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Fusion gene ID: 14076 |
FusionGeneSummary for FUS_ATF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FUS_ATF1 | Fusion gene ID: 14076 | Hgene | Tgene | Gene symbol | FUS | ATF1 | Gene ID | 2521 | 2668 |
| Gene name | FUS RNA binding protein | glial cell derived neurotrophic factor | |
| Synonyms | ALS6|ETM4|FUS1|HNRNPP2|POMP75|TLS | ATF|ATF1|ATF2|HFB1-GDNF|HSCR3 | |
| Cytomap | 16p11.2 | 5p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA-binding protein FUS75 kDa DNA-pairing proteinFUS/ERG chimeric proteinFUS/ERG fusion proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in lip | glial cell line-derived neurotrophic factorastrocyte-derived trophic factor | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | P35637 | P18846 | |
| Ensembl transtripts involved in fusion gene | ENST00000254108, ENST00000380244, ENST00000568685, ENST00000474990, | ENST00000262053, ENST00000539132, | |
| Fusion gene scores | * DoF score | 21 X 23 X 7=3381 | 5 X 7 X 3=105 |
| # samples | 27 | 10 | |
| ** MAII score | log2(27/3381*10)=-3.64641870384255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/105*10)=-0.070389327891398 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FUS [Title/Abstract] AND ATF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ATF1 | GO:0001755 | neural crest cell migration | 15242795 |
| Tgene | ATF1 | GO:0008284 | positive regulation of cell proliferation | 22897442 |
| Tgene | ATF1 | GO:0031175 | neuron projection development | 15242795 |
| Tgene | ATF1 | GO:0032770 | positive regulation of monooxygenase activity | 12358785 |
| Tgene | ATF1 | GO:0043524 | negative regulation of neuron apoptotic process | 8493557 |
| Tgene | ATF1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12358785 |
| Tgene | ATF1 | GO:0048255 | mRNA stabilization | 12358785 |
| Tgene | ATF1 | GO:0051584 | regulation of dopamine uptake involved in synaptic transmission | 8493557 |
| Tgene | ATF1 | GO:0072107 | positive regulation of ureteric bud formation | 8657307 |
| Tgene | ATF1 | GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis | 8657307|17229286 |
| Tgene | ATF1 | GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | 10921886 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AJ295163 | FUS | chr16 | 31195717 | + | ATF1 | chr12 | 51207791 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000254108 | ENST00000262053 | FUS | chr16 | 31195717 | + | ATF1 | chr12 | 51207791 | + |
| 5CDS-5UTR | ENST00000254108 | ENST00000539132 | FUS | chr16 | 31195717 | + | ATF1 | chr12 | 51207791 | + |
| In-frame | ENST00000380244 | ENST00000262053 | FUS | chr16 | 31195717 | + | ATF1 | chr12 | 51207791 | + |
| 5CDS-5UTR | ENST00000380244 | ENST00000539132 | FUS | chr16 | 31195717 | + | ATF1 | chr12 | 51207791 | + |
| In-frame | ENST00000568685 | ENST00000262053 | FUS | chr16 | 31195717 | + | ATF1 | chr12 | 51207791 | + |
| 5CDS-5UTR | ENST00000568685 | ENST00000539132 | FUS | chr16 | 31195717 | + | ATF1 | chr12 | 51207791 | + |
| intron-3CDS | ENST00000474990 | ENST00000262053 | FUS | chr16 | 31195717 | + | ATF1 | chr12 | 51207791 | + |
| intron-5UTR | ENST00000474990 | ENST00000539132 | FUS | chr16 | 31195717 | + | ATF1 | chr12 | 51207791 | + |
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FusionProtFeatures for FUS_ATF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FUS | ATF1 |
| Binds both single-stranded and double-stranded DNA andpromotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-strandedDNA. May play a role in maintenance of genomic integrity. | This protein binds the cAMP response element (CRE)(consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in manyviral and cellular promoters. Binds to the Tax-responsive element(TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reportergenes. Represses the expression of FTH1 and other antioxidantdetoxification genes. Triggers cell proliferation andtransformation. {ECO:0000269|PubMed:18794154,ECO:0000269|PubMed:20980392}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FUS | chr16:31195717 | chr12:51207791 | ENST00000254108 | + | 5 | 15 | 1_165 | 174 | 527 | Compositional bias | Note=Gln/Gly/Ser/Tyr-rich |
| Hgene | FUS | chr16:31195717 | chr12:51207791 | ENST00000380244 | + | 5 | 15 | 1_165 | 173 | 526 | Compositional bias | Note=Gln/Gly/Ser/Tyr-rich |
| Tgene | >ATF1 | chr16:31195717 | chr12:51207791 | ENST00000262053 | + | 3 | 7 | 213_271 | 109 | 272 | Domain | bZIP |
| Tgene | >ATF1 | chr16:31195717 | chr12:51207791 | ENST00000262053 | + | 3 | 7 | 215_239 | 109 | 272 | Region | Basic motif |
| Tgene | >ATF1 | chr16:31195717 | chr12:51207791 | ENST00000262053 | + | 3 | 7 | 241_262 | 109 | 272 | Region | Leucine-zipper |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >FUS | chr16:31195717 | chr12:51207791 | ENST00000254108 | + | 5 | 15 | 166_267 | 174 | 527 | Compositional bias | Note=Gly-rich |
| Hgene | >FUS | chr16:31195717 | chr12:51207791 | ENST00000254108 | + | 5 | 15 | 371_526 | 174 | 527 | Compositional bias | Note=Arg/Gly-rich |
| Hgene | >FUS | chr16:31195717 | chr12:51207791 | ENST00000380244 | + | 5 | 15 | 166_267 | 173 | 526 | Compositional bias | Note=Gly-rich |
| Hgene | >FUS | chr16:31195717 | chr12:51207791 | ENST00000380244 | + | 5 | 15 | 371_526 | 173 | 526 | Compositional bias | Note=Arg/Gly-rich |
