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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14023

FusionGeneSummary for FSTL5_NFYC

check button Fusion gene summary
Fusion gene informationFusion gene name: FSTL5_NFYC
Fusion gene ID: 14023
HgeneTgene
Gene symbol

FSTL5

NFYC

Gene ID

56884

4802

Gene namefollistatin like 5nuclear transcription factor Y subunit gamma
Synonyms-CBF-C|CBFC|H1TF2A|HAP5|HSM|NF-YC
Cytomap

4q32.2

1p34.2

Type of geneprotein-codingprotein-coding
Descriptionfollistatin-related protein 5follistatin-like protein 5nuclear transcription factor Y subunit gammaCAAT box DNA-binding protein subunit CCCAAT binding factor subunit CCCAAT transcription binding factor subunit gammahistone H1 transcription factor large subunit 2Anuclear transcription factor Y subunit Cn
Modification date2018051920180523
UniProtAcc

Q8N475

Q13952

Ensembl transtripts involved in fusion geneENST00000306100, ENST00000379164, 
ENST00000536695, ENST00000427802, 
ENST00000511170, 
ENST00000427410, 
ENST00000447388, ENST00000425457, 
ENST00000456393, ENST00000372654, 
ENST00000372653, ENST00000372652, 
ENST00000372651, ENST00000440226, 
ENST00000308733, ENST00000483091, 
Fusion gene scores* DoF score2 X 2 X 1=48 X 5 X 6=240
# samples 29
** MAII scorelog2(2/4*10)=2.32192809488736log2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FSTL5 [Title/Abstract] AND NFYC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNFYC

GO:0006355

regulation of transcription, DNA-templated

15243141


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ012815FSTL5chr4

162785581

-NFYCchr1

41236781

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000306100ENST00000427410FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000306100ENST00000447388FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000306100ENST00000425457FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000306100ENST00000456393FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000306100ENST00000372654FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000306100ENST00000372653FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000306100ENST00000372652FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000306100ENST00000372651FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000306100ENST00000440226FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000306100ENST00000308733FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000306100ENST00000483091FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000379164ENST00000427410FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000379164ENST00000447388FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000379164ENST00000425457FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000379164ENST00000456393FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000379164ENST00000372654FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000379164ENST00000372653FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000379164ENST00000372652FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000379164ENST00000372651FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000379164ENST00000440226FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000379164ENST00000308733FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000379164ENST00000483091FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000536695ENST00000427410FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000536695ENST00000447388FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000536695ENST00000425457FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000536695ENST00000456393FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000536695ENST00000372654FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000536695ENST00000372653FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000536695ENST00000372652FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000536695ENST00000372651FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000536695ENST00000440226FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000536695ENST00000308733FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000536695ENST00000483091FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000427802ENST00000427410FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000427802ENST00000447388FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000427802ENST00000425457FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000427802ENST00000456393FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000427802ENST00000372654FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000427802ENST00000372653FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000427802ENST00000372652FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000427802ENST00000372651FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000427802ENST00000440226FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000427802ENST00000308733FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000427802ENST00000483091FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000511170ENST00000427410FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000511170ENST00000447388FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000511170ENST00000425457FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000511170ENST00000456393FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000511170ENST00000372654FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000511170ENST00000372653FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000511170ENST00000372652FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000511170ENST00000372651FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000511170ENST00000440226FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-3UTRENST00000511170ENST00000308733FSTL5chr4

162785581

-NFYCchr1

41236781

-
intron-intronENST00000511170ENST00000483091FSTL5chr4

162785581

-NFYCchr1

41236781

-

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FusionProtFeatures for FSTL5_NFYC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FSTL5

Q8N475

NFYC

Q13952


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FSTL5_NFYC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FSTL5_NFYC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FSTL5_NFYC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FSTL5_NFYC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource