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Fusion gene ID: 14082 |
FusionGeneSummary for FUS_KAT8 |
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Fusion gene information | Fusion gene name: FUS_KAT8 | Fusion gene ID: 14082 | Hgene | Tgene | Gene symbol | FUS | KAT8 | Gene ID | 2521 | 84148 |
Gene name | FUS RNA binding protein | lysine acetyltransferase 8 | |
Synonyms | ALS6|ETM4|FUS1|HNRNPP2|POMP75|TLS | MOF|MYST1|ZC2HC8|hMOF | |
Cytomap | 16p11.2 | 16p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | RNA-binding protein FUS75 kDa DNA-pairing proteinFUS/ERG chimeric proteinFUS/ERG fusion proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in lip | histone acetyltransferase KAT8K(lysine) acetyltransferase 8MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1MYST histone acetyltransferase 1MYST-1histone acetyltransferase MYST1ortholog of Drosophila males absent on the first (MOF)probable histone acetyltra | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P35637 | Q9H7Z6 | |
Ensembl transtripts involved in fusion gene | ENST00000254108, ENST00000380244, ENST00000568685, ENST00000474990, | ENST00000543774, ENST00000448516, ENST00000219797, | |
Fusion gene scores | * DoF score | 21 X 23 X 7=3381 | 3 X 3 X 3=27 |
# samples | 27 | 3 | |
** MAII score | log2(27/3381*10)=-3.64641870384255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: FUS [Title/Abstract] AND KAT8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | KAT8 | GO:0010506 | regulation of autophagy | 23863932 |
Tgene | KAT8 | GO:0016573 | histone acetylation | 11742995 |
Tgene | KAT8 | GO:0030099 | myeloid cell differentiation | 11742995 |
Tgene | KAT8 | GO:0043981 | histone H4-K5 acetylation | 20018852 |
Tgene | KAT8 | GO:0043982 | histone H4-K8 acetylation | 20018852 |
Tgene | KAT8 | GO:0043984 | histone H4-K16 acetylation | 20018852 |
Tgene | KAT8 | GO:0045892 | negative regulation of transcription, DNA-templated | 11742995 |
Tgene | KAT8 | GO:0045893 | positive regulation of transcription, DNA-templated | 11742995|11965546 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-13-1481-01A | FUS | chr16 | 31191548 | + | KAT8 | chr16 | 31138356 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000254108 | ENST00000543774 | FUS | chr16 | 31191548 | + | KAT8 | chr16 | 31138356 | + |
Frame-shift | ENST00000254108 | ENST00000448516 | FUS | chr16 | 31191548 | + | KAT8 | chr16 | 31138356 | + |
Frame-shift | ENST00000254108 | ENST00000219797 | FUS | chr16 | 31191548 | + | KAT8 | chr16 | 31138356 | + |
Frame-shift | ENST00000380244 | ENST00000543774 | FUS | chr16 | 31191548 | + | KAT8 | chr16 | 31138356 | + |
Frame-shift | ENST00000380244 | ENST00000448516 | FUS | chr16 | 31191548 | + | KAT8 | chr16 | 31138356 | + |
Frame-shift | ENST00000380244 | ENST00000219797 | FUS | chr16 | 31191548 | + | KAT8 | chr16 | 31138356 | + |
Frame-shift | ENST00000568685 | ENST00000543774 | FUS | chr16 | 31191548 | + | KAT8 | chr16 | 31138356 | + |
Frame-shift | ENST00000568685 | ENST00000448516 | FUS | chr16 | 31191548 | + | KAT8 | chr16 | 31138356 | + |
Frame-shift | ENST00000568685 | ENST00000219797 | FUS | chr16 | 31191548 | + | KAT8 | chr16 | 31138356 | + |
intron-3CDS | ENST00000474990 | ENST00000543774 | FUS | chr16 | 31191548 | + | KAT8 | chr16 | 31138356 | + |
intron-3CDS | ENST00000474990 | ENST00000448516 | FUS | chr16 | 31191548 | + | KAT8 | chr16 | 31138356 | + |
intron-3CDS | ENST00000474990 | ENST00000219797 | FUS | chr16 | 31191548 | + | KAT8 | chr16 | 31138356 | + |
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FusionProtFeatures for FUS_KAT8 |
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Hgene | Tgene |
FUS | KAT8 |
Binds both single-stranded and double-stranded DNA andpromotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-strandedDNA. May play a role in maintenance of genomic integrity. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FUS_KAT8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FUS_KAT8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FUS | EIF6, USF2, PRMT1, PTBP2, SRRM1, SPI1, YBX1, ILF3, SF1, SRSF10, THRA, RXRA, RELA, OTUB1, ZMYM2, SARNP, TARDBP, DGCR8, PCM1, SF3A2, SIRT7, SQSTM1, TDRD3, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, ARHGEF28, PA2G4, UBE2I, ATXN1L, GRB2, PIK3R2, HNRNPA3, NONO, EEF1A1, DYNC1H1, GSE1, MBD3, MRPS18B, SAP30BP, RPLP1, ESR1, FN1, VCAM1, TP63, IL7R, UBL4A, ITGA4, CTNNB1, UPF1, LMNA, EWSR1, RBMX, PSMB7, ESRRA, MDH1, TAF15, SRSF9, SAFB2, TNIP1, KHDRBS3, NKD2, MAX, PARK2, SUV39H1, WBP4, HNRNPU, LARS, RPA3, RPA2, RPA1, WWOX, HSPA5, VCP, SFPQ, YWHAZ, YWHAQ, PFN1, FASN, PGK1, CKB, ENO1, LDHB, PAICS, PHGDH, LDHA, GAPDH, PKM, ATXN2L, MTHFD1, ACACA, CA2, ALDOA, GPI, PYCRL, PFKL, PGM1, ABCA1, HPRT1, PM20D2, TKT, UBA1, PSMD12, CDH4, ANXA2P2, GNAS, PLCE1, TRPM4, SLC1A5, UBAP2, UBAP2L, LYZ, CKAP4, YPEL1, HIST4H4, H3F3A, H3F3B, HIST2H2BE, DDX42, HNRNPD, SYNCRIP, DHX40, SF3A1, SF3B3, SF3B4, SERBP1, FANCM, RAD54B, PCNA, PHB, TP73, RPL18, RPL9, RPS9, TBPL1, TRIP4, DNAJC10, SAE1, DLD, GOT2, ATP5A1, GSTP1, HARS2, SLC25A3, KPNA2, RAB7A, SPATA6, UACA, STATH, ANXA5, MAP3K3, UBC, TUBB, CFL1, TUBA1A, ACTB, HNRNPF, HNRNPH1, DHX15, CPSF6, SF3A3, HNRNPK, PSPC1, HNRNPL, RPS5, RPS8, RPL12, RPN2, EEF2, EEF1G, HSP90AA1, CCT5, CCT6A, HSP90AB1, CCT2, CCT4, HSP90B1, CCT3, CCT7, CCT8, HSPA8, PPIL4, TCP1, PDIA3, PPIA, SSBP1, GLUD1, ATP5B, HSPA9, ERAL1, TUFM, HSPD1, PYCR1, MDH2, ABCF2, KPNB1, PRDX1, ERP44, F7, ALB, ARMC6, ADCK5, CCDC88A, GPR101, ITK, DGKA, SLC22A11, HERC6, TUBA1B, MTSS1L, CEP112, COL18A1, SEC13, NAP1L1, SNRPD2, NCAPG2, RBBP4, FLJ22447, LSM12, NUDT21, DDX1, C14orf166, DDX5, HIVEP3, NCOA6, RAVER1, TCEB1, TXNL4B, TTI2, GEN1, RPL14, RPS14, NPM1, RPL11, RPL4, EIF4A1, PCBP2, ST13, NSDHL, MTAP, MAT2A, AHCY, OAT, BCS1L, SLC25A5, TIMM50, MYH10, GOLIM4, CSE1L, RAN, KLHL40, KLHL5, IGKV1-5, C6, GIMAP8, CDC5L, CEP78, DBF4B, AMOT, FAM71F1, MFGE8, FAM98A, C11orf70, RTCB, UFL1, LRRIQ4, NUPR1, CUL7, OBSL1, EZH2, SUZ12, BMI1, ABL1, CHEK1, SIK2, SRPK1, LUZP4, UPF2, UPF3A, FAM58A, YEATS4, RPS6KB2, HNRNPA1, FBXW11, ACAT1, ARMC1, C2orf49, DDX17, DNAJC7, EIF4H, AURKA, PTBP1, TOMM34, TXLNA, UFD1L, HNRNPDL, MEF2D, NAA50, NPLOC4, PFKP, PICALM, TARS, NTRK1, SCARNA22, TCF7L2, KIF22, EMC2, MATR3, MCM2, SNW1, RC3H1, EGFR, TRAF6, CRBN, KCTD6, RPS27, PSRC1, SMCO3, CYLD, TRIM25, BRCA1, HDAC6 | KAT8 | MORF4L1, TP53, KANSL1, BAZ2A, HIST1H4A, MSL1, MSL2, MSL3, HCFC1, MSL3P1, HIST1H3A, KMT2A, RNF2, RBBP5, WDR5, KAT8, ATM, TPR, PRKDC, OGT, CCAR2, PHF20, PHF20L1, MCRS1, H2AFX, YWHAZ, YWHAE, BRD4, TCEB3, FOXP3, SIRT1, TNK2, PPP1CB, DYRK1B, HECW2, PAF1, PLK1, HNRNPA1, HIST1H2BG, PLAU, TP53BP1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FUS_KAT8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FUS_KAT8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FUS | C1842675 | AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) | 6 | UNIPROT |
Hgene | FUS | C0206634 | Liposarcoma, Myxoid | 2 | CTD_human;ORPHANET |
Hgene | FUS | C3539195 | TREMOR, HEREDITARY ESSENTIAL, 4 | 1 | UNIPROT |
Tgene | KAT8 | C0036341 | Schizophrenia | 1 | PSYGENET |