| Hgene | >FUS | chr16:31195717 | chr12:51207791 | ENST00000254108 | + | 5 | 15 | 285_371 | 174 | 527 | Domain | RRM |
| Hgene | >FUS | chr16:31195717 | chr12:51207791 | ENST00000380244 | + | 5 | 15 | 285_371 | 173 | 526 | Domain | RRM |
| Hgene | >FUS | chr16:31195717 | chr12:51207791 | ENST00000254108 | + | 5 | 15 | 422_453 | 174 | 527 | Zinc finger | RanBP2-type |
| Hgene | >FUS | chr16:31195717 | chr12:51207791 | ENST00000380244 | + | 5 | 15 | 422_453 | 173 | 526 | Zinc finger | RanBP2-type |
| Tgene | ATF1 | chr16:31195717 | chr12:51207791 | ENST00000262053 | + | 3 | 7 | 31_90 | 109 | 272 | Domain | KID |
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FusionGeneSequence for FUS_ATF1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FUS_ENST00000254108_chr16_31195717_+_ATF1_ENST00000262053_chr12_51207791_+_337aa MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQSS YGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGVAIAPN GALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQ >In-frame_FUS_ENST00000380244_chr16_31195717_+_ATF1_ENST00000262053_chr12_51207791_+_336aa MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGSSQSSQSSY GQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGVAIAPNG ALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQT >In-frame_FUS_ENST00000568685_chr16_31195717_+_ATF1_ENST00000262053_chr12_51207791_+_337aa MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQSS YGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGVAIAPN GALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FUS_ENST00000254108_chr16_31195717_+_ATF1_ENST00000262053_chr12_51207791_+_1011nt ATGGCCTCAAACGATTATACCCAACAAGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTATTCCCAGCAGAGCAGT CAGCCCTACGGACAGCAGAGTTACAGTGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTATTCTTCTTATGGCCAG AGCCAGAACACAGGCTATGGAACTCAGTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCGTCT TACGGGCAGCAGTCCTCCTACCCTGGCTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGCAGTTCTCAGAGCAGC AGCTATGGGCAGCCCCAGAGTGGGAGCTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAGCAGCAAAGCTATAAT CCCCCTCAGGGCTATGGACAGCAGAACCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGTTGCCATTGCCCCAAAT GGAGCCTTACAGTTGGCAAGTCCAGGCACAGATGGAGTACAGGGACTTCAGACATTAACCATGACAAATTCAGGCAGTACTCAGCAAGGT ACAACTATTCTTCAGTATGCACAGACCTCTGATGGACAGCAGATACTTGTGCCCAGCAATCAGGTGGTCGTACAAACTGCATCAGGAGAT ATGCAAACATATCAGATCCGAACTACACCTTCAGCTACTTCTCTGCCACAAACTGTGGTGATGACATCTCCTGTGACTCTCACCTCTCAG ACAACTAAGACAGATGACCCCCAATTGAAAAGAGAAATAAGGTTAATGAAAAACAGAGAAGCTGCTCGAGAATGTCGCAGAAAGAAGAAA GAATATGTGAAATGCCTGGAAAACCGAGTTGCAGTCCTGGAAAATCAAAATAAAACTCTAATAGAAGAGTTAAAAACTTTGAAGGATCTT >In-frame_FUS_ENST00000380244_chr16_31195717_+_ATF1_ENST00000262053_chr12_51207791_+_1008nt ATGGCCTCAAACGATTATACCCAACAAGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTATTCCCAGCAGAGCAGT CAGCCCTACGGACAGCAGAGTTACAGTGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTATTCTTCTTATGGCCAG AGCCAGAACAGCTATGGAACTCAGTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCGTCTTAC GGGCAGCAGTCCTCCTACCCTGGCTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGCAGTTCTCAGAGCAGCAGC TATGGGCAGCCCCAGAGTGGGAGCTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAGCAGCAAAGCTATAATCCC CCTCAGGGCTATGGACAGCAGAACCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGTTGCCATTGCCCCAAATGGA GCCTTACAGTTGGCAAGTCCAGGCACAGATGGAGTACAGGGACTTCAGACATTAACCATGACAAATTCAGGCAGTACTCAGCAAGGTACA ACTATTCTTCAGTATGCACAGACCTCTGATGGACAGCAGATACTTGTGCCCAGCAATCAGGTGGTCGTACAAACTGCATCAGGAGATATG CAAACATATCAGATCCGAACTACACCTTCAGCTACTTCTCTGCCACAAACTGTGGTGATGACATCTCCTGTGACTCTCACCTCTCAGACA ACTAAGACAGATGACCCCCAATTGAAAAGAGAAATAAGGTTAATGAAAAACAGAGAAGCTGCTCGAGAATGTCGCAGAAAGAAGAAAGAA TATGTGAAATGCCTGGAAAACCGAGTTGCAGTCCTGGAAAATCAAAATAAAACTCTAATAGAAGAGTTAAAAACTTTGAAGGATCTTTAT >In-frame_FUS_ENST00000568685_chr16_31195717_+_ATF1_ENST00000262053_chr12_51207791_+_1011nt ATGGCCTCAAACGATTATACCCAACAAGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTATTCCCAGCAGAGCAGT CAGCCCTACGGACAGCAGAGTTACAGTGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTATTCTTCTTATGGCCAG AGCCAGAACACAGGCTATGGAACTCAGTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCGTCT TACGGGCAGCAGTCCTCCTACCCTGGCTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGCAGTTCTCAGAGCAGC AGCTATGGGCAGCCCCAGAGTGGGAGCTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAGCAGCAAAGCTATAAT CCCCCTCAGGGCTATGGACAGCAGAACCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGTTGCCATTGCCCCAAAT GGAGCCTTACAGTTGGCAAGTCCAGGCACAGATGGAGTACAGGGACTTCAGACATTAACCATGACAAATTCAGGCAGTACTCAGCAAGGT ACAACTATTCTTCAGTATGCACAGACCTCTGATGGACAGCAGATACTTGTGCCCAGCAATCAGGTGGTCGTACAAACTGCATCAGGAGAT ATGCAAACATATCAGATCCGAACTACACCTTCAGCTACTTCTCTGCCACAAACTGTGGTGATGACATCTCCTGTGACTCTCACCTCTCAG ACAACTAAGACAGATGACCCCCAATTGAAAAGAGAAATAAGGTTAATGAAAAACAGAGAAGCTGCTCGAGAATGTCGCAGAAAGAAGAAA GAATATGTGAAATGCCTGGAAAACCGAGTTGCAGTCCTGGAAAATCAAAATAAAACTCTAATAGAAGAGTTAAAAACTTTGAAGGATCTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FUS_ENST00000254108_chr16_31195717_+_ATF1_ENST00000262053_chr12_51207791_+_2459nt ACTTAAGCTTCGACGCAGGAGGCGGGGCTGCTCAGTCCTCCAGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTG CGCGCGTGCGCGGACATGGCCTCAAACGATTATACCCAACAAGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTAT TCCCAGCAGAGCAGTCAGCCCTACGGACAGCAGAGTTACAGTGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTAT TCTTCTTATGGCCAGAGCCAGAACACAGGCTATGGAACTCAGTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAG AGCTCCCAATCGTCTTACGGGCAGCAGTCCTCCTACCCTGGCTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGC AGTTCTCAGAGCAGCAGCTATGGGCAGCCCCAGAGTGGGAGCTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAG CAGCAAAGCTATAATCCCCCTCAGGGCTATGGACAGCAGAACCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGTT GCCATTGCCCCAAATGGAGCCTTACAGTTGGCAAGTCCAGGCACAGATGGAGTACAGGGACTTCAGACATTAACCATGACAAATTCAGGC AGTACTCAGCAAGGTACAACTATTCTTCAGTATGCACAGACCTCTGATGGACAGCAGATACTTGTGCCCAGCAATCAGGTGGTCGTACAA ACTGCATCAGGAGATATGCAAACATATCAGATCCGAACTACACCTTCAGCTACTTCTCTGCCACAAACTGTGGTGATGACATCTCCTGTG ACTCTCACCTCTCAGACAACTAAGACAGATGACCCCCAATTGAAAAGAGAAATAAGGTTAATGAAAAACAGAGAAGCTGCTCGAGAATGT CGCAGAAAGAAGAAAGAATATGTGAAATGCCTGGAAAACCGAGTTGCAGTCCTGGAAAATCAAAATAAAACTCTAATAGAAGAGTTAAAA ACTTTGAAGGATCTTTATTCCAATAAAAGTGTTTGATTCCTAAGAAAGAAAATATTTTTGTGGACATGCATAAAAATTAAATGGATTTCC TAGTGGAGTTTTATAAATTAAAAGGTCAAAACTGAAGCTTTTTATTTAGGCTTTTCCAAATCAAGGATAAATATCTTACGCACGATATCT AGTGACAGAGGAGAAAGTGGAAAATGACCTCAAGGAAGCTACGGGCACAACTGGAAGCTTTGTAGAAATTAAACATATTCAAGGAGCAAG AAATGAACTTTCAGCAGTCTAAATTTTCTAAATAACCAATAGTTGCCAATCTAAAATGGCAGAGAAGATGAAATTTGATAAACTGAATTT TTTTTAAAAATCCATTTACCCTACAGGTTTGCATTTGTTTGCTGAAATTTACCTTTTTTTAGTTATATATATGTGTGTGTGTGTGTGTAA TTTCTGCCAATAAATTCTAAATTACAAAGGTAAGAGAAAACCTAGTACATTACTAAATATATAAAGTATATGTTCTGATTATGTATACTT GTTCTAGTGTCAAGTCTTTTTAAGTGGGTTTTTAAAAGTTTGTTATTGGACTTGAATGGATTTTTGAGACTAGGTTAATTATTTTTGAGG TCTTATCCTAAAAGGCATCTAAGGTACATGAATGGAGTATGGTGATTTTATAACATTTTTTATCAGAATGGAAAAAGAACTGTTTAAAAG TTTGATACTTTTAAATAGTTGGTTTTTTTGCTTACTCTGGTAATGATTTTCTACAAATACATAATAAATTGTTTTTTTGAGTCTATATTC TGTATGCAGTTGAATATCCATTACTTATTCTGCTGTGCTTTAATAGAATGGAATGTTTACAGGCCCTTAAAATATTATTTTTAAAAAACC TTCTGAAGATACATACCAAAGTTTTTCCAAGAAGATTTTATAATCAATTTAATAATGTAAGGTTTATCAGATTCTATAATAGTATAGTTA TTAAGGCAATTTTATGTTAGAGACTATTTTGTAATGTAGTGAGTGGTACCTTTATAAGAAAAGTGACTGCCAATATATTTTTATAGCTGA TCTTTATAAATTCTAATGTTGAGTTTTTAATGATTATTTTAAATGTTTATATAGTTTAGTAAAATTTGCATCTCAAAGTATCATTTTTAT ATTATGGGACGTTTTCAGATTGGCTAATATTTGCATTGTAAATTTTGTATGCAGTTTATCTAAAATTCAAAAATACTGTCAGTACACCAG CGTTTAACATCTATATTCCAATTTGTATACAGTTTAAAATTGTACTGCAAAACTATTGTGTGCTCTTACACAGTATGCATCATATTGTTG >In-frame_FUS_ENST00000380244_chr16_31195717_+_ATF1_ENST00000262053_chr12_51207791_+_2427nt GCTCAGTCCTCCAGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTGCGCGCGTGCGCGGACATGGCCTCAAACGA TTATACCCAACAAGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTATTCCCAGCAGAGCAGTCAGCCCTACGGACA GCAGAGTTACAGTGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTATTCTTCTTATGGCCAGAGCCAGAACAGCTA TGGAACTCAGTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCGTCTTACGGGCAGCAGTCCTC CTACCCTGGCTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGCAGTTCTCAGAGCAGCAGCTATGGGCAGCCCCA GAGTGGGAGCTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAGCAGCAAAGCTATAATCCCCCTCAGGGCTATGG ACAGCAGAACCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGTTGCCATTGCCCCAAATGGAGCCTTACAGTTGGC AAGTCCAGGCACAGATGGAGTACAGGGACTTCAGACATTAACCATGACAAATTCAGGCAGTACTCAGCAAGGTACAACTATTCTTCAGTA TGCACAGACCTCTGATGGACAGCAGATACTTGTGCCCAGCAATCAGGTGGTCGTACAAACTGCATCAGGAGATATGCAAACATATCAGAT CCGAACTACACCTTCAGCTACTTCTCTGCCACAAACTGTGGTGATGACATCTCCTGTGACTCTCACCTCTCAGACAACTAAGACAGATGA CCCCCAATTGAAAAGAGAAATAAGGTTAATGAAAAACAGAGAAGCTGCTCGAGAATGTCGCAGAAAGAAGAAAGAATATGTGAAATGCCT GGAAAACCGAGTTGCAGTCCTGGAAAATCAAAATAAAACTCTAATAGAAGAGTTAAAAACTTTGAAGGATCTTTATTCCAATAAAAGTGT TTGATTCCTAAGAAAGAAAATATTTTTGTGGACATGCATAAAAATTAAATGGATTTCCTAGTGGAGTTTTATAAATTAAAAGGTCAAAAC TGAAGCTTTTTATTTAGGCTTTTCCAAATCAAGGATAAATATCTTACGCACGATATCTAGTGACAGAGGAGAAAGTGGAAAATGACCTCA AGGAAGCTACGGGCACAACTGGAAGCTTTGTAGAAATTAAACATATTCAAGGAGCAAGAAATGAACTTTCAGCAGTCTAAATTTTCTAAA TAACCAATAGTTGCCAATCTAAAATGGCAGAGAAGATGAAATTTGATAAACTGAATTTTTTTTAAAAATCCATTTACCCTACAGGTTTGC ATTTGTTTGCTGAAATTTACCTTTTTTTAGTTATATATATGTGTGTGTGTGTGTGTAATTTCTGCCAATAAATTCTAAATTACAAAGGTA AGAGAAAACCTAGTACATTACTAAATATATAAAGTATATGTTCTGATTATGTATACTTGTTCTAGTGTCAAGTCTTTTTAAGTGGGTTTT TAAAAGTTTGTTATTGGACTTGAATGGATTTTTGAGACTAGGTTAATTATTTTTGAGGTCTTATCCTAAAAGGCATCTAAGGTACATGAA TGGAGTATGGTGATTTTATAACATTTTTTATCAGAATGGAAAAAGAACTGTTTAAAAGTTTGATACTTTTAAATAGTTGGTTTTTTTGCT TACTCTGGTAATGATTTTCTACAAATACATAATAAATTGTTTTTTTGAGTCTATATTCTGTATGCAGTTGAATATCCATTACTTATTCTG CTGTGCTTTAATAGAATGGAATGTTTACAGGCCCTTAAAATATTATTTTTAAAAAACCTTCTGAAGATACATACCAAAGTTTTTCCAAGA AGATTTTATAATCAATTTAATAATGTAAGGTTTATCAGATTCTATAATAGTATAGTTATTAAGGCAATTTTATGTTAGAGACTATTTTGT AATGTAGTGAGTGGTACCTTTATAAGAAAAGTGACTGCCAATATATTTTTATAGCTGATCTTTATAAATTCTAATGTTGAGTTTTTAATG ATTATTTTAAATGTTTATATAGTTTAGTAAAATTTGCATCTCAAAGTATCATTTTTATATTATGGGACGTTTTCAGATTGGCTAATATTT GCATTGTAAATTTTGTATGCAGTTTATCTAAAATTCAAAAATACTGTCAGTACACCAGCGTTTAACATCTATATTCCAATTTGTATACAG >In-frame_FUS_ENST00000568685_chr16_31195717_+_ATF1_ENST00000262053_chr12_51207791_+_2418nt AGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTGCGCGCGTGCGCGGACATGGCCTCAAACGATTATACCCAACA AGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTATTCCCAGCAGAGCAGTCAGCCCTACGGACAGCAGAGTTACAG TGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTATTCTTCTTATGGCCAGAGCCAGAACACAGGCTATGGAACTCA GTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCGTCTTACGGGCAGCAGTCCTCCTACCCTGG CTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGCAGTTCTCAGAGCAGCAGCTATGGGCAGCCCCAGAGTGGGAG CTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAGCAGCAAAGCTATAATCCCCCTCAGGGCTATGGACAGCAGAA CCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGTTGCCATTGCCCCAAATGGAGCCTTACAGTTGGCAAGTCCAGG CACAGATGGAGTACAGGGACTTCAGACATTAACCATGACAAATTCAGGCAGTACTCAGCAAGGTACAACTATTCTTCAGTATGCACAGAC CTCTGATGGACAGCAGATACTTGTGCCCAGCAATCAGGTGGTCGTACAAACTGCATCAGGAGATATGCAAACATATCAGATCCGAACTAC ACCTTCAGCTACTTCTCTGCCACAAACTGTGGTGATGACATCTCCTGTGACTCTCACCTCTCAGACAACTAAGACAGATGACCCCCAATT GAAAAGAGAAATAAGGTTAATGAAAAACAGAGAAGCTGCTCGAGAATGTCGCAGAAAGAAGAAAGAATATGTGAAATGCCTGGAAAACCG AGTTGCAGTCCTGGAAAATCAAAATAAAACTCTAATAGAAGAGTTAAAAACTTTGAAGGATCTTTATTCCAATAAAAGTGTTTGATTCCT AAGAAAGAAAATATTTTTGTGGACATGCATAAAAATTAAATGGATTTCCTAGTGGAGTTTTATAAATTAAAAGGTCAAAACTGAAGCTTT TTATTTAGGCTTTTCCAAATCAAGGATAAATATCTTACGCACGATATCTAGTGACAGAGGAGAAAGTGGAAAATGACCTCAAGGAAGCTA CGGGCACAACTGGAAGCTTTGTAGAAATTAAACATATTCAAGGAGCAAGAAATGAACTTTCAGCAGTCTAAATTTTCTAAATAACCAATA GTTGCCAATCTAAAATGGCAGAGAAGATGAAATTTGATAAACTGAATTTTTTTTAAAAATCCATTTACCCTACAGGTTTGCATTTGTTTG CTGAAATTTACCTTTTTTTAGTTATATATATGTGTGTGTGTGTGTGTAATTTCTGCCAATAAATTCTAAATTACAAAGGTAAGAGAAAAC CTAGTACATTACTAAATATATAAAGTATATGTTCTGATTATGTATACTTGTTCTAGTGTCAAGTCTTTTTAAGTGGGTTTTTAAAAGTTT GTTATTGGACTTGAATGGATTTTTGAGACTAGGTTAATTATTTTTGAGGTCTTATCCTAAAAGGCATCTAAGGTACATGAATGGAGTATG GTGATTTTATAACATTTTTTATCAGAATGGAAAAAGAACTGTTTAAAAGTTTGATACTTTTAAATAGTTGGTTTTTTTGCTTACTCTGGT AATGATTTTCTACAAATACATAATAAATTGTTTTTTTGAGTCTATATTCTGTATGCAGTTGAATATCCATTACTTATTCTGCTGTGCTTT AATAGAATGGAATGTTTACAGGCCCTTAAAATATTATTTTTAAAAAACCTTCTGAAGATACATACCAAAGTTTTTCCAAGAAGATTTTAT AATCAATTTAATAATGTAAGGTTTATCAGATTCTATAATAGTATAGTTATTAAGGCAATTTTATGTTAGAGACTATTTTGTAATGTAGTG AGTGGTACCTTTATAAGAAAAGTGACTGCCAATATATTTTTATAGCTGATCTTTATAAATTCTAATGTTGAGTTTTTAATGATTATTTTA AATGTTTATATAGTTTAGTAAAATTTGCATCTCAAAGTATCATTTTTATATTATGGGACGTTTTCAGATTGGCTAATATTTGCATTGTAA ATTTTGTATGCAGTTTATCTAAAATTCAAAAATACTGTCAGTACACCAGCGTTTAACATCTATATTCCAATTTGTATACAGTTTAAAATT |
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FusionGenePPI for FUS_ATF1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FUS | EIF6, USF2, PRMT1, PTBP2, SRRM1, SPI1, YBX1, ILF3, SF1, SRSF10, THRA, RXRA, RELA, OTUB1, ZMYM2, SARNP, TARDBP, DGCR8, PCM1, SF3A2, SIRT7, SQSTM1, TDRD3, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, ARHGEF28, PA2G4, UBE2I, ATXN1L, GRB2, PIK3R2, HNRNPA3, NONO, EEF1A1, DYNC1H1, GSE1, MBD3, MRPS18B, SAP30BP, RPLP1, ESR1, FN1, VCAM1, TP63, IL7R, UBL4A, ITGA4, CTNNB1, UPF1, LMNA, EWSR1, RBMX, PSMB7, ESRRA, MDH1, TAF15, SRSF9, SAFB2, TNIP1, KHDRBS3, NKD2, MAX, PARK2, SUV39H1, WBP4, HNRNPU, LARS, RPA3, RPA2, RPA1, WWOX, HSPA5, VCP, SFPQ, YWHAZ, YWHAQ, PFN1, FASN, PGK1, CKB, ENO1, LDHB, PAICS, PHGDH, LDHA, GAPDH, PKM, ATXN2L, MTHFD1, ACACA, CA2, ALDOA, GPI, PYCRL, PFKL, PGM1, ABCA1, HPRT1, PM20D2, TKT, UBA1, PSMD12, CDH4, ANXA2P2, GNAS, PLCE1, TRPM4, SLC1A5, UBAP2, UBAP2L, LYZ, CKAP4, YPEL1, HIST4H4, H3F3A, H3F3B, HIST2H2BE, DDX42, HNRNPD, SYNCRIP, DHX40, SF3A1, SF3B3, SF3B4, SERBP1, FANCM, RAD54B, PCNA, PHB, TP73, RPL18, RPL9, RPS9, TBPL1, TRIP4, DNAJC10, SAE1, DLD, GOT2, ATP5A1, GSTP1, HARS2, SLC25A3, KPNA2, RAB7A, SPATA6, UACA, STATH, ANXA5, MAP3K3, UBC, TUBB, CFL1, TUBA1A, ACTB, HNRNPF, HNRNPH1, DHX15, CPSF6, SF3A3, HNRNPK, PSPC1, HNRNPL, RPS5, RPS8, RPL12, RPN2, EEF2, EEF1G, HSP90AA1, CCT5, CCT6A, HSP90AB1, CCT2, CCT4, HSP90B1, CCT3, CCT7, CCT8, HSPA8, PPIL4, TCP1, PDIA3, PPIA, SSBP1, GLUD1, ATP5B, HSPA9, ERAL1, TUFM, HSPD1, PYCR1, MDH2, ABCF2, KPNB1, PRDX1, ERP44, F7, ALB, ARMC6, ADCK5, CCDC88A, GPR101, ITK, DGKA, SLC22A11, HERC6, TUBA1B, MTSS1L, CEP112, COL18A1, SEC13, NAP1L1, SNRPD2, NCAPG2, RBBP4, FLJ22447, LSM12, NUDT21, DDX1, C14orf166, DDX5, HIVEP3, NCOA6, RAVER1, TCEB1, TXNL4B, TTI2, GEN1, RPL14, RPS14, NPM1, RPL11, RPL4, EIF4A1, PCBP2, ST13, NSDHL, MTAP, MAT2A, AHCY, OAT, BCS1L, SLC25A5, TIMM50, MYH10, GOLIM4, CSE1L, RAN, KLHL40, KLHL5, IGKV1-5, C6, GIMAP8, CDC5L, CEP78, DBF4B, AMOT, FAM71F1, MFGE8, FAM98A, C11orf70, RTCB, UFL1, LRRIQ4, NUPR1, CUL7, OBSL1, EZH2, SUZ12, BMI1, ABL1, CHEK1, SIK2, SRPK1, LUZP4, UPF2, UPF3A, FAM58A, YEATS4, RPS6KB2, HNRNPA1, FBXW11, ACAT1, ARMC1, C2orf49, DDX17, DNAJC7, EIF4H, AURKA, PTBP1, TOMM34, TXLNA, UFD1L, HNRNPDL, MEF2D, NAA50, NPLOC4, PFKP, PICALM, TARS, NTRK1, SCARNA22, TCF7L2, KIF22, EMC2, MATR3, MCM2, SNW1, RC3H1, EGFR, TRAF6, CRBN, KCTD6, RPS27, PSRC1, SMCO3, CYLD, TRIM25, BRCA1, HDAC6 | ATF1 | BRCA1, CSNK2A1, CSNK2B, CAMK2A, CREBBP, SPI1, HNF1B, GABPA, FOSL2, SRA1, CACNG2, TRPV5, TUFT1, ATF2, JUNB, CREB1, NFATC1, DNMT3L, MAPKAPK2, MAPKAPK3, RPS6KA5, CTAGE5, ARHGAP22, CCDC97, IDO2, CREBRF, CSGALNACT2, ARIH1, TFAP4, HSPA8, NFIL3, SSH1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FUS_ATF1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | ATF1 | P18846 | DB00852 | Pseudoephedrine | Cyclic AMP-dependent transcription factor ATF-1 | small molecule | approved |
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RelatedDiseases for FUS_ATF1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FUS | C1842675 | AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) | 6 | UNIPROT |
| Hgene | FUS | C0206634 | Liposarcoma, Myxoid | 2 | CTD_human;ORPHANET |
| Hgene | FUS | C3539195 | TREMOR, HEREDITARY ESSENTIAL, 4 | 1 | UNIPROT |
| Tgene | ATF1 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
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