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Fusion gene ID: 14024 |
FusionGeneSummary for FSTL5_PLEKHA7 |
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Fusion gene information | Fusion gene name: FSTL5_PLEKHA7 | Fusion gene ID: 14024 | Hgene | Tgene | Gene symbol | FSTL5 | PLEKHA7 | Gene ID | 56884 | 144100 |
Gene name | follistatin like 5 | pleckstrin homology domain containing A7 | |
Synonyms | - | - | |
Cytomap | 4q32.2 | 11p15.2-p15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | follistatin-related protein 5follistatin-like protein 5 | pleckstrin homology domain-containing family A member 7PH domain-containing family A member 7pleckstrin homology domain containing, family A member 2pleckstrin homology domain containing, family A member 7pleckstrin homology domain-containing family A | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q8N475 | Q6IQ23 | |
Ensembl transtripts involved in fusion gene | ENST00000306100, ENST00000379164, ENST00000536695, ENST00000427802, ENST00000511170, | ENST00000531066, ENST00000355661, ENST00000448080, ENST00000532079, ENST00000332954, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 6 X 5 X 3=90 |
# samples | 2 | 6 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FSTL5 [Title/Abstract] AND PLEKHA7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BC073978 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000306100 | ENST00000531066 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
5CDS-intron | ENST00000306100 | ENST00000355661 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
5CDS-intron | ENST00000306100 | ENST00000448080 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
5CDS-intron | ENST00000306100 | ENST00000532079 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
5CDS-intron | ENST00000306100 | ENST00000332954 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
5CDS-intron | ENST00000379164 | ENST00000531066 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
5CDS-intron | ENST00000379164 | ENST00000355661 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
5CDS-intron | ENST00000379164 | ENST00000448080 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
5CDS-intron | ENST00000379164 | ENST00000532079 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
5CDS-intron | ENST00000379164 | ENST00000332954 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
5CDS-intron | ENST00000536695 | ENST00000531066 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
5CDS-intron | ENST00000536695 | ENST00000355661 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
5CDS-intron | ENST00000536695 | ENST00000448080 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
5CDS-intron | ENST00000536695 | ENST00000532079 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
5CDS-intron | ENST00000536695 | ENST00000332954 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
5CDS-intron | ENST00000427802 | ENST00000531066 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
5CDS-intron | ENST00000427802 | ENST00000355661 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
5CDS-intron | ENST00000427802 | ENST00000448080 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
5CDS-intron | ENST00000427802 | ENST00000532079 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
5CDS-intron | ENST00000427802 | ENST00000332954 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
intron-intron | ENST00000511170 | ENST00000531066 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
intron-intron | ENST00000511170 | ENST00000355661 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
intron-intron | ENST00000511170 | ENST00000448080 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
intron-intron | ENST00000511170 | ENST00000532079 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
intron-intron | ENST00000511170 | ENST00000332954 | FSTL5 | chr4 | 162680566 | - | PLEKHA7 | chr11 | 16996259 | - |
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FusionProtFeatures for FSTL5_PLEKHA7 |
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Hgene | Tgene |
FSTL5 | PLEKHA7 |
Required for zonula adherens biogenesis and maintenance.Acts via its interaction with KIAA1543/Nezha, which anchorsmicrotubules at their minus-ends to zonula adherens, leading tothe recruitment of KIFC3 kinesin to the junctional site.{ECO:0000269|PubMed:19041755}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FSTL5_PLEKHA7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FSTL5_PLEKHA7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FSTL5_PLEKHA7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FSTL5_PLEKHA7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PLEKHA7 | C0017605 | Angle Closure Glaucoma | 2 | CTD_human |