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Fusion gene ID: 14031 |
FusionGeneSummary for FTH1_FAM162A |
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Fusion gene information | Fusion gene name: FTH1_FAM162A | Fusion gene ID: 14031 | Hgene | Tgene | Gene symbol | FTH1 | FAM162A | Gene ID | 2495 | 26355 |
Gene name | ferritin heavy chain 1 | family with sequence similarity 162 member A | |
Synonyms | FHC|FTH|FTHL6|HFE5|PIG15|PLIF | C3orf28|E2IG5|HGTD-P | |
Cytomap | 11q12.3 | 3q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | ferritin heavy chainapoferritincell proliferation-inducing gene 15 proteinferritin H subunitferritin, heavy polypeptide 1placenta immunoregulatory factorproliferation-inducing protein 15 | protein FAM162AE2-induced gene 5 proteinHIF-1 alpha-responsive proapoptotic moleculegrowth and transformation-dependent protein | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P02794 | Q96A26 | |
Ensembl transtripts involved in fusion gene | ENST00000529631, ENST00000529191, ENST00000273550, ENST00000526640, ENST00000532601, | ENST00000232125, ENST00000477892, ENST00000469967, | |
Fusion gene scores | * DoF score | 6 X 6 X 1=36 | 3 X 3 X 2=18 |
# samples | 6 | 3 | |
** MAII score | log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: FTH1 [Title/Abstract] AND FAM162A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FTH1 | GO:0006880 | intracellular sequestering of iron ion | 9924025 |
Hgene | FTH1 | GO:0048147 | negative regulation of fibroblast proliferation | 9924025 |
Tgene | FAM162A | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 15082785 |
Tgene | FAM162A | GO:0043065 | positive regulation of apoptotic process | 15082785 |
Tgene | FAM162A | GO:0071456 | cellular response to hypoxia | 15082785 |
Tgene | FAM162A | GO:0090200 | positive regulation of release of cytochrome c from mitochondria | 15082785 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW020886 | FTH1 | chr11 | 61732036 | - | FAM162A | chr3 | 122126184 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000529631 | ENST00000232125 | FTH1 | chr11 | 61732036 | - | FAM162A | chr3 | 122126184 | + |
intron-3CDS | ENST00000529631 | ENST00000477892 | FTH1 | chr11 | 61732036 | - | FAM162A | chr3 | 122126184 | + |
intron-3CDS | ENST00000529631 | ENST00000469967 | FTH1 | chr11 | 61732036 | - | FAM162A | chr3 | 122126184 | + |
intron-3CDS | ENST00000529191 | ENST00000232125 | FTH1 | chr11 | 61732036 | - | FAM162A | chr3 | 122126184 | + |
intron-3CDS | ENST00000529191 | ENST00000477892 | FTH1 | chr11 | 61732036 | - | FAM162A | chr3 | 122126184 | + |
intron-3CDS | ENST00000529191 | ENST00000469967 | FTH1 | chr11 | 61732036 | - | FAM162A | chr3 | 122126184 | + |
intron-3CDS | ENST00000273550 | ENST00000232125 | FTH1 | chr11 | 61732036 | - | FAM162A | chr3 | 122126184 | + |
intron-3CDS | ENST00000273550 | ENST00000477892 | FTH1 | chr11 | 61732036 | - | FAM162A | chr3 | 122126184 | + |
intron-3CDS | ENST00000273550 | ENST00000469967 | FTH1 | chr11 | 61732036 | - | FAM162A | chr3 | 122126184 | + |
intron-3CDS | ENST00000526640 | ENST00000232125 | FTH1 | chr11 | 61732036 | - | FAM162A | chr3 | 122126184 | + |
intron-3CDS | ENST00000526640 | ENST00000477892 | FTH1 | chr11 | 61732036 | - | FAM162A | chr3 | 122126184 | + |
intron-3CDS | ENST00000526640 | ENST00000469967 | FTH1 | chr11 | 61732036 | - | FAM162A | chr3 | 122126184 | + |
intron-3CDS | ENST00000532601 | ENST00000232125 | FTH1 | chr11 | 61732036 | - | FAM162A | chr3 | 122126184 | + |
intron-3CDS | ENST00000532601 | ENST00000477892 | FTH1 | chr11 | 61732036 | - | FAM162A | chr3 | 122126184 | + |
intron-3CDS | ENST00000532601 | ENST00000469967 | FTH1 | chr11 | 61732036 | - | FAM162A | chr3 | 122126184 | + |
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FusionProtFeatures for FTH1_FAM162A |
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Hgene | Tgene |
FTH1 | FAM162A |
Stores iron in a soluble, non-toxic, readily availableform. Important for iron homeostasis. Has ferroxidase activity.Iron is taken up in the ferrous form and deposited as ferrichydroxides after oxidation. Also plays a role in delivery of ironto cells. Mediates iron uptake in capsule cells of the developingkidney (By similarity). {ECO:0000250}. | Proposed to be involved in regulation of apoptosis; theexact mechanism may differ between cell types/tissues. May beinvolved in hypoxia-induced cell death of transformed cellsimplicating cytochrome C release and caspase activation (such asCASP9) and inducing mitochondrial permeability transition. May beinvolved in hypoxia-induced cell death of neuronal cells probablyby promoting release of AIFM1 from mitochondria to cytoplasm andits translocation to the nucleus; however, the involvement ofcaspases has been reported conflictingly.{ECO:0000269|PubMed:15082785}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FTH1_FAM162A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FTH1_FAM162A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FTH1_FAM162A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | FTH1 | P02794 | DB01592 | Iron | Ferritin heavy chain | small molecule | approved |
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RelatedDiseases for FTH1_FAM162A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FTH1 | C0011581 | Depressive disorder | 1 | CTD_human |
Hgene | FTH1 | C0011616 | Contact Dermatitis | 1 | CTD_human |
Hgene | FTH1 | C0017638 | Glioma | 1 | CTD_human |
Hgene | FTH1 | C0022548 | Keloid | 1 | CTD_human |
Hgene | FTH1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | FTH1 | C0032927 | Precancerous Conditions | 1 | CTD_human |
Hgene | FTH1 | C0282193 | Iron Overload | 1 | CTD_human |
Hgene | FTH1 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Hgene | FTH1 | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |