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Fusion gene ID: 13988 |
FusionGeneSummary for FRYL_LNX1 |
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Fusion gene information | Fusion gene name: FRYL_LNX1 | Fusion gene ID: 13988 | Hgene | Tgene | Gene symbol | FRYL | LNX1 | Gene ID | 285527 | 84708 |
Gene name | FRY like transcription coactivator | ligand of numb-protein X 1 | |
Synonyms | AF4p12|KIAA0826|MOR2 | LNX|MPDZ|PDZRN2 | |
Cytomap | 4p11 | 4q12 | |
Type of gene | protein-coding | protein-coding | |
Description | protein furry homolog-likeALL1-fused gene from chromosome 4p12 proteinFRY-likefurry homolog-likefurry-likemor2 cell polarity protein homolog | E3 ubiquitin-protein ligase LNXPDZ domain-containing ring finger protein 2RING-type E3 ubiquitin transferase LNXligand of numb-protein X 1, E3 ubiquitin protein ligasemulti-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNXnumb-binding pr | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | O94915 | Q8TBB1 | |
Ensembl transtripts involved in fusion gene | ENST00000503238, ENST00000358350, ENST00000537810, ENST00000264319, ENST00000507711, ENST00000514783, ENST00000507873, ENST00000506685, | ENST00000306888, ENST00000263925, ENST00000504605, | |
Fusion gene scores | * DoF score | 14 X 11 X 11=1694 | 4 X 4 X 4=64 |
# samples | 21 | 4 | |
** MAII score | log2(21/1694*10)=-3.01197264166608 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FRYL [Title/Abstract] AND LNX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A8-A08J-01A | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000503238 | ENST00000306888 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
intron-intron | ENST00000503238 | ENST00000263925 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
intron-intron | ENST00000503238 | ENST00000504605 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
5UTR-intron | ENST00000358350 | ENST00000306888 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
5UTR-intron | ENST00000358350 | ENST00000263925 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
5UTR-intron | ENST00000358350 | ENST00000504605 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
5UTR-intron | ENST00000537810 | ENST00000306888 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
5UTR-intron | ENST00000537810 | ENST00000263925 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
5UTR-intron | ENST00000537810 | ENST00000504605 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
5UTR-intron | ENST00000264319 | ENST00000306888 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
5UTR-intron | ENST00000264319 | ENST00000263925 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
5UTR-intron | ENST00000264319 | ENST00000504605 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
5UTR-intron | ENST00000507711 | ENST00000306888 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
5UTR-intron | ENST00000507711 | ENST00000263925 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
5UTR-intron | ENST00000507711 | ENST00000504605 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
intron-intron | ENST00000514783 | ENST00000306888 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
intron-intron | ENST00000514783 | ENST00000263925 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
intron-intron | ENST00000514783 | ENST00000504605 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
intron-intron | ENST00000507873 | ENST00000306888 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
intron-intron | ENST00000507873 | ENST00000263925 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
intron-intron | ENST00000507873 | ENST00000504605 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
intron-intron | ENST00000506685 | ENST00000306888 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
intron-intron | ENST00000506685 | ENST00000263925 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
intron-intron | ENST00000506685 | ENST00000504605 | FRYL | chr4 | 48712536 | - | LNX1 | chr4 | 54562306 | - |
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FusionProtFeatures for FRYL_LNX1 |
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Hgene | Tgene |
FRYL | LNX1 |
Plays a key role in maintaining the integrity ofpolarized cell extensions during morphogenesis, regulates theactin cytoskeleton and plays a key role in patterning sensoryneuron dendritic fields by promoting avoidance between homologousdendrites as well as by limiting dendritic branching (Bysimilarity). May function as a transcriptional activator.{ECO:0000250, ECO:0000269|PubMed:16061630}. | E3 ubiquitin-protein ligase that mediates ubiquitinationand subsequent proteasomal degradation of NUMB. E3 ubiquitinligases accept ubiquitin from an E2 ubiquitin-conjugating enzymein the form of a thioester and then directly transfers theubiquitin to targeted substrates. Mediates ubiquitination ofisoform p66 and isoform p72 of NUMB, but not that of isoform p71or isoform p65. {ECO:0000250|UniProtKB:O70263}. Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.{ECO:0000250|UniProtKB:O70263}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FRYL_LNX1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FRYL_LNX1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FRYL | HOMER3, YWHAG, BAK1, YWHAB, DISC1, SIRT7, GRK5, NOTCH1, MMS19, PELI2, SLMAP, ABCF1, KIAA0930, MARK2, POLH, YWHAH, TACC3, PDZK1, FRY, HOMER1, FLNC, RNF138, FAM78B | LNX1 | MAGEA11, DCTD, LDOC1, CUTC, CALCOCO2, SRSF1, NADK, ENOX1, RBMX, RPIA, TRAF2, KHDRBS3, CCDC85B, PAFAH1B3, KLHL12, TRIP13, TIFA, CEP72, RABAC1, PCBD1, KRTAP4-12, NAGK, KCTD13, MAGEB18, AIMP2, APIP, KCTD17, DDX17, FHL3, TRIM23, NECAB2, SAT1, TSC22D4, ZBTB43, AKIRIN2, KXD1, KRT15, DVL3, EHMT2, PAICS, RAD54B, FBP1, ZBTB8A, NUMB, RHOC, CD8A, SRC, AMMECR1L, AURKB, AURKC, FAM212B, CAMK2N2, DAPK1, DEPTOR, EBF4, EPHB3, KIAA1598, MRPS24, MUSTN1, NKD2, PLEKHG5, PPID, RASL11B, SCLT1, SNCB, ZADH2, WWP1, SAPCD1, TMEM14C, WAC, STX5, PAK6, PBK, TYK2, KCNA4, PRKCA, SDK1, INSC, NRCAM, ABCB1, KALRN, CLDN17, GPR142, EXOC8, DOCK9, LRRC3B, GRIN1, ARHGAP6, LNX2, SSTR3, ADRA1D, SLC6A15, LGR6, TYRO3, CITED1, CGN, PTGIR, SLC6A5, HUNK, GIPR, ARVCF, CTNND2, PKP4, GAS2L2, CLDN1, TSC2, GJD4, TNFRSF18, CLDN2, ILF3, CTSO, VRK2, WNT8A, STRN, ARHGEF16, PQBP1, CDC42EP4, ORMDL3, BPIFA1, ABR, JOSD1, NUP37, BCR, HTR2B, PKDREJ, PDZRN3, PDZRN4, CXADR, ABCA1, SNW1, COIL, UBE2D2, APP, HSP90AA1, NACAP1, PRPH, IL3RA, ULK2, SUV39H1, SUV39H2, IGSF5, SPHKAP, CTBP1, ACAT2, ALDOC, BLVRA, CA8, CDA, CIRBP, CLK2, DAB1, GDI1, GRB2, HSBP1, PKM, PPIA, MAPK9, PTS, RAD51D, RBMY1A1, DPF2, SNRPF, TPM4, VCP, EIF4H, NCK2, SSNA1, RFPL3, NEK6, RUVBL2, MTUS2, ISCU, DNPEP, OSBP2, NME7, OSGIN1, ZNF593, MEMO1, ZNF581, PRR13, ROPN1, ZCCHC10, FBXL12, FAM118A, TRMT12, GOLPH3L, POMGNT1, ZFP64, NXT2, TRIM39, LGALS14, AGTRAP, TRIM54, HOMEZ, LSM2, PBLD, ROBO3, AIDA, MTMR9, HMBOX1, SNRNP25, CCDC102B, THAP7, APOL4, TSSK3, KRTAP9-2, ATRIP, DCUN1D5, LNX1, KRTAP4-2, MVB12B, ATPAF2, ACY3, CCDC114, CCDC101, C1QTNF1, MRFAP1L1, CIB3, METTL21A, FAM9B, KCTD6, TBCEL, FAM124A, ALKBH3, CPNE2, LCLAT1, NUDT14, CATSPERD, KCTD1, RUFY4, STAC2, NOTCH2NL, JAK3, PTPN11, SH2D2A, SOCS6, LRFN4, NXF2B |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FRYL_LNX1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FRYL_LNX1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |