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Fusion gene ID: 13984 |
FusionGeneSummary for FRYL_DTD1 |
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Fusion gene information | Fusion gene name: FRYL_DTD1 | Fusion gene ID: 13984 | Hgene | Tgene | Gene symbol | FRYL | DTD1 | Gene ID | 285527 | 92675 |
Gene name | FRY like transcription coactivator | D-tyrosyl-tRNA deacylase 1 | |
Synonyms | AF4p12|KIAA0826|MOR2 | C20orf88|DTD|DUE-B|DUEB|HARS2|pqn-68 | |
Cytomap | 4p11 | 20p11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | protein furry homolog-likeALL1-fused gene from chromosome 4p12 proteinFRY-likefurry homolog-likefurry-likemor2 cell polarity protein homolog | D-aminoacyl-tRNA deacylase 1D-tyrosyl-tRNA deacylase 1 homologD-tyrosyl-tRNA(Tyr) deacylase 1DNA-unwinding element-binding protein Bgly-tRNA(Ala) deacylasehistidyl-tRNA synthase-relatedhistidyl-tRNA synthetase 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O94915 | Q8TEA8 | |
Ensembl transtripts involved in fusion gene | ENST00000503238, ENST00000358350, ENST00000537810, ENST00000264319, ENST00000507711, ENST00000514783, ENST00000507873, ENST00000506685, | ENST00000377452, ENST00000494921, | |
Fusion gene scores | * DoF score | 14 X 11 X 11=1694 | 12 X 5 X 8=480 |
# samples | 21 | 13 | |
** MAII score | log2(21/1694*10)=-3.01197264166608 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/480*10)=-1.88452278258006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FRYL [Title/Abstract] AND DTD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-OL-A5D7-01A | FRYL | chr4 | 48621291 | - | DTD1 | chr20 | 18724744 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000503238 | ENST00000377452 | FRYL | chr4 | 48621291 | - | DTD1 | chr20 | 18724744 | + |
5CDS-intron | ENST00000503238 | ENST00000494921 | FRYL | chr4 | 48621291 | - | DTD1 | chr20 | 18724744 | + |
Frame-shift | ENST00000358350 | ENST00000377452 | FRYL | chr4 | 48621291 | - | DTD1 | chr20 | 18724744 | + |
5CDS-intron | ENST00000358350 | ENST00000494921 | FRYL | chr4 | 48621291 | - | DTD1 | chr20 | 18724744 | + |
Frame-shift | ENST00000537810 | ENST00000377452 | FRYL | chr4 | 48621291 | - | DTD1 | chr20 | 18724744 | + |
5CDS-intron | ENST00000537810 | ENST00000494921 | FRYL | chr4 | 48621291 | - | DTD1 | chr20 | 18724744 | + |
5UTR-3CDS | ENST00000264319 | ENST00000377452 | FRYL | chr4 | 48621291 | - | DTD1 | chr20 | 18724744 | + |
5UTR-intron | ENST00000264319 | ENST00000494921 | FRYL | chr4 | 48621291 | - | DTD1 | chr20 | 18724744 | + |
Frame-shift | ENST00000507711 | ENST00000377452 | FRYL | chr4 | 48621291 | - | DTD1 | chr20 | 18724744 | + |
5CDS-intron | ENST00000507711 | ENST00000494921 | FRYL | chr4 | 48621291 | - | DTD1 | chr20 | 18724744 | + |
intron-3CDS | ENST00000514783 | ENST00000377452 | FRYL | chr4 | 48621291 | - | DTD1 | chr20 | 18724744 | + |
intron-intron | ENST00000514783 | ENST00000494921 | FRYL | chr4 | 48621291 | - | DTD1 | chr20 | 18724744 | + |
intron-3CDS | ENST00000507873 | ENST00000377452 | FRYL | chr4 | 48621291 | - | DTD1 | chr20 | 18724744 | + |
intron-intron | ENST00000507873 | ENST00000494921 | FRYL | chr4 | 48621291 | - | DTD1 | chr20 | 18724744 | + |
intron-3CDS | ENST00000506685 | ENST00000377452 | FRYL | chr4 | 48621291 | - | DTD1 | chr20 | 18724744 | + |
intron-intron | ENST00000506685 | ENST00000494921 | FRYL | chr4 | 48621291 | - | DTD1 | chr20 | 18724744 | + |
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FusionProtFeatures for FRYL_DTD1 |
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Hgene | Tgene |
FRYL | DTD1 |
Plays a key role in maintaining the integrity ofpolarized cell extensions during morphogenesis, regulates theactin cytoskeleton and plays a key role in patterning sensoryneuron dendritic fields by promoting avoidance between homologousdendrites as well as by limiting dendritic branching (Bysimilarity). May function as a transcriptional activator.{ECO:0000250, ECO:0000269|PubMed:16061630}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FRYL_DTD1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FRYL_DTD1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FRYL | HOMER3, YWHAG, BAK1, YWHAB, DISC1, SIRT7, GRK5, NOTCH1, MMS19, PELI2, SLMAP, ABCF1, KIAA0930, MARK2, POLH, YWHAH, TACC3, PDZK1, FRY, HOMER1, FLNC, RNF138, FAM78B | DTD1 | IQCB1, CDC45, TOPBP1, CSNK2A1, ANKMY2, HSF1, CYP1A1, CSNK1E, HARS, MAN2B1, SH2D4A, NEK2, POLK |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FRYL_DTD1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FRYL_DTD1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |