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Fusion gene ID: 1395 |
FusionGeneSummary for AKR1C3_AKR1E2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AKR1C3_AKR1E2 | Fusion gene ID: 1395 | Hgene | Tgene | Gene symbol | AKR1C3 | AKR1E2 | Gene ID | 8644 | 83592 |
| Gene name | aldo-keto reductase family 1 member C3 | aldo-keto reductase family 1 member E2 | |
| Synonyms | DD3|DDX|HA1753|HAKRB|HAKRe|HSD17B5|PGFS|hluPGFS | AKR1CL2|AKRDC1|LoopADR|TAKR|hTSP|htAKR | |
| Cytomap | 10p15.1 | 10p15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | aldo-keto reductase family 1 member C33-alpha hydroxysteroid dehydrogenase, type II3-alpha-HSD type II, brainchlordecone reductase homolog HAKRbdihydrodiol dehydrogenase 3dihydrodiol dehydrogenase Xindanol dehydrogenaseprostaglandin F synthasetest | 1,5-anhydro-D-fructose reductaseAF reductasealdo-keto reductase family 1 member C-like protein 2aldo-keto reductase family 1, member C-like 2aldo-keto reductase loopADRtestis aldo-keto reductasetestis-specific protein | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P42330 | Q96JD6 | |
| Ensembl transtripts involved in fusion gene | ENST00000470862, ENST00000605149, ENST00000439082, ENST00000380554, | ENST00000298375, ENST00000525281, ENST00000532248, ENST00000334019, ENST00000345253, | |
| Fusion gene scores | * DoF score | 2 X 3 X 2=12 | 5 X 2 X 5=50 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: AKR1C3 [Title/Abstract] AND AKR1E2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AKR1C3 | GO:0000060 | protein import into nucleus, translocation | 21787718 |
| Hgene | AKR1C3 | GO:0007186 | G-protein coupled receptor signaling pathway | 18508192 |
| Hgene | AKR1C3 | GO:0008284 | positive regulation of cell proliferation | 18508192|20036328 |
| Hgene | AKR1C3 | GO:0010942 | positive regulation of cell death | 21787718 |
| Hgene | AKR1C3 | GO:0016488 | farnesol catabolic process | 21187079 |
| Hgene | AKR1C3 | GO:0034614 | cellular response to reactive oxygen species | 21787718 |
| Hgene | AKR1C3 | GO:0042448 | progesterone metabolic process | 21232532 |
| Hgene | AKR1C3 | GO:0042574 | retinal metabolic process | 21851338 |
| Hgene | AKR1C3 | GO:0048385 | regulation of retinoic acid receptor signaling pathway | 21851338 |
| Hgene | AKR1C3 | GO:0051897 | positive regulation of protein kinase B signaling | 18508192 |
| Hgene | AKR1C3 | GO:0055114 | oxidation-reduction process | 16983398|19442656|21232532 |
| Hgene | AKR1C3 | GO:0071276 | cellular response to cadmium ion | 21787718 |
| Hgene | AKR1C3 | GO:0071277 | cellular response to calcium ion | 22170488 |
| Hgene | AKR1C3 | GO:0071379 | cellular response to prostaglandin stimulus | 22170488 |
| Hgene | AKR1C3 | GO:0071384 | cellular response to corticosteroid stimulus | 19336506 |
| Hgene | AKR1C3 | GO:0071395 | cellular response to jasmonic acid stimulus | 19487289 |
| Hgene | AKR1C3 | GO:0071799 | cellular response to prostaglandin D stimulus | 18508192 |
| Hgene | AKR1C3 | GO:1900053 | negative regulation of retinoic acid biosynthetic process | 21851338 |
| Hgene | AKR1C3 | GO:2000353 | positive regulation of endothelial cell apoptotic process | 19442656 |
| Hgene | AKR1C3 | GO:2000379 | positive regulation of reactive oxygen species metabolic process | 19442656 |
| Tgene | AKR1E2 | GO:0055114 | oxidation-reduction process | 15118078 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-66-2759-01A | AKR1C3 | chr10 | 5144842 | + | AKR1E2 | chr10 | 4877867 | + |
| TCGA | LD | LUSC | TCGA-68-A59J-01A | AKR1C3 | chr10 | 5139742 | + | AKR1E2 | chr10 | 4872867 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000470862 | ENST00000298375 | AKR1C3 | chr10 | 5144842 | + | AKR1E2 | chr10 | 4877867 | + |
| intron-3UTR | ENST00000470862 | ENST00000525281 | AKR1C3 | chr10 | 5144842 | + | AKR1E2 | chr10 | 4877867 | + |
| intron-3UTR | ENST00000470862 | ENST00000532248 | AKR1C3 | chr10 | 5144842 | + | AKR1E2 | chr10 | 4877867 | + |
| intron-3UTR | ENST00000470862 | ENST00000334019 | AKR1C3 | chr10 | 5144842 | + | AKR1E2 | chr10 | 4877867 | + |
| intron-3UTR | ENST00000470862 | ENST00000345253 | AKR1C3 | chr10 | 5144842 | + | AKR1E2 | chr10 | 4877867 | + |
| In-frame | ENST00000605149 | ENST00000298375 | AKR1C3 | chr10 | 5144842 | + | AKR1E2 | chr10 | 4877867 | + |
| 5CDS-3UTR | ENST00000605149 | ENST00000525281 | AKR1C3 | chr10 | 5144842 | + | AKR1E2 | chr10 | 4877867 | + |
| 5CDS-3UTR | ENST00000605149 | ENST00000532248 | AKR1C3 | chr10 | 5144842 | + | AKR1E2 | chr10 | 4877867 | + |
| 5CDS-3UTR | ENST00000605149 | ENST00000334019 | AKR1C3 | chr10 | 5144842 | + | AKR1E2 | chr10 | 4877867 | + |
| 5CDS-3UTR | ENST00000605149 | ENST00000345253 | AKR1C3 | chr10 | 5144842 | + | AKR1E2 | chr10 | 4877867 | + |
| In-frame | ENST00000439082 | ENST00000298375 | AKR1C3 | chr10 | 5144842 | + | AKR1E2 | chr10 | 4877867 | + |
| 5CDS-3UTR | ENST00000439082 | ENST00000525281 | AKR1C3 | chr10 | 5144842 | + | AKR1E2 | chr10 | 4877867 | + |
| 5CDS-3UTR | ENST00000439082 | ENST00000532248 | AKR1C3 | chr10 | 5144842 | + | AKR1E2 | chr10 | 4877867 | + |
| 5CDS-3UTR | ENST00000439082 | ENST00000334019 | AKR1C3 | chr10 | 5144842 | + | AKR1E2 | chr10 | 4877867 | + |
| 5CDS-3UTR | ENST00000439082 | ENST00000345253 | AKR1C3 | chr10 | 5144842 | + | AKR1E2 | chr10 | 4877867 | + |
| In-frame | ENST00000380554 | ENST00000298375 | AKR1C3 | chr10 | 5144842 | + | AKR1E2 | chr10 | 4877867 | + |
| 5CDS-3UTR | ENST00000380554 | ENST00000525281 | AKR1C3 | chr10 | 5144842 | + | AKR1E2 | chr10 | 4877867 | + |
| 5CDS-3UTR | ENST00000380554 | ENST00000532248 | AKR1C3 | chr10 | 5144842 | + | AKR1E2 | chr10 | 4877867 | + |
| 5CDS-3UTR | ENST00000380554 | ENST00000334019 | AKR1C3 | chr10 | 5144842 | + | AKR1E2 | chr10 | 4877867 | + |
| 5CDS-3UTR | ENST00000380554 | ENST00000345253 | AKR1C3 | chr10 | 5144842 | + | AKR1E2 | chr10 | 4877867 | + |
| intron-3CDS | ENST00000470862 | ENST00000298375 | AKR1C3 | chr10 | 5139742 | + | AKR1E2 | chr10 | 4872867 | + |
| intron-3UTR | ENST00000470862 | ENST00000525281 | AKR1C3 | chr10 | 5139742 | + | AKR1E2 | chr10 | 4872867 | + |
| intron-3UTR | ENST00000470862 | ENST00000532248 | AKR1C3 | chr10 | 5139742 | + | AKR1E2 | chr10 | 4872867 | + |
| intron-3UTR | ENST00000470862 | ENST00000334019 | AKR1C3 | chr10 | 5139742 | + | AKR1E2 | chr10 | 4872867 | + |
| intron-3UTR | ENST00000470862 | ENST00000345253 | AKR1C3 | chr10 | 5139742 | + | AKR1E2 | chr10 | 4872867 | + |
| In-frame | ENST00000605149 | ENST00000298375 | AKR1C3 | chr10 | 5139742 | + | AKR1E2 | chr10 | 4872867 | + |
| 5CDS-3UTR | ENST00000605149 | ENST00000525281 | AKR1C3 | chr10 | 5139742 | + | AKR1E2 | chr10 | 4872867 | + |
| 5CDS-3UTR | ENST00000605149 | ENST00000532248 | AKR1C3 | chr10 | 5139742 | + | AKR1E2 | chr10 | 4872867 | + |
| 5CDS-3UTR | ENST00000605149 | ENST00000334019 | AKR1C3 | chr10 | 5139742 | + | AKR1E2 | chr10 | 4872867 | + |
| 5CDS-3UTR | ENST00000605149 | ENST00000345253 | AKR1C3 | chr10 | 5139742 | + | AKR1E2 | chr10 | 4872867 | + |
| In-frame | ENST00000439082 | ENST00000298375 | AKR1C3 | chr10 | 5139742 | + | AKR1E2 | chr10 | 4872867 | + |
| 5CDS-3UTR | ENST00000439082 | ENST00000525281 | AKR1C3 | chr10 | 5139742 | + | AKR1E2 | chr10 | 4872867 | + |
| 5CDS-3UTR | ENST00000439082 | ENST00000532248 | AKR1C3 | chr10 | 5139742 | + | AKR1E2 | chr10 | 4872867 | + |
| 5CDS-3UTR | ENST00000439082 | ENST00000334019 | AKR1C3 | chr10 | 5139742 | + | AKR1E2 | chr10 | 4872867 | + |
| 5CDS-3UTR | ENST00000439082 | ENST00000345253 | AKR1C3 | chr10 | 5139742 | + | AKR1E2 | chr10 | 4872867 | + |
| In-frame | ENST00000380554 | ENST00000298375 | AKR1C3 | chr10 | 5139742 | + | AKR1E2 | chr10 | 4872867 | + |
| 5CDS-3UTR | ENST00000380554 | ENST00000525281 | AKR1C3 | chr10 | 5139742 | + | AKR1E2 | chr10 | 4872867 | + |
| 5CDS-3UTR | ENST00000380554 | ENST00000532248 | AKR1C3 | chr10 | 5139742 | + | AKR1E2 | chr10 | 4872867 | + |
| 5CDS-3UTR | ENST00000380554 | ENST00000334019 | AKR1C3 | chr10 | 5139742 | + | AKR1E2 | chr10 | 4872867 | + |
| 5CDS-3UTR | ENST00000380554 | ENST00000345253 | AKR1C3 | chr10 | 5139742 | + | AKR1E2 | chr10 | 4872867 | + |
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FusionProtFeatures for AKR1C3_AKR1E2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AKR1C3 | AKR1E2 |
| Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol (By similarity). Has lowNADPH-dependent reductase activity towards 9,10-phenanthrenequinone (in vitro) (PubMed:12604216, PubMed:15118078).{ECO:0000250|UniProtKB:Q9DCT1, ECO:0000269|PubMed:12604216,ECO:0000269|PubMed:15118078}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AKR1C3_AKR1E2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_AKR1C3_ENST00000605149_chr10_5144842_+_AKR1E2_ENST00000298375_chr10_4877867_+_472aa MQISQVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDL YLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLL DFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQPPHPEWIMSCS ELSFCLSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQIECHPYLTQKNLISF CQSRDVSVTAYRPLGGSCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRN >In-frame_AKR1C3_ENST00000439082_chr10_5144842_+_AKR1E2_ENST00000298375_chr10_4877867_+_376aa MSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSK DIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQPPHPEWIMSCSELSFCL SHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQIECHPYLTQKNLISFCQSRDV SVTAYRPLGGSCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMF >In-frame_AKR1C3_ENST00000380554_chr10_5144842_+_AKR1E2_ENST00000298375_chr10_4877867_+_495aa MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFH RPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAK SYNEQRIRQNVQPPHPEWIMSCSELSFCLSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGL RFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKE >In-frame_AKR1C3_ENST00000605149_chr10_5139742_+_AKR1E2_ENST00000298375_chr10_4872867_+_408aa MQISQVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDL YLIHSPMSLKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVETACRKSLKALKL NYLDLYLIHWPMGFKPPHPEWIMSCSELSFCLSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNK PGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSH >In-frame_AKR1C3_ENST00000439082_chr10_5139742_+_AKR1E2_ENST00000298375_chr10_4872867_+_312aa MSLKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLY LIHWPMGFKPPHPEWIMSCSELSFCLSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFK PLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKENIQ >In-frame_AKR1C3_ENST00000380554_chr10_5139742_+_AKR1E2_ENST00000298375_chr10_4872867_+_431aa MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFH RPELVRPALENSLKKAQLDYVDLYLIHSPMSLKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKL WCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPMGFKPPHPEWIMSCSELSFCLSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVI TGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVDLIDNPVIKRIAKEHGKSPA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_AKR1C3_ENST00000605149_chr10_5144842_+_AKR1E2_ENST00000298375_chr10_4877867_+_1416nt ATGCAAATATCACAGGTTCCGAGAAGTAAAGCTTTGGAGGTCACAAAATTAGCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTCAT TTATACAATAATGAGGAGCAGGTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTCTACACTTCA AAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGTCCGACCAGCCTTGGAAAACTCACTGAAGAAAGCTCAATTGGACTATGTTGACCTC TATCTTATTCATTCTCCAATGTCTCTAAAGCCAGGTGAGGAACTTTCACCAACAGATGAAAATGGAAAAGTAATATTTGACATAGTGGAT CTCTGTACCACCTGGGAGGCCATGGAGAAGTGTAAGGATGCAGGATTGGCCAAGTCCATTGGGGTGTCAAACTTCAACCGCAGGCAGCTG GAGATGATCCTCAACAAGCCAGGACTCAAGTACAAGCCTGTCTGCAACCAGGTAGAATGTCATCCGTATTTCAACCGGAGTAAATTGCTA GATTTCTGCAAGTCGAAAGATATTGTTCTGGTTGCCTATAGTGCTCTGGGATCTCAACGAGACAAACGATGGGTGGACCCGAACTCCCCG GTGCTCTTGGAGGACCCAGTCCTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAGCTGCAGCGT GGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAACGTGCAGCCTCCTCATCCAGAATGGATCATGAGCTGCAGT GAACTTTCCTTCTGCCTCTCACATCCTCGAGTGCAGGACTTGCCTCTGGACGAGAGCAACATGGTTATTCCCAGTGACACGGACTTCCTG GACACGTGGGAGGCCATGGAGGACCTGGTGATCACCGGGCTGGTGAAGAACATCGGGGTGTCAAACTTCAACCATGAACAGCTTGAGAGG CTTTTGAATAAGCCTGGGTTGAGGTTCAAGCCACTAACCAACCAGATTGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTTTT TGCCAATCCAGAGATGTGTCCGTGACTGCTTACCGTCCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTGATAGACAACCCTGTGATCAAG AGGATTGCAAAGGAGCACGGCAAGTCTCCTGCTCAGATTTTGATCCGATTTCAAATCCAGAGGAATGTGATAGTGATCCCCGGATCTATC ACCCCAAGTCACATTAAAGAGAATATCCAGGTGTTTGATTTTGAATTAACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGAAT >In-frame_AKR1C3_ENST00000439082_chr10_5144842_+_AKR1E2_ENST00000298375_chr10_4877867_+_1128nt ATGTCTCTAAAGCCAGGTGAGGAACTTTCACCAACAGATGAAAATGGAAAAGTAATATTTGACATAGTGGATCTCTGTACCACCTGGGAG GCCATGGAGAAGTGTAAGGATGCAGGATTGGCCAAGTCCATTGGGGTGTCAAACTTCAACCGCAGGCAGCTGGAGATGATCCTCAACAAG CCAGGACTCAAGTACAAGCCTGTCTGCAACCAGGTAGAATGTCATCCGTATTTCAACCGGAGTAAATTGCTAGATTTCTGCAAGTCGAAA GATATTGTTCTGGTTGCCTATAGTGCTCTGGGATCTCAACGAGACAAACGATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAGGACCCA GTCCTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAGCTGCAGCGTGGGGTTGTGGTCCTGGCC AAGAGCTACAATGAGCAGCGCATCAGACAGAACGTGCAGCCTCCTCATCCAGAATGGATCATGAGCTGCAGTGAACTTTCCTTCTGCCTC TCACATCCTCGAGTGCAGGACTTGCCTCTGGACGAGAGCAACATGGTTATTCCCAGTGACACGGACTTCCTGGACACGTGGGAGGCCATG GAGGACCTGGTGATCACCGGGCTGGTGAAGAACATCGGGGTGTCAAACTTCAACCATGAACAGCTTGAGAGGCTTTTGAATAAGCCTGGG TTGAGGTTCAAGCCACTAACCAACCAGATTGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTTTTTGCCAATCCAGAGATGTG TCCGTGACTGCTTACCGTCCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTGATAGACAACCCTGTGATCAAGAGGATTGCAAAGGAGCAC GGCAAGTCTCCTGCTCAGATTTTGATCCGATTTCAAATCCAGAGGAATGTGATAGTGATCCCCGGATCTATCACCCCAAGTCACATTAAA GAGAATATCCAGGTGTTTGATTTTGAATTAACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGAATCTCCGACTGGCCATGTTC >In-frame_AKR1C3_ENST00000380554_chr10_5144842_+_AKR1E2_ENST00000298375_chr10_4877867_+_1485nt ATGGATTCCAAACACCAGTGTGTAAAGCTAAATGATGGCCACTTCATGCCTGTATTGGGATTTGGCACCTATGCACCTCCAGAGGTTCCG AGAAGTAAAGCTTTGGAGGTCACAAAATTAGCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTCATTTATACAATAATGAGGAGCAG GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTCTACACTTCAAAGCTTTGGTCCACTTTTCAT CGACCAGAGTTGGTCCGACCAGCCTTGGAAAACTCACTGAAGAAAGCTCAATTGGACTATGTTGACCTCTATCTTATTCATTCTCCAATG TCTCTAAAGCCAGGTGAGGAACTTTCACCAACAGATGAAAATGGAAAAGTAATATTTGACATAGTGGATCTCTGTACCACCTGGGAGGCC ATGGAGAAGTGTAAGGATGCAGGATTGGCCAAGTCCATTGGGGTGTCAAACTTCAACCGCAGGCAGCTGGAGATGATCCTCAACAAGCCA GGACTCAAGTACAAGCCTGTCTGCAACCAGGTAGAATGTCATCCGTATTTCAACCGGAGTAAATTGCTAGATTTCTGCAAGTCGAAAGAT ATTGTTCTGGTTGCCTATAGTGCTCTGGGATCTCAACGAGACAAACGATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAGGACCCAGTC CTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAGCTGCAGCGTGGGGTTGTGGTCCTGGCCAAG AGCTACAATGAGCAGCGCATCAGACAGAACGTGCAGCCTCCTCATCCAGAATGGATCATGAGCTGCAGTGAACTTTCCTTCTGCCTCTCA CATCCTCGAGTGCAGGACTTGCCTCTGGACGAGAGCAACATGGTTATTCCCAGTGACACGGACTTCCTGGACACGTGGGAGGCCATGGAG GACCTGGTGATCACCGGGCTGGTGAAGAACATCGGGGTGTCAAACTTCAACCATGAACAGCTTGAGAGGCTTTTGAATAAGCCTGGGTTG AGGTTCAAGCCACTAACCAACCAGATTGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTTTTTGCCAATCCAGAGATGTGTCC GTGACTGCTTACCGTCCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTGATAGACAACCCTGTGATCAAGAGGATTGCAAAGGAGCACGGC AAGTCTCCTGCTCAGATTTTGATCCGATTTCAAATCCAGAGGAATGTGATAGTGATCCCCGGATCTATCACCCCAAGTCACATTAAAGAG AATATCCAGGTGTTTGATTTTGAATTAACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGAATCTCCGACTGGCCATGTTCCCC >In-frame_AKR1C3_ENST00000605149_chr10_5139742_+_AKR1E2_ENST00000298375_chr10_4872867_+_1224nt ATGCAAATATCACAGGTTCCGAGAAGTAAAGCTTTGGAGGTCACAAAATTAGCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTCAT TTATACAATAATGAGGAGCAGGTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTCTACACTTCA AAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGTCCGACCAGCCTTGGAAAACTCACTGAAGAAAGCTCAATTGGACTATGTTGACCTC TATCTTATTCATTCTCCAATGTCTCTAAAGGCTTCTCCAGGGAAAGTGACCGAGGCAGTGAAAGAGGCCATTGACGCAGGGTACCGGCAC TTCGACTGTGCTTACTTTTACCACAATGAGAGGGAGGTTGGAGCAGGGATCCGTTGCAAGATCAAGGAAGGCGCTGTAAGACGGGAGGAT CTGTTCATTGCCACTAAGCTGTGGTGCACCTGCCATAAGAAGTCCTTGGTGGAAACAGCATGCAGAAAGAGTCTCAAGGCCTTGAAGCTG AACTATTTGGACCTCTACCTCATACACTGGCCCATGGGTTTCAAGCCTCCTCATCCAGAATGGATCATGAGCTGCAGTGAACTTTCCTTC TGCCTCTCACATCCTCGAGTGCAGGACTTGCCTCTGGACGAGAGCAACATGGTTATTCCCAGTGACACGGACTTCCTGGACACGTGGGAG GCCATGGAGGACCTGGTGATCACCGGGCTGGTGAAGAACATCGGGGTGTCAAACTTCAACCATGAACAGCTTGAGAGGCTTTTGAATAAG CCTGGGTTGAGGTTCAAGCCACTAACCAACCAGATTGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTTTTTGCCAATCCAGA GATGTGTCCGTGACTGCTTACCGTCCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTGATAGACAACCCTGTGATCAAGAGGATTGCAAAG GAGCACGGCAAGTCTCCTGCTCAGATTTTGATCCGATTTCAAATCCAGAGGAATGTGATAGTGATCCCCGGATCTATCACCCCAAGTCAC ATTAAAGAGAATATCCAGGTGTTTGATTTTGAATTAACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGAATCTCCGACTGGCC >In-frame_AKR1C3_ENST00000439082_chr10_5139742_+_AKR1E2_ENST00000298375_chr10_4872867_+_936nt ATGTCTCTAAAGGCTTCTCCAGGGAAAGTGACCGAGGCAGTGAAAGAGGCCATTGACGCAGGGTACCGGCACTTCGACTGTGCTTACTTT TACCACAATGAGAGGGAGGTTGGAGCAGGGATCCGTTGCAAGATCAAGGAAGGCGCTGTAAGACGGGAGGATCTGTTCATTGCCACTAAG CTGTGGTGCACCTGCCATAAGAAGTCCTTGGTGGAAACAGCATGCAGAAAGAGTCTCAAGGCCTTGAAGCTGAACTATTTGGACCTCTAC CTCATACACTGGCCCATGGGTTTCAAGCCTCCTCATCCAGAATGGATCATGAGCTGCAGTGAACTTTCCTTCTGCCTCTCACATCCTCGA GTGCAGGACTTGCCTCTGGACGAGAGCAACATGGTTATTCCCAGTGACACGGACTTCCTGGACACGTGGGAGGCCATGGAGGACCTGGTG ATCACCGGGCTGGTGAAGAACATCGGGGTGTCAAACTTCAACCATGAACAGCTTGAGAGGCTTTTGAATAAGCCTGGGTTGAGGTTCAAG CCACTAACCAACCAGATTGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTTTTTGCCAATCCAGAGATGTGTCCGTGACTGCT TACCGTCCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTGATAGACAACCCTGTGATCAAGAGGATTGCAAAGGAGCACGGCAAGTCTCCT GCTCAGATTTTGATCCGATTTCAAATCCAGAGGAATGTGATAGTGATCCCCGGATCTATCACCCCAAGTCACATTAAAGAGAATATCCAG GTGTTTGATTTTGAATTAACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGAATCTCCGACTGGCCATGTTCCCCATAACTAAA >In-frame_AKR1C3_ENST00000380554_chr10_5139742_+_AKR1E2_ENST00000298375_chr10_4872867_+_1293nt ATGGATTCCAAACACCAGTGTGTAAAGCTAAATGATGGCCACTTCATGCCTGTATTGGGATTTGGCACCTATGCACCTCCAGAGGTTCCG AGAAGTAAAGCTTTGGAGGTCACAAAATTAGCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTCATTTATACAATAATGAGGAGCAG GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTCTACACTTCAAAGCTTTGGTCCACTTTTCAT CGACCAGAGTTGGTCCGACCAGCCTTGGAAAACTCACTGAAGAAAGCTCAATTGGACTATGTTGACCTCTATCTTATTCATTCTCCAATG TCTCTAAAGGCTTCTCCAGGGAAAGTGACCGAGGCAGTGAAAGAGGCCATTGACGCAGGGTACCGGCACTTCGACTGTGCTTACTTTTAC CACAATGAGAGGGAGGTTGGAGCAGGGATCCGTTGCAAGATCAAGGAAGGCGCTGTAAGACGGGAGGATCTGTTCATTGCCACTAAGCTG TGGTGCACCTGCCATAAGAAGTCCTTGGTGGAAACAGCATGCAGAAAGAGTCTCAAGGCCTTGAAGCTGAACTATTTGGACCTCTACCTC ATACACTGGCCCATGGGTTTCAAGCCTCCTCATCCAGAATGGATCATGAGCTGCAGTGAACTTTCCTTCTGCCTCTCACATCCTCGAGTG CAGGACTTGCCTCTGGACGAGAGCAACATGGTTATTCCCAGTGACACGGACTTCCTGGACACGTGGGAGGCCATGGAGGACCTGGTGATC ACCGGGCTGGTGAAGAACATCGGGGTGTCAAACTTCAACCATGAACAGCTTGAGAGGCTTTTGAATAAGCCTGGGTTGAGGTTCAAGCCA CTAACCAACCAGATTGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTTTTTGCCAATCCAGAGATGTGTCCGTGACTGCTTAC CGTCCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTGATAGACAACCCTGTGATCAAGAGGATTGCAAAGGAGCACGGCAAGTCTCCTGCT CAGATTTTGATCCGATTTCAAATCCAGAGGAATGTGATAGTGATCCCCGGATCTATCACCCCAAGTCACATTAAAGAGAATATCCAGGTG TTTGATTTTGAATTAACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGAATCTCCGACTGGCCATGTTCCCCATAACTAAAAAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_AKR1C3_ENST00000605149_chr10_5144842_+_AKR1E2_ENST00000298375_chr10_4877867_+_2273nt TTTTTGCTGAACATTCCCCTTAGTAAAATGGCAGGATGGTTTGCTTGCCATTGAAACTAACCAAACATTTAATCCTTTTCCCTTTAGAGA AAAAAGAAAAAAAAAGGTGCAGCTCACTGCCAGTGCCCATTTAGTTTTACATTAACATGTTCCTTGAGGTTGAAGCAAATCTGACCGATT TTCAATGTAAAAATAACATATAAAAACTGTTCTCGGAGTTATTTCTAAACAGAACTAAGATCAGAATTCTTTGAATCATCAGAATCATCT CTTTTGAAAAATCGATTCATCAAATGAATCTTCAGCCAACAACTGTTCAAGAAGGATGCAAATATCACAGGTTCCGAGAAGTAAAGCTTT GGAGGTCACAAAATTAGCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTCATTTATACAATAATGAGGAGCAGGTTGGACTGGCCAT CCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTCTACACTTCAAAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGT CCGACCAGCCTTGGAAAACTCACTGAAGAAAGCTCAATTGGACTATGTTGACCTCTATCTTATTCATTCTCCAATGTCTCTAAAGCCAGG TGAGGAACTTTCACCAACAGATGAAAATGGAAAAGTAATATTTGACATAGTGGATCTCTGTACCACCTGGGAGGCCATGGAGAAGTGTAA GGATGCAGGATTGGCCAAGTCCATTGGGGTGTCAAACTTCAACCGCAGGCAGCTGGAGATGATCCTCAACAAGCCAGGACTCAAGTACAA GCCTGTCTGCAACCAGGTAGAATGTCATCCGTATTTCAACCGGAGTAAATTGCTAGATTTCTGCAAGTCGAAAGATATTGTTCTGGTTGC CTATAGTGCTCTGGGATCTCAACGAGACAAACGATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAGGACCCAGTCCTTTGTGCCTTGGC AAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAGCTGCAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCA GCGCATCAGACAGAACGTGCAGCCTCCTCATCCAGAATGGATCATGAGCTGCAGTGAACTTTCCTTCTGCCTCTCACATCCTCGAGTGCA GGACTTGCCTCTGGACGAGAGCAACATGGTTATTCCCAGTGACACGGACTTCCTGGACACGTGGGAGGCCATGGAGGACCTGGTGATCAC CGGGCTGGTGAAGAACATCGGGGTGTCAAACTTCAACCATGAACAGCTTGAGAGGCTTTTGAATAAGCCTGGGTTGAGGTTCAAGCCACT AACCAACCAGATTGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTTTTTGCCAATCCAGAGATGTGTCCGTGACTGCTTACCG TCCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTGATAGACAACCCTGTGATCAAGAGGATTGCAAAGGAGCACGGCAAGTCTCCTGCTCA GATTTTGATCCGATTTCAAATCCAGAGGAATGTGATAGTGATCCCCGGATCTATCACCCCAAGTCACATTAAAGAGAATATCCAGGTGTT TGATTTTGAATTAACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGAATCTCCGACTGGCCATGTTCCCCATAACTAAAAATCA CAAAGACTATCCTTTCCACATAGAATACTGAGGACGCTTCCCCTTCCTTGTTTCTGCTCAGCCCAGATGCACAGACACTATTGGCAATGT TGACCCTCCTCTGTCATCACAGCGCCAGGGCAGCTGTGCCTGGGACAGGAGCCACACAGTCAGAGGGGGATGTAAGAGCCACCTTCTCTG ACAAATCTGGAGAATTGAGTGTGTTCTAAGTGAAGGCAATGGGGTTTCTCCAAGACAGCCTGTGTGGCCTCTACTCTGAACAAATACACT GATGAGTCATCAGTGAAATTTGCCTTCACATTTTAAGAAAACTTTATCTTATGGAGTTATTTAAGCCATCTACAGAGCTGAGGAAACAGT GTAATGTGTCTCTGCCCCATTGCGCAGCTCCACCCATTGTGCCCCAGGCCAGCCCGCGTCACCTACACTTCCTTCTGTGCCCTGCCAGTG ACCCCCAGGTTATTCTAAAGCAGAGTCCTTCCCTTCCCCCAGTGAGAAGGAAAATGGGATAAGTCTGGGACACTGTTTCAGTTCAATAAA >In-frame_AKR1C3_ENST00000439082_chr10_5144842_+_AKR1E2_ENST00000298375_chr10_4877867_+_2130nt AACATGTTCCTTGAGGTTGAAGCAAATCTGACCGATTTTCAATGTAAAAATAACATATAAAAACTGTTCTCGGAGTTATTTCTAAACAGA ACTAAGATCAGAATTCTTTGAATCATCAGAATCATCTCTTTTGAAAAATCGATTCATCAAATGAATCTTCAGCCAACAACTGTTCAAGAA GGATGCAAATATCACAGGTTCCGAGAAGTAAAGCTTTGGAGGTCACAAAATTAGCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTC ATTTATACAATAATGAGGAGCAGGTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTCTACACTT CAAAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGTCCGACCAGCCTTGGAAAACTCACTGAAGAAAGCTCAATTGGACTATGTTGACC TCTATCTTATTCATTCTCCAATGTCTCTAAAGCCAGGTGAGGAACTTTCACCAACAGATGAAAATGGAAAAGTAATATTTGACATAGTGG ATCTCTGTACCACCTGGGAGGCCATGGAGAAGTGTAAGGATGCAGGATTGGCCAAGTCCATTGGGGTGTCAAACTTCAACCGCAGGCAGC TGGAGATGATCCTCAACAAGCCAGGACTCAAGTACAAGCCTGTCTGCAACCAGGTAGAATGTCATCCGTATTTCAACCGGAGTAAATTGC TAGATTTCTGCAAGTCGAAAGATATTGTTCTGGTTGCCTATAGTGCTCTGGGATCTCAACGAGACAAACGATGGGTGGACCCGAACTCCC CGGTGCTCTTGGAGGACCCAGTCCTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAGCTGCAGC GTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAACGTGCAGCCTCCTCATCCAGAATGGATCATGAGCTGCA GTGAACTTTCCTTCTGCCTCTCACATCCTCGAGTGCAGGACTTGCCTCTGGACGAGAGCAACATGGTTATTCCCAGTGACACGGACTTCC TGGACACGTGGGAGGCCATGGAGGACCTGGTGATCACCGGGCTGGTGAAGAACATCGGGGTGTCAAACTTCAACCATGAACAGCTTGAGA GGCTTTTGAATAAGCCTGGGTTGAGGTTCAAGCCACTAACCAACCAGATTGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTT TTTGCCAATCCAGAGATGTGTCCGTGACTGCTTACCGTCCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTGATAGACAACCCTGTGATCA AGAGGATTGCAAAGGAGCACGGCAAGTCTCCTGCTCAGATTTTGATCCGATTTCAAATCCAGAGGAATGTGATAGTGATCCCCGGATCTA TCACCCCAAGTCACATTAAAGAGAATATCCAGGTGTTTGATTTTGAATTAACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGA ATCTCCGACTGGCCATGTTCCCCATAACTAAAAATCACAAAGACTATCCTTTCCACATAGAATACTGAGGACGCTTCCCCTTCCTTGTTT CTGCTCAGCCCAGATGCACAGACACTATTGGCAATGTTGACCCTCCTCTGTCATCACAGCGCCAGGGCAGCTGTGCCTGGGACAGGAGCC ACACAGTCAGAGGGGGATGTAAGAGCCACCTTCTCTGACAAATCTGGAGAATTGAGTGTGTTCTAAGTGAAGGCAATGGGGTTTCTCCAA GACAGCCTGTGTGGCCTCTACTCTGAACAAATACACTGATGAGTCATCAGTGAAATTTGCCTTCACATTTTAAGAAAACTTTATCTTATG GAGTTATTTAAGCCATCTACAGAGCTGAGGAAACAGTGTAATGTGTCTCTGCCCCATTGCGCAGCTCCACCCATTGTGCCCCAGGCCAGC CCGCGTCACCTACACTTCCTTCTGTGCCCTGCCAGTGACCCCCAGGTTATTCTAAAGCAGAGTCCTTCCCTTCCCCCAGTGAGAAGGAAA >In-frame_AKR1C3_ENST00000380554_chr10_5144842_+_AKR1E2_ENST00000298375_chr10_4877867_+_2669nt CCCTCATCAGGATTACAGCTTTATCAGGACTGCATCTTCTTCAGAAATGAATATTTCTCTTACAACGCAAAGAAAGAAAAATCAAAATAA ATTTTCTGATTGAAAATGTAAAAAGGCAAATATTTTTACAGTTTTAACTTTAATTTTTTATTGAGGACCAACTATTTGAAAAATTCTCAT TAGTCATTCCTTTAAATTATGTGTATGTGAGAGAAAGACGTAAGATGGTTAATTATTTCAAATGATGCAGTATAAAGAAGGGGCATTATC ACGGCAGAAACGAAAAAAGATATTTGTAGCTGGAGGTTTTTATAGTCTAACATATGGTTGCTATTTGTTCTACAAATCCTTTTGAATAAT TTAATATAGAGATTTAGAATAGAAAATAATACTTTAGATAGAAATTAATGAGTTTATTATAACCATATATTATAATAATTTACTTAGGAA TTCTCTTTGATAAGAAACAAATGAACTGAATGCAATTTTCTCCACAGACCATATAAGACTGCCTATGTACCTCCTCCTACATGCCATTGG TTAACCATCAGTCAGTTTGCAGGGGTGGGGGGAGGGGTTTCCTGCCCATTGTTTTTGTAATCTCTGAGGAGAAGCAGCAGCAAACATTTG CTAGTCAGACAAGTGACAGGGAATGGATTCCAAACACCAGTGTGTAAAGCTAAATGATGGCCACTTCATGCCTGTATTGGGATTTGGCAC CTATGCACCTCCAGAGGTTCCGAGAAGTAAAGCTTTGGAGGTCACAAAATTAGCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTCA TTTATACAATAATGAGGAGCAGGTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTCTACACTTC AAAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGTCCGACCAGCCTTGGAAAACTCACTGAAGAAAGCTCAATTGGACTATGTTGACCT CTATCTTATTCATTCTCCAATGTCTCTAAAGCCAGGTGAGGAACTTTCACCAACAGATGAAAATGGAAAAGTAATATTTGACATAGTGGA TCTCTGTACCACCTGGGAGGCCATGGAGAAGTGTAAGGATGCAGGATTGGCCAAGTCCATTGGGGTGTCAAACTTCAACCGCAGGCAGCT GGAGATGATCCTCAACAAGCCAGGACTCAAGTACAAGCCTGTCTGCAACCAGGTAGAATGTCATCCGTATTTCAACCGGAGTAAATTGCT AGATTTCTGCAAGTCGAAAGATATTGTTCTGGTTGCCTATAGTGCTCTGGGATCTCAACGAGACAAACGATGGGTGGACCCGAACTCCCC GGTGCTCTTGGAGGACCCAGTCCTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAGCTGCAGCG TGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAACGTGCAGCCTCCTCATCCAGAATGGATCATGAGCTGCAG TGAACTTTCCTTCTGCCTCTCACATCCTCGAGTGCAGGACTTGCCTCTGGACGAGAGCAACATGGTTATTCCCAGTGACACGGACTTCCT GGACACGTGGGAGGCCATGGAGGACCTGGTGATCACCGGGCTGGTGAAGAACATCGGGGTGTCAAACTTCAACCATGAACAGCTTGAGAG GCTTTTGAATAAGCCTGGGTTGAGGTTCAAGCCACTAACCAACCAGATTGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTTT TTGCCAATCCAGAGATGTGTCCGTGACTGCTTACCGTCCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTGATAGACAACCCTGTGATCAA GAGGATTGCAAAGGAGCACGGCAAGTCTCCTGCTCAGATTTTGATCCGATTTCAAATCCAGAGGAATGTGATAGTGATCCCCGGATCTAT CACCCCAAGTCACATTAAAGAGAATATCCAGGTGTTTGATTTTGAATTAACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGAA TCTCCGACTGGCCATGTTCCCCATAACTAAAAATCACAAAGACTATCCTTTCCACATAGAATACTGAGGACGCTTCCCCTTCCTTGTTTC TGCTCAGCCCAGATGCACAGACACTATTGGCAATGTTGACCCTCCTCTGTCATCACAGCGCCAGGGCAGCTGTGCCTGGGACAGGAGCCA CACAGTCAGAGGGGGATGTAAGAGCCACCTTCTCTGACAAATCTGGAGAATTGAGTGTGTTCTAAGTGAAGGCAATGGGGTTTCTCCAAG ACAGCCTGTGTGGCCTCTACTCTGAACAAATACACTGATGAGTCATCAGTGAAATTTGCCTTCACATTTTAAGAAAACTTTATCTTATGG AGTTATTTAAGCCATCTACAGAGCTGAGGAAACAGTGTAATGTGTCTCTGCCCCATTGCGCAGCTCCACCCATTGTGCCCCAGGCCAGCC CGCGTCACCTACACTTCCTTCTGTGCCCTGCCAGTGACCCCCAGGTTATTCTAAAGCAGAGTCCTTCCCTTCCCCCAGTGAGAAGGAAAA >In-frame_AKR1C3_ENST00000605149_chr10_5139742_+_AKR1E2_ENST00000298375_chr10_4872867_+_2081nt TTTTTGCTGAACATTCCCCTTAGTAAAATGGCAGGATGGTTTGCTTGCCATTGAAACTAACCAAACATTTAATCCTTTTCCCTTTAGAGA AAAAAGAAAAAAAAAGGTGCAGCTCACTGCCAGTGCCCATTTAGTTTTACATTAACATGTTCCTTGAGGTTGAAGCAAATCTGACCGATT TTCAATGTAAAAATAACATATAAAAACTGTTCTCGGAGTTATTTCTAAACAGAACTAAGATCAGAATTCTTTGAATCATCAGAATCATCT CTTTTGAAAAATCGATTCATCAAATGAATCTTCAGCCAACAACTGTTCAAGAAGGATGCAAATATCACAGGTTCCGAGAAGTAAAGCTTT GGAGGTCACAAAATTAGCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTCATTTATACAATAATGAGGAGCAGGTTGGACTGGCCAT CCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTCTACACTTCAAAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGT CCGACCAGCCTTGGAAAACTCACTGAAGAAAGCTCAATTGGACTATGTTGACCTCTATCTTATTCATTCTCCAATGTCTCTAAAGGCTTC TCCAGGGAAAGTGACCGAGGCAGTGAAAGAGGCCATTGACGCAGGGTACCGGCACTTCGACTGTGCTTACTTTTACCACAATGAGAGGGA GGTTGGAGCAGGGATCCGTTGCAAGATCAAGGAAGGCGCTGTAAGACGGGAGGATCTGTTCATTGCCACTAAGCTGTGGTGCACCTGCCA TAAGAAGTCCTTGGTGGAAACAGCATGCAGAAAGAGTCTCAAGGCCTTGAAGCTGAACTATTTGGACCTCTACCTCATACACTGGCCCAT GGGTTTCAAGCCTCCTCATCCAGAATGGATCATGAGCTGCAGTGAACTTTCCTTCTGCCTCTCACATCCTCGAGTGCAGGACTTGCCTCT GGACGAGAGCAACATGGTTATTCCCAGTGACACGGACTTCCTGGACACGTGGGAGGCCATGGAGGACCTGGTGATCACCGGGCTGGTGAA GAACATCGGGGTGTCAAACTTCAACCATGAACAGCTTGAGAGGCTTTTGAATAAGCCTGGGTTGAGGTTCAAGCCACTAACCAACCAGAT TGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTTTTTGCCAATCCAGAGATGTGTCCGTGACTGCTTACCGTCCTCTTGGTGG CTCGTGTGAGGGGGTTGACCTGATAGACAACCCTGTGATCAAGAGGATTGCAAAGGAGCACGGCAAGTCTCCTGCTCAGATTTTGATCCG ATTTCAAATCCAGAGGAATGTGATAGTGATCCCCGGATCTATCACCCCAAGTCACATTAAAGAGAATATCCAGGTGTTTGATTTTGAATT AACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGAATCTCCGACTGGCCATGTTCCCCATAACTAAAAATCACAAAGACTATCC TTTCCACATAGAATACTGAGGACGCTTCCCCTTCCTTGTTTCTGCTCAGCCCAGATGCACAGACACTATTGGCAATGTTGACCCTCCTCT GTCATCACAGCGCCAGGGCAGCTGTGCCTGGGACAGGAGCCACACAGTCAGAGGGGGATGTAAGAGCCACCTTCTCTGACAAATCTGGAG AATTGAGTGTGTTCTAAGTGAAGGCAATGGGGTTTCTCCAAGACAGCCTGTGTGGCCTCTACTCTGAACAAATACACTGATGAGTCATCA GTGAAATTTGCCTTCACATTTTAAGAAAACTTTATCTTATGGAGTTATTTAAGCCATCTACAGAGCTGAGGAAACAGTGTAATGTGTCTC TGCCCCATTGCGCAGCTCCACCCATTGTGCCCCAGGCCAGCCCGCGTCACCTACACTTCCTTCTGTGCCCTGCCAGTGACCCCCAGGTTA TTCTAAAGCAGAGTCCTTCCCTTCCCCCAGTGAGAAGGAAAATGGGATAAGTCTGGGACACTGTTTCAGTTCAATAAAGAGGCTTTTTTC >In-frame_AKR1C3_ENST00000439082_chr10_5139742_+_AKR1E2_ENST00000298375_chr10_4872867_+_1938nt AACATGTTCCTTGAGGTTGAAGCAAATCTGACCGATTTTCAATGTAAAAATAACATATAAAAACTGTTCTCGGAGTTATTTCTAAACAGA ACTAAGATCAGAATTCTTTGAATCATCAGAATCATCTCTTTTGAAAAATCGATTCATCAAATGAATCTTCAGCCAACAACTGTTCAAGAA GGATGCAAATATCACAGGTTCCGAGAAGTAAAGCTTTGGAGGTCACAAAATTAGCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTC ATTTATACAATAATGAGGAGCAGGTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTCTACACTT CAAAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGTCCGACCAGCCTTGGAAAACTCACTGAAGAAAGCTCAATTGGACTATGTTGACC TCTATCTTATTCATTCTCCAATGTCTCTAAAGGCTTCTCCAGGGAAAGTGACCGAGGCAGTGAAAGAGGCCATTGACGCAGGGTACCGGC ACTTCGACTGTGCTTACTTTTACCACAATGAGAGGGAGGTTGGAGCAGGGATCCGTTGCAAGATCAAGGAAGGCGCTGTAAGACGGGAGG ATCTGTTCATTGCCACTAAGCTGTGGTGCACCTGCCATAAGAAGTCCTTGGTGGAAACAGCATGCAGAAAGAGTCTCAAGGCCTTGAAGC TGAACTATTTGGACCTCTACCTCATACACTGGCCCATGGGTTTCAAGCCTCCTCATCCAGAATGGATCATGAGCTGCAGTGAACTTTCCT TCTGCCTCTCACATCCTCGAGTGCAGGACTTGCCTCTGGACGAGAGCAACATGGTTATTCCCAGTGACACGGACTTCCTGGACACGTGGG AGGCCATGGAGGACCTGGTGATCACCGGGCTGGTGAAGAACATCGGGGTGTCAAACTTCAACCATGAACAGCTTGAGAGGCTTTTGAATA AGCCTGGGTTGAGGTTCAAGCCACTAACCAACCAGATTGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTTTTTGCCAATCCA GAGATGTGTCCGTGACTGCTTACCGTCCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTGATAGACAACCCTGTGATCAAGAGGATTGCAA AGGAGCACGGCAAGTCTCCTGCTCAGATTTTGATCCGATTTCAAATCCAGAGGAATGTGATAGTGATCCCCGGATCTATCACCCCAAGTC ACATTAAAGAGAATATCCAGGTGTTTGATTTTGAATTAACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGAATCTCCGACTGG CCATGTTCCCCATAACTAAAAATCACAAAGACTATCCTTTCCACATAGAATACTGAGGACGCTTCCCCTTCCTTGTTTCTGCTCAGCCCA GATGCACAGACACTATTGGCAATGTTGACCCTCCTCTGTCATCACAGCGCCAGGGCAGCTGTGCCTGGGACAGGAGCCACACAGTCAGAG GGGGATGTAAGAGCCACCTTCTCTGACAAATCTGGAGAATTGAGTGTGTTCTAAGTGAAGGCAATGGGGTTTCTCCAAGACAGCCTGTGT GGCCTCTACTCTGAACAAATACACTGATGAGTCATCAGTGAAATTTGCCTTCACATTTTAAGAAAACTTTATCTTATGGAGTTATTTAAG CCATCTACAGAGCTGAGGAAACAGTGTAATGTGTCTCTGCCCCATTGCGCAGCTCCACCCATTGTGCCCCAGGCCAGCCCGCGTCACCTA CACTTCCTTCTGTGCCCTGCCAGTGACCCCCAGGTTATTCTAAAGCAGAGTCCTTCCCTTCCCCCAGTGAGAAGGAAAATGGGATAAGTC >In-frame_AKR1C3_ENST00000380554_chr10_5139742_+_AKR1E2_ENST00000298375_chr10_4872867_+_2477nt CCCTCATCAGGATTACAGCTTTATCAGGACTGCATCTTCTTCAGAAATGAATATTTCTCTTACAACGCAAAGAAAGAAAAATCAAAATAA ATTTTCTGATTGAAAATGTAAAAAGGCAAATATTTTTACAGTTTTAACTTTAATTTTTTATTGAGGACCAACTATTTGAAAAATTCTCAT TAGTCATTCCTTTAAATTATGTGTATGTGAGAGAAAGACGTAAGATGGTTAATTATTTCAAATGATGCAGTATAAAGAAGGGGCATTATC ACGGCAGAAACGAAAAAAGATATTTGTAGCTGGAGGTTTTTATAGTCTAACATATGGTTGCTATTTGTTCTACAAATCCTTTTGAATAAT TTAATATAGAGATTTAGAATAGAAAATAATACTTTAGATAGAAATTAATGAGTTTATTATAACCATATATTATAATAATTTACTTAGGAA TTCTCTTTGATAAGAAACAAATGAACTGAATGCAATTTTCTCCACAGACCATATAAGACTGCCTATGTACCTCCTCCTACATGCCATTGG TTAACCATCAGTCAGTTTGCAGGGGTGGGGGGAGGGGTTTCCTGCCCATTGTTTTTGTAATCTCTGAGGAGAAGCAGCAGCAAACATTTG CTAGTCAGACAAGTGACAGGGAATGGATTCCAAACACCAGTGTGTAAAGCTAAATGATGGCCACTTCATGCCTGTATTGGGATTTGGCAC CTATGCACCTCCAGAGGTTCCGAGAAGTAAAGCTTTGGAGGTCACAAAATTAGCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTCA TTTATACAATAATGAGGAGCAGGTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTCTACACTTC AAAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGTCCGACCAGCCTTGGAAAACTCACTGAAGAAAGCTCAATTGGACTATGTTGACCT CTATCTTATTCATTCTCCAATGTCTCTAAAGGCTTCTCCAGGGAAAGTGACCGAGGCAGTGAAAGAGGCCATTGACGCAGGGTACCGGCA CTTCGACTGTGCTTACTTTTACCACAATGAGAGGGAGGTTGGAGCAGGGATCCGTTGCAAGATCAAGGAAGGCGCTGTAAGACGGGAGGA TCTGTTCATTGCCACTAAGCTGTGGTGCACCTGCCATAAGAAGTCCTTGGTGGAAACAGCATGCAGAAAGAGTCTCAAGGCCTTGAAGCT GAACTATTTGGACCTCTACCTCATACACTGGCCCATGGGTTTCAAGCCTCCTCATCCAGAATGGATCATGAGCTGCAGTGAACTTTCCTT CTGCCTCTCACATCCTCGAGTGCAGGACTTGCCTCTGGACGAGAGCAACATGGTTATTCCCAGTGACACGGACTTCCTGGACACGTGGGA GGCCATGGAGGACCTGGTGATCACCGGGCTGGTGAAGAACATCGGGGTGTCAAACTTCAACCATGAACAGCTTGAGAGGCTTTTGAATAA GCCTGGGTTGAGGTTCAAGCCACTAACCAACCAGATTGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTTTTTGCCAATCCAG AGATGTGTCCGTGACTGCTTACCGTCCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTGATAGACAACCCTGTGATCAAGAGGATTGCAAA GGAGCACGGCAAGTCTCCTGCTCAGATTTTGATCCGATTTCAAATCCAGAGGAATGTGATAGTGATCCCCGGATCTATCACCCCAAGTCA CATTAAAGAGAATATCCAGGTGTTTGATTTTGAATTAACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGAATCTCCGACTGGC CATGTTCCCCATAACTAAAAATCACAAAGACTATCCTTTCCACATAGAATACTGAGGACGCTTCCCCTTCCTTGTTTCTGCTCAGCCCAG ATGCACAGACACTATTGGCAATGTTGACCCTCCTCTGTCATCACAGCGCCAGGGCAGCTGTGCCTGGGACAGGAGCCACACAGTCAGAGG GGGATGTAAGAGCCACCTTCTCTGACAAATCTGGAGAATTGAGTGTGTTCTAAGTGAAGGCAATGGGGTTTCTCCAAGACAGCCTGTGTG GCCTCTACTCTGAACAAATACACTGATGAGTCATCAGTGAAATTTGCCTTCACATTTTAAGAAAACTTTATCTTATGGAGTTATTTAAGC CATCTACAGAGCTGAGGAAACAGTGTAATGTGTCTCTGCCCCATTGCGCAGCTCCACCCATTGTGCCCCAGGCCAGCCCGCGTCACCTAC ACTTCCTTCTGTGCCCTGCCAGTGACCCCCAGGTTATTCTAAAGCAGAGTCCTTCCCTTCCCCCAGTGAGAAGGAAAATGGGATAAGTCT |
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FusionGenePPI for AKR1C3_AKR1E2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| AKR1C3 | MAGEA11, UBE2W, ZHX1, LRIF1, AKR1C2, AKR1C4, AKR1C1, AKR1D1, SIAH2 | AKR1E2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AKR1C3_AKR1E2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | AKR1C3 | P42330 | DB00328 | Indomethacin | Aldo-keto reductase family 1 member C3 | small molecule | approved|investigational |
| Hgene | AKR1C3 | P42330 | DB00905 | Bimatoprost | Aldo-keto reductase family 1 member C3 | small molecule | approved|investigational |
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RelatedDiseases for AKR1C3_AKR1E2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | AKR1C3 | C0032460 | Polycystic Ovary Syndrome | 3 | CTD_human |
| Hgene | AKR1C3 | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
| Hgene | AKR1C3 | C0014175 | Endometriosis | 2 | CTD_human |
| Hgene | AKR1C3 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Hgene | AKR1C3 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | AKR1C3 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| Hgene | AKR1C3 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| Hgene | AKR1C3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | AKR1C3 | C0027661 | Neoplasms, Hormone-Dependent | 1 | CTD_human |
| Hgene | AKR1C3 | C0028754 | Obesity | 1 | CTD_human |
| Hgene | AKR1C3 | C0036875 | Disorders of Sex Development | 1 | CTD_human |
| Hgene | AKR1C3 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Hgene | AKR1C3 | C0338831 | Manic | 1 | PSYGENET |
| Hgene | AKR1C3 | C0564408 | Manic mood | 1 | PSYGENET |
| Hgene | AKR1C3 | C3658267 | Prostatic Neoplasms, Castration-Resistant | 1 | CTD_human |
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