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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14104

FusionGeneSummary for FUT8_AGBL4

check button Fusion gene summary
Fusion gene informationFusion gene name: FUT8_AGBL4
Fusion gene ID: 14104
HgeneTgene
Gene symbol

FUT8

AGBL4

Gene ID

2530

84871

Gene namefucosyltransferase 8ATP/GTP binding protein like 4
Synonyms-CCP6
Cytomap

14q23.3

1p33

Type of geneprotein-codingprotein-coding
Descriptionalpha-(1,6)-fucosyltransferaseGDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferaseGDP-fucose--glycoprotein fucosyltransferasealpha1-6FucTfucosyltransferase 8 (alpha (1,6) fucosyltransferase)glycoprotein 6-alpha-L-fucosyltransferasecytosolic carboxypeptidase 6
Modification date2018052320180403
UniProtAcc

Q9BYC5

Q5VU57

Ensembl transtripts involved in fusion geneENST00000360689, ENST00000394586, 
ENST00000557164, ENST00000394585, 
ENST00000358307, ENST00000417683, 
ENST00000554765, 		ENST00000371839, 
ENST00000371838, ENST00000371836, 
ENST00000334103, ENST00000497451, 
Fusion gene scores* DoF score4 X 5 X 4=8012 X 10 X 7=840
# samples 412
** MAII scorelog2(4/80*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/840*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FUT8 [Title/Abstract] AND AGBL4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFUT8

GO:0018279

protein N-linked glycosylation via asparagine

17172260

HgeneFUT8

GO:0046368

GDP-L-fucose metabolic process

17172260


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-C8-A26Z-01AFUT8chr14

65879932

+AGBL4chr1

49711536

-
TCGALDBRCATCGA-C8-A26Z-01AFUT8chr14

65878711

+AGBL4chr1

49711536

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000360689ENST00000371839FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-3CDSENST00000360689ENST00000371838FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-3CDSENST00000360689ENST00000371836FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-intronENST00000360689ENST00000334103FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-intronENST00000360689ENST00000497451FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-3CDSENST00000394586ENST00000371839FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-3CDSENST00000394586ENST00000371838FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-3CDSENST00000394586ENST00000371836FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-intronENST00000394586ENST00000334103FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-intronENST00000394586ENST00000497451FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-3CDSENST00000557164ENST00000371839FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-3CDSENST00000557164ENST00000371838FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-3CDSENST00000557164ENST00000371836FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-intronENST00000557164ENST00000334103FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-intronENST00000557164ENST00000497451FUT8chr14

65879932

+AGBL4chr1

49711536

-
5UTR-3CDSENST00000394585ENST00000371839FUT8chr14

65879932

+AGBL4chr1

49711536

-
5UTR-3CDSENST00000394585ENST00000371838FUT8chr14

65879932

+AGBL4chr1

49711536

-
5UTR-3CDSENST00000394585ENST00000371836FUT8chr14

65879932

+AGBL4chr1

49711536

-
5UTR-intronENST00000394585ENST00000334103FUT8chr14

65879932

+AGBL4chr1

49711536

-
5UTR-intronENST00000394585ENST00000497451FUT8chr14

65879932

+AGBL4chr1

49711536

-
5UTR-3CDSENST00000358307ENST00000371839FUT8chr14

65879932

+AGBL4chr1

49711536

-
5UTR-3CDSENST00000358307ENST00000371838FUT8chr14

65879932

+AGBL4chr1

49711536

-
5UTR-3CDSENST00000358307ENST00000371836FUT8chr14

65879932

+AGBL4chr1

49711536

-
5UTR-intronENST00000358307ENST00000334103FUT8chr14

65879932

+AGBL4chr1

49711536

-
5UTR-intronENST00000358307ENST00000497451FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-3CDSENST00000417683ENST00000371839FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-3CDSENST00000417683ENST00000371838FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-3CDSENST00000417683ENST00000371836FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-intronENST00000417683ENST00000334103FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-intronENST00000417683ENST00000497451FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-3CDSENST00000554765ENST00000371839FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-3CDSENST00000554765ENST00000371838FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-3CDSENST00000554765ENST00000371836FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-intronENST00000554765ENST00000334103FUT8chr14

