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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13984

FusionGeneSummary for FRYL_DTD1

check button Fusion gene summary
Fusion gene informationFusion gene name: FRYL_DTD1
Fusion gene ID: 13984
HgeneTgene
Gene symbol

FRYL

DTD1

Gene ID

285527

92675

Gene nameFRY like transcription coactivatorD-tyrosyl-tRNA deacylase 1
SynonymsAF4p12|KIAA0826|MOR2C20orf88|DTD|DUE-B|DUEB|HARS2|pqn-68
Cytomap

4p11

20p11.23

Type of geneprotein-codingprotein-coding
Descriptionprotein furry homolog-likeALL1-fused gene from chromosome 4p12 proteinFRY-likefurry homolog-likefurry-likemor2 cell polarity protein homologD-aminoacyl-tRNA deacylase 1D-tyrosyl-tRNA deacylase 1 homologD-tyrosyl-tRNA(Tyr) deacylase 1DNA-unwinding element-binding protein Bgly-tRNA(Ala) deacylasehistidyl-tRNA synthase-relatedhistidyl-tRNA synthetase 2
Modification date2018052320180523
UniProtAcc

O94915

Q8TEA8

Ensembl transtripts involved in fusion geneENST00000503238, ENST00000358350, 
ENST00000537810, ENST00000264319, 
ENST00000507711, ENST00000514783, 
ENST00000507873, ENST00000506685, 
ENST00000377452, ENST00000494921, 
Fusion gene scores* DoF score14 X 11 X 11=169412 X 5 X 8=480
# samples 2113
** MAII scorelog2(21/1694*10)=-3.01197264166608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/480*10)=-1.88452278258006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FRYL [Title/Abstract] AND DTD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-OL-A5D7-01AFRYLchr4

48621291

-DTD1chr20

18724744

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000503238ENST00000377452FRYLchr4

48621291

-DTD1chr20

18724744

+
5CDS-intronENST00000503238ENST00000494921FRYLchr4

48621291

-DTD1chr20

18724744

+
Frame-shitENST00000358350ENST00000377452FRYLchr4

48621291

-DTD1chr20

18724744

+
5CDS-intronENST00000358350ENST00000494921FRYLchr4

48621291

-DTD1chr20

18724744

+
Frame-shitENST00000537810ENST00000377452FRYLchr4

48621291

-DTD1chr20

18724744

+
5CDS-intronENST00000537810ENST00000494921FRYLchr4

48621291

-DTD1chr20

18724744

+
5UTR-3CDSENST00000264319ENST00000377452FRYLchr4

48621291

-DTD1chr20

18724744

+
5UTR-intronENST00000264319ENST00000494921FRYLchr4

48621291

-DTD1chr20

18724744

+
Frame-shitENST00000507711ENST00000377452FRYLchr4

48621291

-DTD1chr20

18724744

+
5CDS-intronENST00000507711ENST00000494921FRYLchr4

48621291

-DTD1chr20

18724744

+
intron-3CDSENST00000514783ENST00000377452FRYLchr4

48621291

-DTD1chr20

18724744

+
intron-intronENST00000514783ENST00000494921FRYLchr4

48621291

-DTD1chr20

18724744

+
intron-3CDSENST00000507873ENST00000377452FRYLchr4

48621291

-DTD1chr20

18724744

+
intron-intronENST00000507873ENST00000494921FRYLchr4

48621291

-DTD1chr20

18724744

+
intron-3CDSENST00000506685ENST00000377452FRYLchr4

48621291

-DTD1chr20

18724744

+
intron-intronENST00000506685ENST00000494921FRYLchr4

48621291

-DTD1chr20

18724744

+

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FusionProtFeatures for FRYL_DTD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FRYL

O94915

DTD1

Q8TEA8

Plays a key role in maintaining the integrity ofpolarized cell extensions during morphogenesis, regulates theactin cytoskeleton and plays a key role in patterning sensoryneuron dendritic fields by promoting avoidance between homologousdendrites as well as by limiting dendritic branching (Bysimilarity). May function as a transcriptional activator.{ECO:0000250, ECO:0000269|PubMed:16061630}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FRYL_DTD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FRYL_DTD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FRYLHOMER3, YWHAG, BAK1, YWHAB, DISC1, SIRT7, GRK5, NOTCH1, MMS19, PELI2, SLMAP, ABCF1, KIAA0930, MARK2, POLH, YWHAH, TACC3, PDZK1, FRY, HOMER1, FLNC, RNF138, FAM78BDTD1IQCB1, CDC45, TOPBP1, CSNK2A1, ANKMY2, HSF1, CYP1A1, CSNK1E, HARS, MAN2B1, SH2D4A, NEK2, POLK


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FRYL_DTD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FRYL_DTD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource