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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14024

FusionGeneSummary for FSTL5_PLEKHA7

check button Fusion gene summary
Fusion gene informationFusion gene name: FSTL5_PLEKHA7
Fusion gene ID: 14024
HgeneTgene
Gene symbol

FSTL5

PLEKHA7

Gene ID

56884

144100

Gene namefollistatin like 5pleckstrin homology domain containing A7
Synonyms--
Cytomap

4q32.2

11p15.2-p15.1

Type of geneprotein-codingprotein-coding
Descriptionfollistatin-related protein 5follistatin-like protein 5pleckstrin homology domain-containing family A member 7PH domain-containing family A member 7pleckstrin homology domain containing, family A member 2pleckstrin homology domain containing, family A member 7pleckstrin homology domain-containing family A
Modification date2018051920180522
UniProtAcc

Q8N475

Q6IQ23

Ensembl transtripts involved in fusion geneENST00000306100, ENST00000379164, 
ENST00000536695, ENST00000427802, 
ENST00000511170, 
ENST00000531066, 
ENST00000355661, ENST00000448080, 
ENST00000532079, ENST00000332954, 
Fusion gene scores* DoF score2 X 2 X 1=46 X 5 X 3=90
# samples 26
** MAII scorelog2(2/4*10)=2.32192809488736log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FSTL5 [Title/Abstract] AND PLEKHA7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC073978FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000306100ENST00000531066FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
5CDS-intronENST00000306100ENST00000355661FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
5CDS-intronENST00000306100ENST00000448080FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
5CDS-intronENST00000306100ENST00000532079FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
5CDS-intronENST00000306100ENST00000332954FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
5CDS-intronENST00000379164ENST00000531066FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
5CDS-intronENST00000379164ENST00000355661FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
5CDS-intronENST00000379164ENST00000448080FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
5CDS-intronENST00000379164ENST00000532079FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
5CDS-intronENST00000379164ENST00000332954FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
5CDS-intronENST00000536695ENST00000531066FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
5CDS-intronENST00000536695ENST00000355661FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
5CDS-intronENST00000536695ENST00000448080FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
5CDS-intronENST00000536695ENST00000532079FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
5CDS-intronENST00000536695ENST00000332954FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
5CDS-intronENST00000427802ENST00000531066FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
5CDS-intronENST00000427802ENST00000355661FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
5CDS-intronENST00000427802ENST00000448080FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
5CDS-intronENST00000427802ENST00000532079FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
5CDS-intronENST00000427802ENST00000332954FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
intron-intronENST00000511170ENST00000531066FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
intron-intronENST00000511170ENST00000355661FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
intron-intronENST00000511170ENST00000448080FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
intron-intronENST00000511170ENST00000532079FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-
intron-intronENST00000511170ENST00000332954FSTL5chr4

162680566

-PLEKHA7chr11

16996259

-

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FusionProtFeatures for FSTL5_PLEKHA7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FSTL5

Q8N475

PLEKHA7

Q6IQ23

Required for zonula adherens biogenesis and maintenance.Acts via its interaction with KIAA1543/Nezha, which anchorsmicrotubules at their minus-ends to zonula adherens, leading tothe recruitment of KIFC3 kinesin to the junctional site.{ECO:0000269|PubMed:19041755}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FSTL5_PLEKHA7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FSTL5_PLEKHA7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FSTL5_PLEKHA7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FSTL5_PLEKHA7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePLEKHA7C0017605Angle Closure Glaucoma2CTD_human