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Fusion gene ID: 13988 |
FusionGeneSummary for FRYL_LNX1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FRYL_LNX1 | Fusion gene ID: 13988 | Hgene | Tgene | Gene symbol | FRYL | LNX1 | Gene ID | 285527 | 84708 |
| Gene name | FRY like transcription coactivator | ligand of numb-protein X 1 | |
| Synonyms | AF4p12|KIAA0826|MOR2 | LNX|MPDZ|PDZRN2 | |
| Cytomap | 4p11 | 4q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein furry homolog-likeALL1-fused gene from chromosome 4p12 proteinFRY-likefurry homolog-likefurry-likemor2 cell polarity protein homolog | E3 ubiquitin-protein ligase LNXPDZ domain-containing ring finger protein 2RING-type E3 ubiquitin transferase LNXligand of numb-protein X 1, E3 ubiquitin protein ligasemulti-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNXnumb-binding pr | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O94915 | Q8TBB1 | |
| Ensembl transtripts involved in fusion gene | ENST00000503238, ENST00000358350, ENST00000537810, ENST00000264319, ENST00000507711, ENST00000514783, ENST00000507873, ENST00000506685, | ENST00000306888, ENST00000263925, ENST00000504605, | |
| Fusion gene scores | * DoF score | 14 X 11 X 11=1694 | 4 X 4 X 4=64 |
| # samples | 21 | 4 | |
| ** MAII score | log2(21/1694*10)=-3.01197264166608 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FRYL [Title/Abstract] AND LNX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A8-A08J-01A | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000503238 | ENST00000306888 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| intron-intron | ENST00000503238 | ENST00000263925 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| intron-intron | ENST00000503238 | ENST00000504605 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| 5UTR-intron | ENST00000358350 | ENST00000306888 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| 5UTR-intron | ENST00000358350 | ENST00000263925 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| 5UTR-intron | ENST00000358350 | ENST00000504605 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| 5UTR-intron | ENST00000537810 | ENST00000306888 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| 5UTR-intron | ENST00000537810 | ENST00000263925 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| 5UTR-intron | ENST00000537810 | ENST00000504605 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| 5UTR-intron | ENST00000264319 | ENST00000306888 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| 5UTR-intron | ENST00000264319 | ENST00000263925 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| 5UTR-intron | ENST00000264319 | ENST00000504605 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| 5UTR-intron | ENST00000507711 | ENST00000306888 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| 5UTR-intron | ENST00000507711 | ENST00000263925 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| 5UTR-intron | ENST00000507711 | ENST00000504605 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| intron-intron | ENST00000514783 | ENST00000306888 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| intron-intron | ENST00000514783 | ENST00000263925 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| intron-intron | ENST00000514783 | ENST00000504605 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| intron-intron | ENST00000507873 | ENST00000306888 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| intron-intron | ENST00000507873 | ENST00000263925 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| intron-intron | ENST00000507873 | ENST00000504605 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| intron-intron | ENST00000506685 | ENST00000306888 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| intron-intron | ENST00000506685 | ENST00000263925 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
