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Fusion gene ID: 14047 |
FusionGeneSummary for FTO_RBL2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FTO_RBL2 | Fusion gene ID: 14047 | Hgene | Tgene | Gene symbol | FTO | RBL2 | Gene ID | 79068 | 5934 |
| Gene name | FTO, alpha-ketoglutarate dependent dioxygenase | RB transcriptional corepressor like 2 | |
| Synonyms | ALKBH9|BMIQ14|GDFD | P130|Rb2 | |
| Cytomap | 16q12.2 | 16q12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | alpha-ketoglutarate-dependent dioxygenase FTOAlkB homolog 9fat mass and obesity associatedfat mass and obesity-associated protein | retinoblastoma-like protein 2130 kDa retinoblastoma-associated proteinPRB2RBR-2retinoblastoma-like 2retinoblastoma-related protein 2 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q9C0B1 | Q08999 | |
| Ensembl transtripts involved in fusion gene | ENST00000471389, ENST00000394647, ENST00000431610, ENST00000460382, ENST00000463855, ENST00000472835, | ENST00000262133, ENST00000379935, ENST00000544545, | |
| Fusion gene scores | * DoF score | 5 X 2 X 5=50 | 4 X 3 X 3=36 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/50*10)=0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FTO [Title/Abstract] AND RBL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FTO | GO:0006307 | DNA dealkylation involved in DNA repair | 18775698|20376003 |
| Hgene | FTO | GO:0035552 | oxidative single-stranded DNA demethylation | 18775698|20376003 |
| Hgene | FTO | GO:0035553 | oxidative single-stranded RNA demethylation | 18775698|22002720 |
| Hgene | FTO | GO:0042245 | RNA repair | 18775698 |
| Hgene | FTO | GO:0070989 | oxidative demethylation | 18775698 |
| Hgene | FTO | GO:0080111 | DNA demethylation | 18775698 |
| Tgene | RBL2 | GO:0043550 | regulation of lipid kinase activity | 16286473 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-95-8039-01A | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000471389 | ENST00000262133 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| 5CDS-intron | ENST00000471389 | ENST00000379935 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| 5CDS-intron | ENST00000471389 | ENST00000544545 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| 5UTR-3CDS | ENST00000394647 | ENST00000262133 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| 5UTR-intron | ENST00000394647 | ENST00000379935 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| 5UTR-intron | ENST00000394647 | ENST00000544545 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-3CDS | ENST00000431610 | ENST00000262133 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-intron | ENST00000431610 | ENST00000379935 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-intron | ENST00000431610 | ENST00000544545 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-3CDS | ENST00000460382 | ENST00000262133 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-intron | ENST00000460382 | ENST00000379935 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-intron | ENST00000460382 | ENST00000544545 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-3CDS | ENST00000463855 | ENST00000262133 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-intron | ENST00000463855 | ENST00000379935 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-intron | ENST00000463855 | ENST00000544545 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-3CDS | ENST00000472835 | ENST00000262133 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-intron | ENST00000472835 | ENST00000379935 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-intron | ENST00000472835 | ENST00000544545 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
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FusionProtFeatures for FTO_RBL2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FTO | RBL2 |
| Dioxygenase that repairs alkylated DNA and RNA byoxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylaseactivity towards single-stranded DNA containing 1-methyladenine or3-methylcytosine (PubMed:18775698, PubMed:20376003). Specificallydemethylates N(6)-methyladenosine (m6A) RNA, the most prevalentinternal modification of messenger RNA (mRNA) in higher eukaryotes(PubMed:22002720, PubMed:26458103). Has no activity towards 1-methylguanine. Has no detectable activity towards double-strandedDNA. Requires molecular oxygen, alpha-ketoglutarate and iron.Contributes to the regulation of the global metabolic rate, energyexpenditure and energy homeostasis. Contributes to the regulationof body size and body fat accumulation (PubMed:18775698,PubMed:20376003). In particular, it is involved in the regulationof thermogenesis and the control of adipocyte differentiation intobrown or white fat cells (PubMed:26287746).{ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:20376003,ECO:0000269|PubMed:22002720, ECO:0000269|PubMed:26287746,ECO:0000269|PubMed:26458103}. | Key regulator of entry into cell division. Directlyinvolved in heterochromatin formation by maintaining overallchromatin structure and, in particular, that of constitutiveheterochromatin by stabilizing histone methylation. Recruits andtargets histone methyltransferases KMT5B and KMT5C, leading toepigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor byrecruiting chromatin-modifying enzymes to promoters. Potentinhibitor of E2F-mediated trans-activation, associatespreferentially with E2F5. Binds to cyclins A and E. Binds to andmay be involved in the transforming capacity of the adenovirus E1Aprotein. May act as a tumor suppressor. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >RBL2 | chr16:53738141 | chr16:53472928 | ENST00000262133 | + | 0 | 22 | 998_1001 | 80 | 1140 | Compositional bias | Note=Poly-Glu |
| Tgene | >RBL2 | chr16:53738141 | chr16:53472928 | ENST00000262133 | + | 0 | 22 | 417_1024 | 80 | 1140 | Region | Note=Pocket%3B binds E1A |
| Tgene | >RBL2 | chr16:53738141 | chr16:53472928 | ENST00000262133 | + | 0 | 22 | 417_616 | 80 | 1140 | Region | Note=Domain A |
| Tgene | >RBL2 | chr16:53738141 | chr16:53472928 | ENST00000262133 | + | 0 | 22 | 617_827 | 80 | 1140 | Region | Note=Spacer |
| Tgene | >RBL2 | chr16:53738141 | chr16:53472928 | ENST00000262133 | + | 0 | 22 | 828_1024 | 80 | 1140 | Region | Note=Domain B |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >FTO | chr16:53738141 | chr16:53472928 | ENST00000431610 | + | 1 | 5 | 213_224 | -55 | 107 | Region | Note=Loop L1%3B predicted to block binding of double-stranded DNA or RNA |
| Hgene | >FTO | chr16:53738141 | chr16:53472928 | ENST00000431610 | + | 1 | 5 | 231_234 | -55 | 107 | Region | Note=Substrate binding |
| Hgene | >FTO | chr16:53738141 | chr16:53472928 | ENST00000431610 | + | 1 | 5 | 316_318 | -55 | 107 | Region | Note=Alpha-ketoglutarate binding |
| Hgene | >FTO | chr16:53738141 | chr16:53472928 | ENST00000431610 | + | 1 | 5 | 32_327 | -55 | 107 | Region | Note=Fe2OG dioxygenase domain |
| Hgene | >FTO | chr16:53738141 | chr16:53472928 | ENST00000460382 | + | 1 | 4 | 213_224 | -42 | 107 | Region | Note=Loop L1%3B predicted to block binding of double-stranded DNA or RNA |
| Hgene | >FTO | chr16:53738141 | chr16:53472928 | ENST00000460382 | + | 1 | 4 | 231_234 | -42 | 107 | Region | Note=Substrate binding |
| Hgene | >FTO | chr16:53738141 | chr16:53472928 | ENST00000460382 | + | 1 | 4 | 316_318 | -42 | 107 | Region | Note=Alpha-ketoglutarate binding |
| Hgene | >FTO | chr16:53738141 | chr16:53472928 | ENST00000460382 | + | 1 | 4 | 32_327 | -42 | 107 | Region | Note=Fe2OG dioxygenase domain |
| Hgene | >FTO | chr16:53738141 | chr16:53472928 | ENST00000463855 | + | 1 | 3 | 213_224 | -42 | 128 | Region | Note=Loop L1%3B predicted to block binding of double-stranded DNA or RNA |
| Hgene | >FTO | chr16:53738141 | chr16:53472928 | ENST00000463855 | + | 1 | 3 | 231_234 | -42 | 128 | Region | Note=Substrate binding |
