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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13996

FusionGeneSummary for FRY_TMEM127

check button Fusion gene summary
Fusion gene informationFusion gene name: FRY_TMEM127
Fusion gene ID: 13996
HgeneTgene
Gene symbol

FRY

TMEM127

Gene ID

10129

55654

Gene nameFRY microtubule binding proteintransmembrane protein 127
Synonyms13CDNA73|214K23.2|C13orf14|CG003|bA207N4.2|bA37E23.1-
Cytomap

13q13.1

2q11.2

Type of geneprotein-codingprotein-coding
Descriptionprotein furry homologWUGSC:H_2G3A.1furry homologtransmembrane protein 127
Modification date2018052320180519
UniProtAcc

Q5TBA9

O75204

Ensembl transtripts involved in fusion geneENST00000380250, ENST00000463566, 
ENST00000542859, ENST00000380217, 
ENST00000258439, ENST00000432959, 
ENST00000435268, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 2=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FRY [Title/Abstract] AND TMEM127 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM311860FRYchr13

32861063

+TMEM127chr2

96917068

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000380250ENST00000258439FRYchr13

32861063

+TMEM127chr2

96917068

-
intron-intronENST00000380250ENST00000432959FRYchr13

32861063

+TMEM127chr2

96917068

-
intron-intronENST00000380250ENST00000435268FRYchr13

32861063

+TMEM127chr2

96917068

-
intron-3UTRENST00000463566ENST00000258439FRYchr13

32861063

+TMEM127chr2

96917068

-
intron-intronENST00000463566ENST00000432959FRYchr13

32861063

+TMEM127chr2

96917068

-
intron-intronENST00000463566ENST00000435268FRYchr13

32861063

+TMEM127chr2

96917068

-
intron-3UTRENST00000542859ENST00000258439FRYchr13

32861063

+TMEM127chr2

96917068

-
intron-intronENST00000542859ENST00000432959FRYchr13

32861063

+TMEM127chr2

96917068

-
intron-intronENST00000542859ENST00000435268FRYchr13

32861063

+TMEM127chr2

96917068

-
intron-3UTRENST00000380217ENST00000258439FRYchr13

32861063

+TMEM127chr2

96917068

-
intron-intronENST00000380217ENST00000432959FRYchr13

32861063

+TMEM127chr2

96917068

-
intron-intronENST00000380217ENST00000435268FRYchr13

32861063

+TMEM127chr2

96917068

-

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FusionProtFeatures for FRY_TMEM127


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FRY

Q5TBA9

TMEM127

O75204

Plays a crucial role in the structural integrity ofmitotic centrosomes and in the maintenance of spindle bipolarityby promoting PLK1 activity at the spindle poles in early mitosis.May function as a scaffold promoting the interaction between AURKAand PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.{ECO:0000269|PubMed:22753416}. Controls cell proliferation acting as a negativeregulator of TOR signaling pathway mediated by mTORC1. May act asa tumor suppressor. {ECO:0000269|PubMed:20154675}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FRY_TMEM127


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FRY_TMEM127


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FRY_TMEM127


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FRY_TMEM127


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFRYC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneFRYC3714756Intellectual Disability1CTD_human
TgeneTMEM127C0031511Pheochromocytoma2CTD_human;UNIPROT