![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 14063 |
FusionGeneSummary for FUCA2_SSR2 |
![]() |
Fusion gene information | Fusion gene name: FUCA2_SSR2 | Fusion gene ID: 14063 | Hgene | Tgene | Gene symbol | FUCA2 | SSR2 | Gene ID | 2519 | 6746 |
Gene name | alpha-L-fucosidase 2 | signal sequence receptor subunit 2 | |
Synonyms | dJ20N2.5 | HSD25|TLAP|TRAP-BETA|TRAPB | |
Cytomap | 6q24.2 | 1q22 | |
Type of gene | protein-coding | protein-coding | |
Description | plasma alpha-L-fucosidaseI+/--L-fucosidase 2a-L-fucosidase 2alpha-L-fucoside fucohydrolase 2fucosidase, alpha-L- 2, plasmaplasma fucosidase | translocon-associated protein subunit betaSSR-betasignal sequence receptor subunit betasignal sequence receptor, beta (translocon-associated protein beta)translocon-associated protein beta | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9BTY2 | P43308 | |
Ensembl transtripts involved in fusion gene | ENST00000002165, ENST00000438118, ENST00000367585, | ENST00000295702, ENST00000529008, ENST00000496742, ENST00000480567, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 7 X 4=168 |
# samples | 1 | 7 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FUCA2 [Title/Abstract] AND SSR2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FUCA2 | GO:0006004 | fucose metabolic process | 19666478 |
Hgene | FUCA2 | GO:0016139 | glycoside catabolic process | 19666478 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE837584 | FUCA2 | chr6 | 143816937 | - | SSR2 | chr1 | 155979271 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000002165 | ENST00000295702 | FUCA2 | chr6 | 143816937 | - | SSR2 | chr1 | 155979271 | + |
intron-3UTR | ENST00000002165 | ENST00000529008 | FUCA2 | chr6 | 143816937 | - | SSR2 | chr1 | 155979271 | + |
intron-3UTR | ENST00000002165 | ENST00000496742 | FUCA2 | chr6 | 143816937 | - | SSR2 | chr1 | 155979271 | + |
intron-3UTR | ENST00000002165 | ENST00000480567 | FUCA2 | chr6 | 143816937 | - | SSR2 | chr1 | 155979271 | + |
intron-3UTR | ENST00000438118 | ENST00000295702 | FUCA2 | chr6 | 143816937 | - | SSR2 | chr1 | 155979271 | + |
intron-3UTR | ENST00000438118 | ENST00000529008 | FUCA2 | chr6 | 143816937 | - | SSR2 | chr1 | 155979271 | + |
intron-3UTR | ENST00000438118 | ENST00000496742 | FUCA2 | chr6 | 143816937 | - | SSR2 | chr1 | 155979271 | + |
intron-3UTR | ENST00000438118 | ENST00000480567 | FUCA2 | chr6 | 143816937 | - | SSR2 | chr1 | 155979271 | + |
intron-3UTR | ENST00000367585 | ENST00000295702 | FUCA2 | chr6 | 143816937 | - | SSR2 | chr1 | 155979271 | + |
intron-3UTR | ENST00000367585 | ENST00000529008 | FUCA2 | chr6 | 143816937 | - | SSR2 | chr1 | 155979271 | + |
intron-3UTR | ENST00000367585 | ENST00000496742 | FUCA2 | chr6 | 143816937 | - | SSR2 | chr1 | 155979271 | + |
intron-3UTR | ENST00000367585 | ENST00000480567 | FUCA2 | chr6 | 143816937 | - | SSR2 | chr1 | 155979271 | + |
Top |
FusionProtFeatures for FUCA2_SSR2 |
![]() |
Hgene | Tgene |
FUCA2 | SSR2 |
Alpha-L-fucosidase is responsible for hydrolyzing thealpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. | TRAP proteins are part of a complex whose function is tobind calcium to the ER membrane and thereby regulate the retentionof ER resident proteins. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for FUCA2_SSR2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for FUCA2_SSR2 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for FUCA2_SSR2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for FUCA2_SSR2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SSR2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |