|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 14002 |
FusionGeneSummary for FSCN1_FAR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FSCN1_FAR1 | Fusion gene ID: 14002 | Hgene | Tgene | Gene symbol | FSCN1 | FAR1 | Gene ID | 6624 | 84188 |
| Gene name | fascin actin-bundling protein 1 | fatty acyl-CoA reductase 1 | |
| Synonyms | FAN1|HSN|SNL|p55 | MLSTD2|PFCRD|SDR10E1 | |
| Cytomap | 7p22.1 | 11p15.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fascin55 kDa actin-bundling proteinfascin homolog 1, actin-bundling proteinsinged-like (fascin homolog, sea urchin) | fatty acyl-CoA reductase 1male sterility domain-containing protein 2short chain dehydrogenase/reductase family 10E, member 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q16658 | Q8WVX9 | |
| Ensembl transtripts involved in fusion gene | ENST00000340250, ENST00000382361, | ENST00000354817, ENST00000527202, ENST00000532502, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 28 X 8 X 12=2688 |
| # samples | 6 | 31 | |
| ** MAII score | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(31/2688*10)=-3.11619301750452 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FSCN1 [Title/Abstract] AND FAR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FSCN1 | GO:0007043 | cell-cell junction assembly | 9571235 |
| Hgene | FSCN1 | GO:0010592 | positive regulation of lamellipodium assembly | 9571235 |
| Hgene | FSCN1 | GO:0030035 | microspike assembly | 9571235 |
| Hgene | FSCN1 | GO:0030036 | actin cytoskeleton organization | 9571235 |
| Hgene | FSCN1 | GO:0032534 | regulation of microvillus assembly | 9571235 |
| Hgene | FSCN1 | GO:0032956 | regulation of actin cytoskeleton organization | 20137952 |
| Hgene | FSCN1 | GO:0035089 | establishment of apical/basal cell polarity | 9571235 |
| Hgene | FSCN1 | GO:0048870 | cell motility | 9571235 |
| Hgene | FSCN1 | GO:0051017 | actin filament bundle assembly | 20393565 |
| Hgene | FSCN1 | GO:0051491 | positive regulation of filopodium assembly | 9571235 |
| Hgene | FSCN1 | GO:0071803 | positive regulation of podosome assembly | 20137952 |
| Hgene | FSCN1 | GO:0090091 | positive regulation of extracellular matrix disassembly | 20137952 |
| Tgene | FAR1 | GO:0008611 | ether lipid biosynthetic process | 24108123 |
| Tgene | FAR1 | GO:0035336 | long-chain fatty-acyl-CoA metabolic process | 15220348 |
| Tgene | FAR1 | GO:0046474 | glycerophospholipid biosynthetic process | 20071337 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-CN-5364-01A | FSCN1 | chr7 | 5646279 | + | FAR1 | chr11 | 13744912 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000340250 | ENST00000354817 | FSCN1 | chr7 | 5646279 | + | FAR1 | chr11 | 13744912 | + |
| 5CDS-intron | ENST00000340250 | ENST00000527202 | FSCN1 | chr7 | 5646279 | + | FAR1 | chr11 | 13744912 | + |
| 5CDS-intron | ENST00000340250 | ENST00000532502 | FSCN1 | chr7 | 5646279 | + | FAR1 | chr11 | 13744912 | + |
| 3UTR-intron | ENST00000382361 | ENST00000354817 | FSCN1 | chr7 | 5646279 | + | FAR1 | chr11 | 13744912 | + |
| 3UTR-intron | ENST00000382361 | ENST00000527202 | FSCN1 | chr7 | 5646279 | + | FAR1 | chr11 | 13744912 | + |
| 3UTR-intron | ENST00000382361 | ENST00000532502 | FSCN1 | chr7 | 5646279 | + | FAR1 | chr11 | 13744912 | + |
Top |
FusionProtFeatures for FSCN1_FAR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FSCN1 | FAR1 |
| Organizes filamentous actin into bundles with a minimumof 4.1:1 actin/fascin ratio. Plays a role in the organization ofactin filament bundles and the formation of microspikes, membraneruffles, and stress fibers. Important for the formation of adiverse set of cell protrusions, such as filopodia, and for cellmotility and migration. {ECO:0000269|PubMed:20137952,ECO:0000269|PubMed:20393565, ECO:0000269|PubMed:9362073,ECO:0000269|PubMed:9571235}. | Catalyzes the reduction of saturated and unsaturated C16or C18 fatty acyl-CoA to fatty alcohols (PubMed:15220348,PubMed:24108123). It plays an essential role in the production ofether lipids/plasmalogens which synthesis requires fatty alcohols(PubMed:20071337, PubMed:24108123). In parallel, it is alsorequired for wax monoesters production since fatty alcohols alsoconstitute a substrate for their synthesis (By similarity).{ECO:0000250|UniProtKB:Q922J9, ECO:0000269|PubMed:15220348,ECO:0000269|PubMed:20071337, ECO:0000269|PubMed:24108123}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for FSCN1_FAR1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for FSCN1_FAR1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FSCN1 | GNAS, VHL, PRKCA, NGFR, RAB1A, DNAJB9, ACTA1, MAPK8IP2, SIRT7, CDK2, ACTA2, AIFM1, SEPT11, ZYX, CNN2, FN1, VCAM1, ATF2, IQCB1, MAPK7, YWHAQ, ASS1, COTL1, CRYZ, AK2, IMPA2, FUBP1, MIF, PCBP1, PRDX1, PRDX2, TKT, NTRK1, DBN1, FLNA, ANLN, MCM2, SMURF1, CDH1, DLST, TRIM25, G3BP1, TES | FAR1 | C20orf24, SLC2A4, CUL3, CUL5, ATXN1, IQCB1, PEX14, CLN3, CCDC8, EGFR, CYLD |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for FSCN1_FAR1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for FSCN1_FAR1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | FAR1 | C4015344 | PEROXISOMAL FATTY ACYL-CoA REDUCTASE 1 DISORDER | 1 | ORPHANET;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|