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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14078

FusionGeneSummary for FUS_DDIT3

check button Fusion gene summary
Fusion gene informationFusion gene name: FUS_DDIT3
Fusion gene ID: 14078
HgeneTgene
Gene symbol

FUS

DDIT3

Gene ID

2521

1649

Gene nameFUS RNA binding proteinDNA damage inducible transcript 3
SynonymsALS6|ETM4|FUS1|HNRNPP2|POMP75|TLSC/EBPzeta|CEBPZ|CHOP|CHOP-10|CHOP10|GADD153
Cytomap

16p11.2

12q13.3

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein FUS75 kDa DNA-pairing proteinFUS/ERG chimeric proteinFUS/ERG fusion proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in lipDNA damage-inducible transcript 3 proteinC/EBP zetaCCAAT/enhancer-binding protein homologous proteinc/EBP-homologous protein 10growth arrest and DNA damage-inducible protein GADD153
Modification date2018052720180527
UniProtAcc

P35637

P35638

Ensembl transtripts involved in fusion geneENST00000254108, ENST00000380244, 
ENST00000568685, ENST00000474990, 
ENST00000547303, ENST00000551116, 
ENST00000346473, ENST00000552740, 
Fusion gene scores* DoF score21 X 23 X 7=33811 X 3 X 2=6
# samples 273
** MAII scorelog2(27/3381*10)=-3.64641870384255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/6*10)=2.32192809488736
Context

PubMed: FUS [Title/Abstract] AND DDIT3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDDIT3

GO:0000122

negative regulation of transcription by RNA polymerase II

18940792

TgeneDDIT3

GO:0006986

response to unfolded protein

18940792

TgeneDDIT3

GO:0007050

cell cycle arrest

22496745

TgeneDDIT3

GO:0032792

negative regulation of CREB transcription factor activity

8622660

TgeneDDIT3

GO:0034976

response to endoplasmic reticulum stress

18940792|19061639|20829347

TgeneDDIT3

GO:0042789

mRNA transcription by RNA polymerase II

14667815

TgeneDDIT3

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

17872950

TgeneDDIT3

GO:0043433

negative regulation of DNA binding transcription factor activity

16434966

TgeneDDIT3

GO:0045454

cell redox homeostasis

14667815

TgeneDDIT3

GO:0045892

negative regulation of transcription, DNA-templated

18940792

TgeneDDIT3

GO:0045893

positive regulation of transcription, DNA-templated

15322075|15775988

TgeneDDIT3

GO:0045944

positive regulation of transcription by RNA polymerase II

22065586

TgeneDDIT3

GO:0051259

protein complex oligomerization

18534616

TgeneDDIT3

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

18940792|20829347

TgeneDDIT3

GO:1903026

negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding

8622660

TgeneDDIT3

GO:1990440

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

15322075|24939851

TgeneDDIT3

GO:2000016

negative regulation of determination of dorsal identity

16434966


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-Z4-A9VC-01AFUSchr16

31199678

+DDIT3chr12

57911536

-
ChiTaRS3.1Y10002FUSchr16

31198614

+DDIT3chr12

57912734

-
ChiTaRS3.1AJ301613FUSchr16

31202431

+DDIT3chr12

57912902

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000254108ENST00000547303FUSchr16

31199678

+DDIT3chr12

57911536

-
5CDS-5UTRENST00000254108ENST00000551116FUSchr16

31199678

+DDIT3chr12

57911536

-
5CDS-5UTRENST00000254108ENST00000346473FUSchr16

31199678

+DDIT3chr12

57911536

-
5CDS-5UTRENST00000254108ENST00000552740FUSchr16

31199678

+DDIT3chr12

57911536

-
5CDS-5UTRENST00000380244ENST00000547303FUSchr16

31199678

+DDIT3chr12

57911536

-
5CDS-5UTRENST00000380244ENST00000551116FUSchr16

31199678

+DDIT3chr12

57911536

-
5CDS-5UTRENST00000380244ENST00000346473FUSchr16

31199678

+DDIT3chr12

57911536

-
5CDS-5UTRENST00000380244ENST00000552740FUSchr16

31199678

+DDIT3chr12

57911536

-
5CDS-5UTRENST00000568685ENST00000547303FUSchr16

31199678

+DDIT3chr12

57911536

-
5CDS-5UTRENST00000568685ENST00000551116FUSchr16

31199678

+DDIT3chr12

57911536

-
5CDS-5UTRENST00000568685ENST00000346473FUSchr16

31199678

+DDIT3chr12

57911536

-
5CDS-5UTRENST00000568685ENST00000552740FUSchr16

31199678

+DDIT3chr12

57911536

-
3UTR-5UTRENST00000474990ENST00000547303FUSchr16

31199678

+DDIT3chr12

57911536

-
3UTR-5UTRENST00000474990ENST00000551116FUSchr16

31199678

+DDIT3chr12

57911536

-
3UTR-5UTRENST00000474990ENST00000346473FUSchr16

31199678

+DDIT3chr12

57911536

-
3UTR-5UTRENST00000474990ENST00000552740FUSchr16

31199678

+DDIT3chr12

57911536

-
intron-intronENST00000254108ENST00000547303FUSchr16

31198614

+DDIT3chr12

57912734

-
intron-intronENST00000254108ENST00000551116FUSchr16

31198614

+DDIT3chr12

57912734

-
intron-intronENST00000254108ENST00000346473FUSchr16

31198614

+DDIT3chr12

57912734

-
intron-intronENST00000254108ENST00000552740FUSchr16

31198614

+DDIT3chr12

57912734

-
intron-intronENST00000380244ENST00000547303FUSchr16

31198614

+DDIT3chr12

57912734

-
intron-intronENST00000380244ENST00000551116FUSchr16

31198614

+DDIT3chr12

57912734

-
intron-intronENST00000380244ENST00000346473FUSchr16

31198614

+DDIT3chr12

57912734

-
intron-intronENST00000380244ENST00000552740FUSchr16

31198614

+DDIT3chr12

57912734

-
intron-intronENST00000568685ENST00000547303FUSchr16

31198614

+DDIT3chr12

57912734

-
intron-intronENST00000568685ENST00000551116FUSchr16

31198614

+DDIT3chr12

57912734

-
intron-intronENST00000568685ENST00000346473FUSchr16

31198614

+DDIT3chr12

57912734

-
intron-intronENST00000568685ENST00000552740FUSchr16

31198614

+DDIT3chr12

57912734

-
intron-intronENST00000474990ENST00000547303FUSchr16

31198614

+DDIT3chr12

57912734

-
intron-intronENST00000474990ENST00000551116FUSchr16

31198614

+DDIT3chr12

57912734

-
intron-intronENST00000474990ENST00000346473FUSchr16

31198614

+DDIT3chr12

57912734

-
intron-intronENST00000474990ENST00000552740FUSchr16

31198614

+DDIT3chr12

57912734

-
5CDS-intronENST00000254108ENST00000547303FUSchr16

31202431

+DDIT3chr12

57912902

-
5CDS-intronENST00000254108ENST00000551116FUSchr16

31202431

+DDIT3chr12

57912902

-
5CDS-intronENST00000254108ENST00000346473FUSchr16

31202431

+DDIT3chr12

57912902

-
5CDS-intronENST00000254108ENST00000552740FUSchr16

31202431

+DDIT3chr12

57912902

-
5CDS-intronENST00000380244ENST00000547303FUSchr16

31202431

+DDIT3chr12

57912902

-
5CDS-intronENST00000380244ENST00000551116FUSchr16

31202431

+DDIT3chr12

57912902

-
5CDS-intronENST00000380244ENST00000346473FUSchr16

31202431

+DDIT3chr12

57912902

-
5CDS-intronENST00000380244ENST00000552740FUSchr16

31202431

+DDIT3chr12

57912902

-
5CDS-intronENST00000568685ENST00000547303FUSchr16

31202431

+DDIT3chr12

57912902

-
5CDS-intronENST00000568685ENST00000551116FUSchr16

31202431

+DDIT3chr12

57912902

-
5CDS-intronENST00000568685ENST00000346473FUSchr16

31202431

+DDIT3chr12

57912902

-
5CDS-intronENST00000568685ENST00000552740FUSchr16

31202431

+DDIT3chr12

57912902

-
intron-intronENST00000474990ENST00000547303FUSchr16

31202431

+DDIT3chr12

57912902

-
intron-intronENST00000474990ENST00000551116FUSchr16

31202431

+DDIT3chr12

57912902

-
intron-intronENST00000474990ENST00000346473FUSchr16

31202431

+DDIT3chr12

57912902

-
intron-intronENST00000474990ENST00000552740FUSchr16

31202431

+DDIT3chr12

57912902

-

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FusionProtFeatures for FUS_DDIT3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FUS

P35637

DDIT3

P35638

Binds both single-stranded and double-stranded DNA andpromotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-strandedDNA. May play a role in maintenance of genomic integrity. Multifunctional transcription factor in ER stressresponse. Plays an essential role in the response to a widevariety of cell stresses and induces cell cycle arrest andapoptosis in response to ER stress. Plays a dual role both as aninhibitor of CCAAT/enhancer-binding protein (C/EBP) function andas an activator of other genes. Acts as a dominant-negativeregulator of C/EBP-induced transcription: dimerizes with membersof the C/EBP family, impairs their association with C/EBP bindingsites in the promoter regions, and inhibits the expression ofC/EBP regulated genes. Positively regulates the transcription ofTRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA,BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2and MYOD1, ATF4-dependent transcriptional activation of asparaginesynthetase (ASNS), CEBPA-dependent transcriptional activation ofhepcidin (HAMP) and CEBPB-mediated expression of peroxisomeproliferator-activated receptor gamma (PPARG). Inhibits thecanonical Wnt signaling pathway by binding to TCF7L2/TCF4,impairing its DNA-binding properties and repressing itstranscriptional activity. Plays a regulatory role in theinflammatory response through the induction of caspase-11(CASP4/CASP11) which induces the activation of caspase-1 (CASP1)and both these caspases increase the activation of pro-IL1B tomature IL1B which is involved in the inflammatory response.{ECO:0000269|PubMed:15322075, ECO:0000269|PubMed:15775988,ECO:0000269|PubMed:16434966, ECO:0000269|PubMed:17709599,ECO:0000269|PubMed:18940792, ECO:0000269|PubMed:19672300,ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:20876114,ECO:0000269|PubMed:22761832}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FUS_DDIT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FUS_DDIT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FUSEIF6, USF2, PRMT1, PTBP2, SRRM1, SPI1, YBX1, ILF3, SF1, SRSF10, THRA, RXRA, RELA, OTUB1, ZMYM2, SARNP, TARDBP, DGCR8, PCM1, SF3A2, SIRT7, SQSTM1, TDRD3, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, ARHGEF28, PA2G4, UBE2I, ATXN1L, GRB2, PIK3R2, HNRNPA3, NONO, EEF1A1, DYNC1H1, GSE1, MBD3, MRPS18B, SAP30BP, RPLP1, ESR1, FN1, VCAM1, TP63, IL7R, UBL4A, ITGA4, CTNNB1, UPF1, LMNA, EWSR1, RBMX, PSMB7, ESRRA, MDH1, TAF15, SRSF9, SAFB2, TNIP1, KHDRBS3, NKD2, MAX, PARK2, SUV39H1, WBP4, HNRNPU, LARS, RPA3, RPA2, RPA1, WWOX, HSPA5, VCP, SFPQ, YWHAZ, YWHAQ, PFN1, FASN, PGK1, CKB, ENO1, LDHB, PAICS, PHGDH, LDHA, GAPDH, PKM, ATXN2L, MTHFD1, ACACA, CA2, ALDOA, GPI, PYCRL, PFKL, PGM1, ABCA1, HPRT1, PM20D2, TKT, UBA1, PSMD12, CDH4, ANXA2P2, GNAS, PLCE1, TRPM4, SLC1A5, UBAP2, UBAP2L, LYZ, CKAP4, YPEL1, HIST4H4, H3F3A, H3F3B, HIST2H2BE, DDX42, HNRNPD, SYNCRIP, DHX40, SF3A1, SF3B3, SF3B4, SERBP1, FANCM, RAD54B, PCNA, PHB, TP73, RPL18, RPL9, RPS9, TBPL1, TRIP4, DNAJC10, SAE1, DLD, GOT2, ATP5A1, GSTP1, HARS2, SLC25A3, KPNA2, RAB7A, SPATA6, UACA, STATH, ANXA5, MAP3K3, UBC, TUBB, CFL1, TUBA1A, ACTB, HNRNPF, HNRNPH1, DHX15, CPSF6, SF3A3, HNRNPK, PSPC1, HNRNPL, RPS5, RPS8, RPL12, RPN2, EEF2, EEF1G, HSP90AA1, CCT5, CCT6A, HSP90AB1, CCT2, CCT4, HSP90B1, CCT3, CCT7, CCT8, HSPA8, PPIL4, TCP1, PDIA3, PPIA, SSBP1, GLUD1, ATP5B, HSPA9, ERAL1, TUFM, HSPD1, PYCR1, MDH2, ABCF2, KPNB1, PRDX1, ERP44, F7, ALB, ARMC6, ADCK5, CCDC88A, GPR101, ITK, DGKA, SLC22A11, HERC6, TUBA1B, MTSS1L, CEP112, COL18A1, SEC13, NAP1L1, SNRPD2, NCAPG2, RBBP4, FLJ22447, LSM12, NUDT21, DDX1, C14orf166, DDX5, HIVEP3, NCOA6, RAVER1, TCEB1, TXNL4B, TTI2, GEN1, RPL14, RPS14, NPM1, RPL11, RPL4, EIF4A1, PCBP2, ST13, NSDHL, MTAP, MAT2A, AHCY, OAT, BCS1L, SLC25A5, TIMM50, MYH10, GOLIM4, CSE1L, RAN, KLHL40, KLHL5, IGKV1-5, C6, GIMAP8, CDC5L, CEP78, DBF4B, AMOT, FAM71F1, MFGE8, FAM98A, C11orf70, RTCB, UFL1, LRRIQ4, NUPR1, CUL7, OBSL1, EZH2, SUZ12, BMI1, ABL1, CHEK1, SIK2, SRPK1, LUZP4, UPF2, UPF3A, FAM58A, YEATS4, RPS6KB2, HNRNPA1, FBXW11, ACAT1, ARMC1, C2orf49, DDX17, DNAJC7, EIF4H, AURKA, PTBP1, TOMM34, TXLNA, UFD1L, HNRNPDL, MEF2D, NAA50, NPLOC4, PFKP, PICALM, TARS, NTRK1, SCARNA22, TCF7L2, KIF22, EMC2, MATR3, MCM2, SNW1, RC3H1, EGFR, TRAF6, CRBN, KCTD6, RPS27, PSRC1, SMCO3, CYLD, TRIM25, BRCA1, HDAC6DDIT3HSD17B14, MCMBP, SPOP, BATF, CEBPG, CSNK2A1, CEBPB, JUND, FOS, JUN, ATF3, RPS3A, MAPK14, C14orf80, LDOC1L, HOXA5, SSX3, RAI1, ZSCAN31, HDAC1, CEBPE, SRA1, COPS7A, COPS8, CUL3, CUL1, COPS3, KEAP1, CDK6, BATF2, ATF4, EPAS1, DBP, BACH2, BACH1, MAFG, MAFF, BATF3, FOSL1, JUNB, ATF2, NFIL3, CREB3L1, CREB3, DDIT3, F2, GP1BA, KPNA2, IKBKG, DGCR2, POLR1D, PPIB, EP300, GIPC1, TRIB3, HDAC5, HDAC6, FOSL2, LMO2, ZBTB25, TNFSF12, SNAPC5, AMOTL2, VPS37C, C11orf30, ZC3H14, ATPAF2, CCDC153, CREBBP, DNMT3L, GABBR2, GABBR1, CEBPA, FANCA, PARK2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FUS_DDIT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FUS_DDIT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFUSC1842675AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)6UNIPROT
HgeneFUSC0206634Liposarcoma, Myxoid2CTD_human;ORPHANET
HgeneFUSC3539195TREMOR, HEREDITARY ESSENTIAL, 41UNIPROT
TgeneDDIT3C0206634Liposarcoma, Myxoid3CTD_human;HPO;ORPHANET
TgeneDDIT3C0003949Asbestosis1CTD_human
TgeneDDIT3C0011616Contact Dermatitis1CTD_human
TgeneDDIT3C0011854Diabetes Mellitus, Insulin-Dependent1CTD_human
TgeneDDIT3C0021831Intestinal Diseases1CTD_human
TgeneDDIT3C0027051Myocardial Infarction1CTD_human
TgeneDDIT3C0027720Nephrosis1CTD_human
TgeneDDIT3C0028754Obesity1CTD_human
TgeneDDIT3C0028840Ocular Hypertension1CTD_human
TgeneDDIT3C0041582Ulcer1CTD_human
TgeneDDIT3C1458155Mammary Neoplasms1CTD_human
TgeneDDIT3C3495559Juvenile arthritis1CTD_human