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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14089

FusionGeneSummary for FUS_PRSS36

check button Fusion gene summary
Fusion gene informationFusion gene name: FUS_PRSS36
Fusion gene ID: 14089
HgeneTgene
Gene symbol

FUS

PRSS36

Gene ID

2521

146547

Gene nameFUS RNA binding proteinserine protease 36
SynonymsALS6|ETM4|FUS1|HNRNPP2|POMP75|TLS-
Cytomap

16p11.2

16p11.2

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein FUS75 kDa DNA-pairing proteinFUS/ERG chimeric proteinFUS/ERG fusion proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in lippolyserase-2polyserine protease-2protease, serine 36
Modification date2018052720180523
UniProtAcc

P35637

Q5K4E3

Ensembl transtripts involved in fusion geneENST00000254108, ENST00000380244, 
ENST00000568685, ENST00000474990, 
ENST00000268281, ENST00000418068, 
ENST00000569305, 
Fusion gene scores* DoF score21 X 23 X 7=33811 X 1 X 1=1
# samples 271
** MAII scorelog2(27/3381*10)=-3.64641870384255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: FUS [Title/Abstract] AND PRSS36 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CV-6941-01AFUSchr16

31195717

+PRSS36chr16

31161052

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000254108ENST00000268281FUSchr16

31195717

+PRSS36chr16

31161052

-
In-frameENST00000254108ENST00000418068FUSchr16

31195717

+PRSS36chr16

31161052

-
In-frameENST00000254108ENST00000569305FUSchr16

31195717

+PRSS36chr16

31161052

-
In-frameENST00000380244ENST00000268281FUSchr16

31195717

+PRSS36chr16

31161052

-
In-frameENST00000380244ENST00000418068FUSchr16

31195717

+PRSS36chr16

31161052

-
In-frameENST00000380244ENST00000569305FUSchr16

31195717

+PRSS36chr16

31161052

-
In-frameENST00000568685ENST00000268281FUSchr16

31195717

+PRSS36chr16

31161052

-
In-frameENST00000568685ENST00000418068FUSchr16

31195717

+PRSS36chr16

31161052

-
In-frameENST00000568685ENST00000569305FUSchr16

31195717

+PRSS36chr16

31161052

-
intron-3CDSENST00000474990ENST00000268281FUSchr16

31195717

+PRSS36chr16

31161052

-
intron-3CDSENST00000474990ENST00000418068FUSchr16

31195717

+PRSS36chr16

31161052

-
intron-3CDSENST00000474990ENST00000569305FUSchr16

31195717

+PRSS36chr16

31161052

-

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FusionProtFeatures for FUS_PRSS36


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FUS

P35637

PRSS36

Q5K4E3

Binds both single-stranded and double-stranded DNA andpromotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-strandedDNA. May play a role in maintenance of genomic integrity. Serine protease. Hydrolyzes the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent,N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has apreference for substrates with an Arg instead of a Lys residue inposition P1.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFUSchr16:31195717chr16:31161052ENST00000254108+5151_165174527Compositional biasNote=Gln/Gly/Ser/Tyr-rich
HgeneFUSchr16:31195717chr16:31161052ENST00000380244+5151_165173526Compositional biasNote=Gln/Gly/Ser/Tyr-rich
TgenePRSS36chr16:31195717chr16:31161052ENST00000268281-015323_55512856DomainPeptidase S1 2
TgenePRSS36chr16:31195717chr16:31161052ENST00000268281-01547_29112856DomainPeptidase S1 1
TgenePRSS36chr16:31195717chr16:31161052ENST00000268281-015590_80812856DomainPeptidase S1 3
TgenePRSS36chr16:31195717chr16:31161052ENST00000418068-014323_55512753DomainPeptidase S1 2
TgenePRSS36chr16:31195717chr16:31161052ENST00000418068-01447_29112753DomainPeptidase S1 1
TgenePRSS36chr16:31195717chr16:31161052ENST00000418068-014590_80812753DomainPeptidase S1 3
TgenePRSS36chr16:31195717chr16:31161052ENST00000569305-015323_55512851DomainPeptidase S1 2
TgenePRSS36chr16:31195717chr16:31161052ENST00000569305-01547_29112851DomainPeptidase S1 1
TgenePRSS36chr16:31195717chr16:31161052ENST00000569305-015590_80812851DomainPeptidase S1 3

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFUSchr16:31195717chr16:31161052ENST00000254108+515166_267174527Compositional biasNote=Gly-rich
HgeneFUSchr16:31195717chr16:31161052ENST00000254108+515371_526174527Compositional biasNote=Arg/Gly-rich
HgeneFUSchr16:31195717chr16:31161052ENST00000380244+515166_267173526Compositional biasNote=Gly-rich
HgeneFUSchr16:31195717chr16:31161052ENST00000380244+515371_526173526Compositional biasNote=Arg/Gly-rich
HgeneFUSchr16:31195717chr16:31161052ENST00000254108+515285_371174527DomainRRM
HgeneFUSchr16:31195717chr16:31161052ENST00000380244+515285_371173526DomainRRM
HgeneFUSchr16:31195717chr16:31161052ENST00000254108+515422_453174527Zinc fingerRanBP2-type
HgeneFUSchr16:31195717chr16:31161052ENST00000380244+515422_453173526Zinc fingerRanBP2-type


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FusionGeneSequence for FUS_PRSS36


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FUS_PRSS36


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FUSEIF6, USF2, PRMT1, PTBP2, SRRM1, SPI1, YBX1, ILF3, SF1, SRSF10, THRA, RXRA, RELA, OTUB1, ZMYM2, SARNP, TARDBP, DGCR8, PCM1, SF3A2, SIRT7, SQSTM1, TDRD3, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, ARHGEF28, PA2G4, UBE2I, ATXN1L, GRB2, PIK3R2, HNRNPA3, NONO, EEF1A1, DYNC1H1, GSE1, MBD3, MRPS18B, SAP30BP, RPLP1, ESR1, FN1, VCAM1, TP63, IL7R, UBL4A, ITGA4, CTNNB1, UPF1, LMNA, EWSR1, RBMX, PSMB7, ESRRA, MDH1, TAF15, SRSF9, SAFB2, TNIP1, KHDRBS3, NKD2, MAX, PARK2, SUV39H1, WBP4, HNRNPU, LARS, RPA3, RPA2, RPA1, WWOX, HSPA5, VCP, SFPQ, YWHAZ, YWHAQ, PFN1, FASN, PGK1, CKB, ENO1, LDHB, PAICS, PHGDH, LDHA, GAPDH, PKM, ATXN2L, MTHFD1, ACACA, CA2, ALDOA, GPI, PYCRL, PFKL, PGM1, ABCA1, HPRT1, PM20D2, TKT, UBA1, PSMD12, CDH4, ANXA2P2, GNAS, PLCE1, TRPM4, SLC1A5, UBAP2, UBAP2L, LYZ, CKAP4, YPEL1, HIST4H4, H3F3A, H3F3B, HIST2H2BE, DDX42, HNRNPD, SYNCRIP, DHX40, SF3A1, SF3B3, SF3B4, SERBP1, FANCM, RAD54B, PCNA, PHB, TP73, RPL18, RPL9, RPS9, TBPL1, TRIP4, DNAJC10, SAE1, DLD, GOT2, ATP5A1, GSTP1, HARS2, SLC25A3, KPNA2, RAB7A, SPATA6, UACA, STATH, ANXA5, MAP3K3, UBC, TUBB, CFL1, TUBA1A, ACTB, HNRNPF, HNRNPH1, DHX15, CPSF6, SF3A3, HNRNPK, PSPC1, HNRNPL, RPS5, RPS8, RPL12, RPN2, EEF2, EEF1G, HSP90AA1, CCT5, CCT6A, HSP90AB1, CCT2, CCT4, HSP90B1, CCT3, CCT7, CCT8, HSPA8, PPIL4, TCP1, PDIA3, PPIA, SSBP1, GLUD1, ATP5B, HSPA9, ERAL1, TUFM, HSPD1, PYCR1, MDH2, ABCF2, KPNB1, PRDX1, ERP44, F7, ALB, ARMC6, ADCK5, CCDC88A, GPR101, ITK, DGKA, SLC22A11, HERC6, TUBA1B, MTSS1L, CEP112, COL18A1, SEC13, NAP1L1, SNRPD2, NCAPG2, RBBP4, FLJ22447, LSM12, NUDT21, DDX1, C14orf166, DDX5, HIVEP3, NCOA6, RAVER1, TCEB1, TXNL4B, TTI2, GEN1, RPL14, RPS14, NPM1, RPL11, RPL4, EIF4A1, PCBP2, ST13, NSDHL, MTAP, MAT2A, AHCY, OAT, BCS1L, SLC25A5, TIMM50, MYH10, GOLIM4, CSE1L, RAN, KLHL40, KLHL5, IGKV1-5, C6, GIMAP8, CDC5L, CEP78, DBF4B, AMOT, FAM71F1, MFGE8, FAM98A, C11orf70, RTCB, UFL1, LRRIQ4, NUPR1, CUL7, OBSL1, EZH2, SUZ12, BMI1, ABL1, CHEK1, SIK2, SRPK1, LUZP4, UPF2, UPF3A, FAM58A, YEATS4, RPS6KB2, HNRNPA1, FBXW11, ACAT1, ARMC1, C2orf49, DDX17, DNAJC7, EIF4H, AURKA, PTBP1, TOMM34, TXLNA, UFD1L, HNRNPDL, MEF2D, NAA50, NPLOC4, PFKP, PICALM, TARS, NTRK1, SCARNA22, TCF7L2, KIF22, EMC2, MATR3, MCM2, SNW1, RC3H1, EGFR, TRAF6, CRBN, KCTD6, RPS27, PSRC1, SMCO3, CYLD, TRIM25, BRCA1, HDAC6PRSS36


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FUS_PRSS36


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FUS_PRSS36


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFUSC1842675AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)6UNIPROT
HgeneFUSC0206634Liposarcoma, Myxoid2CTD_human;ORPHANET
HgeneFUSC3539195TREMOR, HEREDITARY ESSENTIAL, 41UNIPROT