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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13993

FusionGeneSummary for FRYL_RPL11

check button Fusion gene summary
Fusion gene informationFusion gene name: FRYL_RPL11
Fusion gene ID: 13993
HgeneTgene
Gene symbol

FRYL

RPL11

Gene ID

285527

6135

Gene nameFRY like transcription coactivatorribosomal protein L11
SynonymsAF4p12|KIAA0826|MOR2DBA7|GIG34|L11|uL5
Cytomap

4p11

1p36.11

Type of geneprotein-codingprotein-coding
Descriptionprotein furry homolog-likeALL1-fused gene from chromosome 4p12 proteinFRY-likefurry homolog-likefurry-likemor2 cell polarity protein homolog60S ribosomal protein L11CLL-associated antigen KW-12cell growth-inhibiting protein 34large ribosomal subunit protein uL5
Modification date2018052320180523
UniProtAcc

O94915

P62913

Ensembl transtripts involved in fusion geneENST00000503238, ENST00000358350, 
ENST00000537810, ENST00000264319, 
ENST00000507711, ENST00000514783, 
ENST00000507873, ENST00000506685, 
ENST00000374550, ENST00000482370, 
Fusion gene scores* DoF score14 X 11 X 11=16944 X 4 X 1=16
# samples 214
** MAII scorelog2(21/1694*10)=-3.01197264166608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FRYL [Title/Abstract] AND RPL11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRPL11

GO:0002181

cytoplasmic translation

25957688

TgeneRPL11

GO:0010628

positive regulation of gene expression

18560357

TgeneRPL11

GO:2000435

negative regulation of protein neddylation

18560357


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AU100496FRYLchr4

48531069

+RPL11chr1

24019132

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000503238ENST00000374550FRYLchr4

48531069

+RPL11chr1

24019132

+
intron-3UTRENST00000503238ENST00000482370FRYLchr4

48531069

+RPL11chr1

24019132

+
intron-3CDSENST00000358350ENST00000374550FRYLchr4

48531069

+RPL11chr1

24019132

+
intron-3UTRENST00000358350ENST00000482370FRYLchr4

48531069

+RPL11chr1

24019132

+
intron-3CDSENST00000537810ENST00000374550FRYLchr4

48531069

+RPL11chr1

24019132

+
intron-3UTRENST00000537810ENST00000482370FRYLchr4

48531069

+RPL11chr1

24019132

+
intron-3CDSENST00000264319ENST00000374550FRYLchr4

48531069

+RPL11chr1

24019132

+
intron-3UTRENST00000264319ENST00000482370FRYLchr4

48531069

+RPL11chr1

24019132

+
intron-3CDSENST00000507711ENST00000374550FRYLchr4

48531069

+RPL11chr1

24019132

+
intron-3UTRENST00000507711ENST00000482370FRYLchr4

48531069

+RPL11chr1

24019132

+
intron-3CDSENST00000514783ENST00000374550FRYLchr4

48531069

+RPL11chr1

24019132

+
intron-3UTRENST00000514783ENST00000482370FRYLchr4

48531069

+RPL11chr1

24019132

+
intron-3CDSENST00000507873ENST00000374550FRYLchr4

48531069

+RPL11chr1

24019132

+
intron-3UTRENST00000507873ENST00000482370FRYLchr4

48531069

+RPL11chr1

24019132

+
intron-3CDSENST00000506685ENST00000374550FRYLchr4

48531069

+RPL11chr1

24019132

+
intron-3UTRENST00000506685ENST00000482370FRYLchr4

48531069

+RPL11chr1

24019132

+

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FusionProtFeatures for FRYL_RPL11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FRYL

O94915

RPL11

P62913

Plays a key role in maintaining the integrity ofpolarized cell extensions during morphogenesis, regulates theactin cytoskeleton and plays a key role in patterning sensoryneuron dendritic fields by promoting avoidance between homologousdendrites as well as by limiting dendritic branching (Bysimilarity). May function as a transcriptional activator.{ECO:0000250, ECO:0000269|PubMed:16061630}. Component of the ribosome, a large ribonucleoproteincomplex responsible for the synthesis of proteins in the cell. Thesmall ribosomal subunit (SSU) binds messenger RNAs (mRNAs) andtranslates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) containsthe ribosomal catalytic site termed the peptidyl transferasecenter (PTC), which catalyzes the formation of peptide bonds,thereby polymerizing the amino acids delivered by tRNAs into apolypeptide chain. The nascent polypeptides leave the ribosomethrough a tunnel in the LSU and interact with protein factors thatfunction in enzymatic processing, targeting, and the membraneinsertion of nascent chains at the exit of the ribosomal tunnel.As part of the 5S RNP/5S ribonucleoprotein particle it is anessential component of the LSU, required for its formation and thematuration of rRNAs (PubMed:19061985, PubMed:12962325,PubMed:24120868). It also couples ribosome biogenesis to p53/TP53activation. As part of the 5S RNP it accumulates in thenucleoplasm and inhibits MDM2, when ribosome biogenesis isperturbed, mediating the stabilization and the activation of TP53(PubMed:24120868). Promotes nucleolar location of PML (Bysimilarity). {ECO:0000250|UniProtKB:Q9CXW4,ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985,ECO:0000269|PubMed:24120868}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FRYL_RPL11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FRYL_RPL11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FRYL_RPL11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FRYL_RPL11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRPL11C2675512Diamond-Blackfan Anemia 71CTD_human;UNIPROT