| Hgene | >FTO | chr16:53738141 | chr16:53472928 | ENST00000463855 | + | 1 | 3 | 316_318 | -42 | 128 | Region | Note=Alpha-ketoglutarate binding |
| Hgene | >FTO | chr16:53738141 | chr16:53472928 | ENST00000463855 | + | 1 | 3 | 32_327 | -42 | 128 | Region | Note=Fe2OG dioxygenase domain |
| Hgene | >FTO | chr16:53738141 | chr16:53472928 | ENST00000471389 | + | 1 | 9 | 213_224 | 15 | 506 | Region | Note=Loop L1%3B predicted to block binding of double-stranded DNA or RNA |
| Hgene | >FTO | chr16:53738141 | chr16:53472928 | ENST00000471389 | + | 1 | 9 | 231_234 | 15 | 506 | Region | Note=Substrate binding |
| Hgene | >FTO | chr16:53738141 | chr16:53472928 | ENST00000471389 | + | 1 | 9 | 316_318 | 15 | 506 | Region | Note=Alpha-ketoglutarate binding |
| Hgene | >FTO | chr16:53738141 | chr16:53472928 | ENST00000471389 | + | 1 | 9 | 32_327 | 15 | 506 | Region | Note=Fe2OG dioxygenase domain |
| Tgene | RBL2 | chr16:53738141 | chr16:53472928 | ENST00000262133 | + | 0 | 22 | 17_20 | 80 | 1140 | Compositional bias | Note=Poly-Ala |
| Tgene | RBL2 | chr16:53738141 | chr16:53472928 | ENST00000262133 | + | 0 | 22 | 23_26 | 80 | 1140 | Compositional bias | Note=Poly-Glu |
| Tgene | RBL2 | chr16:53738141 | chr16:53472928 | ENST00000262133 | + | 0 | 22 | 9_16 | 80 | 1140 | Compositional bias | Note=Poly-Pro |
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FusionGeneSequence for FTO_RBL2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FTO_ENST00000471389_chr16_53738141_+_RBL2_ENST00000262133_chr16_53472928_+_1075aa MKRTPTAEEREREAKGNDLHWLACALYVACRKSVPTVSKGTVEGNYVSLTRILKCSEQSLIEFFNKMKKWEDMANLPPHFRERTERLERN FTVSAVIFKKYEPIFQDIFKYPQEEQPRQQRGRKQRRQPCTVSEIFHFCWVLFIYAKGNFPMISDDLVNSYHLLLCALDLVYGNALQCSN RKELVNPNFKGLSEDFHAKDSKPSSDPPCIIEKLCSLHDGLVLEAKGIKEHFWKPYIRKLYEKKLLKGKEENLTGFLEPGNFGESFKAIN KAYEEYVLSVGNLDERIFLGEDAEEEIGTLSRCLNAGSGTETAERVQMKNILQQHFDKSKALRISTPLTGVRYIKENSPCVTPVSTATHS LSRLHTMLTGLRNAPSEKLEQILRTCSRDPTQAIANRLKEMFEIYSQHFQPDEDFSNCAKEIASKHFRFAEMLYYKVLESVIEQEQKRLG DMDLSGILEQDAFHRSLLACCLEVVTFSYKPPGNFPFITEIFDVPLYHFYKVIEVFIRAEDGLCREVVKHLNQIEEQILDHLAWKPESPL WEKIRDNENRVPTCEEVMPPQNLERADEICIAGSPLTPRRVTEVRADTGGLGRSITSPTTLYDRYSSPPASTTRRRLFVENDSPSDGGTP GRMPPQPLVNAVPVQNVSGETVSVTPVPGQTLVTMATATVTANNGQTVTIPVQGIANENGGITFFPVQVNVGGQAQAVTGSIQPLSAQAL AGSLSSQQVTGTTLQVPGQVAIQQISPGGQQQKQGQSVTSSSNRPRKTSSLSLFFRKVYHLAAVRLRDLCAKLDISDELRKKIWTCFEFS IIQCPELMMDRHLDQLLMCAIYVMAKVTKEDKSFQNIMRCYRTQPQARSQVYRSVLIKGKRKRRNSGSSDSRSHQNSPTELNKDRTSRDS SPVMRSSSTLPVPQPSSAPPTPTRLTGANSDMEEEERGDLIQFYNNIYIKQIKTFAMKYSQANMDAPPLSPYPFVRTGSPRRIQLSQNHP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FTO_ENST00000471389_chr16_53738141_+_RBL2_ENST00000262133_chr16_53472928_+_3225nt ATGAAGCGCACCCCGACTGCCGAGGAACGAGAGCGCGAAGCTAAGGGAAATGATCTTCATTGGTTAGCATGTGCCTTATATGTGGCTTGC AGAAAATCTGTTCCAACTGTAAGCAAAGGGACAGTGGAAGGAAACTATGTATCTTTAACTAGAATCCTGAAATGTTCAGAGCAGAGCTTA ATCGAATTTTTTAATAAGATGAAGAAGTGGGAAGACATGGCAAATCTACCCCCACATTTCAGAGAACGTACTGAGAGATTAGAAAGAAAC TTCACTGTTTCTGCTGTAATTTTTAAGAAATATGAACCCATTTTTCAGGACATCTTTAAATACCCTCAAGAGGAGCAACCTCGTCAGCAG CGAGGAAGGAAACAGCGGCGACAGCCCTGTACTGTGTCTGAAATTTTCCATTTTTGTTGGGTGCTTTTTATATATGCAAAAGGTAATTTC CCCATGATTAGTGATGATTTGGTCAATTCTTATCACCTGCTGCTGTGTGCTTTGGACTTAGTTTATGGAAATGCACTTCAGTGTTCTAAT CGTAAAGAACTTGTGAACCCTAATTTTAAAGGCTTATCTGAAGATTTTCATGCTAAAGATTCTAAACCTTCCTCTGACCCCCCTTGTATC ATTGAGAAACTGTGTTCCTTACATGATGGCCTAGTTTTGGAAGCAAAGGGGATAAAGGAACATTTCTGGAAACCCTATATTAGGAAACTT TATGAAAAAAAGCTCCTTAAGGGAAAAGAAGAAAATCTCACTGGGTTTCTAGAACCTGGGAACTTTGGAGAGAGTTTTAAAGCCATCAAT AAGGCCTATGAGGAGTATGTTTTATCTGTTGGGAATTTAGATGAGCGGATATTTCTTGGAGAGGATGCTGAGGAGGAAATTGGGACTCTC TCAAGGTGTCTGAACGCTGGTTCAGGAACAGAGACTGCTGAAAGGGTGCAGATGAAAAACATCTTACAGCAGCATTTTGACAAGTCCAAA GCACTTAGAATCTCCACACCACTAACTGGTGTTAGGTACATTAAGGAGAATAGCCCTTGTGTGACTCCAGTTTCTACAGCTACGCATAGC TTGAGTCGTCTTCACACCATGCTGACAGGCCTCAGGAATGCACCAAGTGAGAAACTGGAACAGATTCTCAGGACATGTTCCAGAGATCCA ACCCAGGCTATTGCTAACAGACTGAAAGAAATGTTTGAAATATATTCTCAGCATTTCCAGCCAGACGAGGATTTCAGTAATTGTGCTAAA GAAATTGCCAGCAAACATTTTCGTTTTGCGGAGATGCTTTACTATAAAGTATTAGAATCTGTTATTGAGCAGGAACAAAAAAGACTAGGA GACATGGATTTATCTGGTATTCTGGAACAAGATGCGTTCCACAGATCTCTCTTGGCCTGCTGCCTTGAGGTCGTCACTTTTTCTTATAAG CCTCCTGGGAATTTTCCATTTATTACTGAAATATTTGATGTGCCTCTTTATCATTTTTATAAGGTGATAGAAGTATTCATTAGAGCAGAA GATGGCCTTTGTAGAGAGGTGGTAAAACACCTTAATCAGATTGAAGAACAGATCTTAGATCATTTGGCATGGAAACCAGAGTCTCCACTC TGGGAAAAAATTAGAGACAATGAAAACAGAGTTCCTACATGTGAAGAGGTCATGCCACCTCAGAACCTGGAAAGGGCAGATGAAATTTGC ATTGCTGGCTCCCCTTTGACTCCCAGAAGGGTGACTGAAGTTCGTGCTGATACTGGAGGACTTGGAAGGAGCATAACATCTCCAACCACA TTATACGATAGGTACAGCTCCCCACCAGCCAGCACTACCAGAAGGCGGCTATTTGTTGAGAATGATAGCCCCTCTGATGGAGGGACGCCT GGGCGCATGCCCCCACAGCCCCTAGTCAATGCTGTCCCTGTGCAGAATGTATCTGGGGAGACTGTTTCTGTCACACCAGTTCCTGGACAG ACTTTGGTCACCATGGCAACCGCCACTGTCACAGCCAACAATGGGCAAACGGTAACCATTCCTGTGCAAGGTATTGCCAATGAAAATGGA GGGATAACATTCTTCCCTGTCCAAGTCAATGTTGGGGGGCAGGCACAAGCTGTGACAGGCTCCATCCAGCCCCTCAGTGCTCAGGCCCTG GCTGGAAGTCTGAGCTCTCAACAGGTGACAGGAACAACTTTGCAAGTCCCTGGTCAAGTGGCCATTCAACAGATTTCCCCAGGTGGCCAA CAGCAGAAGCAAGGCCAGTCTGTAACCAGCAGTAGTAATAGACCCAGGAAGACCAGCTCTTTATCGCTTTTCTTTAGAAAGGTATACCAT TTAGCAGCTGTCCGCCTTCGGGATCTCTGTGCCAAACTAGATATTTCAGATGAATTGAGGAAAAAAATCTGGACCTGCTTTGAATTCTCC ATAATTCAGTGTCCTGAACTTATGATGGACAGACATCTGGACCAGTTATTAATGTGTGCCATTTATGTGATGGCAAAGGTCACAAAAGAA GATAAGTCCTTCCAGAACATTATGCGTTGTTATAGGACTCAGCCGCAGGCCCGGAGCCAGGTGTATAGAAGTGTTTTGATAAAAGGGAAA AGAAAAAGAAGAAATTCTGGCAGCAGTGATAGCAGAAGCCATCAGAATTCTCCAACAGAACTAAACAAAGATAGAACCAGTAGAGACTCC AGTCCAGTTATGAGGTCAAGCAGCACCTTGCCAGTTCCACAGCCCAGCAGTGCTCCTCCCACACCTACTCGCCTCACAGGTGCCAACAGT GACATGGAAGAAGAGGAGAGGGGAGACCTCATTCAGTTCTACAACAACATCTACATCAAACAGATTAAGACATTTGCCATGAAGTACTCA CAGGCAAATATGGATGCTCCTCCACTCTCTCCCTATCCATTTGTAAGAACAGGCTCCCCTCGCCGAATACAGTTGTCTCAAAATCATCCT GTCTACATTTCCCCACATAAAAATGAAACAATGCTTTCTCCTCGAGAAAAGATTTTCTATTACTTCAGCAACAGTCCTTCAAAGAGACTG AGAGAAATTAATAGTATGATACGCACAGGAGAAACTCCTACTAAAAAGAGAGGAATTCTTTTGGAAGATGGAAGTGAATCACCTGCAAAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FTO_ENST00000471389_chr16_53738141_+_RBL2_ENST00000262133_chr16_53472928_+_4796nt CTACGCTCTTCCAGCTGTCGGACCTGGGAAATTCTCCTGTGCTAAATCCCGTGGCGCTCGCGGGTGTCGCCGCGGTGCATCCTGGGAGTT GTAGTTTTTTCTACTCAGAGGGAGAATAGCTCCAGACGGGAGCAGGACGCTGAGAGAACTACATGCAGGAGGCGGGGTCCAGGGCGAGGG ATCTACGCAGCTTGCGGTGGCGAAGGCGGCTTTAGTGGCAGCATGAAGCGCACCCCGACTGCCGAGGAACGAGAGCGCGAAGCTAAGGGA AATGATCTTCATTGGTTAGCATGTGCCTTATATGTGGCTTGCAGAAAATCTGTTCCAACTGTAAGCAAAGGGACAGTGGAAGGAAACTAT GTATCTTTAACTAGAATCCTGAAATGTTCAGAGCAGAGCTTAATCGAATTTTTTAATAAGATGAAGAAGTGGGAAGACATGGCAAATCTA CCCCCACATTTCAGAGAACGTACTGAGAGATTAGAAAGAAACTTCACTGTTTCTGCTGTAATTTTTAAGAAATATGAACCCATTTTTCAG GACATCTTTAAATACCCTCAAGAGGAGCAACCTCGTCAGCAGCGAGGAAGGAAACAGCGGCGACAGCCCTGTACTGTGTCTGAAATTTTC CATTTTTGTTGGGTGCTTTTTATATATGCAAAAGGTAATTTCCCCATGATTAGTGATGATTTGGTCAATTCTTATCACCTGCTGCTGTGT GCTTTGGACTTAGTTTATGGAAATGCACTTCAGTGTTCTAATCGTAAAGAACTTGTGAACCCTAATTTTAAAGGCTTATCTGAAGATTTT CATGCTAAAGATTCTAAACCTTCCTCTGACCCCCCTTGTATCATTGAGAAACTGTGTTCCTTACATGATGGCCTAGTTTTGGAAGCAAAG GGGATAAAGGAACATTTCTGGAAACCCTATATTAGGAAACTTTATGAAAAAAAGCTCCTTAAGGGAAAAGAAGAAAATCTCACTGGGTTT CTAGAACCTGGGAACTTTGGAGAGAGTTTTAAAGCCATCAATAAGGCCTATGAGGAGTATGTTTTATCTGTTGGGAATTTAGATGAGCGG ATATTTCTTGGAGAGGATGCTGAGGAGGAAATTGGGACTCTCTCAAGGTGTCTGAACGCTGGTTCAGGAACAGAGACTGCTGAAAGGGTG CAGATGAAAAACATCTTACAGCAGCATTTTGACAAGTCCAAAGCACTTAGAATCTCCACACCACTAACTGGTGTTAGGTACATTAAGGAG AATAGCCCTTGTGTGACTCCAGTTTCTACAGCTACGCATAGCTTGAGTCGTCTTCACACCATGCTGACAGGCCTCAGGAATGCACCAAGT GAGAAACTGGAACAGATTCTCAGGACATGTTCCAGAGATCCAACCCAGGCTATTGCTAACAGACTGAAAGAAATGTTTGAAATATATTCT CAGCATTTCCAGCCAGACGAGGATTTCAGTAATTGTGCTAAAGAAATTGCCAGCAAACATTTTCGTTTTGCGGAGATGCTTTACTATAAA GTATTAGAATCTGTTATTGAGCAGGAACAAAAAAGACTAGGAGACATGGATTTATCTGGTATTCTGGAACAAGATGCGTTCCACAGATCT CTCTTGGCCTGCTGCCTTGAGGTCGTCACTTTTTCTTATAAGCCTCCTGGGAATTTTCCATTTATTACTGAAATATTTGATGTGCCTCTT