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Fusion gene ID: 14085 |
FusionGeneSummary for FUS_MAEA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FUS_MAEA | Fusion gene ID: 14085 | Hgene | Tgene | Gene symbol | FUS | MAEA | Gene ID | 2521 | 10296 |
| Gene name | FUS RNA binding protein | macrophage erythroblast attacher | |
| Synonyms | ALS6|ETM4|FUS1|HNRNPP2|POMP75|TLS | EMLP|EMP|GID9|HLC-10|PIG5 | |
| Cytomap | 16p11.2 | 4p16.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA-binding protein FUS75 kDa DNA-pairing proteinFUS/ERG chimeric proteinFUS/ERG fusion proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in lip | macrophage erythroblast attacherGID complex subunit 9, FYV10 homologcell proliferation-inducing gene 5 proteinerythroblast macrophage proteinhuman lung cancer oncogene 10 proteinlung cancer-related protein 10 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P35637 | Q7L5Y9 | |
| Ensembl transtripts involved in fusion gene | ENST00000254108, ENST00000380244, ENST00000568685, ENST00000474990, | ENST00000303400, ENST00000505177, ENST00000264750, ENST00000452175, ENST00000514708, ENST00000510794, ENST00000505839, ENST00000512289, | |
| Fusion gene scores | * DoF score | 21 X 23 X 7=3381 | 2 X 4 X 1=8 |
| # samples | 27 | 4 | |
| ** MAII score | log2(27/3381*10)=-3.64641870384255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/8*10)=2.32192809488736 | |
| Context | PubMed: FUS [Title/Abstract] AND MAEA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MAEA | GO:0007155 | cell adhesion | 9763581 |
| Tgene | MAEA | GO:0033033 | negative regulation of myeloid cell apoptotic process | 9763581 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CX872911 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000254108 | ENST00000303400 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| In-frame | ENST00000254108 | ENST00000505177 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| In-frame | ENST00000254108 | ENST00000264750 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| In-frame | ENST00000254108 | ENST00000452175 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| Frame-shift | ENST00000254108 | ENST00000514708 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| In-frame | ENST00000254108 | ENST00000510794 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| In-frame | ENST00000254108 | ENST00000505839 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| 5CDS-3UTR | ENST00000254108 | ENST00000512289 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| In-frame | ENST00000380244 | ENST00000303400 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| In-frame | ENST00000380244 | ENST00000505177 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| In-frame | ENST00000380244 | ENST00000264750 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| In-frame | ENST00000380244 | ENST00000452175 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| Frame-shift | ENST00000380244 | ENST00000514708 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| In-frame | ENST00000380244 | ENST00000510794 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| In-frame | ENST00000380244 | ENST00000505839 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| 5CDS-3UTR | ENST00000380244 | ENST00000512289 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| In-frame | ENST00000568685 | ENST00000303400 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| In-frame | ENST00000568685 | ENST00000505177 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| In-frame | ENST00000568685 | ENST00000264750 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| In-frame | ENST00000568685 | ENST00000452175 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| Frame-shift | ENST00000568685 | ENST00000514708 