| intron-intron | ENST00000506685 | ENST00000504605 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
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FusionProtFeatures for FRYL_LNX1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FRYL | LNX1 |
| Plays a key role in maintaining the integrity ofpolarized cell extensions during morphogenesis, regulates theactin cytoskeleton and plays a key role in patterning sensoryneuron dendritic fields by promoting avoidance between homologousdendrites as well as by limiting dendritic branching (Bysimilarity). May function as a transcriptional activator.{ECO:0000250, ECO:0000269|PubMed:16061630}. | E3 ubiquitin-protein ligase that mediates ubiquitinationand subsequent proteasomal degradation of NUMB. E3 ubiquitinligases accept ubiquitin from an E2 ubiquitin-conjugating enzymein the form of a thioester and then directly transfers theubiquitin to targeted substrates. Mediates ubiquitination ofisoform p66 and isoform p72 of NUMB, but not that of isoform p71or isoform p65. {ECO:0000250|UniProtKB:O70263}. Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.{ECO:0000250|UniProtKB:O70263}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FRYL_LNX1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FRYL_LNX1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FRYL | HOMER3, YWHAG, BAK1, YWHAB, DISC1, SIRT7, GRK5, NOTCH1, MMS19, PELI2, SLMAP, ABCF1, KIAA0930, MARK2, POLH, YWHAH, TACC3, PDZK1, FRY, HOMER1, FLNC, RNF138, FAM78B | LNX1 | MAGEA11, DCTD, LDOC1, CUTC, CALCOCO2, SRSF1, NADK, ENOX1, RBMX, RPIA, TRAF2, KHDRBS3, CCDC85B, PAFAH1B3, KLHL12, TRIP13, TIFA, CEP72, RABAC1, PCBD1, KRTAP4-12, NAGK, KCTD13, MAGEB18, AIMP2, APIP, KCTD17, DDX17, FHL3, TRIM23, NECAB2, SAT1, TSC22D4, ZBTB43, AKIRIN2, KXD1, KRT15, DVL3, EHMT2, PAICS, RAD54B, FBP1, ZBTB8A, NUMB, RHOC, CD8A, SRC, AMMECR1L, AURKB, AURKC, FAM212B, CAMK2N2, DAPK1, DEPTOR, EBF4, EPHB3, KIAA1598, MRPS24, MUSTN1, NKD2, PLEKHG5, PPID, RASL11B, SCLT1, SNCB, ZADH2, WWP1, SAPCD1, TMEM14C, WAC, STX5, PAK6, PBK, TYK2, KCNA4, PRKCA, SDK1, INSC, NRCAM, ABCB1, KALRN, CLDN17, GPR142, EXOC8, DOCK9, LRRC3B, GRIN1, ARHGAP6, LNX2, SSTR3, ADRA1D, SLC6A15, LGR6, TYRO3, CITED1, CGN, PTGIR, SLC6A5, HUNK, GIPR, ARVCF, CTNND2, PKP4, GAS2L2, CLDN1, TSC2, GJD4, TNFRSF18, CLDN2, ILF3, CTSO, VRK2, WNT8A, STRN, ARHGEF16, PQBP1, CDC42EP4, ORMDL3, BPIFA1, ABR, JOSD1, NUP37, BCR, HTR2B, PKDREJ, PDZRN3, PDZRN4, CXADR, ABCA1, SNW1, COIL, UBE2D2, APP, HSP90AA1, NACAP1, PRPH, IL3RA, ULK2, SUV39H1, SUV39H2, IGSF5, SPHKAP, CTBP1, ACAT2, ALDOC, BLVRA, CA8, CDA, CIRBP, CLK2, DAB1, GDI1, GRB2, HSBP1, PKM, PPIA, MAPK9, PTS, RAD51D, RBMY1A1, DPF2, SNRPF, TPM4, VCP, EIF4H, NCK2, SSNA1, RFPL3, NEK6, RUVBL2, MTUS2, ISCU, DNPEP, OSBP2, NME7, OSGIN1, ZNF593, MEMO1, ZNF581, PRR13, ROPN1, ZCCHC10, FBXL12, FAM118A, TRMT12, GOLPH3L, POMGNT1, ZFP64, NXT2, TRIM39, LGALS14, AGTRAP, TRIM54, HOMEZ, LSM2, PBLD, ROBO3, AIDA, MTMR9, HMBOX1, SNRNP25, CCDC102B, THAP7, APOL4, TSSK3, KRTAP9-2, ATRIP, DCUN1D5, LNX1, KRTAP4-2, MVB12B, ATPAF2, ACY3, CCDC114, CCDC101, C1QTNF1, MRFAP1L1, CIB3, METTL21A, FAM9B, KCTD6, TBCEL, FAM124A, ALKBH3, CPNE2, LCLAT1, NUDT14, CATSPERD, KCTD1, RUFY4, STAC2, NOTCH2NL, JAK3, PTPN11, SH2D2A, SOCS6, LRFN4, NXF2B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FRYL_LNX1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FRYL_LNX1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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