATGTTAAATT |
Top |
FusionGenePPI for AKT3_ADSS |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| AKT3 | TCL1A, PRKCZ, NEDD4, TTC3, NEDD4L, GSK3B, PLEKHO1, EIF4EBP1, RPE, CASP3, AKT1, HSP90AB4P, HSP90AB3P, HSP90AA4P, HSP90AA5P, PIANP, HSP90AB1, FKBP5, HSP90AA1, CDC37, SNX8, TOX2, PRMT6, PPP2CA | ADSS | ATG10, CUL3, RNH1, SGTA, SMYD1, ANXA6, CBX3, CHMP4A, CHRAC1, DCK, GSR, IDH1, MAPK14, OXCT1, THOP1, FDPS, HSPE1, KYNU, PDIA3, PTMS, RBBP7, TALDO1, WDR1, AASDHPPT, CTBP1, OAT, AGL, ARFIP1, C6orf211, GART, GNPNAT1, HSD17B10, IMPA2, NME1-NME2, NME2, PCBD1, PFKL, RPE, TANGO2, UMPS, ADSSL1, NPB, LGALS7, TRIM25, YAP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for AKT3_ADSS |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for AKT3_ADSS |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | AKT3 | C4014738 | MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2 | 3 | UNIPROT |
| Hgene | AKT3 | C1863924 | Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome | 1 | CTD_human |
| Hgene | AKT3 | C1955869 | Malformations of Cortical Development | 1 | CTD_human |
| Tgene | ADSS | C0036341 | Schizophrenia | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|