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| In-frame | ENST00000568685 | ENST00000510794 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| In-frame | ENST00000568685 | ENST00000505839 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| 5CDS-3UTR | ENST00000568685 | ENST00000512289 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| intron-3CDS | ENST00000474990 | ENST00000303400 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| intron-3CDS | ENST00000474990 | ENST00000505177 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| intron-3CDS | ENST00000474990 | ENST00000264750 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| intron-3CDS | ENST00000474990 | ENST00000452175 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| intron-3CDS | ENST00000474990 | ENST00000514708 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| intron-3CDS | ENST00000474990 | ENST00000510794 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| intron-3CDS | ENST00000474990 | ENST00000505839 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
| intron-3UTR | ENST00000474990 | ENST00000512289 | FUS | chr16 | 31196500 | + | MAEA | chr4 | 1326544 | + |
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FusionProtFeatures for FUS_MAEA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FUS | MAEA |
| Binds both single-stranded and double-stranded DNA andpromotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-strandedDNA. May play a role in maintenance of genomic integrity. | Plays a role in erythroblast enucleation and in thedevelopment of the mature macrophages. Mediates the attachment oferythroid cell to mature macrophages, in correlation with thepresence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participatesin erythroblastic island formation, which is the functional unitof definitive erythropoiesis. Associates with F-actin to regulateactin distribution in erythroblasts and macrophages. Maycontribute to nuclear architecture and cells division events.{ECO:0000269|PubMed:16510120, ECO:0000269|PubMed:9763581}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FUS | chr16:31196500 | chr4:1326544 | ENST00000254108 | + | 6 | 15 | 1_165 | 254 | 527 | Compositional bias | Note=Gln/Gly/Ser/Tyr-rich |
| Hgene | FUS | chr16:31196500 | chr4:1326544 | ENST00000380244 | + | 6 | 15 | 1_165 | 253 | 526 | Compositional bias | Note=Gln/Gly/Ser/Tyr-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >FUS | chr16:31196500 | chr4:1326544 | ENST00000254108 | + | 6 | 15 | 166_267 | 254 | 527 | Compositional bias | Note=Gly-rich |
| Hgene | >FUS | chr16:31196500 | chr4:1326544 | ENST00000254108 | + | 6 | 15 | 371_526 | 254 | 527 | Compositional bias | Note=Arg/Gly-rich |
| Hgene | >FUS | chr16:31196500 | chr4:1326544 | ENST00000380244 | + | 6 | 15 | 166_267 | 253 | 526 | Compositional bias | Note=Gly-rich |
| Hgene | >FUS | chr16:31196500 | chr4:1326544 | ENST00000380244 | + | 6 | 15 | 371_526 | 253 | 526 | Compositional bias | Note=Arg/Gly-rich |
| Hgene | >FUS | chr16:31196500 | chr4:1326544 | ENST00000254108 | + | 6 | 15 | 285_371 | 254 | 527 | Domain | RRM |
| Hgene | >FUS | chr16:31196500 | chr4:1326544 | ENST00000380244 | + | 6 | 15 | 285_371 | 253 | 526 | Domain | RRM |
| Hgene | >FUS | chr16:31196500 | chr4:1326544 | ENST00000254108 | + | 6 | 15 | 422_453 | 254 | 527 | Zinc finger | RanBP2-type |
| Hgene | >FUS | chr16:31196500 | chr4:1326544 | ENST00000380244 | + | 6 | 15 | 422_453 | 253 | 526 | Zinc finger | RanBP2-type |
| Tgene | MAEA | chr16:31196500 | chr4:1326544 | ENST00000264750 | + | 3 | 8 | 121_153 | 177 | 356 | Domain | LisH |
| Tgene | MAEA | chr16:31196500 | chr4:1326544 | ENST00000264750 | + | 3 | 8 | 159_216 | 177 | 356 | Domain | CTLH |
| Tgene | MAEA | chr16:31196500 | chr4:1326544 | ENST00000303400 | + | 4 | 9 | 121_153 | 218 | 397 | Domain | LisH |
| Tgene | MAEA | chr16:31196500 | chr4:1326544 | ENST00000303400 | + | 4 | 9 | 159_216 | 218 | 397 | Domain | CTLH |
| Tgene | MAEA | chr16:31196500 | chr4:1326544 | ENST00000264750 | + | 3 | 8 | 1_124 | 177 | 356 | Region | Note=Extracellular and involved in cell to cell contact |
| Tgene | MAEA | chr16:31196500 | chr4:1326544 | ENST00000303400 | + | 4 | 9 | 1_124 | 218 | 397 | Region | Note=Extracellular and involved in cell to cell contact |
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FusionGeneSequence for FUS_MAEA |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FUS_MAEA |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FUS | EIF6, USF2, PRMT1, PTBP2, SRRM1, SPI1, YBX1, ILF3, SF1, SRSF10, THRA, RXRA, RELA, OTUB1, ZMYM2, SARNP, TARDBP, DGCR8, PCM1, SF3A2, SIRT7, SQSTM1, TDRD3, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, ARHGEF28, PA2G4, UBE2I, ATXN1L, GRB2, PIK3R2, HNRNPA3, NONO, EEF1A1, DYNC1H1, GSE1, MBD3, MRPS18B, SAP30BP, RPLP1, ESR1, FN1, VCAM1, TP63, IL7R, UBL4A, ITGA4, CTNNB1, UPF1, LMNA, EWSR1, RBMX, PSMB7, ESRRA, MDH1, TAF15, SRSF9, SAFB2, TNIP1, KHDRBS3, NKD2, MAX, PARK2, SUV39H1, WBP4, HNRNPU, LARS, RPA3, RPA2, RPA1, WWOX, HSPA5, VCP, SFPQ, YWHAZ, YWHAQ, PFN1, FASN, PGK1, CKB, ENO1, LDHB, PAICS, PHGDH, LDHA, GAPDH, PKM, ATXN2L, MTHFD1, ACACA, CA2, ALDOA, GPI, PYCRL, PFKL, PGM1, ABCA1, HPRT1, PM20D2, TKT, UBA1, PSMD12, CDH4, ANXA2P2, GNAS, PLCE1, TRPM4, SLC1A5, UBAP2, UBAP2L, LYZ, CKAP4, YPEL1, HIST4H4, H3F3A, H3F3B, HIST2H2BE, DDX42, HNRNPD, SYNCRIP, DHX40, SF3A1, SF3B3, SF3B4, SERBP1, FANCM, RAD54B, PCNA, PHB, TP73, RPL18, RPL9, RPS9, TBPL1, TRIP4, DNAJC10, SAE1, DLD, GOT2, ATP5A1, GSTP1, HARS2, SLC25A3, KPNA2, RAB7A, SPATA6, UACA, STATH, ANXA5, MAP3K3, UBC, TUBB, CFL1, TUBA1A, ACTB, HNRNPF, HNRNPH1, DHX15, CPSF6, SF3A3, HNRNPK, PSPC1, HNRNPL, RPS5, RPS8, RPL12, RPN2, EEF2, EEF1G, HSP90AA1, CCT5, CCT6A, HSP90AB1, CCT2, CCT4, HSP90B1, CCT3, CCT7, CCT8, HSPA8, PPIL4, TCP1, PDIA3, PPIA, SSBP1, GLUD1, ATP5B, HSPA9, ERAL1, TUFM, HSPD1, PYCR1, MDH2, ABCF2, KPNB1, PRDX1, ERP44, F7, ALB, ARMC6, ADCK5, CCDC88A, GPR101, ITK, DGKA, SLC22A11, HERC6, TUBA1B, MTSS1L, CEP112, COL18A1, SEC13, NAP1L1, SNRPD2, NCAPG2, RBBP4, FLJ22447, LSM12, NUDT21, DDX1, C14orf166, DDX5, HIVEP3, NCOA6, RAVER1, TCEB1, TXNL4B, TTI2, GEN1, RPL14, RPS14, NPM1, RPL11, RPL4, EIF4A1, PCBP2, ST13, NSDHL, MTAP, MAT2A, AHCY, OAT, BCS1L, SLC25A5, TIMM50, MYH10, GOLIM4, CSE1L, RAN, KLHL40, KLHL5, IGKV1-5, C6, GIMAP8, CDC5L, CEP78, DBF4B, AMOT, FAM71F1, MFGE8, FAM98A, C11orf70, RTCB, UFL1, LRRIQ4, NUPR1, CUL7, OBSL1, EZH2, SUZ12, BMI1, ABL1, CHEK1, SIK2, SRPK1, LUZP4, UPF2, UPF3A, FAM58A, YEATS4, RPS6KB2, HNRNPA1, FBXW11, ACAT1, ARMC1, C2orf49, DDX17, DNAJC7, EIF4H, AURKA, PTBP1, TOMM34, TXLNA, UFD1L, HNRNPDL, MEF2D, NAA50, NPLOC4, PFKP, PICALM, TARS, NTRK1, SCARNA22, TCF7L2, KIF22, EMC2, MATR3, MCM2, SNW1, RC3H1, EGFR, TRAF6, CRBN, KCTD6, RPS27, PSRC1, SMCO3, CYLD, TRIM25, BRCA1, HDAC6 | MAEA | UBC, MYOC, GRK5, RANBP9, MKLN1, GID8, RMND5A, FLOT1, SOX2, CLIP1, GDNF, GLIPR1L2, MMP7, SFRP2, TDGF1, MRPL4, GPS2, PRG2, BMP1, CCDC120, INSL6, PRICKLE3, PIGT, MRPL38, JPH4, PRG3, PDGFD, TMEM70, TIGD5, PTPN14, RANBP10, RMND5B, ARMC8, WDR26, HTRA2, GID4, DDX5, CCDC51, YPEL5, RAB8A, EFHC2, WWC1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FUS_MAEA |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FUS_MAEA |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FUS | C1842675 | AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) | 6 | UNIPROT |
| Hgene | FUS | C0206634 | Liposarcoma, Myxoid | 2 | CTD_human;ORPHANET |
| Hgene | FUS | C3539195 | TREMOR, HEREDITARY ESSENTIAL, 4 | 1 | UNIPROT |
| Tgene | MAEA | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
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