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Fusion gene ID: 13996 |
FusionGeneSummary for FRY_TMEM127 |
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Fusion gene information | Fusion gene name: FRY_TMEM127 | Fusion gene ID: 13996 | Hgene | Tgene | Gene symbol | FRY | TMEM127 | Gene ID | 10129 | 55654 |
Gene name | FRY microtubule binding protein | transmembrane protein 127 | |
Synonyms | 13CDNA73|214K23.2|C13orf14|CG003|bA207N4.2|bA37E23.1 | - | |
Cytomap | 13q13.1 | 2q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | protein furry homologWUGSC:H_2G3A.1furry homolog | transmembrane protein 127 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q5TBA9 | O75204 | |
Ensembl transtripts involved in fusion gene | ENST00000380250, ENST00000463566, ENST00000542859, ENST00000380217, | ENST00000258439, ENST00000432959, ENST00000435268, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 2=18 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: FRY [Title/Abstract] AND TMEM127 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BM311860 | FRY | chr13 | 32861063 | + | TMEM127 | chr2 | 96917068 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000380250 | ENST00000258439 | FRY | chr13 | 32861063 | + | TMEM127 | chr2 | 96917068 | - |
intron-intron | ENST00000380250 | ENST00000432959 | FRY | chr13 | 32861063 | + | TMEM127 | chr2 | 96917068 | - |
intron-intron | ENST00000380250 | ENST00000435268 | FRY | chr13 | 32861063 | + | TMEM127 | chr2 | 96917068 | - |
intron-3UTR | ENST00000463566 | ENST00000258439 | FRY | chr13 | 32861063 | + | TMEM127 | chr2 | 96917068 | - |
intron-intron | ENST00000463566 | ENST00000432959 | FRY | chr13 | 32861063 | + | TMEM127 | chr2 | 96917068 | - |
intron-intron | ENST00000463566 | ENST00000435268 | FRY | chr13 | 32861063 | + | TMEM127 | chr2 | 96917068 | - |
intron-3UTR | ENST00000542859 | ENST00000258439 | FRY | chr13 | 32861063 | + | TMEM127 | chr2 | 96917068 | - |
intron-intron | ENST00000542859 | ENST00000432959 | FRY | chr13 | 32861063 | + | TMEM127 | chr2 | 96917068 | - |
intron-intron | ENST00000542859 | ENST00000435268 | FRY | chr13 | 32861063 | + | TMEM127 | chr2 | 96917068 | - |
intron-3UTR | ENST00000380217 | ENST00000258439 | FRY | chr13 | 32861063 | + | TMEM127 | chr2 | 96917068 | - |
intron-intron | ENST00000380217 | ENST00000432959 | FRY | chr13 | 32861063 | + | TMEM127 | chr2 | 96917068 | - |
intron-intron | ENST00000380217 | ENST00000435268 | FRY | chr13 | 32861063 | + | TMEM127 | chr2 | 96917068 | - |
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FusionProtFeatures for FRY_TMEM127 |
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Hgene | Tgene |
FRY | TMEM127 |
Plays a crucial role in the structural integrity ofmitotic centrosomes and in the maintenance of spindle bipolarityby promoting PLK1 activity at the spindle poles in early mitosis.May function as a scaffold promoting the interaction between AURKAand PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.{ECO:0000269|PubMed:22753416}. | Controls cell proliferation acting as a negativeregulator of TOR signaling pathway mediated by mTORC1. May act asa tumor suppressor. {ECO:0000269|PubMed:20154675}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FRY_TMEM127 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FRY_TMEM127 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FRY_TMEM127 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FRY_TMEM127 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FRY | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | FRY | C3714756 | Intellectual Disability | 1 | CTD_human |
Tgene | TMEM127 | C0031511 | Pheochromocytoma | 2 | CTD_human;UNIPROT |