TATCATTTTTATAAGGTGATAGAAGTATTCATTAGAGCAGAAGATGGCCTTTGTAGAGAGGTGGTAAAACACCTTAATCAGATTGAAGAA CAGATCTTAGATCATTTGGCATGGAAACCAGAGTCTCCACTCTGGGAAAAAATTAGAGACAATGAAAACAGAGTTCCTACATGTGAAGAG GTCATGCCACCTCAGAACCTGGAAAGGGCAGATGAAATTTGCATTGCTGGCTCCCCTTTGACTCCCAGAAGGGTGACTGAAGTTCGTGCT GATACTGGAGGACTTGGAAGGAGCATAACATCTCCAACCACATTATACGATAGGTACAGCTCCCCACCAGCCAGCACTACCAGAAGGCGG CTATTTGTTGAGAATGATAGCCCCTCTGATGGAGGGACGCCTGGGCGCATGCCCCCACAGCCCCTAGTCAATGCTGTCCCTGTGCAGAAT GTATCTGGGGAGACTGTTTCTGTCACACCAGTTCCTGGACAGACTTTGGTCACCATGGCAACCGCCACTGTCACAGCCAACAATGGGCAA ACGGTAACCATTCCTGTGCAAGGTATTGCCAATGAAAATGGAGGGATAACATTCTTCCCTGTCCAAGTCAATGTTGGGGGGCAGGCACAA GCTGTGACAGGCTCCATCCAGCCCCTCAGTGCTCAGGCCCTGGCTGGAAGTCTGAGCTCTCAACAGGTGACAGGAACAACTTTGCAAGTC CCTGGTCAAGTGGCCATTCAACAGATTTCCCCAGGTGGCCAACAGCAGAAGCAAGGCCAGTCTGTAACCAGCAGTAGTAATAGACCCAGG AAGACCAGCTCTTTATCGCTTTTCTTTAGAAAGGTATACCATTTAGCAGCTGTCCGCCTTCGGGATCTCTGTGCCAAACTAGATATTTCA GATGAATTGAGGAAAAAAATCTGGACCTGCTTTGAATTCTCCATAATTCAGTGTCCTGAACTTATGATGGACAGACATCTGGACCAGTTA TTAATGTGTGCCATTTATGTGATGGCAAAGGTCACAAAAGAAGATAAGTCCTTCCAGAACATTATGCGTTGTTATAGGACTCAGCCGCAG GCCCGGAGCCAGGTGTATAGAAGTGTTTTGATAAAAGGGAAAAGAAAAAGAAGAAATTCTGGCAGCAGTGATAGCAGAAGCCATCAGAAT TCTCCAACAGAACTAAACAAAGATAGAACCAGTAGAGACTCCAGTCCAGTTATGAGGTCAAGCAGCACCTTGCCAGTTCCACAGCCCAGC AGTGCTCCTCCCACACCTACTCGCCTCACAGGTGCCAACAGTGACATGGAAGAAGAGGAGAGGGGAGACCTCATTCAGTTCTACAACAAC ATCTACATCAAACAGATTAAGACATTTGCCATGAAGTACTCACAGGCAAATATGGATGCTCCTCCACTCTCTCCCTATCCATTTGTAAGA ACAGGCTCCCCTCGCCGAATACAGTTGTCTCAAAATCATCCTGTCTACATTTCCCCACATAAAAATGAAACAATGCTTTCTCCTCGAGAA AAGATTTTCTATTACTTCAGCAACAGTCCTTCAAAGAGACTGAGAGAAATTAATAGTATGATACGCACAGGAGAAACTCCTACTAAAAAG AGAGGAATTCTTTTGGAAGATGGAAGTGAATCACCTGCAAAAAGAATTTGCCCAGAAAATCATTCTGCCTTATTACGCCGTCTCCAAGAT GTAGCTAATGACCGTGGTTCCCACTGAGGTTAGTCTCTTGTATTAAACTCTTCACAAAATCTGTTTAGCAGCAGCCTTTAATGCATCTAG ATTATGGAGCTTTTTTCCTTAATCCAGCTGATGAGTTACAGCCTGTTAGTAACATGAGGGGACATTTTGGTGAGAAATGGGACTTAACTC CTTCCAGTGTCCTTAGAACATTTTAATTCATCCCAACTGTCTTTTTTTCCCTACCATTCAGTGATTACTGTCAAGGCTGCTTAGAATCCA AACTTGGATTTTTGACTCTGGCAAAGCTTTTAGAAATACTGCAAGAAAATGATGTGTACCCAAACGTGAGCATAGGAGGCTTCTGTTGAC GTACTCCAACAGAAGAACTGTGTTTCAAGTTCAATCCTACCTGTTTTGTGGTCAGCTGTAGTCCTCATAAAAAGCAAAACAAAAATTAGG TATTTTGTCCTAAAACACCTGGTAGGAGTGTGTGATTTTTTGCATTCCTGACAAAGGAGAGCACACCCAGGTTTGGAGGTCCTAGGTCAT TAGCCCTCGTCTCCCGTTCCCTTTGTGCACATCTTCCCTCTCCCCATTCGGTGTGGTGCAGTGTGAAAAGTCCTTGATTGTTCGGGTGTG CAATGTCTGAGTGAACCTGTATAAGTGGAGGCACTTTAGGGCTGTAAAATGCATGATTTTGTAACCCAGATTTTGCTGTATATTTGTGAT AGCACTTTCTACAATGTGAACTTTATTAAATACAAAACTTCCAGGCTAAACATCCAATATTTTCTTTAATGCTTTTATATTTTTTTAAAA TGTTAAAACCCCTATAGCCACCTTTTGGGAATGTTTTAAATTCTCCAGTTTTTTGTTATATAGGGATCAACCAGCTAAGAAAAGATTTTA ATCAAGTTGAATTGAGGGGATTAATATGAAAACTTATGACCTCTTCCTTTAGGAGGGAGTTATCTAAAAGAAATGTCTATTAAGGTGATA TATTTAAAAATATTTTTGGGTGTTCCTGGCAGTTTAAAAAAATTGGTTGGAGAATTTAGGTTTTTATTAGTACCATAGTACCATTTATAC AAATTAGAAAATGTTATTTAACAGCTGAATTATCTATACATATCTTTATTAATCACTATTGTTCCAGCAGTTTTCAAGTCAAATTAATAA TCTTATTAGGGAGAAAATTCAATTGTAAATTGAATCAGTATAAACAAAGTTACTAGGTAACTTCATATTGCTGAGAGAAATATGGAACTT ACATTGTTCAATTAGAATAGTGTTCTGCAAAAATATTTATAAAACTTCTCAAGATACTGCTACTGTAATTTTATATGAAGATAAGTGTAT |
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FusionGenePPI for FTO_RBL2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FTO | BCCIP, CKB, CNDP2, DAK, EEF2, PEPD, CTSA, LDHA, LDHB, MVD, NDRG1, NPEPPS, SLC9A3R1, ZMAT3, SBF2, GPX7, MPZL1, ZNF232, FSD1, FGB, NFYA, OR5F1, ALX3, DIRAS2, TYW3, SDC1 | RBL2 | HBP1, BRCA1, RBBP8, SUV39H1, HDAC1, CCNE1, CDK2, E2F5, AATF, SNW1, MCM7, RAF1, CCNA2, CCNA1, RBBP9, TAF1, BRF1, PHB, USP4, PCBD1, XBP1, ID2, SERPINB2, PPP2CA, SKP2, SKP1, CUL1, EZH2, E2F4, LIN54, LIN9, LIN37, LIN52, RBL1, TFDP1, TFDP2, RBBP4, IRF3, ELAVL1, TP63, SMARCA4, TOP1, CCND1, CCND3, RINT1, GRAMD4, LBX1, DCTN1, LDHC, RAD50, DGKZ, E2F1, CDK4, CDK6, DYRK1B, DYRK1A, CDKN1A, PML, CCND2, TXNDC11, FOXK1, RARG |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FTO_RBL2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | FTO | Q9C0B1 | DB11638 | Artenimol | Alpha-ketoglutarate-dependent dioxygenase FTO | small molecule | approved|investigational |
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RelatedDiseases for FTO_RBL2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FTO | C0028754 | Obesity | 6 | CTD_human |
| Hgene | FTO | C0001973 | Alcoholic Intoxication, Chronic | 3 | PSYGENET |
| Hgene | FTO | C0011581 | Depressive disorder | 3 | PSYGENET |
| Hgene | FTO | C2752001 | Growth Retardation, Developmental Delay, Coarse Facies, And Early Death | 3 | CTD_human;ORPHANET;UNIPROT |
| Hgene | FTO | C0005910 | Body Weight | 2 | CTD_human |
| Hgene | FTO | C0011570 | Mental Depression | 2 | PSYGENET |
| Hgene | FTO | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| Hgene | FTO | C0025202 | melanoma | 1 | CTD_human |
| Hgene | FTO | C0043094 | Weight Gain | 1 | CTD_human |
| Hgene | FTO | C0525045 | Mood Disorders | 1 | PSYGENET |
| Hgene | FTO | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Hgene | FTO | C2362324 | Pediatric Obesity | 1 | CTD_human |
| Tgene | RBL2 | C0023434 | Chronic Lymphocytic Leukemia | 1 | CTD_human |
| Tgene | RBL2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | RBL2 | C0919267 | ovarian neoplasm | 1 | CTD_human |
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