65879932

+AGBL4chr1

49711536

-
intron-intronENST00000554765ENST00000497451FUT8chr14

65879932

+AGBL4chr1

49711536

-
5UTR-3CDSENST00000360689ENST00000371839FUT8chr14

65878711

+AGBL4chr1

49711536

-
5UTR-3CDSENST00000360689ENST00000371838FUT8chr14

65878711

+AGBL4chr1

49711536

-
5UTR-3CDSENST00000360689ENST00000371836FUT8chr14

65878711

+AGBL4chr1

49711536

-
5UTR-intronENST00000360689ENST00000334103FUT8chr14

65878711

+AGBL4chr1

49711536

-
5UTR-intronENST00000360689ENST00000497451FUT8chr14

65878711

+AGBL4chr1

49711536

-
5UTR-3CDSENST00000394586ENST00000371839FUT8chr14

65878711

+AGBL4chr1

49711536

-
5UTR-3CDSENST00000394586ENST00000371838FUT8chr14

65878711

+AGBL4chr1

49711536

-
5UTR-3CDSENST00000394586ENST00000371836FUT8chr14

65878711

+AGBL4chr1

49711536

-
5UTR-intronENST00000394586ENST00000334103FUT8chr14

65878711

+AGBL4chr1

49711536

-
5UTR-intronENST00000394586ENST00000497451FUT8chr14

65878711

+AGBL4chr1

49711536

-
5UTR-3CDSENST00000557164ENST00000371839FUT8chr14

65878711

+AGBL4chr1

49711536

-
5UTR-3CDSENST00000557164ENST00000371838FUT8chr14

65878711

+AGBL4chr1

49711536

-
5UTR-3CDSENST00000557164ENST00000371836FUT8chr14

65878711

+AGBL4chr1

49711536

-
5UTR-intronENST00000557164ENST00000334103FUT8chr14

65878711

+AGBL4chr1

49711536

-
5UTR-intronENST00000557164ENST00000497451FUT8chr14

65878711

+AGBL4chr1

49711536

-
intron-3CDSENST00000394585ENST00000371839FUT8chr14

65878711

+AGBL4chr1

49711536

-
intron-3CDSENST00000394585ENST00000371838FUT8chr14

65878711

+AGBL4chr1

49711536

-
intron-3CDSENST00000394585ENST00000371836FUT8chr14

65878711

+AGBL4chr1

49711536

-
intron-intronENST00000394585ENST00000334103FUT8chr14

65878711

+AGBL4chr1

49711536

-
intron-intronENST00000394585ENST00000497451FUT8chr14

65878711

+AGBL4chr1

49711536

-
intron-3CDSENST00000358307ENST00000371839FUT8chr14

65878711

+AGBL4chr1

49711536

-
intron-3CDSENST00000358307ENST00000371838FUT8chr14

65878711

+AGBL4chr1

49711536

-
intron-3CDSENST00000358307ENST00000371836FUT8chr14

65878711

+AGBL4chr1

49711536

-
intron-intronENST00000358307ENST00000334103FUT8chr14

65878711

+AGBL4chr1

49711536

-
intron-intronENST00000358307ENST00000497451FUT8chr14

65878711

+AGBL4chr1

49711536

-
intron-3CDSENST00000417683ENST00000371839FUT8chr14

65878711

+AGBL4chr1

49711536

-
intron-3CDSENST00000417683ENST00000371838FUT8chr14

65878711

+AGBL4chr1

49711536

-
intron-3CDSENST00000417683ENST00000371836FUT8chr14

65878711

+AGBL4chr1

49711536

-
intron-intronENST00000417683ENST00000334103FUT8chr14

65878711

+AGBL4chr1

49711536

-
intron-intronENST00000417683ENST00000497451FUT8chr14

65878711

+AGBL4chr1

49711536

-
intron-3CDSENST00000554765ENST00000371839FUT8chr14

65878711

+AGBL4chr1

49711536

-
intron-3CDSENST00000554765ENST00000371838FUT8chr14

65878711

+AGBL4chr1

49711536

-
intron-3CDSENST00000554765ENST00000371836FUT8chr14

65878711

+AGBL4chr1

49711536

-
intron-intronENST00000554765ENST00000334103FUT8chr14

65878711

+AGBL4chr1

49711536

-
intron-intronENST00000554765ENST00000497451FUT8chr14

65878711

+AGBL4chr1

49711536

-

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FusionProtFeatures for FUT8_AGBL4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FUT8

Q9BYC5

AGBL4

Q5VU57

Catalyzes the addition of fucose in alpha 1-6 linkage tothe first GlcNAc residue, next to the peptide chains in N-glycans.{ECO:0000269|PubMed:17172260, ECO:0000269|PubMed:9133635}. Metallocarboxypeptidase that mediates deglutamylation oftarget proteins. Catalyzes the deglutamylation of polyglutamateside chains generated by post-translational polyglutamylation inproteins such as tubulins. Also removes polyglutamates from thecarboxy-terminus of target proteins such as MYLK. Mediatesdeglutamylation of CGAS, regulating the antiviral activity ofCGAS. Acts as a long-chain deglutamylase and specifically shortenslong polyglutamate chains, while it is not able to remove thebranching point glutamate, a process catalyzed by AGBL5/CCP5.{ECO:0000250|UniProtKB:Q09LZ8}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FUT8_AGBL4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FUT8_AGBL4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FUT8ACIN1, SLC25A17, RPL27, DHX15, CEACAM21, B3GALNT1, STX18, SLC39A4, CD200R1, FGL2, HTR3C, PLVAP, CHRNA9, OLFM4, TMEM258, SLC9A6, TMEM30B, MAN2A2, GABRD, MPPE1, STS, MAN2A1, PLTP, MGAT1, ICAM3, ITGAV, HTR3A, CSGALNACT2AGBL4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FUT8_AGBL4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FUT8_AGBL4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFUT8C0036341Schizophrenia2PSYGENET
HgeneFUT8C0809983Schizophrenia and related disorders1PSYGENET
TgeneAGBL4C0236969Substance-Related Disorders1CTD_human